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Ccube: A fast and robust method for estimating cancer cell fractions

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1016/j.cell.2012.04.023openalex-snapshot
The Life History of 21 Breast Cancers
inferredcites →https://doi.org/10.1016/j.neunet.2006.06.009openalex-snapshot
Robust Bayesian clustering
inferredcites →https://doi.org/10.1038/nmeth.2883openalex-snapshot
PyClone: statistical inference of clonal population structure in cancer
inferredcites →https://doi.org/10.1186/1471-2105-15-35openalex-snapshot
Inferring clonal evolution of tumors from single nucleotide somatic mutations
inferredcites →https://doi.org/10.1186/s13059-015-0602-8openalex-snapshot
PhyloWGS: Reconstructing subclonal composition and evolution from whole-genome sequencing of tumors

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1007/978-1-0716-3291-8_6openalex-snapshot
Reconstructing Phylogenetic Relationship in Bladder Cancer: A Methodological Overview
inferred← citeshttps://doi.org/10.1016/j.cels.2021.07.006openalex-snapshot
DeCiFering the elusive cancer cell fraction in tumor heterogeneity and evolution
inferred← citeshttps://doi.org/10.1038/s41408-020-00367-2openalex-snapshot
An enhanced genetic model of relapsed IGH-translocated multiple myeloma evolutionary dynamics
inferred← citeshttps://doi.org/10.1038/s41408-021-00570-9openalex-snapshot
Cancer drivers and clonal dynamics in acute lymphoblastic leukaemia subtypes
inferred← citeshttps://doi.org/10.1038/s41467-020-14351-8openalex-snapshot
Inferring structural variant cancer cell fraction
inferred← citeshttps://doi.org/10.1038/s41467-021-24992-yopenalex-snapshot
CloneSig can jointly infer intra-tumor heterogeneity and mutational signature activity in bulk tumor sequencing data
inferred← citeshttps://doi.org/10.1038/s41467-021-26698-7openalex-snapshot
Benchmarking pipelines for subclonal deconvolution of bulk tumour sequencing data
inferred← citeshttps://doi.org/10.1038/s41467-023-43373-1openalex-snapshot
Genomic profiling of subcutaneous patient-derived xenografts reveals immune constraints on tumor evolution in childhood solid cancer
inferred← citeshttps://doi.org/10.1038/s41467-023-44158-2openalex-snapshot
Clinical application of tumour-in-normal contamination assessment from whole genome sequencing
inferred← citeshttps://doi.org/10.1038/s41467-025-59923-8openalex-snapshot
APOBEC affects tumor evolution and age at onset of lung cancer in smokers
inferred← citeshttps://doi.org/10.1038/s41467-025-66780-yopenalex-snapshot
Microbiome analysis of 940 lung cancers in never-smokers reveals lack of clinically relevant associations
inferred← citeshttps://doi.org/10.1038/s41586-024-08107-3openalex-snapshot
Origins and impact of extrachromosomal DNA
inferred← citeshttps://doi.org/10.1038/s41586-025-09219-0openalex-snapshot
The mutagenic forces shaping the genomes of lung cancer in never smokers
inferred← citeshttps://doi.org/10.1038/s41586-025-09825-yopenalex-snapshot
Uncovering the role of LINE-1 in the evolution of lung adenocarcinoma
inferred← citeshttps://doi.org/10.1038/s41587-024-02250-yopenalex-snapshot
Crowd-sourced benchmarking of single-sample tumor subclonal reconstruction
inferred← citeshttps://doi.org/10.1038/s41588-025-02474-xopenalex-snapshot
Comprehensive repertoire of the chromosomal alteration and mutational signatures across 16 cancer types
inferred← citeshttps://doi.org/10.1093/bioinformatics/btaa672openalex-snapshot
A statistical approach for tracking clonal dynamics in cancer using longitudinal next-generation sequencing data
inferred← citeshttps://doi.org/10.1101/2021.02.13.429885openalex-snapshot
Computational validation of clonal and subclonal copy number alterations from bulk tumour sequencing
inferred← citeshttps://doi.org/10.1101/2022.06.14.495937openalex-snapshot
Crowd-sourced benchmarking of single-sample tumour subclonal reconstruction
inferred← citeshttps://doi.org/10.1101/2024.01.30.24301554openalex-snapshot
Convergence for Inactivation of TGFβ Signaling Is a Common Feature of Advanced Pancreatic Cancer
inferred← citeshttps://doi.org/10.1101/2024.04.02.587805openalex-snapshot
APOBEC shapes tumor evolution and age at onset of lung cancer in smokers
inferred← citeshttps://doi.org/10.1101/2024.05.15.24307318openalex-snapshot
The mutagenic forces shaping the genomic landscape of lung cancer in never smokers
inferred← citeshttps://doi.org/10.1101/2024.07.03.601939openalex-snapshot
Subclonal mutation load predicts survival and response to immunotherapy in cancers with low to moderate tumor mutation burden
inferred← citeshttps://doi.org/10.1101/2025.02.01.636056openalex-snapshot
Longitudinal structural variant phylogenies define tumor evolution under therapeutic selection pressure in metastatic prostate cancer
inferred← citeshttps://doi.org/10.1101/2025.03.14.643063openalex-snapshot
Deciphering lung adenocarcinoma evolution and the role of LINE-1 retrotransposition
inferred← citeshttps://doi.org/10.1101/2025.06.12.655573openalex-snapshot
A Thiopurine-like Mutagenic Process Defines TGCT Subtypes
inferred← citeshttps://doi.org/10.1101/2025.09.09.25335109openalex-snapshot
Panorama of Chromosomal Instability in Lung Cancer
inferred← citeshttps://doi.org/10.1101/825778openalex-snapshot
CloneSig can jointly infer intra-tumor heterogeneity and mutational signature activity in bulk tumor sequencing data
inferred← citeshttps://doi.org/10.1101/836171openalex-snapshot
Correcting reference bias from the Illumina Isaac aligner enables analysis of cancer genomes
inferred← citeshttps://doi.org/10.1136/gutjnl-2025-337030openalex-snapshot
Comparison between germline and somatic loss-of-function RNF43 mutations reveals different genotype-phenotype associations and provides insights into the genetic mechanisms of colorectal tumourigenesis
inferred← citeshttps://doi.org/10.1186/s13059-024-03170-5openalex-snapshot
Computational validation of clonal and subclonal copy number alterations from bulk tumor sequencing using CNAqc
inferred← citeshttps://doi.org/10.21203/rs.3.rs-6735635/v1openalex-snapshot
A Thiopurine-like Mutagenic Process Defines TGCT Subtypes
inferred← citeshttps://doi.org/10.70675/302fb443z8270z4f6ezbbf7z20e95637a756openalex-snapshot
Statistical methods for deciphering intra-tumor hereterogeneity : challenges and opportunities for cancer clinical management
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