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Analysis of metabolic pathways in mycobacteria to aid drug-target identification

https://doi.org/10.1101/535856
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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JOY: protein sequence-structure representation and analysis.
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PSORTb 3.0: improved protein subcellular localization prediction with refined localization subcategories and predictive capabilities for all prokaryotes
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CD-HIT: accelerated for clustering the next-generation sequencing data
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GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit
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DrugBank 5.0: a major update to the DrugBank database for 2018
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Therapeutic target database update 2018: enriched resource for facilitating bench-to-clinic research of targeted therapeutics
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CATH: expanding the horizons of structure-based functional annotations for genome sequences
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Mycobacterium tuberculosis Metabolism
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Computational Analysis of Plasmodium falciparum Metabolism: Organizing Genomic Information to Facilitate Drug Discovery
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MolProbity : all-atom structure validation for macromolecular crystallography
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Preliminary X-ray crystallographic analysis of ornithine acetyltransferase (Rv1653) fromMycobacterium tuberculosis
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Carbon metabolism of intracellular bacteria
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Construction and Phenotypic Characterization of an Auxotrophic Mutant of Mycobacterium tuberculosis Defective in l -Arginine Biosynthesis
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Comparative Genome-Scale Metabolic Reconstruction and Flux Balance Analysis of Multiple Staphylococcus aureus Genomes Identify Novel Antimicrobial Drug Targets
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Cloning and characterization of plasmid-encoded genes for the degradation of 1,2-dichloro-, 1,4-dichloro-, and 1,2,4-trichlorobenzene of Pseudomonas sp. strain P51
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Fermentative arginine degradation in Halobacterium salinarium (formerly Halobacterium halobium): genes, gene products, and transcripts of the arcRACB gene cluster
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Arginine biosynthesis and regulation in Lactobacillus plantarum: the carA gene and the argCJBDF cluster are divergently transcribed
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COBRApy: COnstraints-Based Reconstruction and Analysis for Python
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Updated and standardized genome-scale reconstruction of Mycobacterium tuberculosis H37Rv, iEK1011, simulates flux states indicative of physiological conditions
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A Stochastic Approximation Method
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Non Mycobacterial Virulence Genes in the Genome of the Emerging Pathogen Mycobacterium abscessus
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The microbial physiologist's guide to the leprosy genome

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Growth Dependent Computation of Chokepoints in Metabolic Networks
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Synthesis and Antileprotic Activity of Compounds with Benzofuran, Indene, Triazene, and Hydrazone Fragments
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Strategies for drug target identification in Mycobacterium leprae
inferred← citeshttps://doi.org/10.4018/ijoci.312223openalex-snapshot
A Systematic Literature Review of the Current Status and Future Prospects of Machine Learning Methods and Techniques Applied to Novel Drug Discovery
inferred← citeshttps://doi.org/10.46471/gigabyte.80openalex-snapshot
Mycobacterial metabolic model development for drug target identification
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