On the public citation graph

Blood-brain barrier dysfunction in aging induces hyper-activation of TGF-beta signaling and chronic yet reversible neural dysfunction

0 signed · 113 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.
Claim with ORCID
Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.
See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/archneurol.2009.15openalex-snapshot
Epilepsy and Cognitive Impairments in Alzheimer Disease
inferredcites →https://doi.org/10.1001/jamaneurol.2013.136openalex-snapshot
Seizures and Epileptiform Activity in the Early Stages of Alzheimer Disease
inferredcites →https://doi.org/10.1001/jamaneurol.2014.2682openalex-snapshot
Imaging Blood-Brain Barrier Dysfunction in Football Players
inferredcites →https://doi.org/10.1002/ana.24147openalex-snapshot
Losartan prevents acquired epilepsy via TGF‐β signaling suppression
inferredcites →https://doi.org/10.1002/ana.24794openalex-snapshot
Incidence and impact of subclinical epileptiform activity in Alzheimer's disease
inferredcites →https://doi.org/10.1002/emmm.201202197openalex-snapshot
Vascular‐derived TGF‐β increases in the stem cell niche and perturbs neurogenesis during aging and following irradiation in the adult mouse brain
inferredcites →https://doi.org/10.1007/bf00293954openalex-snapshot
The relationship between plasma protein extravasation and remote tissue changes after experimental brain infarction
inferredcites →https://doi.org/10.1007/s13311-017-0541-zopenalex-snapshot
Targeting Neural Hyperactivity as a Treatment to Stem Progression of Late-Onset Alzheimer's Disease
inferredcites →https://doi.org/10.1016/0013-4694(86)90184-7openalex-snapshot
Computerized EEG spectral analysis in elderly normal, demented and depressed subjects
inferredcites →https://doi.org/10.1016/0166-4328(93)90132-aopenalex-snapshot
The aged mouse as a model of cognitive decline with special emphasis on studies in NMRI mice
inferredcites →https://doi.org/10.1016/j.arcmed.2014.11.016openalex-snapshot
Blood–Brain Barrier Imaging in Human Neuropathologies
inferredcites →https://doi.org/10.1016/j.bbi.2013.12.018openalex-snapshot
Age-dependent changes on TGFβ1 Smad3 pathway modify the pattern of microglial cell activation
inferredcites →https://doi.org/10.1016/j.biopsych.2004.10.034openalex-snapshot
Molecular aging in human prefrontal cortex is selective and continuous throughout adult life
inferredcites →https://doi.org/10.1016/j.brainres.2015.04.056openalex-snapshot
Glio-vascular changes during ageing in wild-type and Alzheimer׳s disease-like APP/PS1 mice
inferredcites →https://doi.org/10.1016/j.cell.2015.10.067openalex-snapshot
Establishment and Dysfunction of the Blood-Brain Barrier
inferredcites →https://doi.org/10.1016/j.celrep.2016.12.011openalex-snapshot
Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging
inferredcites →https://doi.org/10.1016/j.celrep.2017.12.092openalex-snapshot
Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease
inferredcites →https://doi.org/10.1016/j.clinph.2004.01.001openalex-snapshot
EEG dynamics in patients with Alzheimer's disease
inferredcites →https://doi.org/10.1016/j.eplepsyres.2005.07.016openalex-snapshot
Epidemiological and medical aspects of epilepsy in the elderly
inferredcites →https://doi.org/10.1016/j.expneurol.2013.03.012openalex-snapshot
Hippocampal excitability is increased in aged mice
inferredcites →https://doi.org/10.1016/j.jalz.2007.10.008openalex-snapshot
Electroencephalography and event‐related potentials as biomarkers of mild cognitive impairment and mild Alzheimer's disease
inferredcites →https://doi.org/10.1016/j.jneumeth.2005.08.006openalex-snapshot
Fluorescence imaging of blood–brain barrier disruption
inferredcites →https://doi.org/10.1016/j.jneumeth.2014.08.017openalex-snapshot
Finding degrees of separation: Experimental approaches for astroglial and oligodendroglial cell isolation and genetic targeting
inferredcites →https://doi.org/10.1016/j.jns.2009.02.089openalex-snapshot
Blood brain barrier: ageing and microvascular disease-systematic review and meta-analysis
inferredcites →https://doi.org/10.1016/j.lfs.2010.09.004openalex-snapshot
Assessment of spatial memory in mice
inferredcites →https://doi.org/10.1016/j.nbd.2009.07.030openalex-snapshot
Structure and function of the blood–brain barrier
inferredcites →https://doi.org/10.1016/j.nbd.2009.10.006openalex-snapshot
Inflammation, microglia, and alzheimer's disease
inferredcites →https://doi.org/10.1016/j.nbd.2015.02.029openalex-snapshot
Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood–brain barrier dysfunction
inferredcites →https://doi.org/10.1016/j.nbd.2016.03.008openalex-snapshot
Synaptic plasticity in area CA1 of rat hippocampal slices following intraventricular application of albumin
inferredcites →https://doi.org/10.1016/j.nbd.2016.07.007openalex-snapshot
The blood-brain barrier in Alzheimer's disease
inferredcites →https://doi.org/10.1016/j.neubiorev.2004.03.004openalex-snapshot
Regional dissociations within the hippocampus—memory and anxiety
inferredcites →https://doi.org/10.1016/j.neurobiolaging.2003.12.007openalex-snapshot
MRI-derived entorhinal volume is a good predictor of conversion from MCI to AD
inferredcites →https://doi.org/10.1016/j.neurobiolaging.2007.07.015openalex-snapshot
Blood–brain barrier: Ageing and microvascular disease – systematic review and meta-analysis
inferredcites →https://doi.org/10.1016/j.neurobiolaging.2009.10.005openalex-snapshot
Prominent hippocampal CA3 gene expression profile in neurocognitive aging
inferredcites →https://doi.org/10.1016/j.neurobiolaging.2016.10.027openalex-snapshot
Early hippocampal hyperexcitability in PS2APP mice: role of mutant PS2 and APP
inferredcites →https://doi.org/10.1016/j.neurobiolaging.2017.06.028openalex-snapshot
CSF/serum albumin ratio in dementias: a cross-sectional study on 1861 patients
inferredcites →https://doi.org/10.1016/j.neuroimage.2010.03.040openalex-snapshot
High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic Mild Cognitive Impairment
inferredcites →https://doi.org/10.1016/j.neuron.2007.07.025openalex-snapshot
Aberrant Excitatory Neuronal Activity and Compensatory Remodeling of Inhibitory Hippocampal Circuits in Mouse Models of Alzheimer's Disease
inferredcites →https://doi.org/10.1016/j.neuron.2014.12.032openalex-snapshot
Blood-Brain Barrier Breakdown in the Aging Human Hippocampus
inferredcites →https://doi.org/10.1016/j.neuron.2015.09.036openalex-snapshot
Lack of Widespread BBB Disruption in Alzheimer’s Disease Models: Focus on Therapeutic Antibodies
inferredcites →https://doi.org/10.1016/j.neuropharm.2017.10.034openalex-snapshot
MRI measurements of Blood-Brain Barrier function in dementia: A review of recent studies
inferredcites →https://doi.org/10.1016/j.physbeh.2006.09.013openalex-snapshot
Characteristics of object location memory in mice: Behavioral and pharmacological studies
inferredcites →https://doi.org/10.1016/j.yebeh.2012.11.040openalex-snapshot
Shared cognitive and behavioral impairments in epilepsy and Alzheimer's disease and potential underlying mechanisms
inferredcites →https://doi.org/10.1016/s0149-7634(01)00041-0openalex-snapshot
The neurobiological basis of spontaneous alternation
inferredcites →https://doi.org/10.1016/s0165-0270(97)00168-4openalex-snapshot
Changes in blood–brain barrier permeability following neurotoxic lesions of rat brain can be visualised with trypan blue
inferredcites →https://doi.org/10.1016/s1474-4422(16)00070-3openalex-snapshot
CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis
inferredcites →https://doi.org/10.1037/a0020893openalex-snapshot
Pattern separation deficits may contribute to age-associated recognition impairments.
inferredcites →https://doi.org/10.1038/nature02661openalex-snapshot
Gene regulation and DNA damage in the ageing human brain
inferredcites →https://doi.org/10.1038/nature08983openalex-snapshot
Neural mechanisms of ageing and cognitive decline
inferredcites →https://doi.org/10.1038/nature21029openalex-snapshot
Neurotoxic reactive astrocytes are induced by activated microglia
inferredcites →https://doi.org/10.1038/ng.2653openalex-snapshot
The Genotype-Tissue Expression (GTEx) project
inferredcites →https://doi.org/10.1038/nm.3616openalex-snapshot
Obesity- and aging-induced excess of central transforming growth factor-β potentiates diabetic development via an RNA stress response
inferredcites →https://doi.org/10.1038/nm.4330openalex-snapshot
Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease
inferredcites →https://doi.org/10.1038/nn.4017openalex-snapshot
The case for rejecting the amyloid cascade hypothesis
inferredcites →https://doi.org/10.1038/nn.4142openalex-snapshot
Do glia drive synaptic and cognitive impairment in disease?
inferredcites →https://doi.org/10.1038/nn910openalex-snapshot
Spatial memory dissociations in mice lacking GluR1
inferredcites →https://doi.org/10.1038/nprot.2006.2openalex-snapshot
T-maze alternation in the rodent
inferredcites →https://doi.org/10.1038/nrn1886openalex-snapshot
Ageing and neuronal vulnerability
inferredcites →https://doi.org/10.1038/nrn3114openalex-snapshot
Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
inferredcites →https://doi.org/10.1038/nrn3200openalex-snapshot
The ageing cortical synapse: hallmarks and implications for cognitive decline
inferredcites →https://doi.org/10.1038/nrn3230openalex-snapshot
Insights into CNS ageing from animal models of senescence
inferredcites →https://doi.org/10.1038/nrn4020openalex-snapshot
Genomic integrity and the ageing brain
inferredcites →https://doi.org/10.1038/nrneurol.2017.188openalex-snapshot
Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders
inferredcites →https://doi.org/10.1038/s41591-018-0297-yopenalex-snapshot
Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction
inferredcites →https://doi.org/10.1038/s41598-017-07394-3openalex-snapshot
TGFβ signaling is associated with changes in inflammatory gene expression and perineuronal net degradation around inhibitory neurons following various neurological insults
inferredcites →https://doi.org/10.1038/srep20119openalex-snapshot
Interictal spikes during sleep are an early defect in the Tg2576 mouse model of β-amyloid neuropathology
inferredcites →https://doi.org/10.1073/pnas.1800165115openalex-snapshot
Normal aging induces A1-like astrocyte reactivity
inferredcites →https://doi.org/10.1073/pnas.96.9.5280openalex-snapshot
Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway
inferredcites →https://doi.org/10.1080/00365517709091496openalex-snapshot
Principles of albumin and IgG analyses in neurological disorders. I. Establishment of reference values
inferredcites →https://doi.org/10.1080/03610738108259823openalex-snapshot
Age-related differences in behavior across the life span of the C57BL/6J mouse
inferredcites →https://doi.org/10.1093/brain/awl317openalex-snapshot
TGF- receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis
inferredcites →https://doi.org/10.1093/brain/aww243openalex-snapshot
Whole-brain analysis reveals increased neuroanatomical asymmetries in dementia for hippocampus and amygdala
inferredcites →https://doi.org/10.1093/brain/awx350openalex-snapshot
Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model
inferredcites →https://doi.org/10.1093/jnen/74.12.1147openalex-snapshot
Blood-Brain Barrier Disruption Is an Early Event That May Persist for Many Years After Traumatic Brain Injury in Humans
inferredcites →https://doi.org/10.1101/lm.1365609openalex-snapshot
Memory deficits are associated with impaired ability to modulate neuronal excitability in middle-aged mice
inferredcites →https://doi.org/10.1111/j.1528-1157.1993.tb02586.xopenalex-snapshot
Incidence of Epilepsy and Unprovoked Seizures in Rochester, Minnesota: 1935–1984
inferredcites →https://doi.org/10.1111/j.1532-5415.1998.tb06654.xopenalex-snapshot
An Evaluation of Antiepileptic Drug Therapy In Nursing Facilities
inferredcites →https://doi.org/10.1111/j.1532-5415.2010.03011.xopenalex-snapshot
The Blood–Brain Barrier: Geriatric Relevance of a Critical Brain–Body Interface
inferredcites →https://doi.org/10.1148/radiol.2016152244openalex-snapshot
Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease
inferredcites →https://doi.org/10.1155/2011/143908openalex-snapshot
Blood-Brain Barrier Dysfunction in Epileptogenesis of the Temporal Lobe
inferredcites →https://doi.org/10.1155/2011/765923openalex-snapshot
Blood-Brain Barrier Breakdown Following Traumatic Brain Injury: A Possible Role in Posttraumatic Epilepsy
inferredcites →https://doi.org/10.1186/1742-2094-7-62openalex-snapshot
TGFβ signaling in the brain increases with aging and signals to astrocytes and innate immune cells in the weeks after stroke
inferredcites →https://doi.org/10.1186/2045-8118-10-9openalex-snapshot
Quantitative imaging assessment of blood-brain barrier permeability in humans
inferredcites →https://doi.org/10.1186/s13041-016-0191-9openalex-snapshot
Age-related changes in behavior in C57BL/6J mice from young adulthood to middle age
inferredcites →https://doi.org/10.1212/wnl.0000000000000733openalex-snapshot
Recommendations of the Alzheimer's Disease–Related Dementias Conference
inferredcites →https://doi.org/10.14283/jpad.2014.25openalex-snapshot
BLOOD-BRAIN BARRIER PERMEABILITY IN AGING AND ALZHEIMER’S DISEASE
inferredcites →https://doi.org/10.1523/jneurosci.0137-10.2010openalex-snapshot
Fibrinogen Triggers Astrocyte Scar Formation by Promoting the Availability of Active TGF-β after Vascular Damage
inferredcites →https://doi.org/10.1523/jneurosci.0430-09.2009openalex-snapshot
Transcriptome Profiling Reveals TGF- Signaling Involvement in Epileptogenesis
inferredcites →https://doi.org/10.1523/jneurosci.1698-15.2015openalex-snapshot
ComplementC3-Deficient Mice Fail to Display Age-Related Hippocampal Decline
inferredcites →https://doi.org/10.1523/jneurosci.1751-04.2004openalex-snapshot
Lasting Blood-Brain Barrier Disruption Induces Epileptic Focus in the Rat Somatosensory Cortex
inferredcites →https://doi.org/10.1523/jneurosci.2323-09.2009openalex-snapshot
Astrocytic Dysfunction in Epileptogenesis: Consequence of Altered Potassium and Glutamate Homeostasis?
inferredcites →https://doi.org/10.1523/jneurosci.2446-16.2017openalex-snapshot
Electrocorticographic Dynamics as a Novel Biomarker in Five Models of Epileptogenesis
inferredcites →https://doi.org/10.1523/jneurosci.4178-07.2008openalex-snapshot
A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function
inferredcites →https://doi.org/10.1667/rr14403.2openalex-snapshot
IPW-5371 Proves Effective as a Radiation Countermeasure by Mitigating Radiation-Induced Late Effects
inferredcites →https://doi.org/10.18632/oncotarget.3851openalex-snapshot
Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal
inferredcites →https://doi.org/10.3233/jad-130080openalex-snapshot
Altered Default Mode Network Connectivity in Older Adults with Cognitive Complaints and Amnestic Mild Cognitive Impairment
inferredcites →https://doi.org/10.3389/fnagi.2017.00261openalex-snapshot
The Abnormality of Topological Asymmetry between Hemispheric Brain White Matter Networks in Alzheimer’s Disease and Mild Cognitive Impairment
inferredcites →https://doi.org/10.3389/fpsyt.2010.00011openalex-snapshot
Mild cognitive disorders are associated with different patterns of brain asymmetry than normal aging: the PATH through life study
inferredcites →https://doi.org/10.3389/fpsyt.2018.00226openalex-snapshot
Asymmetry of Hippocampus and Amygdala Defect in Subjective Cognitive Decline Among the Community Dwelling Chinese
inferredcites →https://doi.org/10.4049/jimmunol.1401446openalex-snapshot
Differential TGF-β Signaling in Glial Subsets Underlies IL-6–Mediated Epileptogenesis in Mice

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1007/s10072-021-05339-3openalex-snapshot
Why is delirium more frequent in the elderly?
inferred← citeshttps://doi.org/10.1007/s11064-022-03773-zopenalex-snapshot
Overview Article Astrocytes as Initiators of Epilepsy
inferred← citeshttps://doi.org/10.1007/s11357-024-01404-9openalex-snapshot
Aging disrupts blood–brain and blood-spinal cord barrier homeostasis, but does not increase paracellular permeability
inferred← citeshttps://doi.org/10.1038/s41467-020-18405-9openalex-snapshot
Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging
inferred← citeshttps://doi.org/10.1093/med/9780197549469.003.0028openalex-snapshot
Inflammatory Astrocytic TGFβ Signaling Induced by Blood–Brain Barrier Dysfunction Drives Epileptogenesis
inferred← citeshttps://doi.org/10.1101/2023.03.06.530999openalex-snapshot
Molecular Consequences of Peripheral Influenza A Infection on Cell Populations in the Murine Hypothalamus
inferred← citeshttps://doi.org/10.1111/acel.13747openalex-snapshot
Blood–brain barrier dysfunction promotes astrocyte senescence through albumin‐induced TGFβ signaling activation
inferred← citeshttps://doi.org/10.1186/s12987-020-00216-1openalex-snapshot
The potential role of microvascular pathology in the neurological manifestations of coronavirus infection
inferred← citeshttps://doi.org/10.14336/ad.2023.1225openalex-snapshot
Aging Increases Hypoxia-Induced Endothelial Permeability and Blood-Brain Barrier Dysfunction by Upregulating Arginase-II
inferred← citeshttps://doi.org/10.21203/rs.3.rs-86988/v1openalex-snapshot
The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells
inferred← citeshttps://doi.org/10.31234/osf.io/gxepropenalex-snapshot
Investigating the Reversal of Blood-Brain Barrier Dysfunction in Human Subjects in a Neuroethical Context
inferred← citeshttps://doi.org/10.3390/ijms23116217openalex-snapshot
Blood–Brain Barrier Dysfunction and Astrocyte Senescence as Reciprocal Drivers of Neuropathology in Aging
inferred← citeshttps://doi.org/10.64898/2026.09.30.755839openalex-snapshot
Disease stage-sensitive MFSD2A-caveolae axis insigates hippocampal blood–brain barrier disruption in Alzheimer’s disease
Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.