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The pharmacodynamic inoculum effect from the perspective of bacterial population modeling

https://doi.org/10.1101/550368
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/jps.2600751108openalex-snapshot
A Pharmacodynamic Model for the Activity of Antibiotics Against Microorganisms under Nonsaturable Conditions
inferredcites →https://doi.org/10.1007/bf02490038openalex-snapshot
Diagnosis of Measles Pneumonia from Bronchoalveolar Lavage Fluid by Reverse-Transcriptase Polymerase Chain Reaction: Case Report
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An examination of single-hit and multi-hit hypotheses in relation to the possible kinetics of colicin adsorption
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Substance P as a baro- and chemoreceptor afferent neurotransmitter: Immunocytochemical and neurochemical evidence in the rat
inferredcites →https://doi.org/10.1016/0732-8893(83)90031-7openalex-snapshot
Considerations about the relationship of inhibitory concentrations and the pharmacologic and toxic properties of antimicrobial agents
inferredcites →https://doi.org/10.1016/j.bbamem.2020.183291openalex-snapshot
Binding of an antimicrobial peptide to bacterial cells: Interaction with different species, strains and cellular components
inferredcites →https://doi.org/10.1016/j.diagmicrobio.2003.11.007openalex-snapshot
In vitro killing of parenteral beta-lactams against standard and high inocula of extended-spectrum beta-lactamase and non-esbl producing klebsiella pneumoniae
inferredcites →https://doi.org/10.1016/j.diagmicrobio.2004.07.006openalex-snapshot
The inoculum effect: Fact or artifact?
inferredcites →https://doi.org/10.1016/j.diagmicrobio.2015.07.011openalex-snapshot
The cefazolin inoculum effect in methicillin-susceptible Staphylococcus aureus blood isolates: their association with dysfunctional accessory gene regulator (agr)
inferredcites →https://doi.org/10.1016/j.epidem.2008.07.001openalex-snapshot
No coexistence for free: Neutral null models for multistrain pathogens
inferredcites →https://doi.org/10.1016/j.jiac.2017.10.021openalex-snapshot
Inoculum effect of high concentrations of methicillin-susceptible Staphylococcus aureus on the efficacy of cefazolin and other beta-lactams
inferredcites →https://doi.org/10.1016/j.jtbi.2011.06.004openalex-snapshot
Restricted occupancy models for neutralization of HIV virions and populations
inferredcites →https://doi.org/10.1016/j.peptides.2009.11.010openalex-snapshot
Antimicrobial mechanism of pore-forming protegrin peptides: 100 pores to kill E. coli
inferredcites →https://doi.org/10.1016/s0169-5347(01)02144-9openalex-snapshot
How should pathogen transmission be modelled?
inferredcites →https://doi.org/10.1021/acschembio.6b00910openalex-snapshot
Cell-Density Dependence of Host-Defense Peptide Activity and Selectivity in the Presence of Host Cells
inferredcites →https://doi.org/10.1021/cb500426ropenalex-snapshot
How Many Antimicrobial Peptide Molecules Kill a Bacterium? The Case of PMAP-23
inferredcites →https://doi.org/10.1023/a:1016085402278openalex-snapshot
Pharmacokinetic-Pharmacodynamic Modeling of the Antibiotic Effect of Piperacillin in Vitro
inferredcites →https://doi.org/10.1038/msb.2012.49openalex-snapshot
The inoculum effect and band‐pass bacterial response to periodic antibiotic treatment
inferredcites →https://doi.org/10.1038/nprot.2007.521openalex-snapshot
Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances
inferredcites →https://doi.org/10.1038/nrmicro1445openalex-snapshot
Non-inherited antibiotic resistance
inferredcites →https://doi.org/10.1038/nrmicro862openalex-snapshot
Antimicrobial pharmacodynamics: critical interactions of 'bug and drug'
inferredcites →https://doi.org/10.1038/s41559-018-0786-xopenalex-snapshot
Within-host dynamics shape antibiotic resistance in commensal bacteria
inferredcites →https://doi.org/10.1038/s41579-019-0207-4openalex-snapshot
Publisher Correction: Definitions and guidelines for research on antibiotic persistence
inferredcites →https://doi.org/10.1046/j.1198-743x.2001.xopenalex-snapshot
Effect of inoculum size on the antibacterial activity of cefpirome and cefepime against Klebsiella pneumoniae strains producing SHV extended-spectrum β-lactamases
inferredcites →https://doi.org/10.1073/pnas.1400352111openalex-snapshot
Exploring the collaboration between antibiotics and the immune response in the treatment of acute, self-limiting infections
inferredcites →https://doi.org/10.1073/pnas.2014364118openalex-snapshot
Inoculum effect of antimicrobial peptides
inferredcites →https://doi.org/10.1086/511642openalex-snapshot
Mutant Selection Window Hypothesis Updated
inferredcites →https://doi.org/10.1093/femsle/fnaa012openalex-snapshot
Mathematical modeling of the ‘inoculum effect': six applicable models and the MIC advancement point concept
inferredcites →https://doi.org/10.1093/jac/1.1.91openalex-snapshot
Susceptibifity of Bacteroides fragilis to spectinomycin
inferredcites →https://doi.org/10.1093/jac/dkh462openalex-snapshot
Cefepime and the inoculum effect in tests with Klebsiella pneumoniae producing plasmid-mediated AmpC-type β-lactamase
inferredcites →https://doi.org/10.1093/jac/dki079openalex-snapshot
Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs: an update
inferredcites →https://doi.org/10.1093/jac/dki163openalex-snapshot
Influence of inoculum size of Staphylococcus aureus and Pseudomonas aeruginosa on in vitro activities and in vivo efficacy of fluoroquinolones and carbapenems
inferredcites →https://doi.org/10.1093/jac/dkn554openalex-snapshot
Functional relationship between bacterial cell density and the efficacy of antibiotics
inferredcites →https://doi.org/10.1093/jac/dkz226openalex-snapshot
Inoculum effect of β-lactam antibiotics
inferredcites →https://doi.org/10.1098/rspb.2017.2687openalex-snapshot
Predicting drug resistance evolution: insights from antimicrobial peptides and antibiotics
inferredcites →https://doi.org/10.1098/rstb.2015.0292openalex-snapshot
Bacterial strategies of resistance to antimicrobial peptides
inferredcites →https://doi.org/10.1098/rstb.2015.0294openalex-snapshot
Antimicrobial combinations: Bliss independence and Loewe additivity derived from mechanistic multi-hit models
inferredcites →https://doi.org/10.1126/science.1099390openalex-snapshot
Bacterial Persistence as a Phenotypic Switch
inferredcites →https://doi.org/10.1126/science.aaj2191openalex-snapshot
Antibiotic tolerance facilitates the evolution of resistance
inferredcites →https://doi.org/10.1126/scitranslmed.aaa8760openalex-snapshot
Classic reaction kinetics can explain complex patterns of antibiotic action
inferredcites →https://doi.org/10.1128/aac.00381-10openalex-snapshot
Population Dynamics of Antibiotic Treatment: a Mathematical Model and Hypotheses for Time-Kill and Continuous-Culture Experiments
inferredcites →https://doi.org/10.1128/aac.00433-18openalex-snapshot
The Inoculum Effect in the Era of Multidrug Resistance: Minor Differences in Inoculum Have Dramatic Effect on MIC Determination
inferredcites →https://doi.org/10.1128/aac.00533-15openalex-snapshot
Effect of Resistance Mechanisms on the Inoculum Effect of Carbapenem in Klebsiella pneumoniae Isolates with Borderline Carbapenem Resistance
inferredcites →https://doi.org/10.1128/aac.00881-09openalex-snapshot
Attenuation of Colistin Bactericidal Activity by High Inoculum ofPseudomonas aeruginosaCharacterized by a New Mechanism-Based Population Pharmacodynamic Model
inferredcites →https://doi.org/10.1128/aac.01325-06openalex-snapshot
Antimicrobial Activities of Ceragenins against Clinical Isolates of Resistant Staphylococcus aureus
inferredcites →https://doi.org/10.1128/aac.01325-09openalex-snapshot
Determination of an Inoculum Effect with Various Cephalosporins among Clinical Isolates of Methicillin-Susceptible Staphylococcus aureus
inferredcites →https://doi.org/10.1128/aac.01831-09openalex-snapshot
Mathematical Modeling To Characterize the Inoculum Effect
inferredcites →https://doi.org/10.1128/aac.45.12.3548-3554.2001openalex-snapshot
Cefepime, Piperacillin-Tazobactam, and the Inoculum Effect in Tests with Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae
inferredcites →https://doi.org/10.1128/aac.48.10.3670-3676.2004openalex-snapshot
Pharmacodynamic Functions: a Multiparameter Approach to the Design of Antibiotic Treatment Regimens
inferredcites →https://doi.org/10.1128/aac.48.12.4673-4679.2004openalex-snapshot
Degradation of Human Antimicrobial Peptide LL-37 by Staphylococcus aureus -Derived Proteinases
inferredcites →https://doi.org/10.1128/aac.49.4.1483-1494.2005openalex-snapshot
Phenotypic Tolerance: Antibiotic Enrichment of Noninherited Resistance in Bacterial Populations
inferredcites →https://doi.org/10.1186/s12866-015-0617-zopenalex-snapshot
Contributions of tropodithietic acid and biofilm formation to the probiotic activity of Phaeobacter inhibens
inferredcites →https://doi.org/10.1186/s12866-016-0838-9openalex-snapshot
Time-kill curve analysis and pharmacodynamic modelling for in vitro evaluation of antimicrobials against Neisseria gonorrhoeae
inferredcites →https://doi.org/10.1371/journal.pcbi.1005098openalex-snapshot
Population Density Modulates Drug Inhibition and Gives Rise to Potential Bistability of Treatment Outcomes for Bacterial Infections
inferredcites →https://doi.org/10.1371/journal.pone.0144611openalex-snapshot
Comparative Evaluation of the Antimicrobial Activity of Different Antimicrobial Peptides against a Range of Pathogenic Bacteria
inferredcites →https://doi.org/10.1371/journal.ppat.1002158openalex-snapshot
Selection of Resistant Bacteria at Very Low Antibiotic Concentrations
inferredcites →https://doi.org/10.1371/journal.ppat.1002487openalex-snapshot
Two-Drug Antimicrobial Chemotherapy: A Mathematical Model and Experiments with Mycobacterium marinum
inferredcites →https://doi.org/10.1371/journal.ppat.1009443openalex-snapshot
Bacteria primed by antimicrobial peptides develop tolerance and persist
inferredcites →https://doi.org/10.15252/msb.20145949openalex-snapshot
Growth‐dependent bacterial susceptibility to ribosome‐targeting antibiotics
inferredcites →https://doi.org/10.18637/jss.v009.i01openalex-snapshot
Smoothing with Mixed Model Software
inferredcites →https://doi.org/10.18637/jss.v033.i09openalex-snapshot
Solving Differential Equations in R : Package deSolve
inferredcites →https://doi.org/10.2165/00003088-200544020-00005openalex-snapshot
Pharmacokinetic/Pharmacodynamic Modelling of Antibacterials In Vitro and In Vivo Using Bacterial Growth and Kill Kinetics
inferredcites →https://doi.org/10.32614/cran.package.sfsmiscopenalex-snapshot
sfsmisc: Utilities from 'Seminar fuer Statistik' ETH Zurich
inferredcites →https://doi.org/10.3389/fmicb.2013.00114openalex-snapshot
Interference of bacterial cell-to-cell communication: A new concept of antimicrobial chemotherapy breaks antibiotic
inferredcites →https://doi.org/10.3389/fmicb.2020.00103openalex-snapshot
Resistance Evolution Against Antimicrobial Peptides in Staphylococcus aureus Alters Pharmacodynamics Beyond the MIC

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1007/s00018-019-03376-yopenalex-snapshot
Multi-scale modeling of drug binding kinetics to predict drug efficacy
inferred← citeshttps://doi.org/10.1073/pnas.2014364118openalex-snapshot
Inoculum effect of antimicrobial peptides
inferred← citeshttps://doi.org/10.1093/jacamr/dlag145openalex-snapshot
Pharmacokinetics determine persister formation in Escherichia coli
inferred← citeshttps://doi.org/10.1099/mic.0.001368openalex-snapshot
The pharmacokinetic–pharmacodynamic modelling framework as a tool to predict drug resistance evolution
inferred← citeshttps://doi.org/10.1101/2025.04.25.650648openalex-snapshot
Speed Kills: Accelerated Pharmacokinetics Reduce Persisters in Escherichia coli
inferred← citeshttps://doi.org/10.1101/2025.11.26.690803openalex-snapshot
Quantifying antibiotic susceptibility and inoculum effects using transient dynamics of Pseudomonas aeruginosa
inferred← citeshttps://doi.org/10.1371/journal.pcbi.1014827openalex-snapshot
Quantifying antibiotic susceptibility and inoculum effects using transient dynamics of Pseudomonas aeruginosa
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