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Variation of human neural stem cells generating organizer states in vitro before committing to cortical excitatory or inhibitory neuronal fates

https://doi.org/10.1101/577544
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FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders
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Molecular Identity of Human Outer Radial Glia during Cortical Development
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Area and layer patterning in the developing cerebral cortex
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Human Stiff person syndrome IgG-containing high-titer anti-GAD65 autoantibodies induce motor dysfunction in rats
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Asymmetric Distribution of EGFR Receptor during Mitosis Generates Diverse CNS Progenitor Cells
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PDGFRα-Positive B Cells Are Neural Stem Cells in the Adult SVZ that Form Glioma-like Growths in Response to Increased PDGF Signaling
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Area Patterning of the Mammalian Cortex
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The Cerebrospinal Fluid Provides a Proliferative Niche for Neural Progenitor Cells
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Cortical Evolution: Judge the Brain by Its Cover
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CORTECON: A Temporal Transcriptome Analysis of In Vitro Human Cerebral Cortex Development from Human Embryonic Stem Cells
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Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons
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Transformation of the Radial Glia Scaffold Demarcates Two Stages of Human Cerebral Cortex Development
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Non-colony type monolayer culture of human embryonic stem cells
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Potency and Fate Specification in CNS Stem Cell Populations In Vitro
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Directed Differentiation and Functional Maturation of Cortical Interneurons from Human Embryonic Stem Cells
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Epigenetic Variation between Human Induced Pluripotent Stem Cell Lines Is an Indicator of Differentiation Capacity
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Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity
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Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes
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Autism and Cancer Share Risk Genes, Pathways, and Drug Targets
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Proliferation and Differentiation Deficits are a Major Convergence Point for Neurodevelopmental Disorders
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Response Diversity and the Timing of Progenitor Cell Maturation Are Regulated by Developmental Changes in EGFR Expression in the Cortex
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Patterning of the Dorsal Telencephalon and Cerebral Cortex by a Roof Plate-Lhx2 Pathway
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LIM-homeodomain gene Lhx2 regulates the formation of the cortical hem
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Erratum: Dendritic Ih normalizes temporal summation in hippocampal CA1 neurons
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Autoradiographic Study of Cell Migration during Histogenesis of Cerebral Cortex in the Mouse
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Proliferation and differentiation of neuronal stem cells regulated by nerve growth factor
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Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
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Neurons derived from radial glial cells establish radial units in neocortex
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Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis
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Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia
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Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities
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Altered proliferation and networks in neural cells derived from idiopathic autistic individuals
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Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease
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Notch signalling regulates stem cell numbers in vitro and in vivo
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Neurogenic radial glia in the outer subventricular zone of human neocortex
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Transcriptional landscape of the prenatal human brain
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A comprehensive transcriptional map of primate brain development
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Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
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Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells
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Integrating single-cell transcriptomic data across different conditions, technologies, and species
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Analysing human neural stem cell ontogeny by consecutive isolation of Notch active neural progenitors
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Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue
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Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6
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Identification of PDGFR as a receptor for AAV-5 transduction
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Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses
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Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice
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The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells
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COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas
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Genetic and activity-dependent mechanisms underlying interneuron diversity
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Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection
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Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent
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Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis
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Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons
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Patterning of frontal cortex subdivisions by Fgf17
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Lmx1a regulates fates and location of cells originating from the cerebellar rhombic lip and telencephalic cortical hem
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Modeling human cortical development in vitro using induced pluripotent stem cells
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Gliogenesis in the outer subventricular zone promotes enlargement and gyrification of the primate cerebrum
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CoGAPS: an R/C++ package to identify patterns and biological process activity in transcriptomic data
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PatternMarkers & GWCoGAPS for novel data-driven biomarkers via whole transcriptome NMF
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Is Pax6 Critical for Neurogenesis in the Human Fetal Brain?
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Single factors direct the differentiation of stem cells from the fetal and adult central nervous system.
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The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone
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Anterior–posterior patterning of neural differentiated embryonic stem cells by canonical Wnts, Fgfs, Bmp4 and their respective antagonists
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Neocortex Patterning by the Secreted Signaling Molecule FGF8
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Patterning and Plasticity of the Cerebral Cortex
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Lhx2 Selector Activity Specifies Cortical Identity and Suppresses Hippocampal Organizer Fate
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Regulation of Area Identity in the Mammalian Neocortex by Emx2 and Pax6
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Specification of Cerebral Cortical Areas
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Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system
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Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex
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Transcriptome and epigenome landscape of human cortical development modeled in organoids
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Integrative functional genomic analysis of human brain development and neuropsychiatric risks
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Spatiotemporal transcriptomic divergence across human and macaque brain development
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G ENERATING THE C EREBRAL C ORTICAL A REA M AP
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Gene expression signatures modulated by epidermal growth factor receptor activation and their relationship to cetuximab resistance in head and neck squamous cell carcinoma
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Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers
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Transcriptional co-regulation of neuronal migration and laminar identity in the neocortex
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The cortical hem regulates the size and patterning of neocortex
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The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice
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BMP and FGF regulate the development of EGF-responsive neural progenitor cells
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Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage
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Fibroblast Growth Factor 8 Regulates Neocortical Guidance of Area-Specific Thalamic Innervation
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Neuronal Differentiation of Precursors in the Neocortical Ventricular Zone Is Triggered by BMP
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Multiple Roles of Bone Morphogenetic Protein Signaling in the Regulation of Cortical Cell Number and Phenotype
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Bipotent Cortical Progenitor Cells Process Conflicting Cues for Neurons and Glia in a Hierarchical Manner
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Basic Fibroblast Growth Factor (Fgf2) Is Necessary for Cell Proliferation and Neurogenesis in the Developing Cerebral Cortex
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Fibroblast Growth Factor 2 Is Necessary for the Growth of Glutamate Projection Neurons in the Anterior Neocortex
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Identification of aPax6-Dependent Epidermal Growth Factor Family Signaling Source at the Lateral Edge of the Embryonic Cerebral Cortex
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Pax6, Tbr2, and Tbr1 Are Expressed Sequentially by Radial Glia, Intermediate Progenitor Cells, and Postmitotic Neurons in Developing Neocortex
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Cortical Gyrification Induced by Fibroblast Growth Factor 2 in the Mouse Brain
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FGF Signaling Expands Embryonic Cortical Surface Area by Regulating Notch-Dependent Neurogenesis
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Cell Type-Specific Expression Analysis to Identify Putative Cellular Mechanisms for Neurogenetic Disorders
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Self‐organized developmental patterning and differentiation in cerebral organoids
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