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Quantitative mitochondrial DNA copy number determination using droplet digital PCR with single cell resolution: a focus on aging and cancer

https://doi.org/10.1101/579789
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/jcb.20743openalex-snapshot
Nuclear control of respiratory gene expression in mammalian cells
inferredcites →https://doi.org/10.1002/jcp.1041360316openalex-snapshot
Mitochondrial DNA molecules and virtual number of mitochondria per cell in mammalian cells
inferredcites →https://doi.org/10.1002/jcp.1041430122openalex-snapshot
Distinct genomic copy number in mitochondria of different mammalian organs
inferredcites →https://doi.org/10.1007/s00439-014-1458-9openalex-snapshot
Mitochondrial DNA copy number in peripheral blood cells declines with age and is associated with general health among elderly
inferredcites →https://doi.org/10.1007/s10147-017-1156-4openalex-snapshot
Targeting metabolic reprogramming in KRAS-driven cancers
inferredcites →https://doi.org/10.1007/s11010-012-1276-0openalex-snapshot
Accelerated aging as evidenced by increased telomere shortening and mitochondrial DNA depletion in patients with type 2 diabetes
inferredcites →https://doi.org/10.1016/0167-5699(93)90231-9openalex-snapshot
Activation-induced cell death (apoptosis) of mature peripheral T lymphocytes
inferredcites →https://doi.org/10.1016/j.ab.2007.06.024openalex-snapshot
A multiplex real-time PCR method to detect and quantify mitochondrial DNA deletions in individual cells
inferredcites →https://doi.org/10.1016/j.bbcan.2016.12.004openalex-snapshot
Linking metabolic reprogramming to therapy resistance in cancer
inferredcites →https://doi.org/10.1016/j.bbrc.2011.06.067openalex-snapshot
Mitochondrial DNA as a non-invasive biomarker: Accurate quantification using real time quantitative PCR without co-amplification of pseudogenes and dilution bias
inferredcites →https://doi.org/10.1016/j.ccr.2012.02.014openalex-snapshot
Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
inferredcites →https://doi.org/10.1016/j.diabres.2009.07.002openalex-snapshot
Increased peripheral blood mitochondrial DNA in type 2 diabetic patients with nephropathy
inferredcites →https://doi.org/10.1016/j.exger.2008.03.004openalex-snapshot
The 4977bp deletion of mitochondrial DNA in human skeletal muscle, heart and different areas of the brain: A useful biomarker or more?
inferredcites →https://doi.org/10.1016/j.exger.2015.04.002openalex-snapshot
Association of telomere length and mitochondrial DNA copy number in a community sample of healthy adults
inferredcites →https://doi.org/10.1016/j.mad.2015.02.003openalex-snapshot
Molecular responses in the telomere-mitochondrial axis of ageing in the elderly: A candidate gene approach
inferredcites →https://doi.org/10.1016/j.mito.2007.08.001openalex-snapshot
Convergence of multiple signaling pathways is required to coordinately up-regulate mtDNA and mitochondrial biogenesis during T cell activation
inferredcites →https://doi.org/10.1016/j.mito.2009.02.006openalex-snapshot
Quantification of mitochondrial DNA copy number: Pre-analytical factors
inferredcites →https://doi.org/10.1016/j.mito.2018.12.003openalex-snapshot
Circulating mitochondria DNA, a non-invasive cancer diagnostic biomarker candidate
inferredcites →https://doi.org/10.1016/j.molcel.2009.08.007openalex-snapshot
Unraveling the Secrets of Regulating Mitochondrial DNA Replication
inferredcites →https://doi.org/10.1016/j.neurobiolaging.2015.10.033openalex-snapshot
Reduced mitochondrial DNA copy number is a biomarker of Parkinson's disease
inferredcites →https://doi.org/10.1016/s0021-9258(18)77184-6openalex-snapshot
Mitochondrial DNA copy number is proportional to total cell DNA under a variety of growth conditions.
inferredcites →https://doi.org/10.1016/s0168-9525(01)02238-7openalex-snapshot
What regulates mitochondrial DNA copy number in animal cells?
inferredcites →https://doi.org/10.1016/s1097-2765(04)00179-0openalex-snapshot
Mitochondrial Signaling
inferredcites →https://doi.org/10.1016/s1525-1578(10)60595-8openalex-snapshot
Simultaneous Detection and Quantification of Mitochondrial DNA Deletion(s), Depletion, and Over-Replication in Patients with Mitochondrial Disease
inferredcites →https://doi.org/10.1016/s1673-8527(08)60099-5openalex-snapshot
Number matters: control of mammalian mitochondrial DNA copy number
inferredcites →https://doi.org/10.1021/ac202028gopenalex-snapshot
High-Throughput Droplet Digital PCR System for Absolute Quantitation of DNA Copy Number
inferredcites →https://doi.org/10.1021/ac202578xopenalex-snapshot
Evaluation of a Droplet Digital Polymerase Chain Reaction Format for DNA Copy Number Quantification
inferredcites →https://doi.org/10.1038/cddis.2015.34openalex-snapshot
Mitochondrial DNA copy number is regulated by DNA methylation and demethylation of POLGA in stem and cancer cells and their differentiated progeny
inferredcites →https://doi.org/10.1038/nature02517openalex-snapshot
Premature ageing in mice expressing defective mitochondrial DNA polymerase
inferredcites →https://doi.org/10.1038/nature09663openalex-snapshot
A role for mitochondria in NLRP3 inflammasome activation
inferredcites →https://doi.org/10.1038/s41586-018-0372-zopenalex-snapshot
New mitochondrial DNA synthesis enables NLRP3 inflammasome activation
inferredcites →https://doi.org/10.1038/s41598-017-05174-7openalex-snapshot
The Maintenance of Telomere Length in CD28+ T Cells During T Lymphocyte Stimulation
inferredcites →https://doi.org/10.1038/sj.onc.1206046openalex-snapshot
Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells
inferredcites →https://doi.org/10.1038/srep00222openalex-snapshot
Accurate RT-qPCR gene expression analysis on cell culture lysates
inferredcites →https://doi.org/10.1038/srep24067openalex-snapshot
Comparison of DNA Quantification Methods for Next Generation Sequencing
inferredcites →https://doi.org/10.1038/srep35859openalex-snapshot
Altered mitochondrial DNA copy number contributes to human cancer risk: evidence from an updated meta-analysis
inferredcites →https://doi.org/10.1038/srep37404openalex-snapshot
Elevated Mitochondrial DNA Copy Number in Peripheral Blood and Tissue Predict the Opposite Outcome of Cancer: A Meta-Analysis
inferredcites →https://doi.org/10.1073/pnas.0606714103openalex-snapshot
Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1α transcription and mitochondrial biogenesis in muscle cells
inferredcites →https://doi.org/10.1073/pnas.89.16.7370openalex-snapshot
A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues.
inferredcites →https://doi.org/10.1080/15384101.2015.1022697openalex-snapshot
Metabolic control of cancer cell stemness: Lessons from iPS cells
inferredcites →https://doi.org/10.1093/nar/18.23.6927openalex-snapshot
Detection of a specific mitochondrial DNA deletion in tissues of older humans
inferredcites →https://doi.org/10.1093/nar/gku439openalex-snapshot
Quantitative telomerase enzyme activity determination using droplet digital PCR with single cell resolution
inferredcites →https://doi.org/10.1101/gr.178426.114openalex-snapshot
Global variability in gene expression and alternative splicing is modulated by mitochondrial content
inferredcites →https://doi.org/10.1111/acel.12424openalex-snapshot
Using measures of single‐cell physiology and physiological state to understand organismic aging
inferredcites →https://doi.org/10.1111/acel.12814openalex-snapshot
Clonal expansion of mitochondrial DNA deletions is a private mechanism of aging in long‐lived animals
inferredcites →https://doi.org/10.1111/acel.12859openalex-snapshot
Telomere length and telomerase activity in T cells are biomarkers of high‐performing centenarians
inferredcites →https://doi.org/10.1111/imm.12655openalex-snapshot
T‐cell metabolism governing activation, proliferation and differentiation; a modular view
inferredcites →https://doi.org/10.1128/mcb.25.14.6225-6234.2005openalex-snapshot
Myc Stimulates Nuclearly Encoded Mitochondrial Genes and Mitochondrial Biogenesis
inferredcites →https://doi.org/10.1158/0008-5472.can-11-0794openalex-snapshot
Functional Parsing of Driver Mutations in the Colorectal Cancer Genome Reveals Numerous Suppressors of Anchorage-Independent Growth
inferredcites →https://doi.org/10.1158/0008-5472.can-16-2844openalex-snapshot
Defining Cancer Subpopulations by Adaptive Strategies Rather Than Molecular Properties Provides Novel Insights into Intratumoral Evolution
inferredcites →https://doi.org/10.1186/1471-2164-16-s1-s8openalex-snapshot
Exome Sequencing of Normal and Isogenic Transformed Human Colonic Epithelial Cells (HCECs) Reveals Novel Genes Potentially Involved in the Early Stages of Colorectal Tumorigenesis
inferredcites →https://doi.org/10.1186/1471-2164-16-s13-s8openalex-snapshot
A comparison of the transcriptome of Drosophila melanogaster in response to entomopathogenic fungus, ionizing radiation, starvation and cold shock
inferredcites →https://doi.org/10.1186/1471-2199-11-57openalex-snapshot
Experimental comparison of relative RT-qPCR quantification approaches for gene expression studies in poplar
inferredcites →https://doi.org/10.1186/1471-2350-12-8openalex-snapshot
The mitochondrial DNA 4,977-bp deletion and its implication in copy number alteration in colorectal cancer
inferredcites →https://doi.org/10.1371/journal.pgen.1005939openalex-snapshot
Age-Related and Heteroplasmy-Related Variation in Human mtDNA Copy Number
inferredcites →https://doi.org/10.1371/journal.pone.0067227openalex-snapshot
The Relationship between Leukocyte Mitochondrial DNA Copy Number and Telomere Length in Community-Dwelling Elderly Women
inferredcites →https://doi.org/10.1371/journal.pone.0078644openalex-snapshot
Comparison of RNA-Seq and Microarray in Transcriptome Profiling of Activated T Cells
inferredcites →https://doi.org/10.1371/journal.pone.0085999openalex-snapshot
Comparison of Droplet Digital PCR and Seminested Real-Time PCR for Quantification of Cell-Associated HIV-1 RNA
inferredcites →https://doi.org/10.1371/journal.pone.0159004openalex-snapshot
Comparison of Droplet Digital PCR and Quantitative PCR Assays for Quantitative Detection of Xanthomonas citri Subsp. citri
inferredcites →https://doi.org/10.1371/journal.pone.0206003openalex-snapshot
Association between mitochondrial DNA copy number and cardiovascular disease: Current evidence based on a systematic review and meta-analysis
inferredcites →https://doi.org/10.3233/jad-131715openalex-snapshot
Mitochondrial DNA Copy Numbers in Pyramidal Neurons are Decreased and Mitochondrial Biogenesis Transcriptome Signaling is Disrupted in Alzheimer's Disease Hippocampi
inferredcites →https://doi.org/10.3233/jad-142808openalex-snapshot
Leukocyte Telomere Length in Alzheimer’s Disease Patients with a Different Rate of Progression
inferredcites →https://doi.org/10.3390/microarrays4040540openalex-snapshot
Evaluating the Effect of Cell Culture on Gene Expression in Primary Tissue Samples Using Microfluidic-Based Single Cell Transcriptional Analysis
inferredcites →https://doi.org/10.7754/clin.lab.2014.140313openalex-snapshot
The Association between Leukocyte Telomere Length and Mitochondrial DNA Copy Number in Pregnant Women: A Pilot Study

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1007/978-3-030-89340-8_5openalex-snapshot
Unraveling the Molecular Impact of Sperm DNA Damage on Human Reproduction
inferred← citeshttps://doi.org/10.1016/j.ajpath.2020.03.018openalex-snapshot
An in Situ Atlas of Mitochondrial DNA in Mammalian Tissues Reveals High Content in Stem and Proliferative Compartments
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