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Multi-trait genome-wide association meta-analysis of dietary intake identifies new loci and genetic and functional links with metabolic traits
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Association Between Dietary Factors and Mortality From Heart Disease, Stroke, and Type 2 Diabetes in the United States
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MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes
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The Hunger Genes: Pathways to Obesity
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The Molecular Signatures Database Hallmark Gene Set Collection
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The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes
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Hypothalamic Tanycytes Are an ERK-Gated Conduit for Leptin into the Brain
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FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans
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Toward a Wiring Diagram Understanding of Appetite Control
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GDNF and GFRα: a versatile molecular complex for developing neurons
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Hypothalamic Tanycytes: A Key Component of Brain–Endocrine Interaction
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The global obesity pandemic: shaped by global drivers and local environments
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Role of melanocortin signalling in the preference for dietary macronutrients in human beings
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Health effects of dietary risks in 195 countries, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
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Prevalence trends tell us what did not precipitate the US obesity epidemic
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Dietary assessment in UK Biobank: an evaluation of the performance of the touchscreen dietary questionnaire
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Genetic and Environmental Factors in Breakfast Eating Patterns
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Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
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Genetic studies of body mass index yield new insights for obesity biology
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Integrative analysis of 111 reference human epigenomes
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Structures of β-klotho reveal a ‘zip code’-like mechanism for endocrine FGF signalling
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Divergent effects of central melanocortin signalling on fat and sucrose preference in humans
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Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel
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Biological interpretation of genome-wide association studies using predicted gene functions
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Common variants of FUT2 are associated with plasma vitamin B12 levels
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Fast and accurate genotype imputation in genome-wide association studies through pre-phasing
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Discovery and refinement of loci associated with lipid levels
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A general framework for estimating the relative pathogenicity of human genetic variants
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Efficient Bayesian mixed-model analysis increases association power in large cohorts
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LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
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Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers
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Somatic ERCC2 mutations are associated with a distinct genomic signature in urothelial tumors
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A reference panel of 64,976 haplotypes for genotype imputation
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Next-generation genotype imputation service and methods
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Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits
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Association analyses based on false discovery rate implicate new loci for coronary artery disease
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Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
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ChromHMM: automating chromatin-state discovery and characterization
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Improved whole-chromosome phasing for disease and population genetic studies
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A molecular census of arcuate hypothalamus and median eminence cell types
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Genomic variant annotation and prioritization with ANNOVAR and wANNOVAR
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Convergence between biological, behavioural and genetic determinants of obesity
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Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium
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Functional mapping and annotation of genetic associations with FUMA
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The UK Biobank resource with deep phenotyping and genomic data
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Multi-trait analysis of genome-wide association summary statistics using MTAG
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Genetic identification of brain cell types underlying schizophrenia
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Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
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Sequence and Expression of a Candidate for the Human Secretor Blood Group α(1,2)Fucosyltransferase Gene (FUT2)
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METAL: fast and efficient meta-analysis of genomewide association scans
inferredcites →https://doi.org/10.1093/bioinformatics/btu704openalex-snapshot
minimac2: faster genotype imputation
inferredcites →https://doi.org/10.1093/hmg/ddt032openalex-snapshot
Novel locus including FGF21 is associated with dietary macronutrient intake
inferredcites →https://doi.org/10.1093/ije/dyw173openalex-snapshot
Adiposity among 132 479 UK Biobank participants; contribution of sugar intake vs other macronutrients
inferredcites →https://doi.org/10.1101/610287openalex-snapshot
The more the merrier? Multivariate approaches to genome-wide association analysis
inferredcites →https://doi.org/10.1101/gr.137323.112openalex-snapshot
Annotation of functional variation in personal genomes using RegulomeDB
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Automatic Relevance Determination in Nonnegative Matrix Factorization with the /spl beta/-Divergence
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Impaired behavioural flexibility and memory in mice lacking GDNF family receptor α2
inferredcites →https://doi.org/10.1126/science.1262110openalex-snapshot
The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans
inferredcites →https://doi.org/10.1126/science.8493557openalex-snapshot
GDNF: a Glial Cell Line-Derived Neurotrophic Factor for Midbrain Dopaminergic Neurons
inferredcites →https://doi.org/10.1126/science.aau2096openalex-snapshot
Dietary fat: From foe to friend?
inferredcites →https://doi.org/10.1161/circgenetics.108.829747openalex-snapshot
Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium
inferredcites →https://doi.org/10.1371/journal.pcbi.1004219openalex-snapshot
MAGMA: Generalized Gene-Set Analysis of GWAS Data
inferredcites →https://doi.org/10.1371/journal.pgen.1002254openalex-snapshot
Pervasive Sharing of Genetic Effects in Autoimmune Disease
inferredcites →https://doi.org/10.1371/journal.pmed.1001779openalex-snapshot
UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age
inferredcites →https://doi.org/10.1371/journal.pmed.1002654openalex-snapshot
Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis
inferredcites →https://doi.org/10.3389/fnins.2015.00387openalex-snapshot
Hypothalamic tanycytes—masters and servants of metabolic, neuroendocrine, and neurogenic functions
inferredcites →https://doi.org/10.3390/jpm6010002openalex-snapshot
Building the Partners HealthCare Biobank at Partners Personalized Medicine: Informed Consent, Return of Research Results, Recruitment Lessons and Operational Considerations
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Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1038/s41467-020-15193-0openalex-snapshot
Comprehensive genomic analysis of dietary habits in UK Biobank identifies hundreds of genetic associations
inferred← citeshttps://doi.org/10.3390/biomedicines9091148openalex-snapshot
High-Fat Diet Induces Pre-Diabetes and Distinct Sex-Specific Metabolic Alterations in Negr1-Deficient Mice
inferred← citeshttps://doi.org/10.3390/brainsci11040435openalex-snapshot
Chronic Alcohol Use Induces Molecular Genetic Changes in the Dorsomedial Thalamus of People with Alcohol-Related Disorders
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