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Discovery of tumoricidal DNA oligonucleotides by effect-directed in-vitro evolution

https://doi.org/10.1101/629105
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Drug Resistance in Bacteria, Fungi, Malaria, and Cancer
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Philosophy of Cancer
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A phase II trial of AS1411 (a novel nucleolin-targeted DNA aptamer) in metastatic renal cell carcinoma
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Isolation of a ribozyme with 5′-5′ ligase activity
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Application of aptamers for in vivo molecular imaging and theranostics
inferredcites →https://doi.org/10.1016/j.biomaterials.2015.07.020openalex-snapshot
2-fluoro-RNA oligonucleotide CD40 targeted aptamers for the control of B lymphoma and bone-marrow aplasia
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Recent advances in CAR T-cell toxicity: Mechanisms, manifestations and management
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Assembling OX40 Aptamers on a Molecular Scaffold to Create a Receptor-Activating Aptamer
inferredcites →https://doi.org/10.1016/j.intimp.2015.10.013openalex-snapshot
Cancer immunotherapy via nucleic acid aptamers
inferredcites →https://doi.org/10.1016/j.pan.2013.07.209openalex-snapshot
Aptamer 1 and 146 developed by cell-SELEX are specific to pancreatic cancer stem cells
inferredcites →https://doi.org/10.1016/j.stemcr.2018.07.010openalex-snapshot
In Vivo Expansion of Cancer Stemness Affords Novel Cancer Stem Cell Targets: Malignant Rhabdoid Tumor as an Example
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In vitro selection of RNA molecules that bind specific ligands
inferredcites →https://doi.org/10.1038/36375openalex-snapshot
Peptide bond formation by in vitro selected ribozymes
inferredcites →https://doi.org/10.1038/374777a0openalex-snapshot
In vitro evolution of a self-alkylatlng ribozyme
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A natural ribozyme with 3′,5′ RNA ligase activity
inferredcites →https://doi.org/10.1038/ncomms7169openalex-snapshot
Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity
inferredcites →https://doi.org/10.1038/nprot.2010.163openalex-snapshot
Fluorescence-activated cell sorting for aptamer SELEX with cell mixtures
inferredcites →https://doi.org/10.1038/s41598-017-05840-wopenalex-snapshot
Selection and characterization of DNA aptamer against glucagon receptor by cell-SELEX
inferredcites →https://doi.org/10.1038/srep19772openalex-snapshot
A novel method for evaluating antibody-dependent cell-mediated cytotoxicity by flowcytometry using cryopreserved human peripheral blood mononuclear cells
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Aptamer to ErbB-2/HER2 enhances degradation of the target and inhibits tumorigenic growth
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Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients
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Ev vivo organ culture as potential prioritization tool for breast cancer targeted therapy
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Digital therapeutics for distributed response to global pandemics
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A randomized, repeat‐dose, pharmacodynamic and safety study of an antidote‐controlled factor IXa inhibitor
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Acceleration of Emergence of Bacterial Antibiotic Resistance in Connected Microenvironments
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Selection of a Ribozyme That Functions as a Superior Template in a Self-Copying Reaction
inferredcites →https://doi.org/10.1126/science.2200121openalex-snapshot
Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA Polymerase
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Spatiotemporal microbial evolution on antibiotic landscapes
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Availability of evidence of benefits on overall survival and quality of life of cancer drugs approved by European Medicines Agency: retrospective cohort study of drug approvals 2009-13
inferredcites →https://doi.org/10.1158/1078-0432.ccr-12-2067openalex-snapshot
Use of Oligonucleotide Aptamer Ligands to Modulate the Function of Immune Receptors
inferredcites →https://doi.org/10.1160/th11-02-0069openalex-snapshot
A dose ranging phase I/II trial of the von Willebrand factor inhibiting aptamer ARC1779 in patients with congenital thrombotic thrombo - cytopenic purpura
inferredcites →https://doi.org/10.1201/9780203852569openalex-snapshot
The Biology of Cancer
inferredcites →https://doi.org/10.1371/journal.pone.0046393openalex-snapshot
Identification, Characterization and Application of a G-Quadruplex Structured DNA Aptamer against Cancer Biomarker Protein Anterior Gradient Homolog 2
inferredcites →https://doi.org/10.1371/journal.pone.0082667openalex-snapshot
RAPID-SELEX for RNA Aptamers
inferredcites →https://doi.org/10.1371/journal.pone.0149387openalex-snapshot
Ex Vivo and In Vivo Imaging and Biodistribution of Aptamers Targeting the Human Matrix MetalloProtease-9 in Melanomas
inferredcites →https://doi.org/10.2147/ott.s130131openalex-snapshot
PD-1 blockade restores impaired function of ex vivo expanded CD8+ T cells and enhances apoptosis in mismatch repair deficient EpCAM+PD-L1+ cancer cells
inferredcites →https://doi.org/10.2174/0929867322666150227144909openalex-snapshot
Nucleic Acid-Based Aptamers: Applications, Development and Clinical Trials

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1101/630830openalex-snapshot
Ab-initio discovery of tumoricidal oligonucleotides in a DNA sequencing machine
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