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Interruption of Continuous Opioid Exposure Exacerbates Drug-Evoked Adaptations in the Mesolimbic Dopamine System

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Characterization of a mouse strain expressing Cre recombinase from the 3′ untranslated region of the dopamine transporter locus
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Long lasting changes in morphine‐induced mesolimbic dopamine release after chronic morphine exposure
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Repeated exposures intensify rather than diminish the rewarding effects of amphetamine, morphine, and cocaine
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Tolerance and selective cross-tolerance to the motivational effects of opioids
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Behavioral sensitization and tolerance to cocaine and the occupation of dopamine receptors by dopamine
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Chronic and intermittent morphine treatment differently regulates opioid and dopamine systems: a role in locomotor sensitization
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Context- and time-dependent neurobiological and behavioral sensitization induced by a single morphine exposure in mice
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Less is more: prolonged intermittent access cocaine self-administration produces incentive-sensitization and addiction-like behavior
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High and escalating levels of cocaine intake are dissociable from subsequent incentive motivation for the drug in rats
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Morphine-induced long-term sensitization to the locomotor effects of morphine and amphetamine depends on the temporal pattern of the pretreatment regimen
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Ethanol, like psychostimulants and morphine, causes long-lasting hyperreactivity of dopamine and acetylcholine neurons of rat nucleus accumbens: possible role in behavioural sensitization
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Altered cocaine potency in the nucleus accumbens following 7-day withdrawal from intermittent but not continuous treatment: voltammetric assessment of dopamine uptake in the rat
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Mesoaccumbens dopamine signaling alteration underlies behavioral transition from tolerance to sensitization to morphine rewarding properties during morphine withdrawal
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Reinforcing effects of morphine in the nucleus accumbens
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Repeated and chronic morphine administration causes differential long-lasting changes in dopaminergic neurotransmission in rat striatum without changing its δ- and κ-opioid receptor regulation
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Sensitization to the conditioned rewarding effects of morphine: pharmacology and temporal characteristics
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Intermittent versus continuous stimulation: Effect of time interval on the development of sensitization or tolerance
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Persistence of chronic morphine effects upon activity in rats 8 months after ceasing the treatment
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Enhanced stereotypies after repeated injections but not continuous amphetamines
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Long-term sensitization to the excitatory effects of morphine
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Intermittent and Continuous cocaine Administration: Residual Behavioral states during withdrawal
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The neural basis of drug craving: An incentive-sensitization theory of addiction
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Evidence of a complete independence of the neurobiological substrates for the induction and expression of behavioral sensitization to amphetamine
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Gene expression analysis of heat shock proteins in the nucleus accumbens of rats with different morphine seeking behaviours
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Tumor Necrosis Factor-α and Its Inducer Inhibit Morphine-Induced Rewarding Effects and Sensitization
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Distinct Roles of Adenylyl Cyclases 1 and 8 in Opiate Dependence: Behavioral, Electrophysiological, and Molecular Studies
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The Influence of GABRA2, Childhood Trauma, and Their Interaction on Alcohol, Heroin, and Cocaine Dependence
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Behavioral and Morphological Responses to Cocaine Require Kalirin7
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Incubation of Cocaine Craving After Intermittent-Access Self-administration: Sex Differences and Estrous Cycle
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Striatal Dopamine Release in Response to Morphine: A [11C]Raclopride Positron Emission Tomography Study in Healthy Men
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Extracellular Matrix Signaling Through β3 Integrin Mediates Cocaine Cue–Induced Transient Synaptic Plasticity and Relapse
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The Opioid-Addicted Tetrapartite Synapse
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Nucleus Accumbens Fast-Spiking Interneurons Constrain Impulsive Action
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Alterations in morphine-induced reward, locomotor activity, and thermoregulation in CREB-deficient mice
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Single-Cell RNA-Seq Uncovers a Robust Transcriptional Response to Morphine by Glia
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Chronic morphine treatment induces over-expression of HSP70 in mice striatum related with abnormal ubiquitin-proteasome degradation
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Geranylgeranylacetone protects mice against morphine-induced hyperlocomotion, rewarding effect, and withdrawal syndrome
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Role of pharmacokinetic and pharmacodynamic parameters in neuroadaptations induced by drugs of abuse, with a focus on opioids and psychostimulants
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Role for mTOR Signaling and Neuronal Activity in Morphine-Induced Adaptations in Ventral Tegmental Area Dopamine Neurons
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The Molecular Basis of Drug Addiction: Linking Epigenetic to Synaptic and Circuit Mechanisms
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Deletion of guanine nucleotide binding protein αz subunit in mice induces a gene dose dependent tolerance to morphine
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Morphine-induced analgesic tolerance, locomotor sensitization and physical dependence do not require modification of mu opioid receptor, cdk5 and adenylate cyclase activity
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Sensitized nucleus accumbens dopamine terminal responses to methylphenidate and dopamine transporter releasers after intermittent-access self-administration
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Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse
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Transient amelioration of the sensitization of cocaine-induced behaviors in rats by the induction of tolerance
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Increased running response to morphine in morphine-pretreated mice.
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Withdrawal from continuous or intermittent cocaine administration: changes in D2 receptor function.
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Cocaine disposition in the brain after continuous or intermittent treatment and locomotor stimulation in mice.
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Delayed occurrence of enhanced striatal preprodynorphin gene expression in behaviorally sensitized rats: differential long-term effects of intermittent and chronic morphine administration
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Altered sensitivity of dopamine autoreceptors in rat accumbens 1 and 7 days after intermittent or continuous cocaine withdrawal
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Sensitization of the Locomotor Response to Psychostimulants after Repeated Opiate Exposure: Role of the Nucleus Accumbens
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Alterations in Baseline Activity and Quinpirole Sensitivity in Putative Dopamine Neurons in the Substantia Nigra and Ventral Tegmental Area after Withdrawal from Cocaine Pretreatment
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Transcription and protein synthesis inhibitors reduce the induction of behavioural sensitization to a single morphine exposure and regulate Hsp70 expression in the mouse nucleus accumbens
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Molecular chaperone heat shock protein 70 participates in the labile phase of the development of behavioural sensitization induced by a single morphine exposure in mice
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Chaperone heat shock protein 70 in nucleus accumbens core: a novel biological target of behavioural sensitization to morphine in rats
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Preclinical Efficacy and Characterization of Candidate Vaccines for Treatment of Opioid Use Disorders Using Clinically Viable Carrier Proteins
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Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene
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Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease
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Independent optical excitation of distinct neural populations
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HISAT: a fast spliced aligner with low memory requirements
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Targeted expression of μ-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward
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Opposing mechanisms mediate morphine- and cocaine-induced generation of silent synapses
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IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates
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Selective Boosting of Transcriptional and Behavioral Responses to Drugs of Abuse by Histone Deacetylase Inhibition
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Episodic Withdrawal Promotes Psychomotor Sensitization to Morphine
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The Motivation to Self-Administer is Increased After a History of Spiking Brain Levels of Cocaine
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Temporal Pattern of Cocaine Intake Determines Tolerance vs Sensitization of Cocaine Effects at the Dopamine Transporter
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Loss of BDNF Signaling in D1R-Expressing NAc Neurons Enhances Morphine Reward by Reducing GABA Inhibition
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Brief Intermittent Cocaine Self-Administration and Abstinence Sensitizes Cocaine Effects on the Dopamine Transporter and Increases Drug Seeking
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Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases
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Regulation of heat shock transcription factors and their roles in physiology and disease
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Transcriptional and epigenetic mechanisms of addiction
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The dopamine theory of addiction: 40 years of highs and lows
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The gut microbiota mediates reward and sensory responses associated with regimen-selective morphine dependence
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Untangling the complexity of opioid receptor function
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Relapse to opioid seeking in rat models: behavior, pharmacology and circuits
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Opioid receptors: drivers to addiction?
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Dissociable dopamine dynamics for learning and motivation
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The R7 Subfamily of RGS Proteins Assists Tachyphylaxis and Acute Tolerance at μ-Opioid Receptors
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Intermittent Morphine Administration Induces Dependence and is a Chronic Stressor in Rats
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Stress Sensitization of Ethanol Withdrawal-Induced Reduction in Social Interaction: Inhibition by CRF-1 and Benzodiazepine Receptor Antagonists and a 5-HT1A-Receptor Agonist
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Modulation of Anxiety-Like Behavior and Morphine Dependence in CREB-Deficient Mice
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Cytoskeletal Genes Regulation by Chronic Morphine Treatment in Rat Striatum
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Expression of Neural RGS-R7 and Gβ5 Proteins in Response to Acute and Chronic Morphine
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Rapid Dopamine Signaling in the Nucleus Accumbens during Contingent and Noncontingent Cocaine Administration
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Brain Regional Fos Expression Elicited by the Activation of μ- but not δ-Opioid Receptors of the Ventral Tegmental Area: Evidence for an Implication of the Ventral Thalamus in Opiate Reward
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Mice lacking the chromodomain helicase DNA-binding 5 chromatin remodeler display autism-like characteristics
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Reversal of morphine-induced cell-type–specific synaptic plasticity in the nucleus accumbens shell blocks reinstatement
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In vivo imaging identifies temporal signature of D1 and D2 medium spiny neurons in cocaine reward
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Suppression of RGSz1 function optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/β-catenin pathway
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CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli
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Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
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Trimmomatic: a flexible trimmer for Illumina sequence data
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HTSeq—a Python framework to work with high-throughput sequencing data
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g:Profiler—a web-based toolset for functional profiling of gene lists from large-scale experiments
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Revisiting long‐access versus short‐access cocaine self‐administration in rats: intermittent intake promotes addiction symptoms independent of session length
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Incentive and dopamine sensitization produced by intermittent but not long access cocaine self‐administration
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Effects of Daily Cocaine and Morphine Treatment on Somatodendritic and Terminal Field Dopamine Release
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Neuroadaptations of total levels of adenylate cyclase, protein kinase A, tyrosine hydroxylase, cdk5 and neurofilaments in the nucleus accumbens and ventral tegmental area do not correlate with expression of sensitized or tolerant locomotor responses to cocaine
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An Oxycodone Conjugate Vaccine Elicits Drug-Specific Antibodies that Reduce Oxycodone Distribution to Brain and Hot-Plate Analgesia
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Calmodulin-Stimulated Adenylyl Cyclase Gene Deletion Affects Morphine Responses
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BDNF Is a Negative Modulator of Morphine Action
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Reduction of Morphine Abstinence in Mice with a Mutation in the Gene Encoding CREB
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Opiate Withdrawal in Utero Increases Neonatal Morbidity in the Rat
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Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors
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Endogenous and Exogenous Opioids in Pain
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Opposing mechanisms underlying differential changes in brain oxygen and temperature induced by intravenous morphine
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WGCNA: an R package for weighted correlation network analysis
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Morphine effects on striatal transcriptome in mice
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Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
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Neurobiology of opioid dependence in creating addiction vulnerability
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Chronic Morphine Alters the Presynaptic Protein Profile: Identification of Novel Molecular Targets Using Proteomics and Network Analysis
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Rapid, transient, and dose-dependent expression of Hsp70 messenger RNA in the rat brain after morphine treatment
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Regulation of Gene Expression by Chronic Morphine and Morphine Withdrawal in the Locus Ceruleus and Ventral Tegmental Area
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Morphine Epigenomically Regulates Behavior through Alterations in Histone H3 Lysine 9 Dimethylation in the Nucleus Accumbens
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Brain Region-Specific Mechanisms for Acute Morphine-Induced Mitogen-Activated Protein Kinase Modulation and Distinct Patterns of Activation during Analgesic Tolerance and Locomotor Sensitization
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Patient-Reported Utilization Patterns of Fentanyl Transdermal System and Oxycodone Hydrochloride Controlled-Release Among Patients With Chronic Nonmalignant Pain
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Fast R Functions for Robust Correlations and Hierarchical Clustering
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A General Framework for Weighted Gene Co-Expression Network Analysis
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Dopamine neurons projecting to medial shell of the nucleus accumbens drive heroin reinforcement
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Optical dopamine monitoring with dLight1 reveals mesolimbic phenotypes in a mouse model of neurofibromatosis type 1

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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The cannabinoid CB2 receptor agonist LY2828360 synergizes with morphine to suppress neuropathic nociception and attenuates morphine reward and physical dependence
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Application of optogenetics and in vivo imaging approaches for elucidating the neurobiology of addiction
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Functional genomic mechanisms of opioid action and opioid use disorder: a systematic review of animal models and human studies
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Individual differences in decision-making shape how mesolimbic dopamine regulates choice confidence and change-of-mind
inferred← citeshttps://doi.org/10.1101/2022.05.15.491856openalex-snapshot
Negative emotional behavior during fentanyl abstinence is mediated by adaptations in nucleus accumbens neuron subtypes
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μ-Opioid Receptor (Oprm1) Copy Number Influences Nucleus Accumbens Microcircuitry and Reciprocal Social Behaviors
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VGF in the Nucleus Accumbens Regulates Synaptic and Opioid-Evoked Plasticity
Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.