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Glioblastoma utilizes fatty acids and ketone bodies for growth allowing progression during ketogenic diet therapy

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/ijc.28809openalex-snapshot

Ketone supplementation decreases tumor cell viability and prolongs survival of mice with metastatic cancer

inferredcites →https://doi.org/10.1002/nbm.1427openalex-snapshot

In vitro, high‐resolution 1H and 31P NMR based analysis of the lipid components in the tissue, serum, and CSF of the patients with primary brain tumors: one possible diagnostic view

inferredcites →https://doi.org/10.1002/stem.15openalex-snapshot

Neurosphere Formation Is an Independent Predictor of Clinical Outcome in Malignant Glioma

inferredcites →https://doi.org/10.1007/8904_2011_35openalex-snapshot

Normal Levels of Plasma Free Carnitine and Acylcarnitines in Follow-Up Samples from a Presymptomatic Case of Carnitine Palmitoyl Transferase 1 (CPT1) Deficiency Detected Through Newborn Screening in Denmark

inferredcites →https://doi.org/10.1007/s00125-018-4744-6openalex-snapshot

Basal fatty acid oxidation increases after recurrent low glucose in human primary astrocytes

inferredcites →https://doi.org/10.1007/s11060-013-1154-yopenalex-snapshot

Caloric restriction reduces edema and prolongs survival in a mouse glioma model

inferredcites →https://doi.org/10.1016/j.bbabio.2010.08.009openalex-snapshot

Metabolic management of brain cancer

inferredcites →https://doi.org/10.1016/j.bbabio.2010.10.022openalex-snapshot

Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells

inferredcites →https://doi.org/10.1016/j.biocel.2015.01.022openalex-snapshot

Mitochondria: The ketogenic diet—A metabolism-based therapy

inferredcites →https://doi.org/10.1016/j.cell.2014.11.025openalex-snapshot

Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases

inferredcites →https://doi.org/10.1016/j.celrep.2017.10.030openalex-snapshot

Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human Glioblastoma

inferredcites →https://doi.org/10.1016/j.cmet.2006.02.002openalex-snapshot

HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

inferredcites →https://doi.org/10.1016/j.cmet.2019.04.004openalex-snapshot

Acyl-CoA-Binding Protein Drives Glioblastoma Tumorigenesis by Sustaining Fatty Acid Oxidation

inferredcites →https://doi.org/10.1016/j.expneurol.2016.08.006openalex-snapshot

Regulation of brain PPARgamma2 contributes to ketogenic diet anti-seizure efficacy

inferredcites →https://doi.org/10.1016/j.jpedsurg.2008.10.042openalex-snapshot

Ketone bodies inhibit the viability of human neuroblastoma cells

inferredcites →https://doi.org/10.1016/j.metabol.2005.03.018openalex-snapshot

Despite transient ketosis, the classic high-fat ketogenic diet induces marked changes in fatty acid metabolism in rats

inferredcites →https://doi.org/10.1016/j.mric.2016.07.003openalex-snapshot

Interrogating Metabolism in Brain Cancer

inferredcites →https://doi.org/10.1016/j.seizure.2017.09.005openalex-snapshot

The mechanisms mediating the antiepileptic effects of the ketogenic diet, and potential opportunities for improvement with metabolism-altering drugs

inferredcites →https://doi.org/10.1016/j.semcancer.2018.07.006openalex-snapshot

Comparison of glioblastoma (GBM) molecular classification methods

inferredcites →https://doi.org/10.1038/cdd.2012.168openalex-snapshot

Depletion of the novel p53-target gene carnitine palmitoyltransferase 1C delays tumor growth in the neurofibromatosis type I tumor model

inferredcites →https://doi.org/10.1038/jcbfm.2013.128openalex-snapshot

Why does Brain Metabolism not Favor Burning of Fatty Acids to Provide Energy? - Reflections on Disadvantages of the Use of Free Fatty Acids as Fuel for Brain

inferredcites →https://doi.org/10.1038/nature08617openalex-snapshot

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

inferredcites →https://doi.org/10.1038/nature14624openalex-snapshot

Correction: Corrigendum: Fatty acid carbon is essential for dNTP synthesis in endothelial cells

inferredcites →https://doi.org/10.1038/s41418-017-0013-3openalex-snapshot

Carnitine palmitoyltransferase 1C regulates cancer cell senescence through mitochondria-associated metabolic reprograming

inferredcites →https://doi.org/10.1038/s42003-019-0455-xopenalex-snapshot

Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma

inferredcites →https://doi.org/10.1038/sj.bjc.6600298openalex-snapshot

Dietary restriction reduces angiogenesis and growth in an orthotopic mouse brain tumour model

inferredcites →https://doi.org/10.1038/sj.bjc.6601269openalex-snapshot

Role of glucose and ketone bodies in the metabolic control of experimental brain cancer

inferredcites →https://doi.org/10.1038/sj.onc.1208622openalex-snapshot

The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid β-oxidation

inferredcites →https://doi.org/10.1056/nejmoa1402121openalex-snapshot

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas

inferredcites →https://doi.org/10.1080/07315724.1995.10718495openalex-snapshot

Effects of a ketogenic diet on tumor metabolism and nutritional status in pediatric oncology patients: two case reports.

inferredcites →https://doi.org/10.1093/carcin/bgx023openalex-snapshot

PPARα regulates tumor cell proliferation and senescence via a novel target gene carnitine palmitoyltransferase 1C

inferredcites →https://doi.org/10.1093/neuonc/not064openalex-snapshot

Spontaneous loss of heterozygosity leading to homozygous R132H in a patient-derived IDH1 mutant cell line

inferredcites →https://doi.org/10.1093/neuonc/nov125openalex-snapshot

Metabolic reprogramming in glioblastoma: the influence of cancer metabolism on epigenetics and unanswered questions

inferredcites →https://doi.org/10.1093/neuonc/now045openalex-snapshot

Large-scale assessment of the gliomasphere model system

inferredcites →https://doi.org/10.1093/neuonc/now088openalex-snapshot

A ketogenic diet increases transport and oxidation of ketone bodies in RG2 and 9L gliomas without affecting tumor growth

inferredcites →https://doi.org/10.1093/neuonc/now128openalex-snapshot

Fatty acid oxidation is required for the respiration and proliferation of malignant glioma cells

inferredcites →https://doi.org/10.1101/gad.1987211openalex-snapshot

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress

inferredcites →https://doi.org/10.1111/j.1471-4159.1986.tb13039.xopenalex-snapshot

Acetoacetate and Glucose as Lipid Precursors and Energy Substrates in Primary Cultures of Astrocytes and Neurons from Mouse Cerebral Cortex

inferredcites →https://doi.org/10.1126/science.1160809openalex-snapshot

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

inferredcites →https://doi.org/10.1126/scisignal.2000446openalex-snapshot

EGFR Signaling Through an Akt-SREBP-1–Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy

inferredcites →https://doi.org/10.1126/scitranslmed.aaf6853openalex-snapshot

Origin of the U87MG glioma cell line: Good news and bad news

inferredcites →https://doi.org/10.1126/scitranslmed.aaq1427openalex-snapshot

IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response

inferredcites →https://doi.org/10.1158/0008-5472.can-03-2904openalex-snapshot

Akt Stimulates Aerobic Glycolysis in Cancer Cells

inferredcites →https://doi.org/10.1158/0008-5472.can-07-2489openalex-snapshot

Fatty Acid Synthase Gene Is Up-regulated by Hypoxia via Activation of Akt and Sterol Regulatory Element Binding Protein-1

inferredcites →https://doi.org/10.1158/0008-5472.can-09-2266openalex-snapshot

Glioblastoma Cells Require Glutamate Dehydrogenase to Survive Impairments of Glucose Metabolism or Akt Signaling

inferredcites →https://doi.org/10.1172/jci113997openalex-snapshot

Influence of body fat distribution on free fatty acid metabolism in obesity.

inferredcites →https://doi.org/10.1186/1471-2407-11-315openalex-snapshot

Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy

inferredcites →https://doi.org/10.1186/1743-7075-11-23openalex-snapshot

Influence of a ketogenic diet, fish-oil, and calorie restriction on plasma metabolites and lipids in C57BL/6J mice

inferredcites →https://doi.org/10.1186/1743-7075-4-5openalex-snapshot

The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer

inferredcites →https://doi.org/10.1186/1743-7075-7-33openalex-snapshot

Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report

inferredcites →https://doi.org/10.1186/1743-7075-7-74openalex-snapshot

The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma

inferredcites →https://doi.org/10.1186/s12885-016-2337-7openalex-snapshot

Enhanced immunity in a mouse model of malignant glioma is mediated by a therapeutic ketogenic diet

inferredcites →https://doi.org/10.1186/s12943-019-0954-xopenalex-snapshot

Targeting PI3K in cancer: mechanisms and advances in clinical trials

inferredcites →https://doi.org/10.1186/s40170-015-0129-1openalex-snapshot

Treatment of glioma patients with ketogenic diets: report of two cases treated with an IRB-approved energy-restricted ketogenic diet protocol and review of the literature

inferredcites →https://doi.org/10.1186/s40170-018-0177-4openalex-snapshot

Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities

inferredcites →https://doi.org/10.1212/01.wnl.0000049974.74242.c6openalex-snapshot

Elevated polyunsaturated fatty acids in blood serum obtained from children on the ketogenic diet

inferredcites →https://doi.org/10.1371/journal.pone.0036197openalex-snapshot

The Ketogenic Diet Is an Effective Adjuvant to Radiation Therapy for the Treatment of Malignant Glioma

inferredcites →https://doi.org/10.1371/journal.pone.0080397openalex-snapshot

Protective Properties of Radio-Chemoresistant Glioblastoma Stem Cell Clones Are Associated with Metabolic Adaptation to Reduced Glucose Dependence

inferredcites →https://doi.org/10.1523/jneurosci.14-08-05068.1994openalex-snapshot

Extracellular glucose concentration in mammalian brain: continuous monitoring of changes during increased neuronal activity and upon limitation in oxygen supply in normo-, hypo-, and hyperglycemic animals

inferredcites →https://doi.org/10.1590/s1807-59322011001300005openalex-snapshot

Metabolism and Brain Cancer

inferredcites →https://doi.org/10.2174/1570159x15666170517153509openalex-snapshot

The Anticonvulsant Effects of Ketogenic Diet on Epileptic Seizures and Potential Mechanisms

inferredcites →https://doi.org/10.3233/jad-2012-110629openalex-snapshot

Plasma and Brain Fatty Acid Profiles in Mild Cognitive Impairment and Alzheimer's Disease

inferredcites →https://doi.org/10.3389/fcell.2017.00043openalex-snapshot

Metabolic Reprogramming in Glioma

inferredcites →https://doi.org/10.3892/ijo.2014.2382openalex-snapshot

ERGO: A pilot study of ketogenic diet in recurrent glioblastoma

inferredcites →https://doi.org/10.4103/2152-7806.155259openalex-snapshot

The role of metabolic therapy in treating glioblastoma multiforme

inferredcites →https://doi.org/10.4161/cbt.28408openalex-snapshot

High grade glioblastoma is associated with aberrant expression of ZFP57, a protein involved in gene imprinting, and of CPT1A and CPT1C that regulate fatty acid metabolism

inferredcites →https://doi.org/10.5487/tr.2011.27.2.103openalex-snapshot

Lipotoxicity of Palmitic Acid on Neural Progenitor Cells and Hippocampal Neurogenesis

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.3389/fonc.2021.653621openalex-snapshot

Metabolic Rewiring in Radiation Oncology Toward Improving the Therapeutic Ratio

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