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Loss of SHMT2 mediates 5-FU chemoresistance by inducing autophagy in colorectal cancer

https://doi.org/10.1101/680892
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/s13277-015-3800-9openalex-snapshot
Protective autophagy promotes the resistance of HER2-positive breast cancer cells to lapatinib
inferredcites →https://doi.org/10.1016/j.biopha.2018.05.007openalex-snapshot
Autophagy in health and disease: A comprehensive review
inferredcites →https://doi.org/10.1016/j.ceb.2009.12.001openalex-snapshot
Autophagy regulation by p53
inferredcites →https://doi.org/10.1016/j.celrep.2013.08.025openalex-snapshot
A BRISC-SHMT Complex Deubiquitinates IFNAR1 and Regulates Interferon Responses
inferredcites →https://doi.org/10.1016/j.clcc.2014.11.002openalex-snapshot
A Review of the Evolution of Systemic Chemotherapy in the Management of Colorectal Cancer
inferredcites →https://doi.org/10.1016/j.jormas.2017.11.001openalex-snapshot
Autophagy and oral cancers: A short review
inferredcites →https://doi.org/10.1016/j.radonc.2011.06.002openalex-snapshot
Autophagy contributes to resistance of tumor cells to ionizing radiation
inferredcites →https://doi.org/10.1016/j.tibs.2014.02.004openalex-snapshot
Serine and glycine metabolism in cancer
inferredcites →https://doi.org/10.1016/j.tips.2004.02.004openalex-snapshot
The development of Ca2+ indicators: a breakthrough in pharmacological research
inferredcites →https://doi.org/10.1016/j.tips.2004.02.009openalex-snapshot
p53: 25 years after its discovery
inferredcites →https://doi.org/10.1038/cddis.2013.350openalex-snapshot
Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment
inferredcites →https://doi.org/10.1038/cr.2011.203openalex-snapshot
PKM2: A gatekeeper between growth and survival
inferredcites →https://doi.org/10.1038/nature07986openalex-snapshot
Cytoplasmic functions of the tumour suppressor p53
inferredcites →https://doi.org/10.1038/nature10598openalex-snapshot
Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
inferredcites →https://doi.org/10.1038/nature14363openalex-snapshot
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance
inferredcites →https://doi.org/10.1038/ncb1730openalex-snapshot
Regulation of autophagy by cytoplasmic p53
inferredcites →https://doi.org/10.1038/nrc.2017.53openalex-snapshot
Targeting autophagy in cancer
inferredcites →https://doi.org/10.1038/nrc3557openalex-snapshot
Serine, glycine and one-carbon units: cancer metabolism in full circle
inferredcites →https://doi.org/10.1038/s41467-018-06812-yopenalex-snapshot
Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis
inferredcites →https://doi.org/10.1038/srep10434openalex-snapshot
Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects
inferredcites →https://doi.org/10.1042/bsr20171049openalex-snapshot
Autophagy attenuates endothelial-to-mesenchymal transition by promoting Snail degradation in human cardiac microvascular endothelial cells
inferredcites →https://doi.org/10.1056/nejmoa022289openalex-snapshot
Tumor Microsatellite-Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer
inferredcites →https://doi.org/10.1080/15548627.2015.1100356openalex-snapshot
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
inferredcites →https://doi.org/10.1111/cas.13516openalex-snapshot
RBBP 6 increases radioresistance and serves as a therapeutic target for preoperative radiotherapy in colorectal cancer
inferredcites →https://doi.org/10.1126/science.1218595openalex-snapshot
Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation
inferredcites →https://doi.org/10.1155/2018/4369253openalex-snapshot
SHMT2 Overexpression Predicts Poor Prognosis in Intrahepatic Cholangiocarcinoma
inferredcites →https://doi.org/10.1158/0008-5472.can-07-0562openalex-snapshot
Blocked Autophagy Sensitizes Resistant Carcinoma Cells to Radiation Therapy
inferredcites →https://doi.org/10.1158/0008-5472.can-13-2683openalex-snapshot
Comparative Oncogenomics Identifies PSMB4 and SHMT2 as Potential Cancer Driver Genes
inferredcites →https://doi.org/10.1158/0008-5472.can-17-1912openalex-snapshot
SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation
inferredcites →https://doi.org/10.1186/s13046-016-0427-7openalex-snapshot
TIMP1 is a prognostic marker for the progression and metastasis of colon cancer through FAK-PI3K/AKT and MAPK pathway
inferredcites →https://doi.org/10.1371/journal.pone.0005839openalex-snapshot
SHMT1 and SHMT2 Are Functionally Redundant in Nuclear De novo Thymidylate Biosynthesis
inferredcites →https://doi.org/10.1371/journal.ppat.1007071openalex-snapshot
SHMT2 and the BRCC36/BRISC deubiquitinase regulate HIV-1 Tat K63-ubiquitylation and destruction by autophagy
inferredcites →https://doi.org/10.18632/oncotarget.10415openalex-snapshot
Downregulating serine hydroxymethyltransferase 2 (SHMT2) suppresses tumorigenesis in human hepatocellular carcinoma
inferredcites →https://doi.org/10.3171/2014.5.focus1474openalex-snapshot
Sacral fractures
inferredcites →https://doi.org/10.3171/2014.9.focus14504openalex-snapshot
Chloroquine enhances temozolomide cytotoxicity in malignant gliomas by blocking autophagy
inferredcites →https://doi.org/10.3322/caac.21395openalex-snapshot
Colorectal cancer statistics, 2017
inferredcites →https://doi.org/10.3389/fgene.2012.00033openalex-snapshot
Regular Multivitamin Supplement Use, Single Nucleotide Polymorphisms in ATIC, SHMT2, and SLC46A1, and Risk of Ovarian Carcinoma
inferredcites →https://doi.org/10.4161/auto.19496openalex-snapshot
Guidelines for the use and interpretation of assays for monitoring autophagy
inferredcites →https://doi.org/10.7554/elife.10575openalex-snapshot
Mitochondrial dysfunction remodels one-carbon metabolism in human cells

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1111/cas.14532openalex-snapshot
5‐Fluorouracil resistance mechanisms in colorectal cancer: From classical pathways to promising processes
inferred← citeshttps://doi.org/10.3390/cancers11111775openalex-snapshot
Molecular Mechanisms Underlying Autophagy-Mediated Treatment Resistance in Cancer
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