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Age-dependent effects of reduced mTor signalling on life expectancy through distinct physiology
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1 of the 48 references listed on this page is in the Retraction Watch database as retracted (export 2026-11-04): 10.7554/elife.12248 (notice 2018-04-12).
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1001/archinte.159.7.733openalex-snapshot
Cigarette Smoking and Mortality Risk
inferredcites →https://doi.org/10.1016/j.arr.2013.11.002openalex-snapshot
What are the roles of calorie restriction and diet quality in promoting healthy longevity?
inferredcites →https://doi.org/10.1016/j.cell.2006.03.046openalex-snapshot
A Conserved MST-FOXO Signaling Pathway Mediates Oxidative-Stress Responses and Extends Life Span
inferredcites →https://doi.org/10.1016/j.cell.2015.02.020openalex-snapshot
Promoting Health and Longevity through Diet: From Model Organisms to Humans
inferredcites →https://doi.org/10.1016/j.cell.2017.10.037openalex-snapshot
Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling
inferredcites →https://doi.org/10.1016/j.celrep.2016.05.092openalex-snapshot
Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health
inferredcites →https://doi.org/10.1016/j.cmet.2011.09.013openalex-snapshot
Modulation of Longevity and Tissue Homeostasis by the Drosophila PGC-1 Homolog
inferredcites →https://doi.org/10.1016/j.exger.2010.12.002openalex-snapshot
The plate half-full: Status of research on the mechanisms of dietary restriction in Drosophila melanogaster
inferredcites →https://doi.org/10.1016/j.jgg.2019.03.011openalex-snapshot
Organelle aging: Lessons from model organisms
inferredcites →https://doi.org/10.1016/j.mad.2004.09.017openalex-snapshot
Dietary restriction, mortality trajectories, risk and damage
inferredcites →https://doi.org/10.1016/j.mad.2005.03.015openalex-snapshot
Dietary restriction in rodents—delayed or retarded ageing?
inferredcites →https://doi.org/10.1016/j.mad.2009.05.004openalex-snapshot
The steroid hormone receptor EcR finely modulates Drosophila lifespan during adulthood in a sex-specific manner
inferredcites →https://doi.org/10.1016/j.molcel.2007.07.018openalex-snapshot
Rapid, Transcript-Specific Changes in Splicing in Response to Environmental Stress
inferredcites →https://doi.org/10.1016/j.molcel.2014.11.019openalex-snapshot
Phosphorylation of LC3 by the Hippo Kinases STK3/STK4 Is Essential for Autophagy
inferredcites →https://doi.org/10.1016/s0022-1910(01)00138-xopenalex-snapshot
Age-specific mortality and reproduction respond to adult dietary restriction in Drosophila melanogaster
inferredcites →https://doi.org/10.1038/nature02549openalex-snapshot
Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
inferredcites →https://doi.org/10.1038/nature08221openalex-snapshot
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
inferredcites →https://doi.org/10.1038/nature11861openalex-snapshot
mTOR is a key modulator of ageing and age-related disease
inferredcites →https://doi.org/10.1038/nature13492openalex-snapshot
Coordinated regulation of protein synthesis and degradation by mTORC1
inferredcites →https://doi.org/10.1038/nature20789openalex-snapshot
Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans
inferredcites →https://doi.org/10.1038/nmeth.1592openalex-snapshot
A genome-scale shRNA resource for transgenic RNAi in Drosophila
inferredcites →https://doi.org/10.1038/nprot.2016.095openalex-snapshot
Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown
inferredcites →https://doi.org/10.1038/s41467-017-00370-5openalex-snapshot
Differential alternative splicing coupled to nonsense-mediated decay of mRNA ensures dietary restriction-induced longevity
inferredcites →https://doi.org/10.1038/s41467-019-11174-0openalex-snapshot
A novel rapamycin analog is highly selective for mTORC1 in vivo
inferredcites →https://doi.org/10.1038/s41586-018-0457-8openalex-snapshot
Facing up to the global challenges of ageing
inferredcites →https://doi.org/10.1038/s41598-016-0001-8openalex-snapshot
Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease
inferredcites →https://doi.org/10.1038/srep22685openalex-snapshot
Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo
inferredcites →https://doi.org/10.1046/j.1420-9101.1999.00058.xopenalex-snapshot
Model fitting and hypothesis testing for age-specific mortality data
inferredcites →https://doi.org/10.1046/j.1474-9728.2002.00005.xopenalex-snapshot
Pre‐mRNA splicing modulations in senescence
inferredcites →https://doi.org/10.1073/pnas.1521919112openalex-snapshot
mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy
inferredcites →https://doi.org/10.1073/pnas.221303298openalex-snapshot
A conditional tissue-specific transgene expression system using inducible GAL4
inferredcites →https://doi.org/10.1093/emboj/19.4.589openalex-snapshot
Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function
inferredcites →https://doi.org/10.1093/gerona/glp051openalex-snapshot
Life-Span Extension in Mice by Preweaning Food Restriction and by Methionine Restriction in Middle Age
inferredcites →https://doi.org/10.1093/gerona/glw153openalex-snapshot
Meta-Analysis of 29 Experiments Evaluating the Effects of Rapamycin on Life Span in the Laboratory Mouse
inferredcites →https://doi.org/10.1093/gerona/glx010openalex-snapshot
Life-span Extension With Reduced Somatotrophic Signaling: Moderation of Aging Effect by Signal Type, Sex, and Experimental Cohort
inferredcites →https://doi.org/10.1093/nar/gkv007openalex-snapshot
limma powers differential expression analyses for RNA-sequencing and microarray studies
inferredcites →https://doi.org/10.1096/fj.09-142984openalex-snapshot
Life‐span extension by dietary restriction is mediated by NLP‐7 signaling and coelomocyte endocytosis in C. elegans
inferredcites →https://doi.org/10.1101/533711openalex-snapshot
The hidden costs of dietary restriction: implications for its evolutionary and mechanistic origins
inferredcites →https://doi.org/10.1111/acel.12061openalex-snapshot
Dietary restriction of rodents decreases aging rate without affecting initial mortality rate – a meta‐analysis
inferredcites →https://doi.org/10.1111/acel.12489openalex-snapshot
Comparative idiosyncrasies in life extension by reduced mTOR signalling and its distinctiveness from dietary restriction
inferredcites →https://doi.org/10.1126/science.1086016openalex-snapshot
Demography of Dietary Restriction and Death in Drosophila
inferredcites →https://doi.org/10.1126/science.1098219openalex-snapshot
Long-Lived Drosophila with Overexpressed dFOXO in Adult Fat Body
inferredcites →https://doi.org/10.1186/gb-2010-11-2-r14openalex-snapshot
Gene ontology analysis for RNA-seq: accounting for selection bias
inferredcites →https://doi.org/10.1198/1061860031365openalex-snapshot
Penalized Survival Models and Frailty
inferredcites →https://doi.org/10.7554/elife.12248openalex-snapshot
RETRACTED: A mathematical model explains saturating axon guidance responses to molecular gradients
inferredcites →https://doi.org/10.7554/elife.16351openalex-snapshot
Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1007/s11357-022-00691-4openalex-snapshot
Rapamycin not dietary restriction improves resilience against pathogens: a meta-analysis
inferred← citeshttps://doi.org/10.1007/s11357-025-02079-6openalex-snapshot
Knockdown of the fly spliceosome component Rbp1 (orthologue of SRSF1) extends lifespan
inferred← citeshttps://doi.org/10.1038/s41586-025-09694-5openalex-snapshot
Evidence for improved DNA repair in the long-lived bowhead whale
inferred← citeshttps://doi.org/10.1101/2024.09.17.613448openalex-snapshot
Expansion of Drosophila haemocytes using a conditional GeneSwitch driver affects larval haemocyte function, but does not modulate adult lifespan or survival from infection
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