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Single Cell RNAseq Reveals A Critical Role of Chloride Channels in Airway Development

https://doi.org/10.1101/735969
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Surfactant protein D alters allergic lung responses in mice and human subjects
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Protective role of the lung collectins surfactant protein A and surfactant protein D in airway inflammation
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The Role of Scgb1a1+ Clara Cells in the Long-Term Maintenance and Repair of Lung Airway, but Not Alveolar, Epithelium
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Myoepithelial Cells of Submucosal Glands Can Function as Reserve Stem Cells to Regenerate Airways after Injury
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The transmembrane protein TMEM16A is required for normal development of the murine trachea
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FETAL ABNORMALITIES IN CYSTIC FIBROSIS SUGGEST A DEFICIENCY IN PROTEOLYSIS OF CHOLECYSTOKININ
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TMEM16A confers receptor-activated calcium-dependent chloride conductance
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MCIDAS mutations result in a mucociliary clearance disorder with reduced generation of multiple motile cilia
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Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis
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Foxj1 transcription factors are master regulators of the motile ciliogenic program
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Mutations in CCNO result in congenital mucociliary clearance disorder with reduced generation of multiple motile cilia
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Defensins: antimicrobial peptides of innate immunity
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RNA velocity of single cells
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Allergic inflammatory memory in human respiratory epithelial progenitor cells
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DCAMKL-1 Expression Identifies Tuft Cells Rather Than Stem Cells in the Adult Mouse Intestinal Epithelium
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Airway Mucus Function and Dysfunction
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Gel-forming mucins form distinct morphologic structures in airways
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Cytoplasmic Cl − couples membrane remodeling to epithelial morphogenesis
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Relationship of a non-cystic fibrosis transmembrane conductance regulator-mediated chloride conductance to organ-level disease in Cftr(-/-) mice.
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Transmembrane Protein 16A (TMEM16A) Is a Ca2+-regulated Cl– Secretory Channel in Mouse Airways
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Krüppel-like Factor 4 Promotes Esophageal Squamous Cell Carcinoma Differentiation by Up-regulating Keratin 13 Expression
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Roles of Pofut1 and O-Fucose in Mammalian Notch Signaling
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ALLERGEN INDUCED TFF2 IS EXPRESSED BY MUCUS-PRODUCING AIRWAY EPITHELIAL CELLS BUT IS NOT A MAJOR REGULATOR OF INFLAMMATORY RESPONSES IN THE MURINE LUNG
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Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection
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Cell-specific localization of CFTR mRNA shows developmentally regulated expression in human fetal tissues
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Radial spoke proteins regulate otolith formation during early zebrafish development
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Improving the Accuracy of Fetal Foot Length to Confirm Gestational Duration
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Acidic Mammalian Chitinase in Asthmatic Th2 Inflammation and IL-13 Pathway Activation
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TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity
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A Periciliary Brush Promotes the Lung Health by Separating the Mucus Layer from Airway Epithelia
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Parasympathetic neurons originate from nerve-associated peripheral glial progenitors
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Parasympathetic ganglia derive from Schwann cell precursors
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The dynamics of gene expression in vertebrate embryogenesis at single-cell resolution
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Chitinase and Fizz Family Members Are a Generalized Feature of Nematode Infection with Selective Upregulation of Ym1 and Fizz1 by Antigen-Presenting Cells
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Id2 and Id3 Define the Potency of Cell Proliferation and Differentiation Responses to Transforming Growth Factor β and Bone Morphogenetic Protein
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Wnt7b Activates Canonical Signaling in Epithelial and Vascular Smooth Muscle Cells through Interactions with Fzd1, Fzd10, and LRP5
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Histochemistry of the surface mucous gel layer of the human colon.
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Lung Endoderm Morphogenesis: Gasping for Form and Function
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Chloride in Vesicular Trafficking and Function
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The role of regulated CFTR trafficking in epithelial secretion
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Role of f-box factor foxj1 in differentiation of ciliated airway epithelial cells
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Animal Models of Cystic Fibrosis Pathology: Phenotypic Parallels and Divergences
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Prostaglandins and Inflammation
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Loss of Cystic Fibrosis Transmembrane Conductance Regulator Function Produces Abnormalities in Tracheal Development in Neonatal Pigs and Young Children
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CFTR Expression and Chloride Secretion in Polarized Immortal Human Bronchial Epithelial Cells
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Expression and Localization of Epithelial Aquaporins in the Adult Human Lung
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Differential Gene Expression in Human Conducting Airway Surface Epithelia and Submucosal Glands
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Goblet Cells Are Derived from a FOXJ1 -Expressing Progenitor in a Human Airway Epithelium
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A Single Cell Functions as a Tissue-Specific Stem Cell and the In Vitro Niche-Forming Cell
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Human Tracheobronchial Basal Cells. Normal versus Remodeling/Repairing Phenotypes In Vivo and In Vitro
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Localization of cystic fibrosis transmembrane conductance regulator mRNA in human fetal lung tissue by in situ hybridization.
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Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals
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SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production
inferredcites →https://doi.org/10.1172/jci60519openalex-snapshot
Building and maintaining the epithelium of the lung
inferredcites →https://doi.org/10.1183/09031936.00146905openalex-snapshot
Clinical relevance of airway remodelling in airway diseases
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Developmental lung expression and transcriptional regulation of Claudin-6 by TTF-1, Gata-6, and FoxA2
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Airway disease phenotypes in animal models of cystic fibrosis
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The Id-protein family in developmental and cancer-associated pathways
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Notch signaling controls the balance of ciliated and secretory cell fates in developing airways
inferredcites →https://doi.org/10.1242/dev.113.1.305openalex-snapshot
Expression of the cystic fibrosis gene in human development
inferredcites →https://doi.org/10.1242/dev.126342openalex-snapshot
Mcidas and GemC1/Lynkeas are key regulators for the generation of multiciliated ependymal cells in the adult neurogenic niche
inferredcites →https://doi.org/10.1242/dev.129.20.4831openalex-snapshot
Wnt7b regulates mesenchymal proliferation and vascular development in the lung
inferredcites →https://doi.org/10.1242/dev.143859openalex-snapshot
Foxn4 promotes gene expression required for the formation of multiple motile cilia
inferredcites →https://doi.org/10.1242/dmm.006031openalex-snapshot
Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling
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Flowtrace: simple visualization of coherent structures in biological fluid flows
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Immunohistochemical Localization of the Aquaporins AQP1, AQP3, AQP4, and AQP5 in the Mouse Respiratory System
inferredcites →https://doi.org/10.1371/journal.pone.0075106openalex-snapshot
The Tight-Junction Protein Claudin-6 Induces Epithelial Differentiation from Mouse F9 and Embryonic Stem Cells
inferredcites →https://doi.org/10.1371/journal.ppat.1000393openalex-snapshot
Retnla (Relmα/Fizz1) Suppresses Helminth-Induced Th2-Type Immunity
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Effect of aging on respiratory system physiology and immunology
inferredcites →https://doi.org/10.2174/138161209788453202openalex-snapshot
Lactoferrin as a Natural Immune Modulator
inferredcites →https://doi.org/10.2332/allergolint.o-06-449openalex-snapshot
Role of Galectin-3 in Human Pulmonary Fibrosis
inferredcites →https://doi.org/10.4049/jimmunol.1400551openalex-snapshot
CXCL17 Is a Major Chemotactic Factor for Lung Macrophages
inferredcites →https://doi.org/10.4049/jimmunol.166.5.3362openalex-snapshot
Impaired Pulmonary Host Defense in Mice Lacking Expression of the CXC Chemokine Lungkine
inferredcites →https://doi.org/10.4049/jimmunol.168.11.5507openalex-snapshot
Id2 Negatively Regulates B Cell Differentiation in the Spleen
inferredcites →https://doi.org/10.4049/jimmunol.170.3.1452openalex-snapshot
CCL28 Has Dual Roles in Mucosal Immunity as a Chemokine with Broad-Spectrum Antimicrobial Activity
inferredcites →https://doi.org/10.4049/jimmunol.1801069openalex-snapshot
The Immune Function of Tuft Cells at Gut Mucosal Surfaces and Beyond
inferredcites →https://doi.org/10.4161/tisb.24997openalex-snapshot
Barrier function of airway tract epithelium
inferredcites →https://doi.org/10.7554/elife.09693openalex-snapshot
Auxiliary subunits of the CKAMP family differentially modulate AMPA receptor properties
inferredcites →https://doi.org/10.7554/elife.21231openalex-snapshot
Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes
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