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The deubiquitinating activity of Middle East respiratory syndrome coronavirus papain-like protease delays the innate immune response and enhances virulence in a mouse model
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/1873-3468.12827openalex-snapshot
RNA ‐virus proteases counteracting host innate immunity
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Influenza A Virus Lacking the NS1 Gene Replicates in Interferon-Deficient Systems
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Coronaviruses: An Overview of Their Replication and Pathogenesis
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Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology
inferredcites →https://doi.org/10.1007/s13238-013-3096-8openalex-snapshot
The structural and accessory proteins M, ORF 4a, ORF 4b, and ORF 5 of Middle East respiratory syndrome coronavirus (MERS-CoV) are potent interferon antagonists
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Virus isolation and quantitation
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Molecular Basis of Coronavirus Virulence and Vaccine Development
inferredcites →https://doi.org/10.1016/bs.aivir.2016.08.006openalex-snapshot
Interaction of SARS and MERS Coronaviruses with the Antiviral Interferon Response
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Hosts and Sources of Endemic Human Coronaviruses
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Crimean-Congo Hemorrhagic Fever Virus Suppresses Innate Immune Responses via a Ubiquitin and ISG15 Specific Protease
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Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice
inferredcites →https://doi.org/10.1016/j.chom.2017.07.012openalex-snapshot
Ten Strategies of Interferon Evasion by Viruses
inferredcites →https://doi.org/10.1016/j.coviro.2017.03.007openalex-snapshot
Middle East respiratory syndrome coronavirus vaccines: current status and novel approaches
inferredcites →https://doi.org/10.1016/j.ijid.2016.04.008openalex-snapshot
Middle East respiratory syndrome vaccines
inferredcites →https://doi.org/10.1016/j.immuni.2016.06.020openalex-snapshot
Post-Translational Modification Control of Innate Immunity
inferredcites →https://doi.org/10.1016/j.immuni.2019.03.025openalex-snapshot
Shared and Distinct Functions of Type I and Type III Interferons
inferredcites →https://doi.org/10.1016/j.jmb.2017.06.010openalex-snapshot
Structure and Function of Viral Deubiquitinating Enzymes
inferredcites →https://doi.org/10.1016/j.vetmic.2015.04.018openalex-snapshot
In vivo assessment of equine arteritis virus vaccine improvement by disabling the deubiquitinase activity of papain-like protease 2
inferredcites →https://doi.org/10.1016/j.virol.2013.11.040openalex-snapshot
MERS-CoV papain-like protease has deISGylating and deubiquitinating activities
inferredcites →https://doi.org/10.1016/j.virol.2015.02.033openalex-snapshot
Ubiquitination in the antiviral immune response
inferredcites →https://doi.org/10.1016/j.virusres.2007.03.015openalex-snapshot
SARS coronavirus and innate immunity
inferredcites →https://doi.org/10.1016/j.virusres.2014.01.025openalex-snapshot
Nidovirus papain-like proteases: Multifunctional enzymes with protease, deubiquitinating and deISGylating activities
inferredcites →https://doi.org/10.1016/s1473-3099(13)70164-6openalex-snapshot
Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study
inferredcites →https://doi.org/10.1016/s1473-3099(13)70690-xopenalex-snapshot
Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation
inferredcites →https://doi.org/10.1016/s1473-3099(18)30127-0openalex-snapshot
Middle East respiratory syndrome coronavirus: risk factors and determinants of primary, household, and nosocomial transmission
inferredcites →https://doi.org/10.1038/icb.2012.10openalex-snapshot
Role of type I interferons in the activation of autoreactive B cells
inferredcites →https://doi.org/10.1038/icb.2012.7openalex-snapshot
Modulation of T‐cell function by type I interferon
inferredcites →https://doi.org/10.1038/ncb3358openalex-snapshot
The increasing complexity of the ubiquitin code
inferredcites →https://doi.org/10.1038/ni.1979openalex-snapshot
Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5
inferredcites →https://doi.org/10.1038/nsmb.1680openalex-snapshot
A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 protein
inferredcites →https://doi.org/10.1038/s41579-018-0118-9openalex-snapshot
Origin and evolution of pathogenic coronaviruses
inferredcites →https://doi.org/10.1038/s41580-019-0099-1openalex-snapshot
Breaking the chains: deubiquitylating enzyme specificity begets function
inferredcites →https://doi.org/10.1038/sigtrans.2017.23openalex-snapshot
NF-κB signaling in inflammation
inferredcites →https://doi.org/10.1056/nejmoa1211721openalex-snapshot
Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
inferredcites →https://doi.org/10.1073/pnas.070525997openalex-snapshot
Influenza A and B viruses expressing altered NS1 proteins: A vaccine approach
inferredcites →https://doi.org/10.1073/pnas.1218464110openalex-snapshot
Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells
inferredcites →https://doi.org/10.1073/pnas.1311542110openalex-snapshot
Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus
inferredcites →https://doi.org/10.1073/pnas.1618310114openalex-snapshot
Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages
inferredcites →https://doi.org/10.1073/pnas.1619109114openalex-snapshot
Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice
inferredcites →https://doi.org/10.1074/jbc.m114.609644openalex-snapshot
Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression
inferredcites →https://doi.org/10.1074/jbc.m115.662130openalex-snapshot
X-ray Structural and Functional Studies of the Three Tandemly Linked Domains of Non-structural Protein 3 (nsp3) from Murine Hepatitis Virus Reveal Conserved Functions
inferredcites →https://doi.org/10.1074/jbc.m704870200openalex-snapshot
Regulation of IRF-3-dependent Innate Immunity by the Papain-like Protease Domain of the Severe Acute Respiratory Syndrome Coronavirus
inferredcites →https://doi.org/10.1084/jem.20151531openalex-snapshot
Ubiquitin in the activation and attenuation of innate antiviral immunity
inferredcites →https://doi.org/10.1086/649428openalex-snapshot
A Novel Type of Influenza Vaccine: Safety and Immunogenicity of Replication‐Deficient Influenza Virus Created by Deletion of the Interferon Antagonist NS1
inferredcites →https://doi.org/10.1093/infdis/jiv499openalex-snapshot
Middle East Respiratory Syndrome Coronavirus Causes Multiple Organ Damage and Lethal Disease in Mice Transgenic for Human Dipeptidyl Peptidase 4
inferredcites →https://doi.org/10.1099/vir.0.059014-0openalex-snapshot
Proteolytic processing, deubiquitinase and interferon antagonist activities of Middle East respiratory syndrome coronavirus papain-like protease
inferredcites →https://doi.org/10.1126/science.aac8608openalex-snapshot
Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia
inferredcites →https://doi.org/10.1126/science.aad1283openalex-snapshot
An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels
inferredcites →https://doi.org/10.1128/jvi.01199-08openalex-snapshot
Murine Coronavirus Mouse Hepatitis Virus Is Recognized by MDA5 and Induces Type I Interferon in Brain Macrophages/Microglia
inferredcites →https://doi.org/10.1128/jvi.01277-13openalex-snapshot
The Receptor Binding Domain of the New Middle East Respiratory Syndrome Coronavirus Maps to a 231-Residue Region in the Spike Protein That Efficiently Elicits Neutralizing Antibodies
inferredcites →https://doi.org/10.1128/jvi.01352-15openalex-snapshot
Middle East Respiratory Syndrome Coronavirus nsp1 Inhibits Host Gene Expression by Selectively Targeting mRNAs Transcribed in the Nucleus while Sparing mRNAs of Cytoplasmic Origin
inferredcites →https://doi.org/10.1128/jvi.01512-06openalex-snapshot
Mouse Hepatitis Virus Does Not Induce Beta Interferon Synthesis and Does Not Inhibit Its Induction by Double-Stranded RNA
inferredcites →https://doi.org/10.1128/jvi.01845-13openalex-snapshot
Middle East Respiratory Syndrome Coronavirus Accessory Protein 4a Is a Type I Interferon Antagonist
inferredcites →https://doi.org/10.1128/jvi.02671-14openalex-snapshot
Activation of the Chicken Type I Interferon Response by Infectious Bronchitis Coronavirus
inferredcites →https://doi.org/10.1128/jvi.03571-13openalex-snapshot
Attenuation and Restoration of Severe Acute Respiratory Syndrome Coronavirus Mutant Lacking 2′-O-Methyltransferase Activity
inferredcites →https://doi.org/10.1128/jvi.79.24.15199-15208.2005openalex-snapshot
The Papain-Like Protease from the Severe Acute Respiratory Syndrome Coronavirus Is a Deubiquitinating Enzyme
inferredcites →https://doi.org/10.1128/jvi.79.7.4550-4551.2005openalex-snapshot
Deubiquitination, a New Function of the Severe Acute Respiratory Syndrome Coronavirus Papain-Like Protease?
inferredcites →https://doi.org/10.1128/mbio.00258-16openalex-snapshot
Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation
inferredcites →https://doi.org/10.1128/mbio.00473-12openalex-snapshot
Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in Humans
inferredcites →https://doi.org/10.1128/mbio.00611-12openalex-snapshot
Efficient Replication of the Novel Human Betacoronavirus EMC on Primary Human Epithelium Highlights Its Zoonotic Potential
inferredcites →https://doi.org/10.1128/mbio.00650-13openalex-snapshot
Engineering a Replication-Competent, Propagation-Defective Middle East Respiratory Syndrome Coronavirus as a Vaccine Candidate
inferredcites →https://doi.org/10.1128/mbio.00665-17openalex-snapshot
MERS-CoV Accessory ORFs Play Key Role for Infection and Pathogenesis
inferredcites →https://doi.org/10.1128/mbio.01174-14openalex-snapshot
Pathogenic Influenza Viruses and Coronaviruses Utilize Similar and Contrasting Approaches To Control Interferon-Stimulated Gene Responses
inferredcites →https://doi.org/10.1128/mbio.01721-16openalex-snapshot
The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection
inferredcites →https://doi.org/10.1128/msphere.00346-17openalex-snapshot
Middle East Respiratory Syndrome Coronavirus Nonstructural Protein 16 Is Necessary for Interferon Resistance and Viral Pathogenesis
inferredcites →https://doi.org/10.1146/annurev-biochem-060310-170328openalex-snapshot
The Ubiquitin Code
inferredcites →https://doi.org/10.1146/annurev-immunol-032713-120231openalex-snapshot
Interferon-Stimulated Genes: A Complex Web of Host Defenses
inferredcites →https://doi.org/10.1146/annurev-immunol-042617-053309openalex-snapshot
RIG-I and Other RNA Sensors in Antiviral Immunity
inferredcites →https://doi.org/10.1158/0008-5472.can-04-0496openalex-snapshot
Normalization of Real-Time Quantitative Reverse Transcription-PCR Data: A Model-Based Variance Estimation Approach to Identify Genes Suited for Normalization, Applied to Bladder and Colon Cancer Data Sets
inferredcites →https://doi.org/10.1172/jci126363openalex-snapshot
IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes
inferredcites →https://doi.org/10.1242/jcs.183954openalex-snapshot
Ubiquitin chain diversity at a glance
inferredcites →https://doi.org/10.1371/journal.pbio.0060226openalex-snapshot
SARS-Coronavirus Replication Is Supported by a Reticulovesicular Network of Modified Endoplasmic Reticulum
inferredcites →https://doi.org/10.1371/journal.pone.0032857openalex-snapshot
Reverse Genetics of SARS-Related Coronavirus Using Vaccinia Virus-Based Recombination
inferredcites →https://doi.org/10.1371/journal.ppat.1003500openalex-snapshot
The Footprint of Genome Architecture in the Largest Genome Expansion in RNA Viruses
inferredcites →https://doi.org/10.1371/journal.ppat.1004113openalex-snapshot
Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating Activity of SARS-CoV Papain-Like Protease
inferredcites →https://doi.org/10.1371/journal.ppat.1005982openalex-snapshot
Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses
inferredcites →https://doi.org/10.1371/journal.ppat.1006195openalex-snapshot
Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication
inferredcites →https://doi.org/10.1371/journal.ppat.1006838openalex-snapshot
MERS-CoV 4b protein interferes with the NF-κB-dependent innate immune response during infection
inferredcites →https://doi.org/10.1371/journal.ppat.1007296openalex-snapshot
The papain-like protease determines a virulence trait that varies among members of the SARS-coronavirus species
inferredcites →https://doi.org/10.1371/journal.ppat.1007756openalex-snapshot
The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression
inferredcites →https://doi.org/10.17352/2640-7876.000013openalex-snapshot
A bird’s-eye view to the monthly pattern of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in the world, 2012 until 2016
inferredcites →https://doi.org/10.2144/000112096openalex-snapshot
Two-Step Red-Mediated Recombination for versatile High-Efficiency Markerless DNA Manipulation in Escherichia Coli
inferredcites →https://doi.org/10.3201/eid2012.141280openalex-snapshot
Replication and Shedding of MERS-CoV in Upper Respiratory Tract of Inoculated Dromedary Camels
inferredcites →https://doi.org/10.3389/fimmu.2017.01232openalex-snapshot
Interferon-λs: Front-Line Guardians of Immunity and Homeostasis in the Respiratory Tract
inferredcites →https://doi.org/10.3389/fimmu.2018.01083openalex-snapshot
RING-Domain E3 Ligase-Mediated Host–Virus Interactions: Orchestrating Immune Responses by the Host and Antagonizing Immune Defense by Viruses
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1016/b978-0-12-818619-0.00131-3openalex-snapshot
Pattern recognition receptors and the innate immune network
inferred← citeshttps://doi.org/10.1016/j.dsx.2020.04.020openalex-snapshot
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response
inferred← citeshttps://doi.org/10.1016/j.meegid.2021.104773openalex-snapshot
Variants in ACE2; potential influences on virus infection and COVID-19 severity
inferred← citeshttps://doi.org/10.1101/2021.05.20.445077openalex-snapshot
6′,6′-Difluoro-aristeromycin is a potent inhibitor of MERS-coronavirus replication
inferred← citeshttps://doi.org/10.1186/s12863-022-01044-yopenalex-snapshot
Predicted coronavirus Nsp5 protease cleavage sites in the human proteome
inferred← citeshttps://doi.org/10.3390/biom10081137openalex-snapshot
Viral Ubiquitin and Ubiquitin-Like Deconjugases—Swiss Army Knives for Infection
inferred← citeshttps://doi.org/10.3390/v11100961openalex-snapshot
Viral Innate Immune Evasion and the Pathogenesis of Emerging RNA Virus Infections
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