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Evidence of polygenic adaptation at height-associated loci in mainland Europeans and Sardinians

https://doi.org/10.1101/776377
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/bf02447890openalex-snapshot
The peopling of Sardinia (Italy): history and effects
inferredcites →https://doi.org/10.1016/j.ajhg.2008.06.005openalex-snapshot
Long-Range LD Can Confound Genome Scans in Admixed Populations
inferredcites →https://doi.org/10.1016/j.ajhg.2019.05.001openalex-snapshot
Geographic Variation and Bias in the Polygenic Scores of Complex Diseases and Traits in Finland
inferredcites →https://doi.org/10.1016/j.ehb.2014.07.002openalex-snapshot
The role of nutrition and genetics as key determinants of the positive height trend
inferredcites →https://doi.org/10.1016/j.je.2016.12.003openalex-snapshot
Cross-sectional analysis of BioBank Japan clinical data: A large cohort of 200,000 patients with 47 common diseases
inferredcites →https://doi.org/10.1016/j.je.2016.12.005openalex-snapshot
Overview of the BioBank Japan Project: Study design and profile
inferredcites →https://doi.org/10.1038/nature14317openalex-snapshot
Massive migration from the steppe was a source for Indo-European languages in Europe
inferredcites →https://doi.org/10.1038/nature14618openalex-snapshot
Directional dominance on stature and cognition in diverse human populations
inferredcites →https://doi.org/10.1038/nature15393openalex-snapshot
A global reference for human genetic variation
inferredcites →https://doi.org/10.1038/ng.2368openalex-snapshot
Evidence of widespread selection on standing variation in Europe at height-associated SNPs
inferredcites →https://doi.org/10.1038/ng.3097openalex-snapshot
Defining the role of common variation in the genomic and biological architecture of adult human height
inferredcites →https://doi.org/10.1038/ng.3190openalex-snapshot
Efficient Bayesian mixed-model analysis increases association power in large cohorts
inferredcites →https://doi.org/10.1038/ng.3401openalex-snapshot
Population genetic differentiation of height and body mass index across Europe
inferredcites →https://doi.org/10.1038/ng.3403openalex-snapshot
Height-reducing variants and selection for short stature in Sardinia
inferredcites →https://doi.org/10.1038/ng.3679openalex-snapshot
Reference-based phasing using the Haplotype Reference Consortium panel
inferredcites →https://doi.org/10.1038/s41467-018-04191-yopenalex-snapshot
Global genetic differentiation of complex traits shaped by natural selection in humans
inferredcites →https://doi.org/10.1038/s41467-018-08219-1openalex-snapshot
Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis
inferredcites →https://doi.org/10.1038/s41586-019-1457-zopenalex-snapshot
Exome sequencing of Finnish isolates enhances rare-variant association power
inferredcites →https://doi.org/10.1038/s41588-018-0215-8openalex-snapshot
Genomic history of the Sardinian population
inferredcites →https://doi.org/10.1038/s41588-019-0379-xopenalex-snapshot
Clinical use of current polygenic risk scores may exacerbate health disparities
inferredcites →https://doi.org/10.1038/s41588-019-0484-xopenalex-snapshot
A method for genome-wide genealogy estimation for thousands of samples
inferredcites →https://doi.org/10.1073/pnas.1910606116openalex-snapshot
Genetic contributions to variation in human stature in prehistoric Europe
inferredcites →https://doi.org/10.1093/bioinformatics/btv546openalex-snapshot
Approximately independent linkage disequilibrium blocks in human populations
inferredcites →https://doi.org/10.1101/357483openalex-snapshot
Quantification of genetic components of population differentiation in UK Biobank traits reveals signals of polygenic selection
inferredcites →https://doi.org/10.1101/531210openalex-snapshot
The mutational constraint spectrum quantified from variation in 141,456 humans
inferredcites →https://doi.org/10.1101/583104openalex-snapshot
Population history from the Neolithic to present on the Mediterranean island of Sardinia: An ancient DNA perspective
inferredcites →https://doi.org/10.1126/science.aag0776openalex-snapshot
Detection of human adaptation during the past 2000 years
inferredcites →https://doi.org/10.1126/science.aar8486openalex-snapshot
Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia
inferredcites →https://doi.org/10.1186/s13742-015-0047-8openalex-snapshot
Second-generation PLINK: rising to the challenge of larger and richer datasets
inferredcites →https://doi.org/10.1371/journal.pbio.0040321openalex-snapshot
Morphological Evolution Is Accelerated among Island Mammals
inferredcites →https://doi.org/10.1371/journal.pgen.1000471openalex-snapshot
Widespread Genomic Signatures of Natural Selection in Hominid Evolution
inferredcites →https://doi.org/10.1371/journal.pgen.1004412openalex-snapshot
A Population Genetic Signal of Polygenic Adaptation
inferredcites →https://doi.org/10.1371/journal.pgen.1006852openalex-snapshot
The population genomics of archaeological transition in west Iberia: Investigation of ancient substructure using imputation and haplotype-based methods
inferredcites →https://doi.org/10.1534/genetics.118.301687openalex-snapshot
Reconstructing the History of Polygenic Scores Using Coalescent Trees
inferredcites →https://doi.org/10.4314/ijma.v1i1.60356openalex-snapshot
Review Synthetic Article: Sardinian Population (Italy): a Genetic Review
inferredcites →https://doi.org/10.7554/elife.13410openalex-snapshot
A century of trends in adult human height
inferredcites →https://doi.org/10.7554/elife.39702openalex-snapshot
Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies
inferredcites →https://doi.org/10.7554/elife.39725openalex-snapshot
Reduced signal for polygenic adaptation of height in UK Biobank

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.ajhg.2021.02.011openalex-snapshot
Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry
inferred← citeshttps://doi.org/10.1016/j.gde.2020.06.003openalex-snapshot
Human adaptation over the past 40,000 years
inferred← citeshttps://doi.org/10.24072/pcjournal.35openalex-snapshot
How robust are cross-population signatures of polygenic adaptation in humans?
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