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The lipid kinase PI3Kα is required for the cohesion and survival of cancer cells disseminated in serous cavities

https://doi.org/10.1101/777649
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Outgoing claims: the papers this work cites, builds on, or argues with.

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Phosphoinositides in the regulation of actin cortex and cell migration
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Compressive Stress Inhibits Proliferation in Tumor Spheroids through a Volume Limitation
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A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations
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Mesenchymal Stem Cells Induce Resistance to Chemotherapy through the Release of Platinum-Induced Fatty Acids
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PI3K signaling in cancer: beyond AKT
inferredcites →https://doi.org/10.1016/j.cell.2014.07.013openalex-snapshot
Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis
inferredcites →https://doi.org/10.1016/j.ddtec.2017.03.002openalex-snapshot
The production of 3D tumor spheroids for cancer drug discovery
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Targeting PI3K Signaling in Combination Cancer Therapy
inferredcites →https://doi.org/10.1016/j.ygyno.2003.12.034openalex-snapshot
Ovarian carcinoma ascites spheroids adhere to extracellular matrix components and mesothelial cell monolayers
inferredcites →https://doi.org/10.1016/j.ygyno.2008.11.032openalex-snapshot
Multicellular spheroids in ovarian cancer metastases: Biology and pathology
inferredcites →https://doi.org/10.1016/j.ygyno.2015.02.003openalex-snapshot
The PI3K/AKT/mTOR pathway as a therapeutic target in ovarian cancer
inferredcites →https://doi.org/10.1016/s1470-2045(06)70939-1openalex-snapshot
Mechanisms of transcoelomic metastasis in ovarian cancer
inferredcites →https://doi.org/10.1038/nrm2882openalex-snapshot
The emerging mechanisms of isoform-specific PI3K signalling
inferredcites →https://doi.org/10.1038/srep35249openalex-snapshot
The Role of PIK3CA Mutations among Lung Adenocarcinoma Patients with Primary and Acquired Resistance to EGFR Tyrosine Kinase Inhibition
inferredcites →https://doi.org/10.1042/bcj20210004openalex-snapshot
Organismal roles for the PI3Kα and β isoforms: their specificity, redundancy or cooperation is context-dependent
inferredcites →https://doi.org/10.1042/bj20110502openalex-snapshot
A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types
inferredcites →https://doi.org/10.1056/nejmoa1708618openalex-snapshot
Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer
inferredcites →https://doi.org/10.1056/nejmoa1813904openalex-snapshot
Alpelisib for PIK3CA -Mutated, Hormone Receptor–Positive Advanced Breast Cancer
inferredcites →https://doi.org/10.1073/pnas.1216989110openalex-snapshot
Flow induces epithelial-mesenchymal transition, cellular heterogeneity and biomarker modulation in 3D ovarian cancer nodules
inferredcites →https://doi.org/10.1073/pnas.90.8.3294openalex-snapshot
Acquired multicellular-mediated resistance to alkylating agents in cancer.
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Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110α
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Mechanical Control of Cell Proliferation Increases Resistance to Chemotherapeutic Agents
inferredcites →https://doi.org/10.1111/cas.12059openalex-snapshot
Mesenchymal stem cells regulate epithelial–mesenchymal transition and tumor progression of pancreatic cancer cells
inferredcites →https://doi.org/10.1158/0008-5472.can-14-3534openalex-snapshot
Cell–Cell Adhesion and Cytoskeleton Tension Oppose Each Other in Regulating Tumor Cell Aggregation
inferredcites →https://doi.org/10.1158/1078-0432.ccr-04-2142openalex-snapshot
Frequent Mutation of the PIK3CA Gene in Ovarian and Breast Cancers
inferredcites →https://doi.org/10.1158/1078-0432.ccr-16-0134openalex-snapshot
A Phase Ib Study of Alpelisib (BYL719), a PI3Kα-Specific Inhibitor, with Letrozole in ER+/HER2− Metastatic Breast Cancer
inferredcites →https://doi.org/10.1158/1535-7163.mct-13-0865openalex-snapshot
Characterization of the Novel and Specific PI3Kα Inhibitor NVP-BYL719 and Development of the Patient Stratification Strategy for Clinical Trials
inferredcites →https://doi.org/10.1158/1541-7786.mcr-13-0489openalex-snapshot
P-Cadherin Promotes Ovarian Cancer Dissemination Through Tumor Cell Aggregation and Tumor–Peritoneum Interactions
inferredcites →https://doi.org/10.1186/s13046-017-0654-6openalex-snapshot
Microfluidic co-culture of pancreatic tumor spheroids with stellate cells as a novel 3D model for investigation of stroma-mediated cell motility and drug resistance
inferredcites →https://doi.org/10.1200/jco.2015.61.4776openalex-snapshot
Use and Effectiveness of Intraperitoneal Chemotherapy for Treatment of Ovarian Cancer
inferredcites →https://doi.org/10.1242/dmm.034199openalex-snapshot
Modeling the effect of ascites-induced compression on ovarian cancer multicellular aggregates
inferredcites →https://doi.org/10.1369/0022155417742897openalex-snapshot
Development of Peritoneal Carcinomatosis in Epithelial Ovarian Cancer: A Review
inferredcites →https://doi.org/10.1371/journal.pone.0046858openalex-snapshot
Isolation and Characterization of Tumor Cells from the Ascites of Ovarian Cancer Patients: Molecular Phenotype of Chemoresistant Ovarian Tumors
inferredcites →https://doi.org/10.1371/journal.pone.0055971openalex-snapshot
Non-Invasive Imaging of Phosphoinositide-3-Kinase-Catalytic-Subunit-Alpha (PIK3CA) Promoter Modulation in Small Animal Models
inferredcites →https://doi.org/10.1371/journal.pone.0084941openalex-snapshot
Ovarian Cancer Spheroid Cells with Stem Cell-Like Properties Contribute to Tumor Generation, Metastasis and Chemotherapy Resistance through Hypoxia-Resistant Metabolism
inferredcites →https://doi.org/10.1371/journal.pone.0103988openalex-snapshot
Ovarian Cancer Cell Line Panel (OCCP): Clinical Importance of In Vitro Morphological Subtypes
inferredcites →https://doi.org/10.18632/oncotarget.4550openalex-snapshot
The PI3K/AKT/mTOR pathway is a potential predictor of distinct invasive and migratory capacities in human ovarian cancer cell lines
inferredcites →https://doi.org/10.3390/ijms13089545openalex-snapshot
Implication of Tumor Microenvironment in Chemoresistance: Tumor-Associated Stromal Cells Protect Tumor Cells from Cell Death
inferredcites →https://doi.org/10.4161/21541248.2014.989789openalex-snapshot
Crossroads of PI3K and Rac pathways
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