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The Manganese Salt (MnJ) Functions as A Potent Universal Adjuvant

https://doi.org/10.1101/783910
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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NLRP3 inflammasome driven liver injury and fibrosis: Roles of IL‐17 and TNF in mice
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Multifaceted effects of aluminium in neurodegenerative diseases: A review
inferredcites →https://doi.org/10.1016/j.cell.2017.09.039openalex-snapshot
The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3
inferredcites →https://doi.org/10.1016/j.celrep.2015.04.031openalex-snapshot
Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity
inferredcites →https://doi.org/10.1016/j.clim.2019.03.007openalex-snapshot
Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: Insights from an analysis of 500 cases
inferredcites →https://doi.org/10.1016/j.coi.2017.06.005openalex-snapshot
Old and new adjuvants
inferredcites →https://doi.org/10.1016/j.coi.2017.07.010openalex-snapshot
Towards an evidence based approach for the development of adjuvanted vaccines
inferredcites →https://doi.org/10.1016/j.immuni.2008.09.003openalex-snapshot
The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation
inferredcites →https://doi.org/10.1016/j.immuni.2016.02.004openalex-snapshot
The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons
inferredcites →https://doi.org/10.1016/j.immuni.2018.03.017openalex-snapshot
Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses
inferredcites →https://doi.org/10.1016/j.jinorgbio.2015.07.004openalex-snapshot
Highly delayed systemic translocation of aluminum-based adjuvant in CD1 mice following intramuscular injections
inferredcites →https://doi.org/10.1016/j.jtemb.2018.02.025openalex-snapshot
Reconsideration of the immunotherapeutic pediatric safe dose levels of aluminum
inferredcites →https://doi.org/10.1016/j.smim.2018.05.001openalex-snapshot
Correlates of adjuvanticity: A review on adjuvants in licensed vaccines
inferredcites →https://doi.org/10.1016/j.tcb.2017.06.003openalex-snapshot
Metabolic Interactions in the Tumor Microenvironment
inferredcites →https://doi.org/10.1016/j.tox.2016.11.018openalex-snapshot
Non-linear dose-response of aluminium hydroxide adjuvant particles: Selective low dose neurotoxicity
inferredcites →https://doi.org/10.1016/j.vaccine.2014.05.037openalex-snapshot
Freeze-thaw stress of Alhydrogel® alone is sufficient to reduce the immunogenicity of a recombinant hepatitis B vaccine containing native antigen
inferredcites →https://doi.org/10.1016/s0092-1157(84)80051-7openalex-snapshot
The aluminum content of biological products containing aluminum adjuvants: Determination by atomic absorption spectrometry
inferredcites →https://doi.org/10.1016/s0264-410x(02)00168-8openalex-snapshot
The global impact of vaccines containing aluminium adjuvants
inferredcites →https://doi.org/10.1016/s0264-410x(02)00307-9openalex-snapshot
Corrigendum to “Aluminum salts in vaccines—US perspective” [Vaccine 20 (Suppl. 2) (2002) S18–S23]
inferredcites →https://doi.org/10.1038/nature06939openalex-snapshot
Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
inferredcites →https://doi.org/10.1038/nature07317openalex-snapshot
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
inferredcites →https://doi.org/10.1038/nature08300openalex-snapshot
Metalloproteins and metal sensing
inferredcites →https://doi.org/10.1038/ni.2095openalex-snapshot
The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization
inferredcites →https://doi.org/10.1038/nm1210openalex-snapshot
Targeting the innate immune response with improved vaccine adjuvants
inferredcites →https://doi.org/10.1038/nnano.2017.52openalex-snapshot
A STING-activating nanovaccine for cancer immunotherapy
inferredcites →https://doi.org/10.1038/nri2510openalex-snapshot
Towards an understanding of the adjuvant action of aluminium
inferredcites →https://doi.org/10.1038/nri3251openalex-snapshot
Recent progress in mucosal vaccine development: potential and limitations
inferredcites →https://doi.org/10.1038/nri3921openalex-snapshot
STING: infection, inflammation and cancer
inferredcites →https://doi.org/10.1073/pnas.0900850106openalex-snapshot
ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
inferredcites →https://doi.org/10.1073/pnas.0902745106openalex-snapshot
IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation
inferredcites →https://doi.org/10.1080/21691401.2018.1513941openalex-snapshot
Combined adjuvant-delivery system for new generation vaccine antigens: alliance has its own advantage
inferredcites →https://doi.org/10.1084/jem.20071087openalex-snapshot
Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells
inferredcites →https://doi.org/10.1084/jem.20171749openalex-snapshot
A noncanonical function of cGAMP in inflammasome priming and activation
inferredcites →https://doi.org/10.1093/brain/124.9.1821openalex-snapshot
Macrophagic myofasciitis lesions assess long-term persistence of vaccine-derived aluminium hydroxide in muscle
inferredcites →https://doi.org/10.1093/jnci/djy131openalex-snapshot
Combining Tumor Microenvironment Modulating Nanoparticles with Doxorubicin to Enhance Chemotherapeutic Efficacy and Boost Antitumor Immunity
inferredcites →https://doi.org/10.1093/toxsci/kfl020openalex-snapshot
The Interaction of Manganese Nanoparticles with PC-12 Cells Induces Dopamine Depletion
inferredcites →https://doi.org/10.1111/febs.13546openalex-snapshot
IL ‐1α and inflammasome‐independent IL ‐1β promote neutrophil infiltration following alum vaccination
inferredcites →https://doi.org/10.1111/j.0818-9641.2004.01272.xopenalex-snapshot
Vaccine adjuvants: Current state and future trends
inferredcites →https://doi.org/10.1126/science.1232458openalex-snapshot
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
inferredcites →https://doi.org/10.1126/science.1244040openalex-snapshot
Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects
inferredcites →https://doi.org/10.1136/bmj.2.3632.244openalex-snapshot
INSOLUBLE PRECIPITATES IN DIPHTHERIA AND TETANUS IMMUNIZATION
inferredcites →https://doi.org/10.1146/annurev-nutr-071714-034419openalex-snapshot
Manganese Is Essential for Neuronal Health
inferredcites →https://doi.org/10.1152/ajplegacy.1966.211.1.203openalex-snapshot
Dependence of manganese turnover on intake
inferredcites →https://doi.org/10.1155/2016/1459394openalex-snapshot
Adjuvants: Classification, Modus Operandi , and Licensing
inferredcites →https://doi.org/10.1172/jci105760openalex-snapshot
Studies on manganese
inferredcites →https://doi.org/10.1371/journal.pone.0043730openalex-snapshot
Optimisation of Prime–Boost Immunization in Mice Using Novel Protein-Based and Recombinant Vaccinia (Tiantan)-Based HBV Vaccine
inferredcites →https://doi.org/10.1371/journal.pone.0060038openalex-snapshot
The Chemotherapeutic Agent DMXAA as a Unique IRF3-Dependent Type-2 Vaccine Adjuvant
inferredcites →https://doi.org/10.1371/journal.pone.0185843openalex-snapshot
Vaccine adjuvant MF59 promotes the intranodal differentiation of antigen-loaded and activated monocyte-derived dendritic cells
inferredcites →https://doi.org/10.1515/bmc-2012-0045openalex-snapshot
The meaning of aluminium exposure on human health and aluminium-related diseases
inferredcites →https://doi.org/10.3181/00379727-202-43518openalex-snapshot
Manganese Metabolism in Rats: An Improved Methodology for Assessing Gut Endogenous Losses
inferredcites →https://doi.org/10.3389/fneur.2014.00230openalex-snapshot
Clinical Features in Patients with Long-Lasting Macrophagic Myofasciitis
inferredcites →https://doi.org/10.3390/ijerph120707519openalex-snapshot
Manganese-Induced Parkinsonism and Parkinson’s Disease: Shared and Distinguishable Features
inferredcites →https://doi.org/10.4049/jimmunol.1102744openalex-snapshot
CD64 Expression Distinguishes Monocyte-Derived and Conventional Dendritic Cells and Reveals Their Distinct Role during Intramuscular Immunization
inferredcites →https://doi.org/10.4049/jimmunol.1301812openalex-snapshot
MPYS/STING-Mediated TNF-α, Not Type I IFN, Is Essential for the Mucosal Adjuvant Activity of (3′–5′)-Cyclic-Di-Guanosine-Monophosphate In Vivo
inferredcites →https://doi.org/10.4049/jimmunol.1302011openalex-snapshot
Inflammasome-Dependent and -Independent IL-18 Production Mediates Immunity to the ISCOMATRIX Adjuvant
inferredcites →https://doi.org/10.4049/jimmunol.181.1.17openalex-snapshot
Cutting Edge: Inflammasome Activation by Alum and Alum’s Adjuvant Effect Are Mediated by NLRP3
inferredcites →https://doi.org/10.4049/jimmunol.181.6.3755openalex-snapshot
Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome
inferredcites →https://doi.org/10.4161/hv.5.1.6494openalex-snapshot
Characterization of the freeze sensitivity of a hepatitis B vaccine

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.celrep.2021.108915openalex-snapshot
Linear epitope landscape of the SARS-CoV-2 Spike protein constructed from 1,051 COVID-19 patients
inferred← citeshttps://doi.org/10.1093/ofid/ofab028openalex-snapshot
Manganese Breaks the Immune Tolerance of HBs-Ag
inferred← citeshttps://doi.org/10.2147/ijn.s318363openalex-snapshot
Chitosan-Poly(Acrylic Acid) Nanoparticles Loaded with R848 and MnCl2 Inhibit Melanoma via Regulating Macrophage Polarization and Dendritic Cell Maturation
inferred← citeshttps://doi.org/10.3389/fchem.2020.00601openalex-snapshot
Emerging Adjuvants for Cancer Immunotherapy
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