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Mechanistic insights into NAD synthase NMNAT chaperoning phosphorylated Tau from pathological aggregation

https://doi.org/10.1101/800565
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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/9780470123195.ch5openalex-snapshot
Enzymology of Nad + Synthesis
inferredcites →https://doi.org/10.1002/embj.201386917openalex-snapshot
Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging
inferredcites →https://doi.org/10.1006/abio.1995.1315openalex-snapshot
Assay Methods for Nicotinamide Mononucleotide Adenylyltransferase of Wide Applicability
inferredcites →https://doi.org/10.1007/s41048-015-0015-yopenalex-snapshot
Visualizing the Ensemble Structures of Protein Complexes Using Chemical Cross-Linking Coupled with Mass Spectrometry
inferredcites →https://doi.org/10.1016/0896-6273(89)90210-9openalex-snapshot
Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease
inferredcites →https://doi.org/10.1016/0896-6273(93)90279-zopenalex-snapshot
Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: Distinction between PHF-like immunoreactivity and microtubule binding
inferredcites →https://doi.org/10.1016/b978-0-12-381270-4.00019-6openalex-snapshot
Rosetta3
inferredcites →https://doi.org/10.1016/j.ab.2006.10.040openalex-snapshot
Higher-throughput, label-free, real-time molecular interaction analysis
inferredcites →https://doi.org/10.1016/j.bbr.2017.11.030openalex-snapshot
NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy
inferredcites →https://doi.org/10.1016/j.cell.2013.11.037openalex-snapshot
Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging
inferredcites →https://doi.org/10.1016/j.cub.2012.01.065openalex-snapshot
A Novel Drosophila Model of Nerve Injury Reveals an Essential Role of Nmnat in Maintaining Axonal Integrity
inferredcites →https://doi.org/10.1016/j.febslet.2006.02.067openalex-snapshot
Tau phosphorylation and aggregation in Alzheimer's disease pathology
inferredcites →https://doi.org/10.1016/j.gde.2017.03.014openalex-snapshot
NMNAT: It’s an NAD+ synthase… It’s a chaperone… It’s a neuroprotector
inferredcites →https://doi.org/10.1016/j.molcel.2014.05.008openalex-snapshot
Tracing Compartmentalized NADPH Metabolism in the Cytosol and Mitochondria of Mammalian Cells
inferredcites →https://doi.org/10.1016/j.molmed.2006.11.003openalex-snapshot
Brain CHIP: removing the culprits in neurodegenerative disease
inferredcites →https://doi.org/10.1016/j.molmed.2009.01.003openalex-snapshot
Tau phosphorylation: the therapeutic challenge for neurodegenerative disease
inferredcites →https://doi.org/10.1016/j.tibs.2004.08.001openalex-snapshot
MARKing tau for tangles and toxicity
inferredcites →https://doi.org/10.1016/j.tins.2013.07.002openalex-snapshot
NMNATs, evolutionarily conserved neuronal maintenance factors
inferredcites →https://doi.org/10.1016/j.ydbio.2013.04.007openalex-snapshot
Waves of differentiation in the fly visual system
inferredcites →https://doi.org/10.1016/s0006-291x(02)02285-4openalex-snapshot
Identification of a novel human nicotinamide mononucleotide adenylyltransferase
inferredcites →https://doi.org/10.1016/s0076-6879(97)76066-xopenalex-snapshot
[20] Processing of X-ray diffraction data collected in oscillation mode
inferredcites →https://doi.org/10.1016/s0092-8674(00)80208-1openalex-snapshot
MARK, a Novel Family of Protein Kinases That Phosphorylate Microtubule-Associated Proteins and Trigger Microtubule Disruption
inferredcites →https://doi.org/10.1021/bi048953nopenalex-snapshot
Residual Structure in the Repeat Domain of Tau: Echoes of Microtubule Binding and Paired Helical Filament Formation
inferredcites →https://doi.org/10.1021/bi401266nopenalex-snapshot
Phosphorylation of Human Tau Protein by Microtubule Affinity-Regulating Kinase 2
inferredcites →https://doi.org/10.1038/nature06721openalex-snapshot
NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration
inferredcites →https://doi.org/10.1038/ng.2356openalex-snapshot
Mutations in NMNAT1 cause Leber congenital amaurosis and identify a new disease pathway for retinal degeneration
inferredcites →https://doi.org/10.1038/ng.2357openalex-snapshot
Mutations in NMNAT1 cause Leber congenital amaurosis with early-onset severe macular and optic atrophy
inferredcites →https://doi.org/10.1038/ng.2361openalex-snapshot
NMNAT1 mutations cause Leber congenital amaurosis
inferredcites →https://doi.org/10.1038/ng.2370openalex-snapshot
Exome sequencing identifies NMNAT1 mutations as a cause of Leber congenital amaurosis
inferredcites →https://doi.org/10.1038/nmeth.2099openalex-snapshot
Identification of cross-linked peptides from complex samples
inferredcites →https://doi.org/10.1038/nprot.2007.321openalex-snapshot
The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability
inferredcites →https://doi.org/10.1038/nrn.2015.1openalex-snapshot
Tau in physiology and pathology
inferredcites →https://doi.org/10.1038/nrn3680openalex-snapshot
Wallerian degeneration: an emerging axon death pathway linking injury and disease
inferredcites →https://doi.org/10.1038/s41467-017-01289-7openalex-snapshot
Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome
inferredcites →https://doi.org/10.1042/bj2750099openalex-snapshot
Tau in Alzheimer's disease and Down's syndrome is insoluble and abnormally phosphorylated
inferredcites →https://doi.org/10.1046/j.1471-4159.1998.71062465.xopenalex-snapshot
New Phosphorylation Sites Identified in Hyperphosphorylated Tau (Paired Helical Filament‐Tau) from Alzheimer's Disease Brain Using Nanoelectrospray Mass Spectrometry
inferredcites →https://doi.org/10.1074/jbc.m008810200openalex-snapshot
Insights into Ligand Binding and Catalysis of a Central Step in NAD+ Synthesis
inferredcites →https://doi.org/10.1074/jbc.m109.016469openalex-snapshot
Enzymes in the NAD+ Salvage Pathway Regulate SIRT1 Activity at Target Gene Promoters
inferredcites →https://doi.org/10.1074/jbc.m300073200openalex-snapshot
Structural Characterization of a Human Cytosolic NMN/NaMN Adenylyltransferase and Implication in Human NAD Biosynthesis
inferredcites →https://doi.org/10.1074/jbc.r117.796862openalex-snapshot
Chaperone-client interactions: Non-specificity engenders multifunctionality
inferredcites →https://doi.org/10.1083/jcb.132.4.667openalex-snapshot
Selective stabilization of tau in axons and microtubule-associated protein 2C in cell bodies and dendrites contributes to polarized localization of cytoskeletal proteins in mature neurons.
inferredcites →https://doi.org/10.1083/jcb.200807175openalex-snapshot
WldS protein requires Nmnat activity and a short N-terminal sequence to protect axons in mice
inferredcites →https://doi.org/10.1091/mbc.3.10.1141openalex-snapshot
Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau.
inferredcites →https://doi.org/10.1093/bioinformatics/btu830openalex-snapshot
NMRFAM-SPARKY: enhanced software for biomolecular NMR spectroscopy
inferredcites →https://doi.org/10.1093/emboj/cdg447openalex-snapshot
MARKK, a Ste20‐like kinase, activates the polarity‐inducing kinase MARK/PAR‐1
inferredcites →https://doi.org/10.1093/hmg/ddr449openalex-snapshot
NMNAT suppresses Tau-induced neurodegeneration by promoting clearance of hyperphosphorylated Tau oligomers in a Drosophila model of tauopathy
inferredcites →https://doi.org/10.1093/hmg/ddr492openalex-snapshot
CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy
inferredcites →https://doi.org/10.1093/hmg/ddt016openalex-snapshot
NAD+ salvage pathway proteins suppress proteotoxicity in yeast models of neurodegeneration by promoting the clearance of misfolded/oligomerized proteins
inferredcites →https://doi.org/10.1107/s0021889807021206openalex-snapshot
Phaser crystallographic software
inferredcites →https://doi.org/10.1107/s0907444904019158openalex-snapshot
Coot : model-building tools for molecular graphics
inferredcites →https://doi.org/10.1107/s0907444904023510openalex-snapshot
REFMAC 5 dictionary: organization of prior chemical knowledge and guidelines for its use
inferredcites →https://doi.org/10.1107/s0907444904023716openalex-snapshot
Developments in theCCP4 molecular-graphics project
inferredcites →https://doi.org/10.1111/j.1460-9568.2008.06426.xopenalex-snapshot
The WldS gene delays axonal but not somatic degeneration in a rat glaucoma model
inferredcites →https://doi.org/10.1111/j.1471-4159.1993.tb03603.xopenalex-snapshot
Phosphoprotein Phosphatase Activities in Alzheimer Disease Brain
inferredcites →https://doi.org/10.1126/science.1098014openalex-snapshot
Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration
inferredcites →https://doi.org/10.1126/science.1124000openalex-snapshot
Histone H4-K16 Acetylation Controls Chromatin Structure and Protein Interactions
inferredcites →https://doi.org/10.1172/jci29715openalex-snapshot
The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins
inferredcites →https://doi.org/10.1371/journal.pbio.0040416openalex-snapshot
Drosophila NMNAT Maintains Neural Integrity Independent of Its NAD Synthesis Activity
inferredcites →https://doi.org/10.1371/journal.pbio.1002472openalex-snapshot
NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies
inferredcites →https://doi.org/10.1371/journal.pgen.1005917openalex-snapshot
Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity
inferredcites →https://doi.org/10.1371/journal.pone.0018934openalex-snapshot
Rosetta FlexPepDock ab-initio: Simultaneous Folding, Docking and Refinement of Peptides onto Their Receptors
inferredcites →https://doi.org/10.1385/1-59259-809-9:313openalex-snapshot
Using NMRView to Visualize and Analyze the NMR Spectra of Macromolecules
inferredcites →https://doi.org/10.1385/1-59259-874-9:035openalex-snapshot
Purification of Recombinant Tau Protein and Preparation of Alzheimer-Paired Helical Filaments In Vitro
inferredcites →https://doi.org/10.1523/jneurosci.0927-07.2007openalex-snapshot
Swimming against the Tide: Mobility of the Microtubule-Associated Protein Tau in Neurons
inferredcites →https://doi.org/10.2307/3579638openalex-snapshot
Proteolysis of Poly(ADP-Ribose) Polymerase by Caspase 3: Kinetics of Cleavage of Mono(ADP-Ribosyl)ated and DNA-Bound Substrates
inferredcites →https://doi.org/10.3233/jad-2012-121357openalex-snapshot
Elevated MARK2-Dependent Phosphorylation of Tau in Alzheimer's Disease
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