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In silico identification of potential inhibitors against human 2’-5’-oligoadenylate synthetase (OAS) proteins

https://doi.org/10.1101/804716
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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UCSF Chimera—A visualization system for exploratory research and analysis
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AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility
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AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
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Gene structure and function of the 2′-5′-oligoadenylate synthetase family
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Induction and activation of antiviral enzyme 2′,5′-oligoadenylate synthetase by in vitro transcribed insulin mRNA and other cellular RNAs
inferredcites →https://doi.org/10.1007/s12035-017-0460-3openalex-snapshot
OAS Gene Family Expression Is Associated with HIV-Related Neurocognitive Disorders
inferredcites →https://doi.org/10.1016/bs.ai.2016.11.001openalex-snapshot
Nucleic Acid Immunity
inferredcites →https://doi.org/10.1016/j.cell.2010.03.006openalex-snapshot
Inflammation 2010: New Adventures of an Old Flame
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Antagonism of the Interferon-Induced OAS-RNase L Pathway by Murine Coronavirus ns2 Protein Is Required for Virus Replication and Liver Pathology
inferredcites →https://doi.org/10.1016/j.coviro.2015.07.002openalex-snapshot
Inhibition of the OAS/RNase L pathway by viruses
inferredcites →https://doi.org/10.1016/j.immuni.2014.05.007openalex-snapshot
Antiviral Activity of Human OASL Protein Is Mediated by Enhancing Signaling of the RIG-I RNA Sensor
inferredcites →https://doi.org/10.1016/j.str.2015.03.012openalex-snapshot
The Activation Mechanism of 2′-5′-Oligoadenylate Synthetase Gives New Insights Into OAS/cGAS Triggers of Innate Immunity
inferredcites →https://doi.org/10.1016/j.virol.2012.11.014openalex-snapshot
Resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus: Role of type I interferon signaling
inferredcites →https://doi.org/10.1016/s0014-5793(01)02918-0openalex-snapshot
Inhibition of 2′‐5′ oligoadenylate synthetase by divalent metal ions
inferredcites →https://doi.org/10.1016/s0021-9258(18)61434-6openalex-snapshot
Four different forms of interferon-induced 2',5'-oligo(A) synthetase identified by immunoblotting in human cells.
inferredcites →https://doi.org/10.1016/s1097-2765(03)00433-7openalex-snapshot
Crystal Structure of the 2′-Specific and Double-Stranded RNA-Activated Interferon-Induced Antiviral Protein 2′-5′-Oligoadenylate Synthetase
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LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery
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ZINC: A Free Tool to Discover Chemistry for Biology
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Identification of a Novel Inhibitor of Dengue Virus Protease through Use of a Virtual Screening Drug Discovery Web Portal
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Origin and physiological roles of inflammation
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The I-TASSER Suite: protein structure and function prediction
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I-TASSER: a unified platform for automated protein structure and function prediction
inferredcites →https://doi.org/10.1038/nri2314openalex-snapshot
Interferon-inducible antiviral effectors
inferredcites →https://doi.org/10.1038/nri3479openalex-snapshot
Newly described pattern recognition receptors team up against intracellular pathogens
inferredcites →https://doi.org/10.1038/nri3719openalex-snapshot
OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids
inferredcites →https://doi.org/10.1038/nsb1203-980openalex-snapshot
Announcing the worldwide Protein Data Bank
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A subtype of multiple sclerosis defined by an activated immune defense program
inferredcites →https://doi.org/10.1073/pnas.1218528110openalex-snapshot
Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1
inferredcites →https://doi.org/10.1073/pnas.1306917110openalex-snapshot
Homologous 2′,5′-phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunity
inferredcites →https://doi.org/10.1073/pnas.1419409112openalex-snapshot
Structural mechanism of sensing long dsRNA via a noncatalytic domain in human oligoadenylate synthetase 3
inferredcites →https://doi.org/10.1074/jbc.274.36.25535openalex-snapshot
The Nature of the Catalytic Domain of 2′-5′-Oligoadenylate Synthetases
inferredcites →https://doi.org/10.1089/jir.2010.0107openalex-snapshot
The Oligoadenylate Synthetase Family: An Ancient Protein Family with Multiple Antiviral Activities
inferredcites →https://doi.org/10.1093/infdis/jiy084openalex-snapshot
OAS1, 2, and 3: Significance During Active Tuberculosis?
inferredcites →https://doi.org/10.1093/nar/gkh131openalex-snapshot
UniProt: the Universal Protein knowledgebase
inferredcites →https://doi.org/10.1093/nar/gkp858openalex-snapshot
The NCBI BioSystems database
inferredcites →https://doi.org/10.1093/nar/gkr320openalex-snapshot
ChemMine tools: an online service for analyzing and clustering small molecules
inferredcites →https://doi.org/10.1093/nar/gkw1099openalex-snapshot
UniProt: the universal protein knowledgebase
inferredcites →https://doi.org/10.1093/nar/gky1033openalex-snapshot
PubChem 2019 update: improved access to chemical data
inferredcites →https://doi.org/10.1093/nar/gkz268openalex-snapshot
The EMBL-EBI search and sequence analysis tools APIs in 2019
inferredcites →https://doi.org/10.1107/s0907444902003451openalex-snapshot
The Protein Data Bank
inferredcites →https://doi.org/10.1111/imm.12560openalex-snapshot
Extracellular 2′5′‐oligoadenylate synthetase 2 mediates T ‐cell receptor CD 3‐ζ chain down‐regulation via caspase‐3 activation in oral cancer
inferredcites →https://doi.org/10.1126/scitranslmed.aar3619openalex-snapshot
Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria
inferredcites →https://doi.org/10.1128/jvi.00701-15openalex-snapshot
Structural Basis for 2′-5′-Oligoadenylate Binding and Enzyme Activity of a Viral RNase L Antagonist
inferredcites →https://doi.org/10.1177/0961203308089694openalex-snapshot
Increased expression of the type I interferon-inducible gene, lymphocyte antigen 6 complex locus E, in peripheral blood cells is predictive of lupus activity in a large cohort of Chinese lupus patients
inferredcites →https://doi.org/10.1186/1471-2105-9-1openalex-snapshot
Evaluation of time profile reconstruction from complex two-color microarray designs
inferredcites →https://doi.org/10.1186/1471-2105-9-40openalex-snapshot
I-TASSER server for protein 3D structure prediction
inferredcites →https://doi.org/10.1186/s12864-015-1508-2openalex-snapshot
Transcriptional landscape of psoriasis identifies the involvement of IL36 and IL36RN
inferredcites →https://doi.org/10.1186/s12957-018-1475-6openalex-snapshot
Prediction of key genes and pathways involved in trastuzumab-resistant gastric cancer
inferredcites →https://doi.org/10.2337/diabetes.54.5.1588openalex-snapshot
OAS1 Splice Site Polymorphism Controlling Antiviral Enzyme Activity Influences Susceptibility to Type 1 Diabetes
inferredcites →https://doi.org/10.3109/08830185.2010.529976openalex-snapshot
Pathogen Recognition by the Innate Immune System
inferredcites →https://doi.org/10.3109/08916934.2013.866102openalex-snapshot
Differential upregulation of human 2′5′OASgenes on systemic sclerosis: Detection of increased basal levels ofOASLandOAS2 genes through a qPCR based assay

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1186/s12885-020-07034-6openalex-snapshot
Prognostic characterization of OAS1/OAS2/OAS3/OASL in breast cancer
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