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Investigating tissue-relevant causal molecular mechanisms of complex traits using probabilistic TWAS analysis

https://doi.org/10.1101/808295
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Instrumental variables regressions with uncertain exclusion restrictions: a Bayesian approach
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Quantifying heterogeneity in a meta‐analysis
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A framework for the investigation of pleiotropy in two‐sample summary data Mendelian randomization
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Epidemiology, genetic epidemiology and Mendelian randomisation: more need than ever to attend to detail
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Statistical models and shoe leather
inferredcites →https://doi.org/10.1016/j.ajhg.2016.03.029openalex-snapshot
Efficient Integrative Multi-SNP Association Analysis via Deterministic Approximation of Posteriors
inferredcites →https://doi.org/10.1016/j.ajhg.2017.04.005openalex-snapshot
Widespread Allelic Heterogeneity in Complex Traits
inferredcites →https://doi.org/10.1016/j.ajhg.2019.01.002openalex-snapshot
ACAT: A Fast and Powerful p Value Combination Method for Rare-Variant Analysis in Sequencing Studies
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APOUPOPROTEIN E ISOFORMS, SERUM CHOLESTEROL, AND CANCER
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Genetic effects on gene expression across human tissues
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Bayesian refinement of association signals for 14 loci in 3 common diseases
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A gene-based association method for mapping traits using reference transcriptome data
inferredcites →https://doi.org/10.1038/ng.3538openalex-snapshot
Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets
inferredcites →https://doi.org/10.1038/s41467-019-10936-0openalex-snapshot
Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits
inferredcites →https://doi.org/10.1038/s41586-018-0579-zopenalex-snapshot
The UK Biobank resource with deep phenotyping and genomic data
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Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights
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Probabilistic fine-mapping of transcriptome-wide association studies
inferredcites →https://doi.org/10.1093/biostatistics/kxx048openalex-snapshot
An empirical Bayes approach for multiple tissue eQTL analysis
inferredcites →https://doi.org/10.1093/ije/dyq151openalex-snapshot
Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants
inferredcites →https://doi.org/10.1093/ije/dyt093openalex-snapshot
Use of allele scores as instrumental variables for Mendelian randomization
inferredcites →https://doi.org/10.1093/ije/dyv080openalex-snapshot
Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
inferredcites →https://doi.org/10.1093/nar/gkw1133openalex-snapshot
The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)
inferredcites →https://doi.org/10.1097/ede.0000000000000081openalex-snapshot
Methodological Challenges in Mendelian Randomization
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Bayesian Multi-SNP Genetic Association Analysis: Control of FDR and Use of Summary Statistics
inferredcites →https://doi.org/10.1101/787903openalex-snapshot
The GTEx Consortium atlas of genetic regulatory effects across human tissues
inferredcites →https://doi.org/10.1109/tit.2009.2027527openalex-snapshot
Comparing Measures of Sparsity
inferredcites →https://doi.org/10.1126/science.aaz1776openalex-snapshot
The GTEx Consortium atlas of genetic regulatory effects across human tissues
inferredcites →https://doi.org/10.1136/bmj.k3225openalex-snapshot
Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study
inferredcites →https://doi.org/10.1214/11-aoas455openalex-snapshot
Bayesian variable selection regression for genome-wide association studies and other large-scale problems
inferredcites →https://doi.org/10.1371/journal.pgen.1003486openalex-snapshot
A Statistical Framework for Joint eQTL Analysis in Multiple Tissues
inferredcites →https://doi.org/10.1371/journal.pgen.1006423openalex-snapshot
Survey of the Heritability and Sparse Architecture of Gene Expression Traits across Human Tissues
inferredcites →https://doi.org/10.1371/journal.pgen.1006646openalex-snapshot
Integrating molecular QTL data into genome-wide genetic association analysis: Probabilistic assessment of enrichment and colocalization
inferredcites →https://doi.org/10.1534/genetics.114.167908openalex-snapshot
Identifying Causal Variants at Loci with Multiple Signals of Association
inferredcites →https://doi.org/10.17615/6rbf-cv28openalex-snapshot
An empirical Bayes approach for multiple tissue eQTL analysis
inferredcites →https://doi.org/10.2307/270939openalex-snapshot
Statistical Models and Shoe Leather
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Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.ajhg.2020.11.012openalex-snapshot
Probabilistic colocalization of genetic variants from complex and molecular traits: promise and limitations
inferred← citeshttps://doi.org/10.1101/2020.08.17.255059openalex-snapshot
Interspecies variation in hominid gut microbiota controls host gene regulation
inferred← citeshttps://doi.org/10.1371/journal.pgen.1009455openalex-snapshot
MRLocus: Identifying causal genes mediating a trait through Bayesian estimation of allelic heterogeneity
inferred← citeshttps://doi.org/10.15302/j-qb-021-0249openalex-snapshot
Advances and challenges in quantitative delineation of the genetic architecture of complex traits
inferred← citeshttps://doi.org/10.7554/elife.63852openalex-snapshot
Psychosocial experiences modulate asthma-associated genes through gene-environment interactions
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