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Tumor neoantigen heterogeneity thresholds provide a time window for combination immunotherapy

https://doi.org/10.1101/823856
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/humu.22365openalex-snapshot
Accurately Identifying Low-Allelic Fraction Variants in Single Samples with Next-Generation Sequencing: Applications in Tumor Subclone Resolution
inferredcites →https://doi.org/10.1007/s11538-010-9526-3openalex-snapshot
Interactions Between the Immune System and Cancer: A Brief Review of Non-spatial Mathematical Models
inferredcites →https://doi.org/10.1016/j.ccell.2018.03.005openalex-snapshot
Emerging Concepts for Immune Checkpoint Blockade-Based Combination Therapies
inferredcites →https://doi.org/10.1016/j.cell.2011.02.013openalex-snapshot
Hallmarks of Cancer: The Next Generation
inferredcites →https://doi.org/10.1016/j.cell.2017.01.017openalex-snapshot
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
inferredcites →https://doi.org/10.1016/j.cell.2019.08.032openalex-snapshot
UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma
inferredcites →https://doi.org/10.1016/j.jtbi.2019.07.019openalex-snapshot
A stochastic individual-based model to explore the role of spatial interactions and antigen recognition in the immune response against solid tumours
inferredcites →https://doi.org/10.1016/j.molonc.2014.06.005openalex-snapshot
Tumour heterogeneity and the evolution of polyclonal drug resistance
inferredcites →https://doi.org/10.1038/44831openalex-snapshot
Optimizing the success of random searches
inferredcites →https://doi.org/10.1038/nature03095openalex-snapshot
Targeted cancer therapy
inferredcites →https://doi.org/10.1038/nature11098openalex-snapshot
Generalized Lévy walks and the role of chemokines in migration of effector CD8+ T cells
inferredcites →https://doi.org/10.1038/nature14001openalex-snapshot
Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing
inferredcites →https://doi.org/10.1038/nature24473openalex-snapshot
A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy
inferredcites →https://doi.org/10.1038/ng.3489openalex-snapshot
Identification of neutral tumor evolution across cancer types
inferredcites →https://doi.org/10.1038/ni.2703openalex-snapshot
Innate and adaptive immune cells in the tumor microenvironment
inferredcites →https://doi.org/10.1038/nrc3599openalex-snapshot
Cancer drug resistance: an evolving paradigm
inferredcites →https://doi.org/10.1038/nrclinonc.2014.174openalex-snapshot
Entering the mainstream of cancer treatment
inferredcites →https://doi.org/10.1038/nrm2858openalex-snapshot
Genomic instability — an evolving hallmark of cancer
inferredcites →https://doi.org/10.1038/s41588-020-0687-1openalex-snapshot
Evolutionary dynamics of neoantigens in growing tumors
inferredcites →https://doi.org/10.1053/j.seminoncol.2012.02.006openalex-snapshot
The Tipping Point for Combination Therapy: Cancer Vaccines With Radiation, Chemotherapy, or Targeted Small Molecule Inhibitors
inferredcites →https://doi.org/10.1056/nejmoa1406498openalex-snapshot
Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma
inferredcites →https://doi.org/10.1084/jem.20091279openalex-snapshot
CD8+ T cell concentration determines their efficiency in killing cognate antigen–expressing syngeneic mammalian cells in vitro and in mouse tissues
inferredcites →https://doi.org/10.1101/cshperspect.a005710openalex-snapshot
NMDA Receptor-Dependent Long-Term Potentiation and Long-Term Depression (LTP/LTD)
inferredcites →https://doi.org/10.1101/cshperspect.a006957openalex-snapshot
T-Cell Tolerance: Central and Peripheral
inferredcites →https://doi.org/10.1103/revmodphys.69.1219openalex-snapshot
Immunology for physicists
inferredcites →https://doi.org/10.1126/science.aaa1348openalex-snapshot
Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer
inferredcites →https://doi.org/10.1126/science.aaa4971openalex-snapshot
Neoantigens in cancer immunotherapy
inferredcites →https://doi.org/10.1126/science.aad0095openalex-snapshot
Genomic correlates of response to CTLA-4 blockade in metastatic melanoma
inferredcites →https://doi.org/10.1126/science.aaf1490openalex-snapshot
Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade
inferredcites →https://doi.org/10.1126/science.aar4060openalex-snapshot
Cancer immunotherapy using checkpoint blockade
inferredcites →https://doi.org/10.1146/annurev.immunol.21.120601.141107openalex-snapshot
Positive and Negative Selection of T Cells
inferredcites →https://doi.org/10.1158/0008-5472.can-18-3712openalex-snapshot
The Goldilocks Window of Personalized Chemotherapy: Getting the Immune Response Just Right
inferredcites →https://doi.org/10.1158/1538-7445.sabcs18-5302openalex-snapshot
Abstract 5302: Interplay of Parkin, a 'tumor suppressor’ in metabolic deregulation of cancer
inferredcites →https://doi.org/10.1186/s40425-019-0795-6openalex-snapshot
Genetic instability as a driver for immune surveillance
inferredcites →https://doi.org/10.1371/journal.pcbi.1004654openalex-snapshot
Measuring Integrated Information from the Decoding Perspective
inferredcites →https://doi.org/10.1371/journal.pcbi.1004731openalex-snapshot
Quantifying Clonal and Subclonal Passenger Mutations in Cancer Evolution
inferredcites →https://doi.org/10.2307/1266136openalex-snapshot
Handbook of Mathematical Functions with Formulas, Graphs, and Mathematical Tables

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inferred← citeshttps://doi.org/10.3390/cancers13102345openalex-snapshot
Challenges of Neoantigen Targeting in Lynch Syndrome and Constitutional Mismatch Repair Deficiency Syndrome
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