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Foreign body reaction is triggered in vivo by cellular mechanosensing of implants stiffer than host tissue

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Tissue‐Engineered Peripheral Nerve Interfaces

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Complex Stiffness Gradient Substrates for Studying Mechanotactic Cell Migration

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Engineering biomaterials to integrate and heal: The biocompatibility paradigm shifts

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Studies on cultured rat Schwann cells

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Biomechanics: Cell Research and Applications for the Next Decade

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Studies on cultured rat Schwann cells. I. Establishment of purified populations from cultures of peripheral nerve

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Atomic force microscopy-based force measurements on animal cells and tissues

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Phenotypic changes in bone marrow-derived murine macrophages cultured on PEG-based hydrogels activated or not by lipopolysaccharide

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Macrophage polarization: An opportunity for improved outcomes in biomaterials and regenerative medicine

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The alignment and fusion assembly of adipose-derived stem cells on mechanically patterned matrices

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The relationship between glial cell mechanosensitivity and foreign body reactions in the central nervous system

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Linking the foreign body response and protein adsorption to PEG-based hydrogels using proteomics

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Activation of human aortic valve interstitial cells by local stiffness involves YAP-dependent transcriptional signaling

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CNS Cell Distribution and Axon Orientation Determine Local Spinal Cord Mechanical Properties

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Matrix Elasticity Directs Stem Cell Lineage Specification

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Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores

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F-actin dynamics regulates mammalian organ growth and cell fate maintenance

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Brain tissue stiffness is a sensitive marker for acidosis

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Activity-dependent degeneration of axotomized neuromuscular synapses in WldS mice

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Foreign body reaction to biomaterials

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Zwitterionic PEG-PC Hydrogels Modulate the Foreign Body Response in a Modulus-Dependent Manner

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Materials and technologies for soft implantable neuroprostheses

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Universal physical responses to stretch in the living cell

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Role of YAP/TAZ in mechanotransduction

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Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

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Skin-inspired hydrogel–elastomer hybrids with robust interfaces and functional microstructures

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Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates

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Soft and elastic hydrogel-based microelectronics for localized low-voltage neuromodulation

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Biomechanical analysis of silicon microelectrode-induced strain in the brain

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Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

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Electronic dura mater for long-term multimodal neural interfaces

inferredcites →https://doi.org/10.1126/scitranslmed.3007186openalex-snapshot

A Microchannel Neuroprosthesis for Bladder Control After Spinal Cord Injury in Rat

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Mechanics in Neuronal Development and Repair

inferredcites →https://doi.org/10.1152/japplphysiol.01121.2004openalex-snapshot

Cell type-specific response to growth on soft materials

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An extended relationship for the characterization of Young's modulus and Poisson's ratio of tunable polyacrylamide gels

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A Review of the Foreign-body Response to Subcutaneously-implanted Devices: The Role of Macrophages and Cytokines in Biofouling and Fibrosis

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inferredcites →https://doi.org/10.2353/ajpath.2007.070112openalex-snapshot

The Myofibroblast

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Challenges and Opportunities

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Next generation material interfaces for neural engineering

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