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Decoding the genomic basis of osteoarthritis

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/art.24021openalex-snapshot

Lifetime risk of symptomatic knee osteoarthritis

inferredcites →https://doi.org/10.1002/art.24817openalex-snapshot

Induction of an antiinflammatory effect and prevention of cartilage damage in rat knee osteoarthritis by CF101 treatment

inferredcites →https://doi.org/10.1002/art.40545openalex-snapshot

Functional Characterization of the Osteoarthritis Genetic Risk Residing at ALDH1A2 Identifies rs12915901 as a Key Target Variant

inferredcites →https://doi.org/10.1016/j.cell.2017.10.049openalex-snapshot

A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles

inferredcites →https://doi.org/10.1016/j.cellimm.2015.02.002openalex-snapshot

Sex, the aging immune system, and chronic disease

inferredcites →https://doi.org/10.1016/j.jbspin.2012.11.008openalex-snapshot

Estrogens, osteoarthritis and inflammation

inferredcites →https://doi.org/10.1016/j.joca.2007.03.006openalex-snapshot

The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse

inferredcites →https://doi.org/10.1016/j.joca.2009.12.002openalex-snapshot

Genome-wide expression profiling reveals new candidate genes associated with osteoarthritis

inferredcites →https://doi.org/10.1016/j.joca.2010.08.005openalex-snapshot

One in four people may develop symptomatic hip osteoarthritis in his or her lifetime

inferredcites →https://doi.org/10.1016/j.joca.2014.12.020openalex-snapshot

Insights into osteoarthritis progression revealed by analyses of both knee tibiofemoral compartments

inferredcites →https://doi.org/10.1016/j.joca.2016.12.020openalex-snapshot

Association between smoking and risk of knee osteoarthritis: a systematic review and meta-analysis

inferredcites →https://doi.org/10.1016/j.maturitas.2015.09.007openalex-snapshot

Hand osteoarthritis, menopause and menopausal hormone therapy

inferredcites →https://doi.org/10.1016/s0014-5793(00)01819-6openalex-snapshot

Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP)

inferredcites →https://doi.org/10.1016/s0021-9258(18)47100-1openalex-snapshot

Apolipoprotein D gene induction by retinoic acid is concomitant with growth arrest and cell differentiation in human breast cancer cells.

inferredcites →https://doi.org/10.1016/s0140-6736(16)31678-6openalex-snapshot

Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

inferredcites →https://doi.org/10.1016/s0140-6736(17)32154-2openalex-snapshot

Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

inferredcites →https://doi.org/10.1038/nature10163openalex-snapshot

A conditional knockout resource for the genome-wide study of mouse gene function

inferredcites →https://doi.org/10.1038/nature15393openalex-snapshot

A global reference for human genetic variation

inferredcites →https://doi.org/10.1038/nature24277openalex-snapshot

Genetic effects on gene expression across human tissues

inferredcites →https://doi.org/10.1038/ng.2957openalex-snapshot

Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31

inferredcites →https://doi.org/10.1038/ng.3643openalex-snapshot

A reference panel of 64,976 haplotypes for genotype imputation

inferredcites →https://doi.org/10.1038/ng.3656openalex-snapshot

Next-generation genotype imputation service and methods

inferredcites →https://doi.org/10.1038/ng.3979openalex-snapshot

Predicting causal variants affecting expression by using whole-genome sequencing and RNA-seq from multiple human tissues

inferredcites →https://doi.org/10.1038/nmeth.4197openalex-snapshot

Salmon provides fast and bias-aware quantification of transcript expression

inferredcites →https://doi.org/10.1038/nprot.2011.457openalex-snapshot

Using probabilistic estimation of expression residuals (PEER) to obtain increased power and interpretability of gene expression analyses

inferredcites →https://doi.org/10.1038/nrrheum.2017.50openalex-snapshot

The role of metabolism in the pathogenesis of osteoarthritis

inferredcites →https://doi.org/10.1038/s41467-020-20761-5openalex-snapshot

Accelerating functional gene discovery in osteoarthritis

inferredcites →https://doi.org/10.1038/s41588-018-0327-1openalex-snapshot

Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data

inferredcites →https://doi.org/10.1038/s41598-017-09335-6openalex-snapshot

Integrative epigenomics, transcriptomics and proteomics of patient chondrocytes reveal genes and pathways involved in osteoarthritis

inferredcites →https://doi.org/10.1038/s41598-017-13417-wopenalex-snapshot

Vascular Endothelial Growth Factor in Cartilage Development and Osteoarthritis

inferredcites →https://doi.org/10.1038/s41598-018-21917-6openalex-snapshot

Multimorbidity patterns in relation to polypharmacy and dosage frequency: a nationwide, cross-sectional study in a Japanese population

inferredcites →https://doi.org/10.1053/joca.1998.0121openalex-snapshot

Light and electron microscopic hybridization of collagen type I and type II mRNA in the fibrocartilaginous tissue of late-stage osteoarthritis

inferredcites →https://doi.org/10.1073/pnas.082099299openalex-snapshot

Diagnosis of multiple cancer types by shrunken centroids of gene expression

inferredcites →https://doi.org/10.1073/pnas.1530509100openalex-snapshot

Statistical significance for genomewide studies

inferredcites →https://doi.org/10.1086/519795openalex-snapshot

PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses

inferredcites →https://doi.org/10.1093/bioinformatics/btn577openalex-snapshot

A novel signaling pathway impact analysis

inferredcites →https://doi.org/10.1093/bioinformatics/btp352openalex-snapshot

The Sequence Alignment/Map format and SAMtools

inferredcites →https://doi.org/10.1093/bioinformatics/btp616openalex-snapshot

edgeR : a Bioconductor package for differential expression analysis of digital gene expression data

inferredcites →https://doi.org/10.1093/bioinformatics/btq170openalex-snapshot

ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking

inferredcites →https://doi.org/10.1093/bioinformatics/btu375openalex-snapshot

Preserving biological heterogeneity with a permuted surrogate variable analysis for genomics batch correction

inferredcites →https://doi.org/10.1093/bioinformatics/btv722openalex-snapshot

Fast and efficient QTL mapper for thousands of molecular phenotypes

inferredcites →https://doi.org/10.1093/fampra/cmu056openalex-snapshot

Multi-drug therapy in chronic condition multimorbidity: a systematic review

inferredcites →https://doi.org/10.1093/hmg/ddv258openalex-snapshot

Histone deacetylase 1 regulates tissue destruction in rheumatoid arthritis

inferredcites →https://doi.org/10.1093/nar/gks042openalex-snapshot

Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

inferredcites →https://doi.org/10.1093/nar/gku864openalex-snapshot

svaseq: removing batch effects and other unwanted noise from sequencing data

inferredcites →https://doi.org/10.1093/nar/gkv007openalex-snapshot

limma powers differential expression analyses for RNA-sequencing and microarray studies

inferredcites →https://doi.org/10.1093/rheumatology/ken390openalex-snapshot

Limited evidence for a protective effect of unopposed oestrogen therapy for osteoarthritis of the hip: a systematic review

inferredcites →https://doi.org/10.1093/rheumatology/key101openalex-snapshot

Widespread epigenomic, transcriptomic and proteomic differences between hip osteophytic and articular chondrocytes in osteoarthritis

inferredcites →https://doi.org/10.1097/00000542-197810000-00003openalex-snapshot

ASA Physical Status Classifications

inferredcites →https://doi.org/10.1101/cshperspect.a016295openalex-snapshot

IL-6 in Inflammation, Immunity, and Disease

inferredcites →https://doi.org/10.1136/annrheumdis-2012-202783openalex-snapshot

Genome-wide DNA methylation analysis of articular chondrocytes reveals a cluster of osteoarthritic patients

inferredcites →https://doi.org/10.1136/annrheumdis-2017-212603openalex-snapshot

Stratification of knee osteoarthritis: two major patient subgroups identified by genome-wide expression analysis of articular cartilage

inferredcites →https://doi.org/10.1136/ard.2005.042465openalex-snapshot

What are the roles of metalloproteinases in cartilage and bone damage?

inferredcites →https://doi.org/10.1186/1471-2474-15-437openalex-snapshot

Elevated VEGF levels contribute to the pathogenesis of osteoarthritis

inferredcites →https://doi.org/10.1186/1751-0473-9-13openalex-snapshot

biobambam: tools for read pair collation based algorithms on BAM files

inferredcites →https://doi.org/10.1186/ar2791openalex-snapshot

Osteoarthritis associated with estrogen deficiency

inferredcites →https://doi.org/10.1186/gb-2010-11-2-r14openalex-snapshot

Gene ontology analysis for RNA-seq: accounting for selection bias

inferredcites →https://doi.org/10.1186/gb-2010-11-3-r25openalex-snapshot

A scaling normalization method for differential expression analysis of RNA-seq data

inferredcites →https://doi.org/10.1186/gb-2014-15-2-r29openalex-snapshot

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

inferredcites →https://doi.org/10.1186/s13059-014-0550-8openalex-snapshot

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

inferredcites →https://doi.org/10.1186/s13059-016-0881-8openalex-snapshot

A survey of best practices for RNA-seq data analysis

inferredcites →https://doi.org/10.1186/s13075-015-0670-xopenalex-snapshot

Prognostic factors for progression of clinical osteoarthritis of the knee: a systematic review of observational studies

inferredcites →https://doi.org/10.1186/s13742-015-0047-8openalex-snapshot

Second-generation PLINK: rising to the challenge of larger and richer datasets

inferredcites →https://doi.org/10.1210/js.2018-00186openalex-snapshot

The Anti-Inflammatory Effects of Testosterone

inferredcites →https://doi.org/10.1254/jphs.10319fpopenalex-snapshot

Alleviating Effects of AS1892802, a Rho Kinase Inhibitor, on Osteoarthritic Disorders in Rodents

inferredcites →https://doi.org/10.12688/f1000research.7563.1openalex-snapshot

Differential analyses for RNA-seq: transcript-level estimates improve gene-level inferences

inferredcites →https://doi.org/10.1371/journal.pcbi.1004219openalex-snapshot

MAGMA: Generalized Gene-Set Analysis of GWAS Data

inferredcites →https://doi.org/10.1371/journal.pgen.1002555openalex-snapshot

Interpreting Meta-Analyses of Genome-Wide Association Studies

inferredcites →https://doi.org/10.1371/journal.pgen.1003491openalex-snapshot

Effectively Identifying eQTLs from Multiple Tissues by Combining Mixed Model and Meta-analytic Approaches

inferredcites →https://doi.org/10.1371/journal.pgen.1004383openalex-snapshot

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

inferredcites →https://doi.org/10.1371/journal.pone.0103056openalex-snapshot

Genes Involved in the Osteoarthritis Process Identified through Genome Wide Expression Analysis in Articular Cartilage; the RAAK Study

inferredcites →https://doi.org/10.15252/msb.20178124openalex-snapshot

Multi‐Omics Factor Analysis—a framework for unsupervised integration of multi‐omics data sets

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1038/s41467-020-20761-5openalex-snapshot

Accelerating functional gene discovery in osteoarthritis

inferred← citeshttps://doi.org/10.1093/genetics/iyac141openalex-snapshot

3D chromatin structure in chondrocytes identifies putative osteoarthritis risk genes

inferred← citeshttps://doi.org/10.1101/2021.02.22.432314openalex-snapshot

Characterizing gene expression responses to biomechanical strain in an in vitro model of osteoarthritis

inferred← citeshttps://doi.org/10.12688/f1000research.109602.1openalex-snapshot

Characterizing gene expression in an in vitro biomechanical strain model of joint health

inferred← citeshttps://doi.org/10.12688/f1000research.109602.2openalex-snapshot

Characterizing gene expression in an in vitro biomechanical strain model of joint health

inferred← citeshttps://doi.org/10.1371/journal.pgen.1010073openalex-snapshot

Evolutionary insights into primate skeletal gene regulation using a comparative cell culture model

inferred← citeshttps://doi.org/10.31482/mmsl.2022.042openalex-snapshot

EVALUATION OF ALFAXALONE'S ANTI-INFLAMMATORY AND ANTINOCICEPTIVE EFFECTS IN BROILER CHICKS

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