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Genetic risk of cholangiocarcinoma is linked to the autophagy gene ATG7

https://doi.org/10.1101/836767
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Outgoing claims: the papers this work cites, builds on, or argues with.

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Cancer risk in mutation carriers of DNA-mismatch-repair genes
inferredcites →https://doi.org/10.1002/gcc.22129openalex-snapshot
Expanding the clinical phenotype of hereditary BAP1 cancer predisposition syndrome, reporting three new cases
inferredcites →https://doi.org/10.1002/jhbp.70openalex-snapshot
Hilar cholangiocarcinoma is pathologically similar to pancreatic duct adenocarcinoma: suggestions of similar background and development
inferredcites →https://doi.org/10.1016/0022-2836(70)90057-4openalex-snapshot
A general method applicable to the search for similarities in the amino acid sequence of two proteins
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Inherited pancreatic cancer: improvements in our understanding of genetics and screening
inferredcites →https://doi.org/10.1016/j.bpg.2005.10.001openalex-snapshot
Epidemiology and risk factors for pancreatic cancer
inferredcites →https://doi.org/10.1016/j.ccell.2016.04.006openalex-snapshot
p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells
inferredcites →https://doi.org/10.1016/j.ccell.2019.04.007openalex-snapshot
Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes
inferredcites →https://doi.org/10.1016/j.celrep.2017.02.033openalex-snapshot
Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles
inferredcites →https://doi.org/10.1016/j.celrep.2017.06.008openalex-snapshot
Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles
inferredcites →https://doi.org/10.1016/j.cgh.2007.05.020openalex-snapshot
Risk Factors for Intrahepatic and Extrahepatic Cholangiocarcinoma in the United States: A Population-Based Case-Control Study
inferredcites →https://doi.org/10.1016/j.jhep.2003.11.030openalex-snapshot
Rising incidence of intrahepatic cholangiocarcinoma in the United States: a true increase?
inferredcites →https://doi.org/10.1016/j.jhep.2018.01.009openalex-snapshot
Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations
inferredcites →https://doi.org/10.1016/j.molcel.2011.08.034openalex-snapshot
Atg8 Transfer from Atg7 to Atg3: A Distinctive E1-E2 Architecture and Mechanism in the Autophagy Pathway
inferredcites →https://doi.org/10.1016/j.molcel.2011.08.035openalex-snapshot
Structural Basis of Atg8 Activation by a Homodimeric E1, Atg7
inferredcites →https://doi.org/10.1016/s0002-9440(10)65440-5openalex-snapshot
Germline and Somatic Mutations of the STK11/LKB1 Peutz-Jeghers Gene in Pancreatic and Biliary Cancers
inferredcites →https://doi.org/10.1016/s0016-5085(03)82772-5openalex-snapshot
BRCA2 germline mutations in familial pancreatic carcinoma
inferredcites →https://doi.org/10.1016/s0076-6879(08)03612-4openalex-snapshot
Chapter 12 Monitoring Autophagic Degradation of p62/SQSTM1
inferredcites →https://doi.org/10.1038/nature09525openalex-snapshot
Fine-scale recombination rate differences between sexes, populations and individuals
inferredcites →https://doi.org/10.1038/nature19057openalex-snapshot
Analysis of protein-coding genetic variation in 60,706 humans
inferredcites →https://doi.org/10.1038/nbt.3432openalex-snapshot
Haplotyping germline and cancer genomes with high-throughput linked-read sequencing
inferredcites →https://doi.org/10.1038/ncomms12030openalex-snapshot
p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming
inferredcites →https://doi.org/10.1038/ng.216openalex-snapshot
Detection of sharing by descent, long-range phasing and haplotype imputation
inferredcites →https://doi.org/10.1038/ng.3247openalex-snapshot
Large-scale whole-genome sequencing of the Icelandic population
inferredcites →https://doi.org/10.1038/ng.499openalex-snapshot
Exome sequencing identifies the cause of a mendelian disorder
inferredcites →https://doi.org/10.1038/ng.955openalex-snapshot
Mutations in BRIP1 confer high risk of ovarian cancer
inferredcites →https://doi.org/10.1038/nrg3031openalex-snapshot
Exome sequencing as a tool for Mendelian disease gene discovery
inferredcites →https://doi.org/10.1038/s41467-018-02942-5openalex-snapshot
Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer
inferredcites →https://doi.org/10.1038/s41467-018-07338-zopenalex-snapshot
Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap
inferredcites →https://doi.org/10.1038/s41598-018-32694-7openalex-snapshot
A short isoform of ATG7 fails to lipidate LC3/GABARAP
inferredcites →https://doi.org/10.1053/j.gastro.2008.02.084openalex-snapshot
Oncogenic KRAS Induces Progenitor Cell Expansion and Malignant Transformation in Zebrafish Exocrine Pancreas
inferredcites →https://doi.org/10.1053/j.gastro.2017.10.015openalex-snapshot
Exome-Wide Association Study of Pancreatic Cancer Risk
inferredcites →https://doi.org/10.1073/pnas.0712145105openalex-snapshot
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
inferredcites →https://doi.org/10.1073/pnas.1121572109openalex-snapshot
Keap1 degradation by autophagy for the maintenance of redox homeostasis
inferredcites →https://doi.org/10.1073/pnas.1720588115openalex-snapshot
Mutations in the pancreatic secretory enzymes CPA1 and CPB1 are associated with pancreatic cancer
inferredcites →https://doi.org/10.1074/jbc.c000752200openalex-snapshot
The Human Homolog of Saccharomyces cerevisiae Apg7p Is a Protein-activating Enzyme for Multiple Substrates Including Human Apg12p, GATE-16, GABARAP, and MAP-LC3
inferredcites →https://doi.org/10.1083/jcb.201102031openalex-snapshot
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells
inferredcites →https://doi.org/10.1091/mbc.10.5.1367openalex-snapshot
Apg7p/Cvt2p: A Novel Protein-activating Enzyme Essential for Autophagy
inferredcites →https://doi.org/10.1093/bioinformatics/btp324openalex-snapshot
Fast and accurate short read alignment with Burrows–Wheeler transform
inferredcites →https://doi.org/10.1093/bioinformatics/btp698openalex-snapshot
Fast and accurate long-read alignment with Burrows–Wheeler transform
inferredcites →https://doi.org/10.1093/hmg/ddq153openalex-snapshot
Zebrafish MTMR14 is required for excitation–contraction coupling, developmental motor function and the regulation of autophagy
inferredcites →https://doi.org/10.1093/jnci/94.18.1358openalex-snapshot
Cancer Incidence in BRCA1 Mutation Carriers
inferredcites →https://doi.org/10.1093/nar/gkw491openalex-snapshot
Copy number analysis of whole-genome data using BIC-seq2 and its application to detection of cancer susceptibility variants
inferredcites →https://doi.org/10.1093/nar/gkx712openalex-snapshot
Chromosome-scale mega-haplotypes enable digital karyotyping of cancer aneuploidy
inferredcites →https://doi.org/10.1093/nar/gky1016openalex-snapshot
CADD: predicting the deleteriousness of variants throughout the human genome
inferredcites →https://doi.org/10.1093/nar/gky427openalex-snapshot
SWISS-MODEL: homology modelling of protein structures and complexes
inferredcites →https://doi.org/10.1097/00000658-200212000-00005openalex-snapshot
CDKN2A Germline Mutations in Familial Pancreatic Cancer
inferredcites →https://doi.org/10.1097/01.sla.0000251366.62632.d3openalex-snapshot
Cholangiocarcinoma
inferredcites →https://doi.org/10.1101/115717openalex-snapshot
The Sentieon Genomics Tools - A fast and accurate solution to variant calling from next-generation sequence data
inferredcites →https://doi.org/10.1101/gad.2016211openalex-snapshot
Autophagy-deficient mice develop multiple liver tumors
inferredcites →https://doi.org/10.1101/gr.107524.110openalex-snapshot
The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
inferredcites →https://doi.org/10.1126/science.1171202openalex-snapshot
Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene
inferredcites →https://doi.org/10.1126/science.1218395openalex-snapshot
Atg7 Modulates p53 Activity to Regulate Cell Cycle and Survival During Metabolic Stress
inferredcites →https://doi.org/10.1146/annurev.pathmechdis.3.121806.154305openalex-snapshot
Pancreatic Cancer
inferredcites →https://doi.org/10.1158/2159-8290.cd-11-0194openalex-snapshot
ATM Mutations in Patients with Hereditary Pancreatic Cancer
inferredcites →https://doi.org/10.1158/2159-8290.cd-17-0368openalex-snapshot
Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma
inferredcites →https://doi.org/10.1186/s13059-016-0974-4openalex-snapshot
The Ensembl Variant Effect Predictor
inferredcites →https://doi.org/10.1186/s40364-015-0040-5openalex-snapshot
BAP1 hereditary cancer predisposition syndrome: a case report and review of literature
inferredcites →https://doi.org/10.1242/jcs.141036openalex-snapshot
Membrane dynamics in autophagosome biogenesis
inferredcites →https://doi.org/10.1371/journal.pcbi.1004873openalex-snapshot
CNVkit: Genome-Wide Copy Number Detection and Visualization from Targeted DNA Sequencing
inferredcites →https://doi.org/10.3390/cells6030021openalex-snapshot
Studying Autophagy in Zebrafish

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1038/s41467-022-30433-1openalex-snapshot
Autophagy regulation by RNA alternative splicing and implications in human diseases
inferred← citeshttps://doi.org/10.15252/emmm.202114824openalex-snapshot
Emerging roles of ATG7 in human health and disease
inferred← citeshttps://doi.org/10.3390/cells9030614openalex-snapshot
Therapeutic Potential of Autophagy Modulation in Cholangiocarcinoma
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