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Transcriptome-wide association analysis of 211 neuroimaging traits identifies new genes for brain structures and yields insights into the gene-level pleiotropy with other complex traits

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Estimating the Heritability of Structural and Functional Brain Connectivity in Families Affected by Attention-Deficit/Hyperactivity Disorder

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Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression

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Association of Schizophrenia Risk With Disordered Niacin Metabolism in an Indian Genome-wide Association Study

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Genome‐wide association study of schizophrenia in Ashkenazi Jews

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The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease

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What Twin Studies Tell Us About the Heritability of Brain Development, Morphology, and Function: A Review

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Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex

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Leveraging Polygenic Functional Enrichment to Improve GWAS Power

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TIGAR: An Improved Bayesian Tool for Transcriptomic Data Imputation Enhances Gene Mapping of Complex Traits

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Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways

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Extreme Polygenicity of Complex Traits Is Explained by Negative Selection

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The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease

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An Expanded View of Complex Traits: From Polygenic to Omnigenic

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Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets

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SA87BRAIN SCANS FROM 21,297 INDIVIDUALS REVEAL THE GENETIC ARCHITECTURE OF HIPPOCAMPAL SUBFIELD VOLUMES

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Beyond a bigger brain: Multivariable structural brain imaging and intelligence

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The relationship between brain volumes and intelligence in bipolar disorder

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The Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception

inferredcites →https://doi.org/10.1016/j.jalz.2017.11.006openalex-snapshot

Genome‐wide association study of Alzheimer's disease endophenotypes at prediagnosis stages

inferredcites →https://doi.org/10.1016/j.neuroimage.2009.09.043openalex-snapshot

Genetic and environmental influences on the size of specific brain regions in midlife: The VETSA MRI study

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Complex network measures of brain connectivity: Uses and interpretations

inferredcites →https://doi.org/10.1016/j.neuroimage.2013.06.027openalex-snapshot

Heritability of subcortical brain measures: A perspective for future genome-wide association studies

inferredcites →https://doi.org/10.1016/j.neuroimage.2013.07.064openalex-snapshot

Neuroimaging of the Philadelphia Neurodevelopmental Cohort

inferredcites →https://doi.org/10.1016/j.neuroimage.2015.04.057openalex-snapshot

The Pediatric Imaging, Neurocognition, and Genetics (PING) Data Repository

inferredcites →https://doi.org/10.1016/j.neuroimage.2018.08.050openalex-snapshot

The Lifespan Human Connectome Project in Development: A large-scale study of brain connectivity development in 5–21 year olds

inferredcites →https://doi.org/10.1016/j.neuron.2017.12.018openalex-snapshot

Statistical Challenges in “Big Data” Human Neuroimaging

inferredcites →https://doi.org/10.1016/j.neuron.2018.02.027openalex-snapshot

Genome-Wide Analyses Identify KIF5A as a Novel ALS Gene

inferredcites →https://doi.org/10.1016/j.nicl.2013.07.006openalex-snapshot

Effectiveness of regional DTI measures in distinguishing Alzheimer's disease, MCI, and normal aging

inferredcites →https://doi.org/10.1016/j.schres.2014.03.034openalex-snapshot

Genetic underpinnings of white matter ‘connectivity’: Heritability, risk, and heterogeneity in schizophrenia

inferredcites →https://doi.org/10.1016/j.schres.2018.06.048openalex-snapshot

The relationship of IQ and emotional processing with insula volume in schizophrenia

inferredcites →https://doi.org/10.1016/s0140-6736(12)62129-1openalex-snapshot

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis

inferredcites →https://doi.org/10.1016/s0140-6736(16)00143-4openalex-snapshot

Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study

inferredcites →https://doi.org/10.1017/thg.2012.11openalex-snapshot

Genetic and Environmental Influences on Neuroimaging Phenotypes: A Meta-Analytical Perspective on Twin Imaging Studies

inferredcites →https://doi.org/10.1038/mp.2014.99openalex-snapshot

Genomic architecture of human neuroanatomical diversity

inferredcites →https://doi.org/10.1038/mp.2016.45openalex-snapshot

Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112 151)

inferredcites →https://doi.org/10.1038/nature13595openalex-snapshot

Biological insights from 108 schizophrenia-associated genetic loci

inferredcites →https://doi.org/10.1038/nature14101openalex-snapshot

Common genetic variants influence human subcortical brain structures

inferredcites →https://doi.org/10.1038/nature14132openalex-snapshot

New genetic loci link adipose and insulin biology to body fat distribution

inferredcites →https://doi.org/10.1038/ncomms13624openalex-snapshot

Novel genetic loci associated with hippocampal volume

inferredcites →https://doi.org/10.1038/ng.2237openalex-snapshot

Common variants at 12q14 and 12q24 are associated with hippocampal volume

inferredcites →https://doi.org/10.1038/ng.2245openalex-snapshot

Common variants at 6q22 and 17q21 are associated with intracranial volume

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A gene-based association method for mapping traits using reference transcriptome data

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Integrative approaches for large-scale transcriptome-wide association studies

inferredcites →https://doi.org/10.1038/ng.3552openalex-snapshot

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

inferredcites →https://doi.org/10.1038/ng.3622openalex-snapshot

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

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Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia

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Efficient multivariate linear mixed model algorithms for genome-wide association studies

inferredcites →https://doi.org/10.1038/nn.4228openalex-snapshot

Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

inferredcites →https://doi.org/10.1038/nn.4393openalex-snapshot

Multimodal population brain imaging in the UK Biobank prospective epidemiological study

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Novel genetic loci underlying human intracranial volume identified through genome-wide association

inferredcites →https://doi.org/10.1038/nrg.2017.101openalex-snapshot

Genetic architecture: the shape of the genetic contribution to human traits and disease

inferredcites →https://doi.org/10.1038/nrneurol.2011.21openalex-snapshot

White matter lesions in Parkinson disease

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A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence

inferredcites →https://doi.org/10.1038/s41380-018-0262-7openalex-snapshot

Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes

inferredcites →https://doi.org/10.1038/s41380-019-0569-zopenalex-snapshot

Large-scale GWAS reveals genetic architecture of brain white matter microstructure and genetic overlap with cognitive and mental health traits (n = 17,706)

inferredcites →https://doi.org/10.1038/s41467-017-00470-2openalex-snapshot

Non-parametric genetic prediction of complex traits with latent Dirichlet process regression models

inferredcites →https://doi.org/10.1038/s41467-017-01261-5openalex-snapshot

Functional mapping and annotation of genetic associations with FUMA

inferredcites →https://doi.org/10.1038/s41467-018-04362-xopenalex-snapshot

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

inferredcites →https://doi.org/10.1038/s41467-018-04930-1openalex-snapshot

Elucidating the genetic basis of social interaction and isolation

inferredcites →https://doi.org/10.1038/s41467-018-06149-6openalex-snapshot

Gene expression imputation identifies candidate genes and susceptibility loci associated with cutaneous squamous cell carcinoma

inferredcites →https://doi.org/10.1038/s41467-018-08259-7openalex-snapshot

Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms

inferredcites →https://doi.org/10.1038/s41586-018-0571-7openalex-snapshot

Genome-wide association studies of brain imaging phenotypes in UK Biobank

inferredcites →https://doi.org/10.1038/s41586-018-0579-zopenalex-snapshot

The UK Biobank resource with deep phenotyping and genomic data

inferredcites →https://doi.org/10.1038/s41588-018-0090-3openalex-snapshot

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

inferredcites →https://doi.org/10.1038/s41588-018-0092-1openalex-snapshot

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

inferredcites →https://doi.org/10.1038/s41588-018-0147-3openalex-snapshot

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

inferredcites →https://doi.org/10.1038/s41588-018-0152-6openalex-snapshot

Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence

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An atlas of genetic influences on osteoporosis in humans and mice

inferredcites →https://doi.org/10.1038/s41588-018-0309-3openalex-snapshot

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

inferredcites →https://doi.org/10.1038/s41588-018-0333-3openalex-snapshot

Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways

inferredcites →https://doi.org/10.1038/s41588-019-0345-7openalex-snapshot

A statistical framework for cross-tissue transcriptome-wide association analysis

inferredcites →https://doi.org/10.1038/s41588-019-0358-2openalex-snapshot

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

inferredcites →https://doi.org/10.1038/s41588-019-0385-zopenalex-snapshot

Opportunities and challenges for transcriptome-wide association studies

inferredcites →https://doi.org/10.1038/s41588-019-0472-1openalex-snapshot

Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes

inferredcites →https://doi.org/10.1038/s41588-019-0481-0openalex-snapshot

A global overview of pleiotropy and genetic architecture in complex traits

inferredcites →https://doi.org/10.1038/s41588-019-0495-7openalex-snapshot

Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

inferredcites →https://doi.org/10.1038/s41588-019-0516-6openalex-snapshot

Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive and mental health traits

inferredcites →https://doi.org/10.1038/s41593-018-0326-7openalex-snapshot

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

inferredcites →https://doi.org/10.1038/s41593-019-0382-7openalex-snapshot

A Bayesian framework that integrates multi-omics data and gene networks predicts risk genes from schizophrenia GWAS data

inferredcites →https://doi.org/10.1038/srep32760openalex-snapshot

Distinct Genetic Influences on Cortical and Subcortical Brain Structures

inferredcites →https://doi.org/10.1073/pnas.1404623111openalex-snapshot

Common genetic variants associated with cognitive performance identified using the proxy-phenotype method

inferredcites →https://doi.org/10.1093/brain/awy141openalex-snapshot

Genetic study of multimodal imaging Alzheimer’s disease progression score implicates novel loci

inferredcites →https://doi.org/10.1093/cercor/bhy157openalex-snapshot

Heritability of Regional Brain Volumes in Large-Scale Neuroimaging and Genetic Studies

inferredcites →https://doi.org/10.1093/cercor/bhz241openalex-snapshot

Polygenic Architecture of Human Neuroanatomical Diversity

inferredcites →https://doi.org/10.1093/nar/gky1120openalex-snapshot

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

inferredcites →https://doi.org/10.1101/406330openalex-snapshot

Using three-dimensional regulatory chromatin interactions from adult and fetal cortex to interpret genetic results for psychiatric disorders and cognitive traits

inferredcites →https://doi.org/10.1101/409649openalex-snapshot

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

inferredcites →https://doi.org/10.1117/1.jmi.6.2.026501openalex-snapshot

Distance canonical correlation analysis with application to an imaging-genetic study

inferredcites →https://doi.org/10.1126/science.1262110openalex-snapshot

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

inferredcites →https://doi.org/10.1126/science.aay6690openalex-snapshot

The genetic architecture of the human cerebral cortex

inferredcites →https://doi.org/10.1161/circgenetics.114.000858openalex-snapshot

Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI

inferredcites →https://doi.org/10.1161/strokeaha.115.009252openalex-snapshot

White Matter Lesion Progression

inferredcites →https://doi.org/10.1162/jocn_a_00531openalex-snapshot

Conceptual and Data-based Investigation of Genetic Influences and Brain Asymmetry: A Twin Study of Multiple Structural Phenotypes

inferredcites →https://doi.org/10.1186/2040-2392-5-18openalex-snapshot

Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence

inferredcites →https://doi.org/10.1186/s13229-017-0137-9openalex-snapshot

Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia

inferredcites →https://doi.org/10.1371/journal.pcbi.1004219openalex-snapshot

MAGMA: Generalized Gene-Set Analysis of GWAS Data

inferredcites →https://doi.org/10.1371/journal.pmed.1001779openalex-snapshot

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

inferredcites →https://doi.org/10.1371/journal.pone.0200785openalex-snapshot

Identification of 613 new loci associated with heel bone mineral density and a polygenic risk score for bone mineral density, osteoporosis and fracture

inferredcites →https://doi.org/10.1371/journal.pone.0213962openalex-snapshot

Correction: Identification of 613 new loci associated with heel bone mineral density and a polygenic risk score for bone mineral density, osteoporosis and fracture

inferredcites →https://doi.org/10.33702/crbmb.2019.1.1.4openalex-snapshot

Advancements of transcriptome imputation and related transcriptome-wide association studies

inferredcites →https://doi.org/10.3389/fnana.2018.00043openalex-snapshot

Brain Structure Alterations in Respect to Tobacco Consumption and Nicotine Dependence: A Comparative Voxel-Based Morphometry Study

inferredcites →https://doi.org/10.34944/dspace/4648openalex-snapshot

Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics

inferredcites →https://doi.org/10.48550/arxiv.1710.02469openalex-snapshot

Set-Based Tests for Genetic Association Using the Generalized Berk-Jones Statistic

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← backgroundhttps://doi.org/10.5281/zenodo.4649360zenodo-depositor-declared

Codes for transcriptome-wide association analysis of brain structures yields insights into pleiotropy with complex neuropsychiatric traits

inferred← citeshttps://doi.org/10.1007/s40484-020-0202-9openalex-snapshot

Integrating brain imaging endophenotypes with GWAS for Alzheimer’s disease

inferred← citeshttps://doi.org/10.1016/j.neuroimage.2020.117347openalex-snapshot

Implicating causal brain imaging endophenotypes in Alzheimer’s disease using multivariable IWAS and GWAS summary data

inferred← citeshttps://doi.org/10.1016/j.ygeno.2021.05.038openalex-snapshot

Alternative splicing and gene co-expression network-based analysis of dizygotic twins with autism-spectrum disorder and their parents

inferred← citeshttps://doi.org/10.1101/2020.08.07.239103openalex-snapshot

Genetic signatures of human brain structure: A comparison between GWAS and relatedness-based regression

inferred← citeshttps://doi.org/10.15302/j-qb-020-0228openalex-snapshot

Transcriptome wide association studies: general framework and methods

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