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Methylphenidate boosts choices of mental labor over leisure depending on baseline striatal dopamine

https://doi.org/10.1101/859637
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1 of the 59 references listed on this page is in the Retraction Watch database as retracted (export 2026-11-04): 10.1097/jcp.0b013e31816073a5 (notice 2022-03-01).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/bdd.1843openalex-snapshot
Therapeutic drug monitoring and pharmacokinetic compartmental analysis of sulpiride double‐peak absorption profile after oral administration to human volunteers
inferredcites →https://doi.org/10.1002/cne.20723openalex-snapshot
Adaptive gain and the role of the locus coeruleus–norepinephrine system in optimal performance
inferredcites →https://doi.org/10.1002/wcs.1401openalex-snapshot
The costs and benefits of brain dopamine for cognitive control
inferredcites →https://doi.org/10.1007/978-94-007-1787-9_14openalex-snapshot
Towards responsible use of cognitive-enhancing drugs by the healthy
inferredcites →https://doi.org/10.1007/bf00172868openalex-snapshot
Role of monoamine pathways in attention and effort: Effects of clonidine and methylphenidate in normal adult humans
inferredcites →https://doi.org/10.1007/bf00558453openalex-snapshot
The pharmacokinetics of intravenous and oral sulpiride in healthy human subjects
inferredcites →https://doi.org/10.1007/pl00005494openalex-snapshot
Tryptophan depletion impairs stimulus-reward learning while methylphenidate disrupts attentional control in healthy young adults: implications for the monoaminergic basis of impulsive behaviour
inferredcites →https://doi.org/10.1007/s00213-006-0502-4openalex-snapshot
Tonic dopamine: opportunity costs and the control of response vigor
inferredcites →https://doi.org/10.1007/s00213-006-0528-7openalex-snapshot
A role for mesencephalic dopamine in activation: commentary on Berridge (2006)
inferredcites →https://doi.org/10.1007/s00213-015-4059-yopenalex-snapshot
Methylphenidate alters selective attention by amplifying salience
inferredcites →https://doi.org/10.1007/s002130000402openalex-snapshot
Effects of dopaminergic drugs on delayed reward as a measure of impulsive behavior in rats
inferredcites →https://doi.org/10.1007/s002130050284openalex-snapshot
Effects of methylphenidate on spatial working memory and planning in healthy young adults
inferredcites →https://doi.org/10.1016/0014-2999(71)90121-xopenalex-snapshot
Comparative studies of various amphetamine analogues demonstrating different interactions with the metabolism of the catecholamines in the brain
inferredcites →https://doi.org/10.1016/j.biopsych.2011.03.028openalex-snapshot
Inverted-U–Shaped Dopamine Actions on Human Working Memory and Cognitive Control
inferredcites →https://doi.org/10.1016/j.biopsych.2012.10.032openalex-snapshot
A Thalamocorticostriatal Dopamine Network for Psychostimulant-Enhanced Human Cognitive Flexibility
inferredcites →https://doi.org/10.1016/j.biopsycho.2015.06.013openalex-snapshot
The window of my eyes: Task disengagement and mental fatigue covary with pupil dynamics
inferredcites →https://doi.org/10.1016/j.cobeha.2015.05.007openalex-snapshot
The cost of dopamine for dynamic cognitive control
inferredcites →https://doi.org/10.1016/j.cobeha.2018.01.027openalex-snapshot
Chemical neuromodulation of cognitive control avoidance
inferredcites →https://doi.org/10.1016/j.cub.2015.05.038openalex-snapshot
Reward Pays the Cost of Noise Reduction in Motor and Cognitive Control
inferredcites →https://doi.org/10.1016/j.neubiorev.2013.07.003openalex-snapshot
Characterizing the cognitive effects of cocaine: A comprehensive review
inferredcites →https://doi.org/10.1016/j.neuroimage.2009.12.058openalex-snapshot
The test–retest reliability of 18F-DOPA PET in assessing striatal and extrastriatal presynaptic dopaminergic function
inferredcites →https://doi.org/10.1016/j.neuropsychologia.2018.05.006openalex-snapshot
The opportunity cost of time modulates cognitive effort
inferredcites →https://doi.org/10.1016/j.pbb.2011.01.020openalex-snapshot
Catecholamine influences on prefrontal cortical function: Relevance to treatment of attention deficit/hyperactivity disorder and related disorders
inferredcites →https://doi.org/10.1016/j.phrs.2010.04.002openalex-snapshot
Modafinil and methylphenidate for neuroenhancement in healthy individuals: A systematic review
inferredcites →https://doi.org/10.1016/j.tics.2010.11.002openalex-snapshot
Cognitive enhancement by drugs in health and disease
inferredcites →https://doi.org/10.1016/s0014-2999(00)00935-3openalex-snapshot
Antipsychotic drugs classified by their effects on the release of dopamine and noradrenaline in the prefrontal cortex and striatum
inferredcites →https://doi.org/10.1016/s0022-3565(24)38829-9openalex-snapshot
Locomotor Effects of Acute and Repeated Threshold Doses of Amphetamine and Methylphenidate: Relative Roles of Dopamine and Norepinephrine
inferredcites →https://doi.org/10.1016/s1054-3589(08)60846-7openalex-snapshot
The Cortical Dopamine System: Role in Memory and Cognition
inferredcites →https://doi.org/10.1017/s0140525x12003196openalex-snapshot
An opportunity cost model of subjective effort and task performance
inferredcites →https://doi.org/10.1037//1064-1297.7.2.145openalex-snapshot
Sleepiness and the reinforcing and subjective effects of methylphenidate.
inferredcites →https://doi.org/10.1037/a0013646openalex-snapshot
The probabilistic nature of preferential choice.
inferredcites →https://doi.org/10.1037/a0037015openalex-snapshot
Opponent actor learning (OpAL): Modeling interactive effects of striatal dopamine on reinforcement learning and choice incentive.
inferredcites →https://doi.org/10.1037/xge0000523openalex-snapshot
Catecholaminergic modulation of the avoidance of cognitive control.
inferredcites →https://doi.org/10.1038/456702aopenalex-snapshot
Towards responsible use of cognitive-enhancing drugs by the healthy
inferredcites →https://doi.org/10.1038/jcbfm.1983.1openalex-snapshot
Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data
inferredcites →https://doi.org/10.1038/npp.2012.30openalex-snapshot
Sensitivity to Cognitive Effort Mediates Psychostimulant Effects on a Novel Rodent Cost/Benefit Decision-Making Task
inferredcites →https://doi.org/10.1038/npp.2014.285openalex-snapshot
Dopamine Antagonism Decreases Willingness to Expend Physical, But Not Cognitive, Effort: A Comparison of Two Rodent Cost/Benefit Decision-Making Tasks
inferredcites →https://doi.org/10.1038/s41598-025-96980-xopenalex-snapshot
Shielding working memory from distraction is more effortful than flexible updating
inferredcites →https://doi.org/10.1038/sj.npp.1380111openalex-snapshot
Distribution of D1- and D2-Dopamine Receptors, and Dopamine and Its Metabolites in the Human Brain
inferredcites →https://doi.org/10.1093/brain/awt263openalex-snapshot
A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment
inferredcites →https://doi.org/10.1093/brain/aww050openalex-snapshot
Activational and effort-related aspects of motivation: neural mechanisms and implications for psychopathology
inferredcites →https://doi.org/10.1093/brain/awy341openalex-snapshot
Dopamine restores cognitive motivation in Parkinson’s disease
inferredcites →https://doi.org/10.1093/cercor/bhs344openalex-snapshot
Establishing the Dopamine Dependency of Human Striatal Signals During Reward and Punishment Reversal Learning
inferredcites →https://doi.org/10.1093/cercor/bhv243openalex-snapshot
Dopaminergic Modulation of the Functional Ventrodorsal Architecture of the Human Striatum
inferredcites →https://doi.org/10.1097/jcp.0b013e31816073a5openalex-snapshot
Once-Daily High-Dose Pindolol for Paroxetine-Refractory Premature Ejaculation
inferredcites →https://doi.org/10.1097/jcp.0b013e318174f92aopenalex-snapshot
Catecholamine Dysfunction in Attention-Deficit/Hyperactivity Disorder
inferredcites →https://doi.org/10.1124/pr.115.010512openalex-snapshot
Dopamine’s Actions in Primate Prefrontal Cortex: Challenges for Treating Cognitive Disorders
inferredcites →https://doi.org/10.1126/science.aaz5891openalex-snapshot
Dopamine promotes cognitive effort by biasing the benefits versus costs of cognitive work
inferredcites →https://doi.org/10.1162/jocn_a_01065openalex-snapshot
The Neurocognitive Cost of Enhancing Cognition with Methylphenidate: Improved Distractor Resistance but Impaired Updating
inferredcites →https://doi.org/10.1196/annals.1390.018openalex-snapshot
Cost, Benefit, Tonic, Phasic
inferredcites →https://doi.org/10.1371/journal.pone.0054583openalex-snapshot
Positive Outcomes Influence the Rate and Time to Publication, but Not the Impact Factor of Publications of Clinical Trial Results
inferredcites →https://doi.org/10.1371/journal.pone.0165274openalex-snapshot
Pupil Diameter Tracks Lapses of Attention
inferredcites →https://doi.org/10.1523/jneurosci.1560-14.2014openalex-snapshot
Acute and Sustained Effects of Methylphenidate on Cognition and Presynaptic Dopamine Metabolism: An [18F]FDOPA PET Study
inferredcites →https://doi.org/10.1523/jneurosci.4387-11.2011openalex-snapshot
Amping Up Effort: Effects ofd-Amphetamine on Human Effort-Based Decision-Making
inferredcites →https://doi.org/10.1523/jneurosci.4467-15.2016openalex-snapshot
Dopamine Manipulation Affects Response Vigor Independently of Opportunity Cost
inferredcites →https://doi.org/10.2165/00003088-199937060-00002openalex-snapshot
Pharmacokinetics and Clinical Effectiveness of Methylphenidate
inferredcites →https://doi.org/10.3389/fpsyg.2011.00137openalex-snapshot
Modeling single-trial ERP reveals modulation of bottom-up face visual processing by top-down task constraints (in some subjects)
inferredcites →https://doi.org/10.3758/cabn.10.2.252openalex-snapshot
Pupil diameter tracks changes in control state predicted by the adaptive gain theory of locus coeruleus function
inferredcites →https://doi.org/10.7554/elife.58321openalex-snapshot
Dopamine promotes instrumental motivation, but reduces reward-related vigour

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1007/s00213-021-06017-0openalex-snapshot
Effects of average reward rate on vigor as a function of individual variation in striatal dopamine
inferred← citeshttps://doi.org/10.1038/s41598-020-72329-4openalex-snapshot
The cognitive effects of a promised bonus do not depend on dopamine synthesis capacity
inferred← citeshttps://doi.org/10.1101/2020.10.13.337477openalex-snapshot
Does dopamine synthesis capacity predict individual variation in curiosity?
inferred← citeshttps://doi.org/10.31219/osf.io/d3h8eopenalex-snapshot
Predicting effects of methylphenidate and sulpiride on brain and cognition: A pharmaco-fMRI, PET study. Design and descriptives.
inferred← citeshttps://doi.org/10.3389/fpsyt.2020.609874openalex-snapshot
Impaired Learning From Errors and Punishments and Maladaptive Avoidance—General Mechanisms Underlying Self-Regulation Disorders?
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