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Rapamycin rejuvenates oral health in aging mice

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/bf01623458openalex-snapshot

Tartrate-resistant acid phosphate activity as osteoclastic marker: Sensitivity of cytochemical assessment and serum assay in comparison with standardized osteoclast histomorphometry

inferredcites →https://doi.org/10.1007/bf03339694openalex-snapshot

Stress, inflammation and natural immunity in the aging process: a new theory

inferredcites →https://doi.org/10.1007/s00198-013-2313-xopenalex-snapshot

NF-κB signaling and bone resorption

inferredcites →https://doi.org/10.1007/s00248-018-1200-6openalex-snapshot

Discovery of a Novel Periodontal Disease-Associated Bacterium

inferredcites →https://doi.org/10.1007/s10266-006-0060-6openalex-snapshot

Periodontal disease and systemic conditions: a bidirectional relationship

inferredcites →https://doi.org/10.1007/s11357-016-9954-6openalex-snapshot

Geroscience and the trans-NIH Geroscience Interest Group, GSIG

inferredcites →https://doi.org/10.1007/s11357-017-9994-6openalex-snapshot

Rapamycin treatment attenuates age-associated periodontitis in mice

inferredcites →https://doi.org/10.1007/s11357-019-00113-yopenalex-snapshot

Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial

inferredcites →https://doi.org/10.1016/j.arr.2008.07.002openalex-snapshot

Molecular inflammation: Underpinnings of aging and age-related diseases

inferredcites →https://doi.org/10.1016/j.cell.2014.10.039openalex-snapshot

Geroscience: Linking Aging to Chronic Disease

inferredcites →https://doi.org/10.1016/j.febslet.2005.02.055openalex-snapshot

Inflamm‐ageing and lifelong antigenic load as major determinants of ageing rate and longevity

inferredcites →https://doi.org/10.1034/j.1600-051x.2002.291107.xopenalex-snapshot

Porphyromonas gingivalis, Bacteroides forsythus and other putative periodontal pathogens in subjects with and without periodontal destruction

inferredcites →https://doi.org/10.1038/ismej.2011.191openalex-snapshot

Distinct and complex bacterial profiles in human periodontitis and health revealed by 16S pyrosequencing

inferredcites →https://doi.org/10.1038/nature08221openalex-snapshot

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

inferredcites →https://doi.org/10.1038/nature11861openalex-snapshot

mTOR is a key modulator of ageing and age-related disease

inferredcites →https://doi.org/10.1038/nmeth.3869openalex-snapshot

DADA2: High-resolution sample inference from Illumina amplicon data

inferredcites →https://doi.org/10.1038/nrmicro2337openalex-snapshot

Periodontitis: a polymicrobial disruption of host homeostasis

inferredcites →https://doi.org/10.1038/sigtrans.2017.23openalex-snapshot

NF-κB signaling in inflammation

inferredcites →https://doi.org/10.1038/srep30887openalex-snapshot

Chronic Repression of mTOR Complex 2 Induces Changes in the Gut Microbiota of Diet-induced Obese Mice

inferredcites →https://doi.org/10.1080/08916930701694667openalex-snapshot

Tartrate-resistant acid phosphatase (TRAP) and the osteoclast/immune cell dichotomy

inferredcites →https://doi.org/10.1093/gerona/glt056openalex-snapshot

Rapamycin Extends Life and Health in C57BL/6 Mice

inferredcites →https://doi.org/10.1093/nar/gkv468openalex-snapshot

ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap

inferredcites →https://doi.org/10.1101/299537openalex-snapshot

ampvis2: an R package to analyse and visualise 16S rRNA amplicon data

inferredcites →https://doi.org/10.1111/acel.12109openalex-snapshot

Late-life rapamycin treatment reverses age-related heart dysfunction

inferredcites →https://doi.org/10.1111/acel.12194openalex-snapshot

Rapamycin‐mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

inferredcites →https://doi.org/10.1111/acel.12203openalex-snapshot

Altered proteome turnover and remodeling by short‐term caloric restriction or rapamycin rejuvenate the aging heart

inferredcites →https://doi.org/10.1111/acel.12380openalex-snapshot

Chronic mTOR inhibition in mice with rapamycin alters T , B , myeloid, and innate lymphoid cells and gut flora and prolongs life of immune‐deficient mice

inferredcites →https://doi.org/10.1111/j.1600-051x.1998.tb02419.xopenalex-snapshot

Microbial complexes in subgingival plaque

inferredcites →https://doi.org/10.1111/j.1749-6632.2000.tb06651.xopenalex-snapshot

Inflamm‐aging: An Evolutionary Perspective on Immunosenescence

inferredcites →https://doi.org/10.1117/12.935640openalex-snapshot

Drishti: a volume exploration and presentation tool

inferredcites →https://doi.org/10.1126/science.aad3267openalex-snapshot

Healthy aging: The ultimate preventative medicine

inferredcites →https://doi.org/10.1126/scisignal.2000559openalex-snapshot

mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

inferredcites →https://doi.org/10.1126/scitranslmed.3009892openalex-snapshot

mTOR inhibition improves immune function in the elderly

inferredcites →https://doi.org/10.1126/scitranslmed.aaq1564openalex-snapshot

TORC1 inhibition enhances immune function and reduces infections in the elderly

inferredcites →https://doi.org/10.1128/msystems.00187-18openalex-snapshot

New Insights into Human Nostril Microbiome from the Expanded Human Oral Microbiome Database (eHOMD): a Resource for the Microbiome of the Human Aerodigestive Tract

inferredcites →https://doi.org/10.1177/0022034512457373openalex-snapshot

Prevalence of Periodontitis in Adults in the United States: 2009 and 2010

inferredcites →https://doi.org/10.1371/journal.pone.0061217openalex-snapshot

phyloseq: An R Package for Reproducible Interactive Analysis and Graphics of Microbiome Census Data

inferredcites →https://doi.org/10.18632/oncotarget.12532openalex-snapshot

The microbial community shifts of subgingival plaque in patients with generalized aggressive periodontitis following non-surgical periodontal therapy: a pilot study

inferredcites →https://doi.org/10.18637/jss.v086.i01openalex-snapshot

Supervised Multiblock Analysis in R with the ade4 Package

inferredcites →https://doi.org/10.1902/jop.2015.140520openalex-snapshot

Update on Prevalence of Periodontitis in Adults in the United States: NHANES 2009 to 2012

inferredcites →https://doi.org/10.2147/cia.s54630openalex-snapshot

Oral health in the elderly patient and its impact on general well-being: a nonsystematic review

inferredcites →https://doi.org/10.32614/cran.package.veganopenalex-snapshot

vegan: Community Ecology Package

inferredcites →https://doi.org/10.3389/fmicb.2011.00093openalex-snapshot

Environmental and Gut Bacteroidetes: The Food Connection

inferredcites →https://doi.org/10.4103/jisp.jisp_301_16openalex-snapshot

A critique on nuclear factor-kappa B and signal transducer and activator of transcription 3: The key transcription factors in periodontal pathogenesis

inferredcites →https://doi.org/10.7554/elife.16351openalex-snapshot

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.tma.2020.01.002openalex-snapshot

RTB101 and immune function in the elderly: Interpreting an unsuccessful clinical trial

inferred← citeshttps://doi.org/10.1093/stmcls/sxae047openalex-snapshot

Integrin-linked kinase control dental pulp stem cell senescence via the mTOR signaling pathway

inferred← citeshttps://doi.org/10.5114/aoms/191565openalex-snapshot

Impact of Rapamycin on Longevity: Updated Insights

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