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The nucleus measures shape deformation for cellular proprioception and regulates adaptive morphodynamics

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1016/b978-0-12-800281-0.00014-2openalex-snapshot
Methods for Two-Dimensional Cell Confinement
inferredcites →https://doi.org/10.1016/j.bpj.2016.02.013openalex-snapshot
Determining Physical Properties of the Cell Cortex
inferredcites →https://doi.org/10.1016/j.ceb.2009.05.003openalex-snapshot
Mechanical modes of ‘amoeboid’ cell migration
inferredcites →https://doi.org/10.1016/j.ceb.2013.04.010openalex-snapshot
Mechanical guidance of cell migration: lessons from chemotaxis
inferredcites →https://doi.org/10.1016/j.ceb.2016.01.003openalex-snapshot
Actin flows in cell migration: from locomotion and polarity to trajectories
inferredcites →https://doi.org/10.1016/j.ceb.2018.12.002openalex-snapshot
Nuclear positioning as an integrator of cell fate
inferredcites →https://doi.org/10.1016/j.cell.2015.01.007openalex-snapshot
Confinement and Low Adhesion Induce Fast Amoeboid Migration of Slow Mesenchymal Cells
inferredcites →https://doi.org/10.1016/j.cell.2015.01.008openalex-snapshot
Cortical Contractility Triggers a Stochastic Switch to Fast Amoeboid Cell Motility
inferredcites →https://doi.org/10.1016/j.cell.2016.04.016openalex-snapshot
The Cell Nucleus Serves as a Mechanotransducer of Tissue Damage-Induced Inflammation
inferredcites →https://doi.org/10.1016/j.cell.2017.09.011openalex-snapshot
A New Model T on the Horizon?
inferredcites →https://doi.org/10.1016/j.cell.2017.10.008openalex-snapshot
Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores
inferredcites →https://doi.org/10.1016/j.cell.2018.12.038openalex-snapshot
Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment
inferredcites →https://doi.org/10.1016/j.cell.2019.05.052openalex-snapshot
Mechanochemical Feedback Loops in Development and Disease
inferredcites →https://doi.org/10.1016/j.celrep.2016.04.035openalex-snapshot
Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways
inferredcites →https://doi.org/10.1016/j.devcel.2015.01.005openalex-snapshot
Mechanical Tension Drives Cell Membrane Fusion
inferredcites →https://doi.org/10.1016/j.devcel.2018.10.025openalex-snapshot
Adherens Junction Length during Tissue Contraction Is Controlled by the Mechanosensitive Activity of Actomyosin and Junctional Recycling
inferredcites →https://doi.org/10.1016/j.devcel.2018.12.020openalex-snapshot
Polarization of Myosin II Refines Tissue Material Properties to Buffer Mechanical Stress
inferredcites →https://doi.org/10.1016/j.it.2018.04.007openalex-snapshot
Integrating Physical and Molecular Insights on Immune Cell Migration
inferredcites →https://doi.org/10.1016/j.semcdb.2016.05.010openalex-snapshot
Epithelial cell extrusion: Pathways and pathologies
inferredcites →https://doi.org/10.1016/j.tcb.2012.07.001openalex-snapshot
Actin cortex mechanics and cellular morphogenesis
inferredcites →https://doi.org/10.1016/j.tcb.2012.10.009openalex-snapshot
Cell polarity: mechanochemical patterning
inferredcites →https://doi.org/10.1016/j.yexcr.2019.01.028openalex-snapshot
Neuronal stretch reception – Making sense of the mechanosense
inferredcites →https://doi.org/10.1021/cr200085wopenalex-snapshot
Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention
inferredcites →https://doi.org/10.1038/bjc.2014.99openalex-snapshot
Arachidonic acid induction of Rho-mediated transendothelial migration in prostate cancer
inferredcites →https://doi.org/10.1038/nature10984openalex-snapshot
Live-cell delamination counterbalances epithelial growth to limit tissue overcrowding
inferredcites →https://doi.org/10.1038/nature10999openalex-snapshot
Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia
inferredcites →https://doi.org/10.1038/ncb3134openalex-snapshot
Force transmission during adhesion-independent migration
inferredcites →https://doi.org/10.1038/nmat3772openalex-snapshot
Molecular mechanisms of cellular mechanosensing
inferredcites →https://doi.org/10.1038/nrm2592openalex-snapshot
Mechanotransduction in development: a growing role for contractility
inferredcites →https://doi.org/10.1038/nrm2786openalex-snapshot
Non-muscle myosin II takes centre stage in cell adhesion and migration
inferredcites →https://doi.org/10.1038/nrm3897openalex-snapshot
Physical influences of the extracellular environment on cell migration
inferredcites →https://doi.org/10.1038/physci229032c0openalex-snapshot
Structures and Functions
inferredcites →https://doi.org/10.1038/s41556-018-0247-4openalex-snapshot
Fluidization-mediated tissue spreading by mitotic cell rounding and non-canonical Wnt signalling
inferredcites →https://doi.org/10.1038/s41586-019-1087-5openalex-snapshot
Nuclear positioning facilitates amoeboid migration along the path of least resistance
inferredcites →https://doi.org/10.1073/pnas.1502029112openalex-snapshot
Mechanical control of mitotic progression in single animal cells
inferredcites →https://doi.org/10.1096/fj.12-211441openalex-snapshot
Physical confinement alters tumor cell adhesion and migration phenotypes
inferredcites →https://doi.org/10.1126/sciadv.aaw7243openalex-snapshot
Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area
inferredcites →https://doi.org/10.1126/science.1240104openalex-snapshot
Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation
inferredcites →https://doi.org/10.1126/science.1256965openalex-snapshot
Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrix
inferredcites →https://doi.org/10.1126/science.aad7297openalex-snapshot
Nuclear envelope rupture and repair during cancer cell migration
inferredcites →https://doi.org/10.1126/science.aad7611openalex-snapshot
ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death
inferredcites →https://doi.org/10.1146/annurev-cellbio-092910-154251openalex-snapshot
Wound Repair: Toward Understanding and Integration of Single-Cell and Multicellular Wound Responses
inferredcites →https://doi.org/10.1146/annurev-cellbio-100109-104027openalex-snapshot
Force Generation, Transmission, and Integration during Cell and Tissue Morphogenesis
inferredcites →https://doi.org/10.1146/annurev-cellbio-111315-125024openalex-snapshot
Endoplasmic Reticulum–Plasma Membrane Associations: Structures and Functions
inferredcites →https://doi.org/10.1146/annurev-cellbio-111315-125201openalex-snapshot
Plasticity of Cell Migration In Vivo and In Silico
inferredcites →https://doi.org/10.1146/annurev.cellbio.19.111301.153011openalex-snapshot
Adhesion-Dependent Cell Mechanosensitivity
inferredcites →https://doi.org/10.1152/ajpheart.00577.2009openalex-snapshot
Stimulatory effects of arachidonic acid on myosin ATPase activity and contraction of smooth muscle via myosin motor domain
inferredcites →https://doi.org/10.1242/dev.129452openalex-snapshot
Morphogen rules: design principles of gradient-mediated embryo patterning
inferredcites →https://doi.org/10.1242/jcs.01357openalex-snapshot
The nuclear envelope lamina network has elasticity and a compressibility limit suggestive of a molecular shock absorber

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4650792openalex-extracted
Cellular Thermo-Adaptability Regulated via Myosin II Activity Tunes the Efficiency of Immune and Wounding Responses
inferred← citeshttps://doi.org/10.1016/j.tcb.2020.06.007openalex-snapshot
Principles of Leukocyte Migration Strategies
inferred← citeshttps://doi.org/10.1101/2020.06.15.153007openalex-snapshot
Emerin regulation of nuclear stiffness is required for fast amoeboid migration in confined environments
inferred← citeshttps://doi.org/10.1126/science.aba2894openalex-snapshot
The nucleus acts as a ruler tailoring cell responses to spatial constraints
inferred← citeshttps://doi.org/10.1242/dev.187302openalex-snapshot
On growth and force: mechanical forces in development
inferred← citeshttps://doi.org/10.3390/biom16030457openalex-snapshot
Nuclear Mechanics and Nuclear Mechanotransduction in Cancer Cell Migration and Invasion
inferred← citeshttps://doi.org/10.3410/f.738843148.793579855openalex-snapshot
Faculty Opinions recommendation of The nucleus acts as a ruler tailoring cell responses to spatial constraints.
inferred← citeshttps://doi.org/10.70675/15bee3efz986fz4c6ez827azaea5e939a469openalex-snapshot
Study of cellular mechanisms allowing dendritic cell migration in restricted spaces
inferred← citeshttps://doi.org/10.7554/elife.61037openalex-snapshot
A flagellate-to-amoeboid switch in the closest living relatives of animals
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