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PPARγ is a tumor suppressor in basal bladder tumors offering new potential therapeutic opportunities
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1001/jama.2015.7996openalex-snapshot
Pioglitazone Use and Risk of Bladder Cancer and Other Common Cancers in Persons With Diabetes
inferredcites →https://doi.org/10.1002/ijc.10980openalex-snapshot
Expression of peroxisome proliferator‐activated receptors (PPARs) in human urinary bladder carcinoma and growth inhibition by its agonists
inferredcites →https://doi.org/10.1007/s00125-012-2668-0openalex-snapshot
Hospitalised hip fracture risk with rosiglitazone and pioglitazone use compared with other glucose-lowering drugs
inferredcites →https://doi.org/10.1016/j.bbalip.2009.09.005openalex-snapshot
Fine-tuning the lipogenic/lipolytic balance to optimize the metabolic requirements of cancer cell growth: Molecular mechanisms and therapeutic perspectives
inferredcites →https://doi.org/10.1016/j.ccell.2016.05.004openalex-snapshot
Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma
inferredcites →https://doi.org/10.1016/j.ccr.2014.01.009openalex-snapshot
Identification of Distinct Basal and Luminal Subtypes of Muscle-Invasive Bladder Cancer with Different Sensitivities to Frontline Chemotherapy
inferredcites →https://doi.org/10.1016/j.cell.2017.09.007openalex-snapshot
Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer
inferredcites →https://doi.org/10.1016/j.celrep.2014.10.035openalex-snapshot
Independent Component Analysis Uncovers the Landscape of the Bladder Tumor Transcriptome and Reveals Insights into Luminal and Basal Subtypes
inferredcites →https://doi.org/10.1016/j.cmet.2014.08.003openalex-snapshot
Inhibition of Cancer Cell Proliferation by PPARγ Is Mediated by a Metabolic Switch that Increases Reactive Oxygen Species Levels
inferredcites →https://doi.org/10.1016/j.eururo.2019.09.006openalex-snapshot
A Consensus Molecular Classification of Muscle-invasive Bladder Cancer
inferredcites →https://doi.org/10.1016/j.tem.2009.04.005openalex-snapshot
Functional implications of genetic variation in human PPARγ
inferredcites →https://doi.org/10.1016/s1097-2765(01)80012-5openalex-snapshot
Loss-of-Function Mutations in PPARγ Associated with Human Colon Cancer
inferredcites →https://doi.org/10.1038/2036openalex-snapshot
Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCMin/+ mice
inferredcites →https://doi.org/10.1038/2042openalex-snapshot
Activators of the nuclear receptor PPARγ enhance colon polyp formation
inferredcites →https://doi.org/10.1038/cgt.2014.16openalex-snapshot
The PPARγ agonist Troglitazone induces autophagy, apoptosis and necroptosis in bladder cancer cells
inferredcites →https://doi.org/10.1038/nm.3159openalex-snapshot
PPARγ signaling and metabolism: the good, the bad and the future
inferredcites →https://doi.org/10.1038/nm1278openalex-snapshot
Thiazolidinediones expand body fluid volume through PPARγ stimulation of ENaC-mediated renal salt absorption
inferredcites →https://doi.org/10.1038/nrc3214openalex-snapshot
The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention
inferredcites →https://doi.org/10.1038/onc.2011.543openalex-snapshot
MiR-27b targets PPARγ to inhibit growth, tumor progression and the inflammatory response in neuroblastoma cells
inferredcites →https://doi.org/10.1038/s41467-017-00147-wopenalex-snapshot
Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer
inferredcites →https://doi.org/10.1038/s41467-018-08157-yopenalex-snapshot
Recurrent activating mutations of PPARγ associated with luminal bladder tumors
inferredcites →https://doi.org/10.1038/s41467-019-12332-0openalex-snapshot
Pparg promotes differentiation and regulates mitochondrial gene expression in bladder epithelial cells
inferredcites →https://doi.org/10.1038/sj.neo.7900050openalex-snapshot
Expression of Peroxisome Proferator-Activated Receptor γ (PPARγ) in Human Transitional Bladder Cancer and its Role in Inducing Cell Death
inferredcites →https://doi.org/10.1038/srep35783openalex-snapshot
Simvastatin induces cell cycle arrest and inhibits proliferation of bladder cancer cells via PPARγ signalling pathway
inferredcites →https://doi.org/10.1038/srep38531openalex-snapshot
FOXA1, GATA3 and PPARɣ Cooperate to Drive Luminal Subtype in Bladder Cancer: A Molecular Analysis of Established Human Cell Lines
inferredcites →https://doi.org/10.1057/9780230374959.0016openalex-snapshot
The Good, the Bad and the Ugly
inferredcites →https://doi.org/10.1073/pnas.1601571113openalex-snapshot
Sleeping Beauty screen reveals Pparg activation in metastatic prostate cancer
inferredcites →https://doi.org/10.1073/pnas.95.8.4333openalex-snapshot
ADD1/SREBP1 activates PPARγ through the production of endogenous ligand
inferredcites →https://doi.org/10.1093/bioinformatics/19.2.185openalex-snapshot
A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
inferredcites →https://doi.org/10.1093/jnci/djs328openalex-snapshot
Association Between Longer Therapy With Thiazolidinediones and Risk of Bladder Cancer: A Cohort Study
inferredcites →https://doi.org/10.1093/nar/gng015openalex-snapshot
Summaries of Affymetrix GeneChip probe level data
inferredcites →https://doi.org/10.1101/488460openalex-snapshot
The consensus molecular classification of muscle-invasive bladder cancer
inferredcites →https://doi.org/10.1107/s0907444904019158openalex-snapshot
Coot : model-building tools for molecular graphics
inferredcites →https://doi.org/10.1107/s0907444905001617openalex-snapshot
Likelihood-enhanced fast translation functions
inferredcites →https://doi.org/10.1107/s0907444905036693openalex-snapshot
Scaling and assessment of data quality
inferredcites →https://doi.org/10.1107/s0907444909052925openalex-snapshot
PHENIX : a comprehensive Python-based system for macromolecular structure solution
inferredcites →https://doi.org/10.1107/s0907444911056058openalex-snapshot
Exploiting structure similarity in refinement: automated NCS and target-structure restraints inBUSTER
inferredcites →https://doi.org/10.1107/s0907444994003112openalex-snapshot
The CCP4 suite: programs for protein crystallography
inferredcites →https://doi.org/10.1107/s2059798316018210openalex-snapshot
Polder maps: improving OMIT maps by excluding bulk solvent
inferredcites →https://doi.org/10.1126/scitranslmed.3008970openalex-snapshot
EGFR as a potential therapeutic target for a subset of muscle-invasive bladder cancers presenting a basal-like phenotype
inferredcites →https://doi.org/10.1146/annurev.biochem.77.061307.091829openalex-snapshot
Fat and Beyond: The Diverse Biology of PPARγ
inferredcites →https://doi.org/10.1158/0008-5472.can-17-1701openalex-snapshot
Genomic Activation of PPARG Reveals a Candidate Therapeutic Axis in Bladder Cancer
inferredcites →https://doi.org/10.1186/1471-2407-6-53openalex-snapshot
PPARγ-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma
inferredcites →https://doi.org/10.1186/s12885-019-5426-6openalex-snapshot
PPARγ activation serves as therapeutic strategy against bladder cancer via inhibiting PI3K-Akt signaling pathway
inferredcites →https://doi.org/10.1242/jcs.01042openalex-snapshot
Role of PPAR γ and EGFR signalling in the urothelial terminal differentiation programme
inferredcites →https://doi.org/10.17615/za09-dk57openalex-snapshot
Comprehensive molecular characterization of urothelial bladder carcinoma
inferredcites →https://doi.org/10.4161/cbt.4.7.2014openalex-snapshot
PPARγ as a therapeutic target for tumor angiogenesis and metastasis
inferredcites →https://doi.org/10.7554/elife.20010openalex-snapshot
Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage development
inferredcites →https://doi.org/10.7554/elife.30862openalex-snapshot
Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1007/978-3-031-68505-7_17openalex-snapshot
In Vitro Bladder Cancer Models
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c02192openalex-snapshot
A New Era for PPARγ: Covalent Ligands and Therapeutic Applications
inferred← citeshttps://doi.org/10.1038/s41388-023-02876-3openalex-snapshot
The urothelial gene regulatory network: understanding biology to improve bladder cancer management
inferred← citeshttps://doi.org/10.1038/s41467-025-67608-5openalex-snapshot
Structural determinants of non-covalent PPARγ inverse agonism and their therapeutic implications
inferred← citeshttps://doi.org/10.3389/fendo.2021.624112openalex-snapshot
PPARgamma in Metabolism, Immunity, and Cancer: Unified and Diverse Mechanisms of Action
inferred← citeshttps://doi.org/10.3389/fendo.2022.830708openalex-snapshot
Case Report: A New Peroxisome Proliferator-Activated Receptor Gamma Mutation Causes Familial Partial Lipodystrophy Type 3 in a Chinese Patient
inferred← citeshttps://doi.org/10.70675/99f394a9zdd8bz4cb8z8348z6ada0a583d32openalex-snapshot
Mécanisme moléculaires du rôle protumorigénique de PPARgamma et RXRalpha dans les cancers de vessie
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