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PI 3K/ AKT / JNK /p38 signalling pathway‐mediated neural apoptosis in the prefrontal cortex of mice is involved in the antidepressant‐like effect of pioglitazone
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1001/archpsyc.1990.01810160037007openalex-snapshot
Elevated Plasma Concentrations of α1-Acid Glycoprotein, a Putative Endogenous Inhibitor of the Tritiated Imipramine Binding Site, in Depressed Patients
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Brain volume abnormalities in major depressive disorder: A meta‐analysis of magnetic resonance imaging studies
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NMDA receptor involvement in antidepressant-like effect of pioglitazone in the forced swimming test in mice
inferredcites →https://doi.org/10.1007/s12031-008-9122-2openalex-snapshot
Evidence for Involvement of ERK, PI3K, and RSK in Induction of Bcl-2 by Valproate
inferredcites →https://doi.org/10.1016/j.bbi.2006.03.003openalex-snapshot
Immunity and emotions: Lipopolysaccharide increases defensive behaviours and potentiates despair in mice
inferredcites →https://doi.org/10.1016/j.bbi.2009.09.009openalex-snapshot
Depression and immunity: A role for T cells?
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Apigenin ameliorates chronic mild stress-induced depressive behavior by inhibiting interleukin-1β production and NLRP3 inflammasome activation in the rat brain
inferredcites →https://doi.org/10.1016/j.bbr.2016.04.032openalex-snapshot
Metabolomic analysis reveals metabolic disturbances in the prefrontal cortex of the lipopolysaccharide-induced mouse model of depression
inferredcites →https://doi.org/10.1016/j.cellsig.2015.04.006openalex-snapshot
Trazodone treatment protects neuronal-like cells from inflammatory insult by inhibiting NF-κB, p38 and JNK
inferredcites →https://doi.org/10.1016/j.ejphar.2014.10.004openalex-snapshot
Antidepressant-like effect of atorvastatin in the forced swimming test in mice: The role of PPAR-gamma receptor and nitric oxide pathway
inferredcites →https://doi.org/10.1016/j.psyneuen.2010.03.007openalex-snapshot
The glucocorticoid receptor: Pivot of depression and of antidepressant treatment?
inferredcites →https://doi.org/10.1016/s0092-8674(00)80434-1openalex-snapshot
Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade
inferredcites →https://doi.org/10.1016/s0165-1781(96)02783-7openalex-snapshot
Indicators of immune activation in major depression
inferredcites →https://doi.org/10.1016/s1053-8119(09)71571-xopenalex-snapshot
Brain volume abnormalities in major depressive disorder: a Meta-analysis of magnetic resonance imaging studies
inferredcites →https://doi.org/10.1038/aps.2014.60openalex-snapshot
Mig-2 attenuates cisplatin-induced apoptosis of human glioma cells in vitro through AKT/JNK and AKT/p38 signaling pathways
inferredcites →https://doi.org/10.1038/aps.2016.63openalex-snapshot
Salvianolic acid B ameliorates depressive-like behaviors in chronic mild stress-treated mice: involvement of the neuroinflammatory pathway
inferredcites →https://doi.org/10.1038/mp.2010.52openalex-snapshot
Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression
inferredcites →https://doi.org/10.1038/mp.2012.167openalex-snapshot
Pathological parainflammation and endoplasmic reticulum stress in depression: potential translational targets through the CNS insulin, klotho and PPAR-γ systems
inferredcites →https://doi.org/10.1038/npp.2012.58openalex-snapshot
Pioglitazone Adjunctive Therapy for Moderate-to-Severe Major Depressive Disorder: Randomized Double-Blind Placebo-Controlled Trial
inferredcites →https://doi.org/10.1038/sj.npp.1301641openalex-snapshot
Lower Phosphoinositide 3-Kinase (PI 3-kinase) Activity and Differential Expression Levels of Selective Catalytic and Regulatory PI 3-Kinase Subunit Isoforms in Prefrontal Cortex and Hippocampus of Suicide Subjects
inferredcites →https://doi.org/10.1074/jbc.m008552200openalex-snapshot
Akt Activation Protects Hippocampal Neurons from Apoptosis by Inhibiting Transcriptional Activity of p53
inferredcites →https://doi.org/10.1083/jcb.150.2.335openalex-snapshot
p38 Map Kinase Mediates Bax Translocation in Nitric Oxide–Induced Apoptosis in Neurons
inferredcites →https://doi.org/10.1111/bph.12200openalex-snapshot
Neuroprotective activities of ca talpol against CaMKII ‐dependent apoptosis induced by LPS in PC12 cells
inferredcites →https://doi.org/10.1111/j.1749-6632.2000.tb05412.xopenalex-snapshot
Illness, Cytokines, and Depression
inferredcites →https://doi.org/10.1146/annurev.clinpsy.121208.131305openalex-snapshot
Cognition and Depression: Current Status and Future Directions
inferredcites →https://doi.org/10.1155/2015/957248openalex-snapshot
Therapeutic Actions of the Thiazolidinediones in Alzheimer’s Disease
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The role of inflammatory cytokines on the aetiopathogenesis of depression
inferredcites →https://doi.org/10.1177/0269881111424456openalex-snapshot
Involvement of PI3K, GSK-3β and PPARγ in the antidepressant-like effect of folic acid in the forced swimming test in mice
inferredcites →https://doi.org/10.1186/1742-2094-10-87openalex-snapshot
Intracerebroventricular administration of lipopolysaccharide induces indoleamine-2,3-dioxygenase-dependent depression-like behaviors
inferredcites →https://doi.org/10.1186/1742-2094-5-4openalex-snapshot
Pioglitazone inhibition of lipopolysaccharide-induced nitric oxide synthase is associated with altered activity of p38 MAP kinase and PI3K/Akt
inferredcites →https://doi.org/10.1242/dmm.016162openalex-snapshot
Contribution of neural cell death to depressive phenotypes of streptozotocin-induced diabetic mice
inferredcites →https://doi.org/10.1503/jpn.110011openalex-snapshot
A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health
inferredcites →https://doi.org/10.1523/jneurosci.23-25-08692.2003openalex-snapshot
Interleukin-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases.
inferredcites →https://doi.org/10.1523/jneurosci.4486-04.2005openalex-snapshot
Differential Regulation of AMPA Receptor and GABA Receptor Trafficking by Tumor Necrosis Factor-α
inferredcites →https://doi.org/10.2174/1389450111314070004openalex-snapshot
PPAR-γ: Therapeutic Prospects in Parkinson's Disease
inferredcites →https://doi.org/10.3389/fncel.2015.00096openalex-snapshot
Molecular regulation of auditory hair cell death and approaches to protect sensory receptor cells and/or stimulate repair following acoustic trauma
inferredcites →https://doi.org/10.3724/sp.j.1206.2009.00591openalex-snapshot
Molecular Mechanism of JNK/Bim/Bax Apoptotic Pathway Induced by TNF-α in Differentiated PC12 Cells*
inferredcites →https://doi.org/10.4306/pi.2017.14.1.74openalex-snapshot
Reversion of BDNF, Akt and CREB in Hippocampus of Chronic Unpredictable Stress Induced Rats: Effects of Phytochemical,Bacopa Monnieri
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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DL‐3‐n‐butylphthalide‐induced neuroprotection in rat models of asphyxia‐induced cardiac arrest followed by cardiopulmonary resuscitation
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Neuronal activity regulated pentraxin (narp) and GluA4 subunit of AMPA receptor may be targets for fluoxetine modulation
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Berberine exerts antidepressant-like effects via regulating miR-34a-synaptotagmin1/Bcl-2 axis
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Targeting NRF2 in Type 2 diabetes mellitus and depression: Efficacy of natural and synthetic compounds
inferred← citeshttps://doi.org/10.1016/j.euroneuro.2021.01.031openalex-snapshot
P.202 PI3K/Akt pathway involvement in behavioral effects of low-molecular-weight BDNF and NGF mimetics on diabetes model
inferred← citeshttps://doi.org/10.1016/j.jep.2022.115005openalex-snapshot
Xiaoyaosan ethyl acetate fraction alleviates depression-like behaviors in CUMS mice by promoting hippocampal neurogenesis via modulating the IGF-1Rβ/PI3K/Akt signaling pathway
inferred← citeshttps://doi.org/10.1016/j.jff.2022.105263openalex-snapshot
Juglanin ameliorates depression-like behavior in chronic unpredictable mild stress-induced mice by improving AMPK signaling
inferred← citeshttps://doi.org/10.1016/j.jss.2018.11.056openalex-snapshot
Melatonin Attenuates Acute Pancreatitis-Induced Liver Damage Through Akt-Dependent PPAR-γ Pathway
inferred← citeshttps://doi.org/10.1016/j.jtcms.2023.12.001openalex-snapshot
Integrated analyses of transcriptomics and network pharmacology reveal leukocyte characteristics and functional changes in subthreshold depression, elucidating the curative mechanism of Danzhi Xiaoyao powder
inferred← citeshttps://doi.org/10.1016/j.neulet.2023.137350openalex-snapshot
Virgin coconut oil attenuates lipopolysaccharide-induced depression-like behaviors: Integrating network pharmacology analysis and molecular mechanism evaluation
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2019.05.027openalex-snapshot
Modulation of LPA1 receptor-mediated neuronal apoptosis by Saikosaponin-d: A target involved in depression
inferred← citeshttps://doi.org/10.1016/j.pnpbp.2019.02.013openalex-snapshot
Ghrelin exhibited antidepressant and anxiolytic effect via the p38-MAPK signaling pathway in hippocampus
inferred← citeshttps://doi.org/10.1016/j.psyneuen.2020.104674openalex-snapshot
PPARγ-mediated microglial activation phenotype is involved in depressive-like behaviors and neuroinflammation in stressed C57BL/6J and ob/ob mice
inferred← citeshttps://doi.org/10.1016/j.thromres.2018.09.063openalex-snapshot
Reduced nicotinamide adenine dinucleotide phosphate inhibits rat platelet aggregation and p38 phosphorylation
inferred← citeshttps://doi.org/10.1021/acschemneuro.1c00371openalex-snapshot
Quercitrin Rapidly Alleviated Depression-like Behaviors in Lipopolysaccharide-Treated Mice: The Involvement of PI3K/AKT/NF-κB Signaling Suppression and CREB/BDNF Signaling Restoration in the Hippocampus
inferred← citeshttps://doi.org/10.1038/s41598-025-01175-zopenalex-snapshot
Exploring potential diagnostic markers and therapeutic targets for type 2 diabetes mellitus with major depressive disorder through bioinformatics and in vivo experiments
inferred← citeshttps://doi.org/10.1039/c9mt00302aopenalex-snapshot
Selenium deficiency exacerbates LPS-induced necroptosis by regulating miR-16-5p targeting PI3K in chicken tracheal tissue
inferred← citeshttps://doi.org/10.1039/d3fo02222fopenalex-snapshot
Unleashing lactoferrin's antidepressant potential through the PI3K/Akt/mTOR pathway in chronic restraint stress rats
inferred← citeshttps://doi.org/10.1111/cns.14497openalex-snapshot
Neurological and metabolic related pathophysiologies and treatment of comorbid diabetes with depression
inferred← citeshttps://doi.org/10.1155/2019/4650906openalex-snapshot
To Explore the Pathogenesis of Vascular Lesion of Type 2 Diabetes Mellitus Based on the PI3K/Akt Signaling Pathway
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Shentong Zhuyu Decoction Inhibits Inflammatory Response, Migration, and Invasion and Promotes Apoptosis of Rheumatoid Arthritis Fibroblast‐like Synoviocytes via the MAPK p38/PPAR γ /CTGF Pathway
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PPARγ signalling pathway: molecular mechanisms and therapeutic potential in ligamentum flavum hypertrophy and lumbar spinal stenosis
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The JNK signaling pathway as a potential new target for depression
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Research progress on the mechanism of action of hesperetin in cerebral ischemia: a narrative review
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Lithium Carbonate Alleviate Neuronal Apoptosis to Improve Depression Symptoms in Mice by the JNK/c-Jun Signaling Pathway
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Bioinformatic analysis of miR-4792 regulates Radix Tetrastigma hemsleyani flavone to inhibit proliferation, invasion, and induce apoptosis of A549 cells
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Morusin Inhibits Human Osteosarcoma via the PI3K-AKT Signaling Pathway
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Evaluation of Anti-inflammatory Nutraceuticals in LPS-induced Mouse Neuroinflammation Model: An Update
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The Prognostic Significance of Anisomycin-Activated Phospho-c-Jun NH2-Terminal Kinase (p-JNK) in Predicting Breast Cancer Patients’ Survival Time
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inferred← citeshttps://doi.org/10.3389/fnmol.2018.00331openalex-snapshot
Peroxisome Proliferator Activated Receptor Agonists Modulate Transposable Element Expression in Brain and Liver
inferred← citeshttps://doi.org/10.3389/fphar.2018.00977openalex-snapshot
Pioglitazone, a PPAR-γ Activator, Stimulates BKCa but Suppresses IKM in Hippocampal Neurons
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BCATc inhibitor 2 ameliorated mitochondrial dysfunction and apoptosis in oleic acid-induced non-alcoholic fatty liver disease model
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Microglial Inflammatory-Metabolic Pathways and Their Potential Therapeutic Implication in Major Depressive Disorder
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MST1 Regulates Neuronal Cell Death via JNK/Casp3 Signaling Pathway in HFD Mouse Brain and HT22 Cells
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Dietary Protection against Cognitive Impairment, Neuroinflammation and Oxidative Stress in Alzheimer’s Disease Animal Models of Lipopolysaccharide-Induced Inflammation
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