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Tributyrin Supplementation Protects Mice from Acute Ethanol-Induced Gut Injury

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jama.307.9.908openalex-snapshot

Vital Signs: Binge Drinking Prevalence, Frequency, and Intensity Among Adults—United States, 2010

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Endotoxemia and gut barrier dysfunction in alcoholic liver disease†

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Enteric dysbiosis associated with a mouse model of alcoholic liver disease

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Chronic plus binge ethanol feeding synergistically induces neutrophil infiltration and liver injury in mice: A critical role for E-selectin

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Butyrate utilization by the colonic mucosa in inflammatory bowel diseases

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Regulation of monocarboxylate transporter 1 (MCT1) promoter by butyrate in human intestinal epithelial cells: Involvement of NF‐κB pathway

inferredcites →https://doi.org/10.1007/bf02213129openalex-snapshot

Butyrate and the colonocyte

inferredcites →https://doi.org/10.1007/s003940070020openalex-snapshot

Rationale for the luminal provision of butyrate in intestinal diseases

inferredcites →https://doi.org/10.1007/s11605-008-0573-0openalex-snapshot

Sodium-Coupled Transport of the Short Chain Fatty Acid Butyrate by SLC5A8 and Its Relevance to Colon Cancer

inferredcites →https://doi.org/10.1007/s11605-009-1045-xopenalex-snapshot

Colonic Gene Expression in Conventional and Germ-Free Mice with a Focus on the Butyrate Receptor GPR109A and the Butyrate Transporter SLC5A8

inferredcites →https://doi.org/10.1016/0016-5085(95)90027-6openalex-snapshot

Antibiotics prevent liver injury in rats following long-term exposure to ethanol

inferredcites →https://doi.org/10.1016/0304-3835(94)90023-xopenalex-snapshot

Butyrate as a differentiating agent: pharmacokinetics, analogues and current status

inferredcites →https://doi.org/10.1016/j.alcohol.2013.01.003openalex-snapshot

Acute ethanol administration inhibits Toll-like receptor 4 signaling pathway in rat intestinal epithelia

inferredcites →https://doi.org/10.1016/j.freeradbiomed.2009.07.015openalex-snapshot

Formation of γ-ketoaldehyde–protein adducts during ethanol-induced liver injury in mice

inferredcites →https://doi.org/10.1016/s0016-5085(00)70142-9openalex-snapshot

The luminal short-chain fatty acid butyrate modulates NF-κB activity in a human colonic epithelial cell line

inferredcites →https://doi.org/10.1021/pr400362zopenalex-snapshot

Chronic Ethanol Consumption Alters Mammalian Gastrointestinal Content Metabolites

inferredcites →https://doi.org/10.1053/gast.1997.v112.pm9041249openalex-snapshot

Lack of butyrate is associated with induction of Bax and subsequent apoptosis in the proximal colon of guinea pig

inferredcites →https://doi.org/10.1053/j.gastro.2005.02.065openalex-snapshot

Early Growth Response-1 Transcription Factor Is Essential for Ethanol-Induced Fatty Liver Injury in Mice

inferredcites →https://doi.org/10.1053/j.gastro.2007.08.041openalex-snapshot

Down-Regulation of the Monocarboxylate Transporter 1 Is Involved in Butyrate Deficiency During Intestinal Inflammation

inferredcites →https://doi.org/10.1074/jbc.m211609200openalex-snapshot

The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids

inferredcites →https://doi.org/10.1093/ajcn/26.8.831openalex-snapshot

Distribution of ethanol in the human gastrointestinal tract

inferredcites →https://doi.org/10.1093/ajcn/73.2.415sopenalex-snapshot

Prebiotic digestion and fermentation

inferredcites →https://doi.org/10.1093/alcalc/37.4.322openalex-snapshot

MICROBES AND MUCOSA IN THE REGULATION OF INTRACOLONIC ACETALDEHYDE CONCENTRATION DURING ETHANOL CHALLENGE

inferredcites →https://doi.org/10.1093/oxfordjournals.alcalc.a044576openalex-snapshot

CONTRASTING BINGE AND CONTINUOUS ALCOHOLIC DRINKERS USING DEMOGRAPHIC AND DRINKING HISTORY VARIABLES

inferredcites →https://doi.org/10.1111/acer.12011openalex-snapshot

Binge Ethanol and Liver: New Molecular Developments

inferredcites →https://doi.org/10.1111/j.1365-2036.2006.03067.xopenalex-snapshot

Review article: the intestinal lumen as a therapeutic target in inflammatory bowel disease

inferredcites →https://doi.org/10.1111/j.1530-0277.1994.tb00894.xopenalex-snapshot

Acetate‐Mediated Effects of Ethanol

inferredcites →https://doi.org/10.1111/j.1530-0277.2009.01022.xopenalex-snapshot

Intestinal Dysbiosis: A Possible Mechanism of Alcohol‐Induced Endotoxemia and Alcoholic Steatohepatitis in Rats

inferredcites →https://doi.org/10.1111/j.1530-0277.2011.01673.xopenalex-snapshot

The Type of Dietary Fat Modulates Intestinal Tight Junction Integrity, Gut Permeability, and Hepatic Toll‐Like Receptor Expression in a Mouse Model of Alcoholic Liver Disease

inferredcites →https://doi.org/10.1111/j.1749-6632.2012.06553.xopenalex-snapshot

Microbial butyrate and its role for barrier function in the gastrointestinal tract

inferredcites →https://doi.org/10.1124/jpet.108.148643openalex-snapshot

Oats Supplementation Prevents Alcohol-Induced Gut Leakiness in Rats by Preventing Alcohol-Induced Oxidative Tissue Damage

inferredcites →https://doi.org/10.1136/gut.29.11.1539openalex-snapshot

Short chain fatty acid distributions of enema samples from a sigmoidoscopy population: an association of high acetate and low butyrate ratios with adenomatous polyps and colon cancer.

inferredcites →https://doi.org/10.1136/gut.40.4.485openalex-snapshot

Short chain fatty acid rectal irrigation for left-sided ulcerative colitis: a randomised, placebo controlled trial.

inferredcites →https://doi.org/10.1146/annurev-physiol-021909-135817openalex-snapshot

Role of Colonic Short-Chain Fatty Acid Transport in Diarrhea

inferredcites →https://doi.org/10.1146/annurev.nutr.22.011602.092259openalex-snapshot

H OW H OST -M ICROBIAL I NTERACTIONS S HAPE THE N UTRIENT E NVIRONMENT OF THE M AMMALIAN I NTESTINE

inferredcites →https://doi.org/10.1146/annurev.physiol.60.1.121openalex-snapshot

MOLECULAR ARCHITECTURE OF TIGHT JUNCTIONS

inferredcites →https://doi.org/10.1152/ajpcell.00112.2005openalex-snapshot

Expression and membrane localization of MCT isoforms along the length of the human intestine

inferredcites →https://doi.org/10.1152/ajpgi.00024.2012openalex-snapshot

Lactobacillus rhamnosus GG culture supernatant ameliorates acute alcohol-induced intestinal permeability and liver injury

inferredcites →https://doi.org/10.1152/ajpgi.00308.2012openalex-snapshot

A novel nutrient sensing mechanism underlies substrate-induced regulation of monocarboxylate transporter-1

inferredcites →https://doi.org/10.1158/0008-5472.can-08-4466openalex-snapshot

GPR109A Is a G-protein–Coupled Receptor for the Bacterial Fermentation Product Butyrate and Functions as a Tumor Suppressor in Colon

inferredcites →https://doi.org/10.1172/jci104574openalex-snapshot

ETHANOL METABOLISM AND PRODUCTION OF FREE ACETATE IN THE HUMAN LIVER

inferredcites →https://doi.org/10.1177/0148607113486809openalex-snapshot

Lactobacillus GG and Tributyrin Supplementation Reduce Antibiotic‐Induced Intestinal Injury

inferredcites →https://doi.org/10.1186/1472-6904-5-4openalex-snapshot

Distribution of cytochrome P450 2C, 2E1, 3A4, and 3A5 in human colon mucosa

inferredcites →https://doi.org/10.1292/jvms.69.599openalex-snapshot

Expression of Monocarboxylate Transporter 1 (MCT1) in the Dog Intestine

inferredcites →https://doi.org/10.1371/journal.pone.0053028openalex-snapshot

Metagenomic Analyses of Alcohol Induced Pathogenic Alterations in the Intestinal Microbiome and the Effect of Lactobacillus rhamnosus GG Treatment

inferredcites →https://doi.org/10.3748/wjg.v17.i12.1519openalex-snapshot

Potential beneficial effects of butyrate in intestinal and extraintestinal diseases

inferredcites →https://doi.org/10.4049/jimmunol.1002060openalex-snapshot

Adiponectin and Heme Oxygenase-1 Suppress TLR4/MyD88-Independent Signaling in Rat Kupffer Cells and in Mice after Chronic Ethanol Exposure

inferredcites →https://doi.org/10.7326/0003-4819-95-2-198openalex-snapshot

Ethanol, the Liver, and the Gastrointestinal Tract

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Saturated and Unsaturated Dietary Fats Differentially Modulate Ethanol-Induced Changes in Gut Microbiome and Metabolome in a Mouse Model of Alcoholic Liver Disease

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Combined application of glycerol monolaurate and tributyrin improves the growth performance, antioxidant capacity, nonspecific immunity, gene expression and intestinal health of juvenile Litopenaeus vannamei

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Effects of dietary tributyrin supplementation in low fish meal diet containing high-Clostridium autoethanogenum protein on the growth performance, antioxidative capacity, lipid metabolism and intestinal microbiota of largemouth bass (Micropterus salmoides)

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Occludin deficiency promotes ethanol-induced disruption of colonic epithelial junctions, gut barrier dysfunction and liver damage in mice

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Alcohol-induced ketonemia is associated with lowering of blood glucose, downregulation of gluconeogenic genes, and depletion of hepatic glycogen in type 2 diabetic db/db mice

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Structural elucidation of a highly branched α-D-glucan from Huangjiu and its hepatoprotective activity via gut microbiome regulation and intestinal barrier repairment

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Roseburia spp. Abundance Associates with Alcohol Consumption in Humans and Its Administration Ameliorates Alcoholic Fatty Liver in Mice

inferred← citeshttps://doi.org/10.1016/j.chom.2020.07.007openalex-snapshot

Microbiota and Fatty Liver Disease—the Known, the Unknown, and the Future

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Intestinal epithelial β Klotho is a critical protective factor in alcohol-induced intestinal barrier dysfunction and liver injury

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Role of Intestinal Microbiome in Potentiating Inflammation and Predicting Outcomes in Alcohol-Associated Cirrhosis

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FOXO4 ameliorates alcohol-induced chronic liver injury via inhibiting NF-κB and modulating gut microbiota in C57BL/6J mice

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Pathogenesis of Alcohol-Associated Liver Disease

inferred← citeshttps://doi.org/10.1016/j.jcmgh.2019.10.005openalex-snapshot

Tributyrin Inhibits Ethanol-Induced Epigenetic Repression of CPT-1A and Attenuates Hepatic Steatosis and Injury

inferred← citeshttps://doi.org/10.1016/j.jcmgh.2024.04.009openalex-snapshot

Inflammation in Alcohol-Associated Hepatitis: Pathogenesis and Therapeutic Targets

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Microbiome as a therapeutic target in alcohol-related liver disease

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Preventive effects of indole-3-carbinol against alcohol-induced liver injury in mice via antioxidant, anti-inflammatory, and anti-apoptotic mechanisms: Role of gut-liver-adipose tissue axis

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Targeting the gut barrier for the treatment of alcoholic liver disease

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Tributyrin differentially regulates inflammatory markers and modulates goblet cells number along the intestinal tract segments of weaning pigs

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Beneficial effects of Dendrobium officinale National Herbal Drink on metabolic immune crosstalk via regulate SCFAs-Th17/Treg

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Mitochondrial dysfunction and tissue injury by alcohol, high fat, nonalcoholic substances and pathological conditions through post-translational protein modifications

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Kaempferol alleviates acute alcoholic liver injury in mice by regulating intestinal tight junction proteins and butyrate receptors and transporters

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Protective effect of 1,25-dihydroxyvitamin D3 on ethanol-induced intestinal barrier injury both in vitro and in vivo

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Microbiota reprogramming for treatment of alcohol-related liver disease

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Alcohol, microbiome, life style influence alcohol and non-alcoholic organ damage

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Nondigestible carbohydrates and gut microbiota: A dynamic duo in host defense

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Supplementation of sodium butyrate protects mice from the development of non-alcoholic steatohepatitis (NASH)

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Dietary Tributyrin Attenuates Intestinal Inflammation, Enhances Mitochondrial Function, and Induces Mitophagy in Piglets Challenged with Diquat

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Gut microbiome, liver immunology, and liver diseases

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Publisher Correction: The gut–liver axis and the intersection with the microbiome

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Chronic stress and corticosterone exacerbate alcohol-induced tissue injury in the gut-liver-brain axis

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Intestinal dysbiosis and permeability: the yin and yang in alcohol dependence and alcoholic liver disease

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Supplementation of Saturated Long-Chain Fatty Acids Maintains Intestinal Eubiosis and Reduces Ethanol-induced Liver Injury in Mice

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Glucose-independent Acetate Metabolism Promotes Melanoma Cell Survival and Tumor Growth

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Decrease in acetyl-CoA pathway utilizing butyrate-producing bacteria is a key pathogenic feature of alcohol-induced functional gut microbial dysbiosis and development of liver disease in mice

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Solid‐state fermented Chinese alcoholic beverage (baijiu) and ethanol resulted in distinct metabolic and microbiome responses

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Flavor compounds in fermented Chinese alcoholic beverage alter gut microbiota and attenuate ethanol-induced liver damages

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Alcohol Feeding in Mice Promotes Colonic Hyperpermeability and Changes in Colonic Organoid Stem Cell Fate

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Specifically Sized Hyaluronan (35 kDa) Prevents Ethanol‐Induced Disruption of Epithelial Tight Junctions Through a layilin‐Dependent Mechanism in Caco‐2 Cells

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Prophylactic tributyrin treatment mitigates chronic‐binge ethanol‐induced intestinal barrier and liver injury

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The effect of increasing intestinal short‐chain fatty acid concentration on gut permeability and liver injury in the context of liver disease: A systematic review

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Tributyrin Supplementation Protects Immune Responses and Vasculature and Reduces Oxidative Stress in the Proximal Colon of Mice Exposed to Chronic-Binge Ethanol Feeding

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Metformin and Probiotics Interplay in Amelioration of Ethanol‐Induced Oxidative Stress and Inflammatory Response in an In Vitro and In Vivo Model of Hepatic Injury

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Intestinal barrier dysfunction and alcoholic liver disease

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Sodium Butyrate Attenuates Diarrhea in Weaned Piglets and Promotes Tight Junction Protein Expression in Colon in a GPR109A-Dependent Manner

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Targeting pathological changes in the gut protects the CNS from neuropathology.

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The Immunomodulatory Functions of Butyrate

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Skin Immunization Obviates Alcohol-Related Immune Dysfunction

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Intestinal Barrier and Permeability in Health, Obesity and NAFLD

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The Gut–Lung Axis During Ethanol Exposure and a Pseudomonas aeruginosa Bacterial Challenge

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Gut Microbiota as Emerging Players in the Development of Alcohol-Related Liver Disease

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Microbiota-Dependent Effects of IL-22

inferred← citeshttps://doi.org/10.3390/foods11111537openalex-snapshot

Non-Alcoholic Components in Huangjiu as Potential Factors Regulating the Intestinal Barrier and Gut Microbiota in Mouse Model of Alcoholic Liver Injury

inferred← citeshttps://doi.org/10.3390/ijms20184568openalex-snapshot

Alcohol or Gut Microbiota: Who Is the Guilty?

inferred← citeshttps://doi.org/10.3390/ijms23010426openalex-snapshot

Role of Microbiota-Derived Metabolites in Alcoholic and Non-Alcoholic Fatty Liver Diseases

inferred← citeshttps://doi.org/10.3390/ijms23020774openalex-snapshot

Crosstalk between Oxidative Stress and Inflammatory Liver Injury in the Pathogenesis of Alcoholic Liver Disease

inferred← citeshttps://doi.org/10.3390/ijms24098008openalex-snapshot

Tributyrin Intake Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm in LDLR-/- Mice

inferred← citeshttps://doi.org/10.3390/ijms25031665openalex-snapshot

The Postbiotic Butyrate Mitigates Gut Mucosal Disruption Caused by Acute Ethanol Exposure

inferred← citeshttps://doi.org/10.3390/ijms25084431openalex-snapshot

Gut Bacteria Provide Genetic and Molecular Reporter Systems to Identify Specific Diseases

inferred← citeshttps://doi.org/10.3390/jcm9082648openalex-snapshot

Liver Steatosis, Gut-Liver Axis, Microbiome and Environmental Factors. A Never-Ending Bidirectional Cross-Talk

inferred← citeshttps://doi.org/10.3390/microorganisms13061188openalex-snapshot

Impact of Gut Microbiome on Gut Permeability in Liver and Gut Diseases

inferred← citeshttps://doi.org/10.3390/nu11010097openalex-snapshot

A Designer Synbiotic Attenuates Chronic-Binge Ethanol-Induced Gut-Liver Injury in Mice

inferred← citeshttps://doi.org/10.3390/nu11020308openalex-snapshot

Monobutyrin Reduces Liver Cholesterol and Improves Intestinal Barrier Function in Rats Fed High-Fat Diets

inferred← citeshttps://doi.org/10.3390/nu12020373openalex-snapshot

Dietary Synbiotic Supplementation Protects Barrier Integrity of Hepatocytes and Liver Sinusoidal Endothelium in a Mouse Model of Chronic-Binge Ethanol Exposure

inferred← citeshttps://doi.org/10.3390/nu13062069openalex-snapshot

Timing of Tributyrin Supplementation Differentially Modulates Gastrointestinal Inflammation and Gut Microbial Recolonization Following Murine Ileocecal Resection

inferred← citeshttps://doi.org/10.3390/nu13093170openalex-snapshot

Alcohol’s Impact on the Gut and Liver

inferred← citeshttps://doi.org/10.3390/nu15071571openalex-snapshot

The Influence of Alcohol Consumption on Intestinal Nutrient Absorption: A Comprehensive Review

inferred← citeshttps://doi.org/10.3390/nu16132067openalex-snapshot

Bioactives in Oral Nutritional Supplementation: A Pediatric Point of View

inferred← citeshttps://doi.org/10.35946/arcr.v38.2.02openalex-snapshot

Alcohol and Gut-Derived Inflammation

inferred← citeshttps://doi.org/10.3844/ajbbsp.2021.465.477openalex-snapshot

Selenium Enriched Peanut Protein Alleviates Alcohol-Induced Liver Damage in Mice by Modulating the Composition of the Gut Microbiota

inferred← citeshttps://doi.org/10.4172/2329-6488.1000278openalex-snapshot

Potential Molecular Mechanism of Probiotics in Alcoholic Liver Disease

inferred← citeshttps://doi.org/10.70675/f76b0335zd8baz4b14za916zd8a1cbd3325copenalex-snapshot

Le microbiote intestinal comme cible thérapeutique dans la maladie alcoolique du foie : implication des acides biliaires et de la pectine

inferred← citeshttps://doi.org/10.7150/ijbs.53589openalex-snapshot

A perspective of intestinal immune-microbiome interactions in alcohol-associated Liver Disease

inferred← citeshttps://doi.org/10.7939/r3-5jtj-me16openalex-snapshot

Harnessing Gut Microbial Modulation in Chronic Inflammatory Gastrointestinal Disease

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