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Determining maximal achievable effect sizes of antidepressant therapies in placebo‐controlled trials

https://doi.org/10.1111/acps.13340
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jamapsychiatry.2017.3739openalex-snapshot
Efficacy and Safety of Intranasal Esketamine Adjunctive to Oral Antidepressant Therapy in Treatment-Resistant Depression
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WHY DO SOME DEPRESSED OUTPATIENTS WHO ARE NOT IN REMISSION ACCORDING TO THE HAMILTON DEPRESSION RATING SCALE NONETHELESS CONSIDER THEMSELVES TO BE IN REMISSION?
inferredcites →https://doi.org/10.1002/wps.20112openalex-snapshot
Are antidepressants clinically useful? Conclusion of a decade of debate
inferredcites →https://doi.org/10.1016/j.cct.2015.05.005openalex-snapshot
Empirically derived criteria cast doubt on the clinical significance of antidepressant-placebo differences
inferredcites →https://doi.org/10.1016/j.cpr.2015.05.001openalex-snapshot
Dropout from individual psychotherapy for major depression: A meta-analysis of randomized clinical trials
inferredcites →https://doi.org/10.1016/j.jad.2009.01.029openalex-snapshot
Meta-analysis of the placebo response in antidepressant trials
inferredcites →https://doi.org/10.1016/j.jad.2014.02.026openalex-snapshot
The effects of psychotherapies for major depression in adults on remission, recovery and improvement: A meta-analysis
inferredcites →https://doi.org/10.1016/j.jad.2014.06.043openalex-snapshot
Relapse rates after psychotherapy for depression – stable long-term effects? A meta-analysis
inferredcites →https://doi.org/10.1016/j.pnpbp.2019.109836openalex-snapshot
Efficacy and acceptability of transcranial direct current stimulation (tDCS) for major depressive disorder: An individual patient data meta-analysis
inferredcites →https://doi.org/10.1016/s0140-6736(03)12599-8openalex-snapshot
Relapse prevention with antidepressant drug treatment in depressive disorders: a systematic review
inferredcites →https://doi.org/10.1016/s0140-6736(17)32802-7openalex-snapshot
Comparative Efficacy and Acceptability of 21 Antidepressant Drugs for the Acute Treatment of Adults With Major Depressive Disorder: A Systematic Review and Network Meta-Analysis
inferredcites →https://doi.org/10.1016/s2215-0366(19)30216-0openalex-snapshot
Influence of baseline severity on the effects of SSRIs in depression: an item-based, patient-level post-hoc analysis
inferredcites →https://doi.org/10.1017/s0033291713000457openalex-snapshot
Comparison of psychotherapies for adult depression to pill placebo control groups: a meta-analysis
inferredcites →https://doi.org/10.1038/mp.2015.53openalex-snapshot
Consistent superiority of selective serotonin reuptake inhibitors over placebo in reducing depressed mood in patients with major depression
inferredcites →https://doi.org/10.1038/s41380-020-0843-0openalex-snapshot
Discontinuation of antidepressants after remission with antidepressant medication in major depressive disorder: a systematic review and meta-analysis
inferredcites →https://doi.org/10.1038/tp.2016.104openalex-snapshot
A mega-analysis of fixed-dose trials reveals dose-dependency and a rapid onset of action for the antidepressant effect of three selective serotonin reuptake inhibitors
inferredcites →https://doi.org/10.1093/ije/dyy076openalex-snapshot
Impact of placebo arms on outcomes in antidepressant trials: systematic review and meta-regression analysis
inferredcites →https://doi.org/10.1093/ijnp/pyaa068openalex-snapshot
Esketamine Nasal Spray for Rapid Reduction of Depressive Symptoms in Patients With Major Depressive Disorder Who Have Active Suicide Ideation With Intent: Results of a Phase 3, Double-Blind, Randomized Study (ASPIRE II)
inferredcites →https://doi.org/10.1097/01.nmd.0000138226.22761.39openalex-snapshot
A Review of Studies of the Hamilton Depression Rating Scale in Healthy Controls
inferredcites →https://doi.org/10.1111/acps.12995openalex-snapshot
Efficacy of inpatient psychotherapy for major depressive disorder: a meta‐analysis of controlled trials
inferredcites →https://doi.org/10.1136/bmjebm-2019-111238openalex-snapshot
Should antidepressants be used for major depressive disorder?
inferredcites →https://doi.org/10.1176/appi.ajp.2017.17010057openalex-snapshot
Psychodynamic Therapy: As Efficacious as Other Empirically Supported Treatments? A Meta-Analysis Testing Equivalence of Outcomes
inferredcites →https://doi.org/10.1177/0269881120922950openalex-snapshot
One (effect) size does not fit at all: Interpreting clinical significance and effect sizes in depression treatment trials
inferredcites →https://doi.org/10.1186/s12888-016-1173-2openalex-snapshot
Selective serotonin reuptake inhibitors versus placebo in patients with major depressive disorder. A systematic review with meta-analysis and Trial Sequential Analysis
inferredcites →https://doi.org/10.1192/bjp.2017.24openalex-snapshot
Effects of selective serotonin reuptake inhibitors on rating-scale-assessed suicidality in adults with depression
inferredcites →https://doi.org/10.1192/bjp.bp.111.096594openalex-snapshot
Putting the efficacy of psychiatric and general medicine medication into perspective: review of meta-analyses
inferredcites →https://doi.org/10.1371/journal.pmed.0050045openalex-snapshot
Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration
inferredcites →https://doi.org/10.1371/journal.pone.0241497openalex-snapshot
On the treatment effect heterogeneity of antidepressants in major depression: A Bayesian meta-analysis and simulation study
inferredcites →https://doi.org/10.3389/fpsyt.2018.00517openalex-snapshot
Statistically Significant Antidepressant-Placebo Differences on Subjective Symptom-Rating Scales Do Not Prove That the Drugs Work: Effect Size and Method Bias Matter!
inferredcites →https://doi.org/10.4088/jcp.11m07203openalex-snapshot
Why Do Some Depressed Outpatients Who Are in Remission According to the Hamilton Depression Rating Scale Not Consider Themselves to Be in Remission?

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4767641openalex-extracted
Antidepressants for Treating Depression Among Older Adults with Dementia: A Systematic Review and Meta-Analysis
inferred← citeshttps://doi.org/10.1001/jamanetworkopen.2025.24119openalex-snapshot
Control Group Outcomes in Trials of Psilocybin, SSRIs, or Esketamine for Depression
inferred← citeshttps://doi.org/10.1001/jamapsychiatry.2026.2293openalex-snapshot
Blinding Integrity and Psychedelic Drug Trials
inferred← citeshttps://doi.org/10.1016/j.jad.2025.03.124openalex-snapshot
Characterizing the effects of vagus nerve stimulation on symptom improvement in markedly treatment-resistant major depressive disorder: A RECOVER trial report
inferred← citeshttps://doi.org/10.1016/j.jad.2026.121553openalex-snapshot
Assessing the presence of biasing and non-biasing unblinding in a randomized controlled trial of a home-use tDCS device: An exploratory analysis
inferred← citeshttps://doi.org/10.1016/j.jclinepi.2025.111762openalex-snapshot
Applying advanced psychometric approaches yields differential randomized trial effect sizes: secondary analysis of individual participant data from antidepressant studies using the Hamilton rating scale for depression
inferred← citeshttps://doi.org/10.1016/j.joim.2025.06.008openalex-snapshot
Efficacy and safety of acupuncture therapies for adult patients with mild and moderate major depressive disorder: A systematic review and meta-analysis
inferred← citeshttps://doi.org/10.1016/j.ncl.2025.08.009openalex-snapshot
Placebo Effects in the Treatment of Depression—Implications for the Psychedelic Renaissance
inferred← citeshttps://doi.org/10.1016/j.pnpbp.2025.111385openalex-snapshot
Microbiota-based therapies as novel targets for autism spectrum disorder: A systematic review and meta-analysis
inferred← citeshttps://doi.org/10.1016/j.psychres.2024.116114openalex-snapshot
Antidepressants for treating depression among older adults with dementia: A systematic review and meta-analysis
inferred← citeshttps://doi.org/10.1016/j.schres.2025.11.012openalex-snapshot
Estimating the relative efficacy of xanomeline/trospium from placebo-controlled trials
inferred← citeshttps://doi.org/10.1017/s0033291725101785openalex-snapshot
Do complex psychometric analyses really matter? Comparing multiple approaches using individual participant data from antidepressant trials
inferred← citeshttps://doi.org/10.1097/gh9.0000000000000148openalex-snapshot
Unsubstantiated use of Selective serotonin reuptake inhibitors as an alternative for the treatment of depression
inferred← citeshttps://doi.org/10.1186/s40359-025-03103-2openalex-snapshot
The impact of schema therapy and its basic and mode treatment models for depressive disorders: a systematic review
inferred← citeshttps://doi.org/10.31234/osf.io/abgmhopenalex-snapshot
Applying advanced psychometric approaches yields differential randomised trial effect sizes: Secondary analysis of individual participant data from antidepressant studies using the Hamilton Rating Scale for Depression
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