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Topical ivermectin improves allergic skin inflammation

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/s00011-011-0307-8openalex-snapshot
Anti-inflammatory effects of ivermectin in mouse model of allergic asthma
inferredcites →https://doi.org/10.1007/s00726-011-1193-7openalex-snapshot
GABA is an effective immunomodulatory molecule
inferredcites →https://doi.org/10.1007/s11302-012-9336-1openalex-snapshot
Rab5 regulates internalisation of P2X4 receptors and potentiation by ivermectin
inferredcites →https://doi.org/10.1016/0165-2427(94)05308-fopenalex-snapshot
Influence of ivermectin on cellular and humoral immune responses of lambs
inferredcites →https://doi.org/10.1016/j.immuni.2011.03.028openalex-snapshot
Mast Cells Are Key Promoters of Contact Allergy that Mediate the Adjuvant Effects of Haptens
inferredcites →https://doi.org/10.1016/j.intimp.2008.12.016openalex-snapshot
Inhibitory effects of ivermectin on nitric oxide and prostaglandin E2 production in LPS-stimulated RAW 264.7 macrophages
inferredcites →https://doi.org/10.1016/j.jaci.2010.11.022openalex-snapshot
CD8+ T cells are recruited early to allergen exposure sites in atopy patch test reactions in human atopic dermatitis
inferredcites →https://doi.org/10.1016/j.jaci.2010.12.002openalex-snapshot
Histamine receptor H1 signaling on dendritic cells plays a key role in the IFN-γ/IL-17 balance in T cell–mediated skin inflammation
inferredcites →https://doi.org/10.1016/j.jaci.2011.01.054openalex-snapshot
Contrasting pathogenesis of atopic dermatitis and psoriasis—Part II: Immune cell subsets and therapeutic concepts
inferredcites →https://doi.org/10.1016/j.jaci.2012.02.020openalex-snapshot
Mechanisms of IFN-γ–induced apoptosis of human skin keratinocytes in patients with atopic dermatitis
inferredcites →https://doi.org/10.1016/j.jdermsci.2004.01.001openalex-snapshot
Both Th2 and Th1 chemokines (TARC/CCL17, MDC/CCL22, and Mig/CXCL9) are elevated in sera from patients with atopic dermatitis
inferredcites →https://doi.org/10.1016/j.jmii.2014.07.006openalex-snapshot
Tacrolimus suppresses atopic dermatitis-associated cytokines and chemokines in monocytes
inferredcites →https://doi.org/10.1016/j.lfs.2007.02.025openalex-snapshot
Effect of ivermectin on the cellular and humoral immune responses of rabbits
inferredcites →https://doi.org/10.1016/j.pt.2014.07.005openalex-snapshot
Ivermectin: panacea for resource-poor communities?
inferredcites →https://doi.org/10.1016/j.tips.2012.05.002openalex-snapshot
Ivermectin binding sites in human and invertebrate Cys-loop receptors
inferredcites →https://doi.org/10.1038/emboj.2010.126openalex-snapshot
P2X4 receptors mediate PGE2 release by tissue‐resident macrophages and initiate inflammatory pain
inferredcites →https://doi.org/10.1038/jid.2012.239openalex-snapshot
TSLP Produced by Keratinocytes Promotes Allergen Sensitization through Skin and Thereby Triggers Atopic March in Mice
inferredcites →https://doi.org/10.1038/jid.2012.456openalex-snapshot
CD8+ T Cells in the Lesional Skin of Atopic Dermatitis and Psoriasis Patients Are an Important Source of IFN-γ, IL-13, IL-17, and IL-22
inferredcites →https://doi.org/10.1038/jid.2015.141openalex-snapshot
Molecular and Morphological Characterization of Inflammatory Infiltrate in Rosacea Reveals Activation of Th1/Th17 Pathways
inferredcites →https://doi.org/10.1038/nature14052openalex-snapshot
Commensal–dendritic-cell interaction specifies a unique protective skin immune signature
inferredcites →https://doi.org/10.1038/ncomms2924openalex-snapshot
The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism
inferredcites →https://doi.org/10.1038/ni.2992openalex-snapshot
Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin
inferredcites →https://doi.org/10.1042/0264-6021:3440199openalex-snapshot
Ionotrophic 5-hydroxytryptamine type 3 receptor activates the protein kinase C-dependent phospholipase D pathway in human T-cells
inferredcites →https://doi.org/10.1063/1.3253299openalex-snapshot
Kirkwood–Buff theory of molecular and protein association, aggregation, and cellular crowding
inferredcites →https://doi.org/10.1073/pnas.1307321110openalex-snapshot
Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice
inferredcites →https://doi.org/10.1074/jbc.m112.398974openalex-snapshot
Bidirectional Coupling between Ryanodine Receptors and Ca2+ Release-activated Ca2+ (CRAC) Channel Machinery Sustains Store-operated Ca2+ Entry in Human T Lymphocytes
inferredcites →https://doi.org/10.1111/j.1365-2133.2005.06745.xopenalex-snapshot
Cilomilast, tacrolimus and rapamycin modulate dendritic cell function in the elicitation phase of allergic contact dermatitis
inferredcites →https://doi.org/10.1111/j.1476-5381.2009.00287.xopenalex-snapshot
Functional evidence for the expression of P2X1, P2X4 and P2X7 receptors in human lung mast cells
inferredcites →https://doi.org/10.1111/j.1476-5381.2012.01987.xopenalex-snapshot
Positive allosteric modulation by ivermectin of human but not murine P2X7 receptors
inferredcites →https://doi.org/10.1126/science.1225152openalex-snapshot
Compartmentalized Control of Skin Immunity by Resident Commensals
inferredcites →https://doi.org/10.1146/annurev.biophys.37.032807.125817openalex-snapshot
Macromolecular Crowding and Confinement: Biochemical, Biophysical, and Potential Physiological Consequences
inferredcites →https://doi.org/10.1172/jci28034openalex-snapshot
Macrophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy
inferredcites →https://doi.org/10.1172/jci65260openalex-snapshot
Specialized role of migratory dendritic cells in peripheral tolerance induction
inferredcites →https://doi.org/10.1177/1753425911399478openalex-snapshot
Secretion of IL-1β triggered by dynasore in murine peritoneal macrophages
inferredcites →https://doi.org/10.2174/138920112800399248openalex-snapshot
Ivermectin in Human Medicine, An Overview of the Current Status of Its Clinical Applications
inferredcites →https://doi.org/10.2460/ajvr.1991.52.04.593openalex-snapshot
Effect of ivermectin on the immune response in mice
inferredcites →https://doi.org/10.33549/physiolres.932711openalex-snapshot
Allosteric Modulation of Ligand Gated Ion Channels by Ivermectin
inferredcites →https://doi.org/10.4049/jimmunol.1101717openalex-snapshot
Cutting Edge: Expression of XCR1 Defines Mouse Lymphoid-Tissue Resident and Migratory Dendritic Cells of the CD8α+ Type
inferredcites →https://doi.org/10.4049/jimmunol.178.9.5571openalex-snapshot
Skin-Infiltrating CD8+ T Cells Initiate Atopic Dermatitis Lesions

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.3897/pharmacia.71.e114753zenodo-depositor-declared
Effects of topical Ivermectin on imiquimod-induced Psoriasis in mouse model – Novel findings
inferred← citeshttps://doi.org/10.1002/9781394168033.ch10openalex-snapshot
Antiviral Uses of Ivermectin
inferred← citeshttps://doi.org/10.1002/9781394168033.ch11openalex-snapshot
Toxicology, Safety, and Environmental Aspects of Ivermectin
inferred← citeshttps://doi.org/10.1002/9781394168033.ch7openalex-snapshot
Ivermectin as an Anti‐Inflammatory Agent
inferred← citeshttps://doi.org/10.1002/9781394168033.ch9openalex-snapshot
Potential Applications of Ivermectin (IVM) in Dermatology
inferred← citeshttps://doi.org/10.1002/ctm2.1227openalex-snapshot
P2X4 receptor modulates gut inflammation and favours microbial homeostasis in colitis
inferred← citeshttps://doi.org/10.1002/eji.201948318openalex-snapshot
CD8 + T cells mediate ultraviolet A‐induced immunomodulation in a model of extracorporeal photochemotherapy
inferred← citeshttps://doi.org/10.1002/hsr2.71816openalex-snapshot
Comparison of the Effectiveness of Ivermectin 1% Cream and Ketoconazole 2% Cream in Treating Facial Seborrheic Dermatitis: A Double‐Blind, Randomized, Controlled Clinical Trial
inferred← citeshttps://doi.org/10.1007/s00210-020-01902-5openalex-snapshot
Ivermectin, antiviral properties and COVID-19: a possible new mechanism of action
inferred← citeshttps://doi.org/10.1007/s10753-023-01829-yopenalex-snapshot
Ivermectin Protects Against Experimental Autoimmune Encephalomyelitis in Mice by Modulating the Th17/Treg Balance Involved in the IL-2/STAT5 Pathway
inferred← citeshttps://doi.org/10.1007/s10787-024-01605-wopenalex-snapshot
Repositioning anthelmintics for the treatment of inflammatory-based pathological conditions
inferred← citeshttps://doi.org/10.1016/j.alit.2019.08.013openalex-snapshot
Recent developments and advances in atopic dermatitis and food allergy
inferred← citeshttps://doi.org/10.1016/j.apsb.2026.09.023openalex-snapshot
LIMA1/EZR axis promotes MASH progression by reducing chaperone-mediated autophagy dependent-lipophagy in hepatocytes
inferred← citeshttps://doi.org/10.1016/j.biopha.2021.111956openalex-snapshot
A secondary approach with conventional medicines and supplements to recuperate current COVID-19 status
inferred← citeshttps://doi.org/10.1016/j.biopha.2022.113706openalex-snapshot
Ivermectin contributes to attenuating the severity of acute lung injury in mice
inferred← citeshttps://doi.org/10.1016/j.clae.2024.102354openalex-snapshot
Topical Ivermectin-metronidazole gel therapy improves Meibomian gland Function in blepharitis caused by demodex spp.
inferred← citeshttps://doi.org/10.1016/j.coph.2025.102574openalex-snapshot
Ivermectin and non-parasitic disorders: An update
inferred← citeshttps://doi.org/10.1016/j.dsx.2021.102186openalex-snapshot
Ivermectin and mortality in patients with COVID-19: A systematic review, meta-analysis, and meta-regression of randomized controlled trials
inferred← citeshttps://doi.org/10.1016/j.exppara.2023.108568openalex-snapshot
Albendazole – Ivermectin combination decreases inflammation in experimental neurocysticercosis
inferred← citeshttps://doi.org/10.1016/j.fct.2025.115383openalex-snapshot
Acute ivermectin toxicity on skin and brain tissue of adult albino rats: Evaluation of the role of Flumazenil and Vitamin C as new treatment modalities
inferred← citeshttps://doi.org/10.1016/j.heliyon.2021.e07311openalex-snapshot
RETRACTED: Ivermectin-functionalized multiwall carbon nanotube enhanced the locomotor activity and neuropathic pain by modulating M1/M2 macrophage and decrease oxidative stress in rat model of spinal cord injury
inferred← citeshttps://doi.org/10.1016/j.ijpddr.2021.03.004openalex-snapshot
Heartworm disease – Overview, intervention, and industry perspective
inferred← citeshttps://doi.org/10.1016/j.isci.2020.101870openalex-snapshot
A P2rx7 Passenger Mutation Affects the Vitality and Function of T cells in Congenic Mice
inferred← citeshttps://doi.org/10.1016/j.jid.2025.03.031openalex-snapshot
Microbe–Host Interaction in Rosacea and Its Modulation through Topical Ivermectin
inferred← citeshttps://doi.org/10.1016/j.jksus.2022.102349openalex-snapshot
Ivermectin ameliorate the toxic effect of dimethylhydrazine in male Wistar rats
inferred← citeshttps://doi.org/10.1016/j.jsps.2022.06.024openalex-snapshot
Efficacy of ivermectin against colon cancer induced by dimethylhydrazine in male wistar rats
inferred← citeshttps://doi.org/10.1016/j.mehy.2020.110364openalex-snapshot
Inhaled route and anti-inflammatory action of ivermectin: Do they hold promise in fighting against COVID-19?
inferred← citeshttps://doi.org/10.1016/j.pt.2017.02.004openalex-snapshot
Ivermectin – Old Drug, New Tricks?
inferred← citeshttps://doi.org/10.1016/j.retram.2021.103309openalex-snapshot
Potential use of ivermectin for the treatment and prophylaxis of SARS-CoV-2 infection
inferred← citeshttps://doi.org/10.1016/j.vas.2026.100894openalex-snapshot
Ivermectin enhances the transcription of pro-inflammatory cytokines in equine leukocytes stimulated with LPS and nigericin
inferred← citeshttps://doi.org/10.1016/j.vetpar.2024.110335openalex-snapshot
The efficacy of essential oil components with ivermectin against Rhipicephalus annulatus: An in-vitro study
inferred← citeshttps://doi.org/10.1080/08830185.2020.1844195openalex-snapshot
Dendritic cells in COVID-19 immunopathogenesis: insights for a possible role in determining disease outcome
inferred← citeshttps://doi.org/10.1080/09546634.2020.1773378openalex-snapshot
Oral ivermectin for the treatment of red scrotum syndrome
inferred← citeshttps://doi.org/10.1093/ofid/ofab358openalex-snapshot
Retracted: Meta-analysis of Randomized Trials of Ivermectin to Treat SARS-CoV-2 Infection
inferred← citeshttps://doi.org/10.1101/2020.06.10.139410openalex-snapshot
A P2rx7 passenger mutation affects the vitality and function of immune cells in P2X4ko and other transgenic mice
inferred← citeshttps://doi.org/10.1101/2020.11.30.20236570openalex-snapshot
THE THERAPEUTIC POTENTIAL OF IVERMECTIN FOR COVID-19: A SYSTEMATIC REVIEW OF MECHANISMS AND EVIDENCE
inferred← citeshttps://doi.org/10.1111/fcp.12902openalex-snapshot
Evaluation of therapeutic potential of ivermectin against complete Freund's adjuvant‐induced arthritis in rats: Involvement of inflammatory mediators
inferred← citeshttps://doi.org/10.1136/openhrt-2020-001350openalex-snapshot
Ivermectin may be a clinically useful anti-inflammatory agent for late-stage COVID-19
inferred← citeshttps://doi.org/10.1159/000534206openalex-snapshot
The Detrimental Effect of Pre-Treatment with Ivermectin on Myocardial Ischemia
inferred← citeshttps://doi.org/10.1186/s12917-020-02612-zopenalex-snapshot
Mechanisms of ivermectin-induced wound healing
inferred← citeshttps://doi.org/10.1186/s13071-021-04810-6openalex-snapshot
Lack of detectable short-term effects of a single dose of ivermectin on the human immune system
inferred← citeshttps://doi.org/10.14202/vetworld.2019.1204-1211openalex-snapshot
Current therapeutic applications and pharmacokinetic modulations of ivermectin
inferred← citeshttps://doi.org/10.15690/vramn10927openalex-snapshot
Complex Approach to the Management of Acneiform Rash Induced by Epidermal Growth Factor Receptor Inhibitors
inferred← citeshttps://doi.org/10.17533/udea.rccp.v36n4a5openalex-snapshot
Effects of ivermectin on cytokine and immunoglobulin levels in sheep
inferred← citeshttps://doi.org/10.2147/idr.s381715openalex-snapshot
Possible Role of Ivermectin Mucoadhesive Nanosuspension Nasal Spray in Recovery of Post-COVID-19 Anosmia
inferred← citeshttps://doi.org/10.2174/18743722-v16-e2205190openalex-snapshot
Intranasal Ivermectin Spray, the Sunscreen to COVID-19
inferred← citeshttps://doi.org/10.22354/24223794.1105openalex-snapshot
Clinical efficacy and safety of ivermectin (400 ug/kg, single dose) in patients with severe COVID-19: a randomized clinical trial
inferred← citeshttps://doi.org/10.2340/actadv.v102.4391openalex-snapshot
Topical Metronidazole Versus Ivermectin for Low-density Demodex Rosacea: A Rater-blinded, Randomized, Split-face Trial
inferred← citeshttps://doi.org/10.24018/ejpharma.2024.4.1.75openalex-snapshot
The Relationship between Atopic Dermatitis and Food Allergy
inferred← citeshttps://doi.org/10.24884/1682-6655-2019-18-3-68-77openalex-snapshot
Evaluation of the effect of the combined effects of local anti-inflammatory therapy (Ivermectin) and a pulsed dye laser (595 nm) on LL-37 induced rosacea-like inflammation on mice
inferred← citeshttps://doi.org/10.29309/tpmj/2020.27.11.4456openalex-snapshot
Effect of topical tacrolimus ointment on SCORAD index in pediatric atopic dermatitis.
inferred← citeshttps://doi.org/10.33448/rsd-v9i11.10611openalex-snapshot
Ivermectina: é preciso pensar fora da caixa para reposicioná-la
inferred← citeshttps://doi.org/10.3389/fmed.2025.1703912openalex-snapshot
Efficacy and safety of oral ivermectin versus benzyl benzoate for the treatment of scabies: a systematic review and meta-analysis of randomized controlled trials
inferred← citeshttps://doi.org/10.3390/life12091384openalex-snapshot
Ivermectin: A Controversial Focal Point during the COVID-19 Pandemic
inferred← citeshttps://doi.org/10.3390/ph13080196openalex-snapshot
Avermectin Derivatives, Pharmacokinetics, Therapeutic and Toxic Dosages, Mechanism of Action, and Their Biological Effects
inferred← citeshttps://doi.org/10.3390/pharmaceutics17091205openalex-snapshot
A Pilot, Randomised, Placebo-Controlled, Double-Blind Trial of a Single Oral Dose of Ivermectin for Post-Exposure Prophylaxis of SARS-CoV-2
inferred← citeshttps://doi.org/10.4103/jmms.jmms_146_20openalex-snapshot
Role of ivermectin in COVID-19: Wishful thinking or scientific optimism
inferred← citeshttps://doi.org/10.4155/tde-2020-0090openalex-snapshot
Sustained-release Hydrogels of Ivermectin As Alternative Systems to Improve the Treatment of Cutaneous Leishmaniasis
inferred← citeshttps://doi.org/10.6084/m9.figshare.14738634openalex-snapshot
Additional file 1 of Lack of detectable short-term effects of a single dose of ivermectin on the human immune system
inferred← citeshttps://doi.org/10.70675/848d7714za7e9z43d9zacaez47cd7d35182dopenalex-snapshot
Mécanismes de l'immunothérapie épicutanée des allergies alimentaires
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