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Systematic review and meta‐analysis found that intranasal dexmedetomidine was a safe and effective sedative drug during paediatric procedural sedation
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/14651858.cd009491.pub2openalex-snapshot
Midazolam for sedation before procedures
inferredcites →https://doi.org/10.1002/9780470693926openalex-snapshot
Systematic Reviews in Health Care
inferredcites →https://doi.org/10.1007/s12630-017-0917-xopenalex-snapshot
The effects of intranasal dexmedetomidine premedication in children: a systematic review and meta-analysis
inferredcites →https://doi.org/10.1007/s40262-017-0507-7openalex-snapshot
Clinical Pharmacokinetics and Pharmacodynamics of Dexmedetomidine
inferredcites →https://doi.org/10.1007/s40272-015-0145-1openalex-snapshot
Comparison of Two Different Intranasal Doses of Dexmedetomidine in Children for Magnetic Resonance Imaging Sedation
inferredcites →https://doi.org/10.1007/s40272-017-0217-5openalex-snapshot
Intranasal Dexmedetomidine for Procedural Sedation in Children, a Suitable Alternative to Chloral Hydrate
inferredcites →https://doi.org/10.1016/j.ajem.2017.03.021openalex-snapshot
Sedation effects of intranasal dexmedetomidine delivered as sprays versus drops on pediatric response to venous cannulation
inferredcites →https://doi.org/10.1016/j.annemergmed.2008.09.030openalex-snapshot
Consensus-Based Recommendations for Standardizing Terminology and Reporting Adverse Events for Emergency Department Procedural Sedation and Analgesia in Children
inferredcites →https://doi.org/10.1016/j.bja.2017.11.100openalex-snapshot
Pharmacokinetic and pharmacodynamic study of intranasal and intravenous dexmedetomidine
inferredcites →https://doi.org/10.1016/j.jclinane.2017.01.014openalex-snapshot
The sedative effects of the intranasal administration of dexmedetomidine in children undergoing surgeries compared to other sedation methods: A systematic review and meta-analysis
inferredcites →https://doi.org/10.1016/j.jclinane.2020.109736openalex-snapshot
Dexmedetomidine versus other sedatives for non-painful pediatric examinations: A systematic review and meta-analysis of randomized controlled trials
inferredcites →https://doi.org/10.1016/j.ntt.2017.01.001openalex-snapshot
Neuroprotection and neurotoxicity in the developing brain: an update on the effects of dexmedetomidine and xenon
inferredcites →https://doi.org/10.1093/jpepsy/jsv026openalex-snapshot
Acute Pain and Posttraumatic Stress After Pediatric Injury
inferredcites →https://doi.org/10.1097/aln.0000000000001236openalex-snapshot
Sedation with Dexmedetomidine or Propofol Impairs Hypoxic Control of Breathing in Healthy Male Volunteers
inferredcites →https://doi.org/10.1097/jtn.0b013e3181b9e078openalex-snapshot
Beyond the Physical Injuries
inferredcites →https://doi.org/10.1097/md.0000000000007938openalex-snapshot
Efficacy of dexmedetomidine for pain management in knee arthroscopy
inferredcites →https://doi.org/10.1097/pcc.0000000000001451openalex-snapshot
Dexmedetomidine as Single Continuous Sedative During Noninvasive Ventilation: Typical Usage, Hemodynamic Effects, and Withdrawal*
inferredcites →https://doi.org/10.1111/acem.12938openalex-snapshot
What Works and What's Safe in Pediatric Emergency Procedural Sedation: An Overview of Reviews
inferredcites →https://doi.org/10.1111/acem.12998openalex-snapshot
Double‐blind Randomized Controlled Trial of Intranasal Dexmedetomidine Versus Intranasal Midazolam as Anxiolysis Prior to Pediatric Laceration Repair in the Emergency Department
inferredcites →https://doi.org/10.1111/anae.13407openalex-snapshot
A comparison of intranasal dexmedetomidine for sedation in children administered either by atomiser or by drops
inferredcites →https://doi.org/10.1111/anae.13981openalex-snapshot
A randomised controlled trial of oral chloral hydrate vs. intranasal dexmedetomidine before computerised tomography in children
inferredcites →https://doi.org/10.1111/pan.12025openalex-snapshot
Comparison of buccal and nasal dexmedetomidine premedication for pediatric patients
inferredcites →https://doi.org/10.1111/pan.12368openalex-snapshot
Vasovagal syncope and severe bradycardia following intranasal dexmedetomidine for pediatric procedural sedation
inferredcites →https://doi.org/10.1111/pan.12819openalex-snapshot
Comparison of dexmedetomidine and chloral hydrate sedation for transthoracic echocardiography in infants and toddlers: a randomized clinical trial
inferredcites →https://doi.org/10.1111/pan.12854openalex-snapshot
A prospective, randomized, double‐blind trial of intranasal dexmedetomidine and oral chloral hydrate for sedated auditory brainstem response ( ABR ) testing
inferredcites →https://doi.org/10.1111/pan.13010openalex-snapshot
Comparison of oral midazolam with intranasal dexmedetomidine premedication for children undergoing CT imaging: a randomized, double‐blind, and controlled study
inferredcites →https://doi.org/10.1111/pan.13148openalex-snapshot
Comparison of sedation by intranasal dexmedetomidine and oral chloral hydrate for pediatric ophthalmic examination
inferredcites →https://doi.org/10.1136/bjophthalmol-2016-309449openalex-snapshot
Safety and efficacy of chloral hydrate for procedural sedation in paediatric ophthalmology: a systematic review and meta-analysis
inferredcites →https://doi.org/10.1136/bmj.d5928openalex-snapshot
The Cochrane Collaboration's tool for assessing risk of bias in randomised trials
inferredcites →https://doi.org/10.1177/1055665618754949openalex-snapshot
Dexmedetomidine Decreases Postoperative Pain and Narcotic Use in Children Undergoing Alveolar Bone Graft Surgery
inferredcites →https://doi.org/10.1186/1471-2288-14-135openalex-snapshot
Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range
inferredcites →https://doi.org/10.1186/1471-2288-7-5openalex-snapshot
Inclusion of zero total event trials in meta-analyses maintains analytic consistency and incorporates all available data
inferredcites →https://doi.org/10.1213/ane.0b013e31816c8929openalex-snapshot
A Comparison of Intranasal Dexmedetomidine and Oral Midazolam for Premedication in Pediatric Anesthesia: A Double-Blinded Randomized Controlled Trial
inferredcites →https://doi.org/10.1542/peds.105.4.805openalex-snapshot
Adverse Sedation Events in Pediatrics: A Critical Incident Analysis of Contributing Factors
inferredcites →https://doi.org/10.1542/peds.2010-2960openalex-snapshot
Impact of Provider Specialty on Pediatric Procedural Sedation Complication Rates
inferredcites →https://doi.org/10.1542/peds.2016-1212openalex-snapshot
Guidelines for Monitoring and Management of Pediatric Patients Before, During, and After Sedation for Diagnostic and Therapeutic Procedures: Update 2016
inferredcites →https://doi.org/10.15537/smj.2016.9.15003openalex-snapshot
Intranasal sedatives in pediatric dentistry
inferredcites →https://doi.org/10.17796/jcpd.38.3.l828585807482966openalex-snapshot
A Comparative evaluation of Intrnasal Dexmedetomidine, Midazolam and Ketamine for their sedative and analgesic properties: A Triple Blind Randomized Study
inferredcites →https://doi.org/10.2165/00002018-200629010-00005openalex-snapshot
Short-Term Chloral Hydrate Administration and Cancer in Humans
inferredcites →https://doi.org/10.26355/eurrev_201801_14120openalex-snapshot
Intranasal drug administration for procedural sedation in children admitted to pediatric Emergency Room.
inferredcites →https://doi.org/10.4103/jisppd.jisppd_40_18openalex-snapshot
A comparative assessment of intranasal and oral dexmedetomidine for procedural sedation in pediatric dental patients
inferredcites →https://doi.org/10.56645/jmde.v6i14.284openalex-snapshot
Cochrane Handbook for Systematic Reviews of Interventions
inferredcites →https://doi.org/10.6061/clinics/2014(11)12openalex-snapshot
Premedication with dexmedetomidine in pediatric patients: a systematic review and meta-analysis
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4690504openalex-extracted
Effect of Procedural Sedation on Sleep Quality of Pediatric Outpatients: A Single-Centre, Self-Controlled, Observational Study
inferred← citeshttps://doi.org/10.1007/164_2023_705openalex-snapshot
Clinical Use of Adrenergic Receptor Ligands in Acute Care Settings
inferred← citeshttps://doi.org/10.1007/s00431-021-03930-6openalex-snapshot
Pediatric procedural sedation and analgesia in the emergency department: surveying the current European practice
inferred← citeshttps://doi.org/10.1007/s00431-022-04722-2openalex-snapshot
Nurse-driven intranasal dexmedetomidine administration as sedation for non-invasive procedures in children: a single centre audit
inferred← citeshttps://doi.org/10.1007/s11325-021-02342-yopenalex-snapshot
Dexmedetomidine-soaked nasal packing can reduce pain and improve sleep quality after nasal endoscopic surgery: a double-blind, randomized, controlled clinical trial
inferred← citeshttps://doi.org/10.1007/s40268-025-00522-9openalex-snapshot
Drugs for Procedural Sedation and Analgesia in Children: A Systematic Review and Meta-analysis
inferred← citeshttps://doi.org/10.1007/s40272-024-00667-1openalex-snapshot
Dexmedetomidine for Less Invasive Surfactant Administration: A Pilot Study
inferred← citeshttps://doi.org/10.1007/s40746-026-00369-5openalex-snapshot
Safe and Sound: Optimizing Pediatric Procedural Sedation in Emergency Departments — From High-resource Standards to Low-resource Adaptations
inferred← citeshttps://doi.org/10.1007/s44253-024-00055-0openalex-snapshot
Dexmedetomidine for electroencephalogram in children with behavioural disorders: a comparative study between intranasal and intravenous administration
inferred← citeshttps://doi.org/10.1016/j.annemergmed.2026.06.039openalex-snapshot
Unscheduled Procedural Sedation Multidisciplinary Delphi Consensus Guidelines, Part 2: Clinical Practice
inferred← citeshttps://doi.org/10.1016/j.bpa.2025.09.006openalex-snapshot
Advances in procedural sedation: From traditional agents to novel pharmacologic approaches
inferred← citeshttps://doi.org/10.1016/j.jclinane.2022.110908openalex-snapshot
Preoperative sedation in children with congenital heart disease: 50% and 95% effective doses, hemodynamic effects, and safety of intranasal dexmedetomidine
inferred← citeshttps://doi.org/10.1016/j.jopan.2023.02.005openalex-snapshot
Clinical Analysis of Intranasal Dexmedetomidine Combined With Midazolam in Pediatric Cranial Magnetic Resonance Examinations
inferred← citeshttps://doi.org/10.1016/j.jopan.2023.10.006openalex-snapshot
Hypotensive Events in Pediatric Patients Receiving Dexmedetomidine for MRI
inferred← citeshttps://doi.org/10.1016/j.jormas.2023.101396openalex-snapshot
Comparison of sedative effects of intramuscular and intranasal midazolam for pediatric laceration repair in dental emergency department: A randomized controlled study
inferred← citeshttps://doi.org/10.1016/j.jpp.2024.07.009openalex-snapshot
Intoxications domestiques accidentelles de l’enfant
inferred← citeshttps://doi.org/10.1016/j.regg.2026.101817openalex-snapshot
Is dexmedetomidine effective for delirium prevention in older adults? A scoping review
inferred← citeshttps://doi.org/10.1016/j.vaa.2022.08.003openalex-snapshot
Comparison of the sedative effects of intranasal or intramuscular dexmedetomidine at low doses in healthy dogs: a randomized clinical trial
inferred← citeshttps://doi.org/10.1016/s1245-1789(23)47984-xopenalex-snapshot
Intoxicaciones domésticas accidentales en la infancia
inferred← citeshttps://doi.org/10.1016/s1637-5017(22)45193-3openalex-snapshot
10.1016/s1637-5017(22)45193-3
inferred← citeshttps://doi.org/10.1038/s41598-025-18931-wopenalex-snapshot
Nomogram for predicting the success rate of sedation with intranasal dexmedetomidine in paediatric nonpainful diagnostic procedures: a retrospective study
inferred← citeshttps://doi.org/10.1097/aco.0000000000000990openalex-snapshot
A decade later, there are still major issues to be addressed in paediatric anaesthesia
inferred← citeshttps://doi.org/10.1097/md.0000000000023977openalex-snapshot
The risk factors for cognitive dysfunction in elderly patients after laparoscopic surgery
inferred← citeshttps://doi.org/10.1097/pec.0000000000003169openalex-snapshot
Efficacy and Safety of Dexmedetomidine Compared to Other Needle-Free Pharmacological Sedation Methods in Pediatric Patients Undergoing Imaging Procedures
inferred← citeshttps://doi.org/10.1111/1742-6723.70346openalex-snapshot
Intranasal Dexmedetomidine for Paediatric Procedural Sedation in the Emergency Department: A Single‐Centre Retrospective Observational Cohort Study
inferred← citeshttps://doi.org/10.1111/aas.14473openalex-snapshot
Absorption pharmacokinetics and feasibility of intranasal dexmedetomidine in patients under general anaesthesia
inferred← citeshttps://doi.org/10.1111/pan.15141openalex-snapshot
Perspectives on Starting a Pediatric Spinal Anesthesia Program
inferred← citeshttps://doi.org/10.1177/02692163211022184openalex-snapshot
Intranasal dexmedetomidine: Procedural sedation in palliative care: A case report
inferred← citeshttps://doi.org/10.1186/s12871-022-01897-xopenalex-snapshot
Combined use of intranasal Dexmedetomidine and an oral novel formulation of Midazolam for sedation of young children during brain MRI examination: a prospective, single-center, randomized controlled trial
inferred← citeshttps://doi.org/10.1186/s12871-023-02077-1openalex-snapshot
Median effective dose of esketamine for intranasal premedication in children with congenital heart disease
inferred← citeshttps://doi.org/10.1213/ane.0000000000005988openalex-snapshot
Dose Escalation Pharmacokinetic Study of Intranasal Atomized Dexmedetomidine in Pediatric Patients With Congenital Heart Disease
inferred← citeshttps://doi.org/10.1371/journal.pone.0317406openalex-snapshot
Paediatric sedation with intranasal dexmedetomidine: Protocol for a systematic review and meta-analysis
inferred← citeshttps://doi.org/10.17392/1532-22openalex-snapshot
Comparison of dexmedetomidine alone or with other sedatives for paediatric sedation during magnetic resonance imaging: a systematic review
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2027980/v1openalex-snapshot
Nurse-driven intranasal dexmedetomidine administration as sedation for non-invasive procedures in children: a single center audit.
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2812098/v1openalex-snapshot
Dexmedetomidine for Electroencephalogram in patients with behavioural disorders: a comparative study between intranasal and intravenous administration
inferred← citeshttps://doi.org/10.21203/rs.3.rs-3311979/v1openalex-snapshot
Efficacy of intranasal administration of dexmedetomidine in combination with midazolam for sedation in infant with cleft lip and palate: A double blinded prospective randomized trial
inferred← citeshttps://doi.org/10.2147/dddt.s550551openalex-snapshot
Efficacy and Safety of Dexmedetomidine Nasal Spray as a Premedication in Patients Undergoing Fiberoptic Bronchoscopy Under Sedation: A Randomized Controlled Trial
inferred← citeshttps://doi.org/10.2147/dddt.s552047openalex-snapshot
Advances in the Clinical Application of MAC: A Review of Drug Selection, Combination Therapy, and Administration Methods
inferred← citeshttps://doi.org/10.29011/2574-7754.101309openalex-snapshot
Intranasal Dexmedetomidine May be a Worthy Alternative for Sedation in Preterm Infants: A Retrospective Single Center Study
inferred← citeshttps://doi.org/10.31435/ijitss.3(51).2026.5852openalex-snapshot
DEXMEDETOMIDINE FOR SEDATION IN CHILDREN – A NARRATIVE REVIEW OF CLINICAL EVIDENCE, SAFETY CONSIDERATIONS, AND EMERGING THERAPEUTIC ROLES
inferred← citeshttps://doi.org/10.3389/fmed.2023.1186823openalex-snapshot
Procedural sedation in pediatric dentistry: a narrative review
inferred← citeshttps://doi.org/10.3389/fped.2026.1942624openalex-snapshot
Clinical efficacy and safety evaluation of dexmedetomidine hydrochloride nasal spray for sedation before examinations in children aged 2 to 6 years: protocol for a randomized controlled trial
inferred← citeshttps://doi.org/10.3389/fphar.2022.1015357openalex-snapshot
Parental presence and intranasal dexmedetomidine for the prevention of anxiety during anesthesia induction in children undergoing tonsillectomy and/or adenoidectomy surgery: A randomized controlled trial
inferred← citeshttps://doi.org/10.3389/fphar.2022.871492openalex-snapshot
Safety, Pharmacokinetics/Pharmacodynamics, and Absolute Bioavailability of Dexmedetomidine Hydrochloride Nasal Spray in Healthy Subjects: A Randomized, Parallel, Escalating Dose Study
inferred← citeshttps://doi.org/10.3390/audiolres15040082openalex-snapshot
Sedation Methods in Paediatric Auditory Electrophysiologic Testing: A Narrative Review
inferred← citeshttps://doi.org/10.3390/children12060690openalex-snapshot
The Perioperative Use of Dexmedetomidine in Paediatric Patients
inferred← citeshttps://doi.org/10.3390/children13060798openalex-snapshot
Reported Safety and Sedation Outcomes of Intranasal Dexmedetomidine as a Sole Sedative for Magnetic Resonance Imaging (MRI) in Children: A Systematic Review and Meta-Analysis
inferred← citeshttps://doi.org/10.3390/healthcare10020287openalex-snapshot
Sedation with Intranasal Dexmedetomidine in the Pediatric Population for Auditory Brainstem Response Testing: Review of the Existing Literature
inferred← citeshttps://doi.org/10.3390/jcm13123544openalex-snapshot
Evaluating the Quality of Systematic Reviews on Pediatric Sedation in Dentistry: An Umbrella Review
inferred← citeshttps://doi.org/10.34119/bjhrv5n1-084openalex-snapshot
Uso de sedação com cetamina + dexmedetomedina (Ketodex) para reparo endovascular de aneurisma de aorta abdominal – relato de experiência / Use of sedation with ketamine + dexmedetomedine (Ketodex) for endovascular repair of abdominal aortic aneurysms - experience report
inferred← citeshttps://doi.org/10.35975/apic.v26i5.2020openalex-snapshot
Use of Dexmedetomidine for Anesthesia and Pain Management
inferred← citeshttps://doi.org/10.4103/aihb.aihb_32_26openalex-snapshot
Dexmedetomidine for Paediatric Dental Sedation: A Literature-based Perspective
inferred← citeshttps://doi.org/10.4103/ijmr.ijmr_759_20openalex-snapshot
Comparison of intranasal midazolam-fentanyl with dexmedetomidine–fentanyl as pre-medication in the paediatric age group
inferred← citeshttps://doi.org/10.4103/jisppd.jisppd_153_24openalex-snapshot
Comparison of intranasal ketamine with intranasal midazolam and dexmedetomidine combination in pediatric dental patients for procedural sedation: A crossover study
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