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Ether lipids, sphingolipids and toxic 1‐deoxyceramides as hallmarks for lean and obese type 2 diabetic patients

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/1873-3468.13465openalex-snapshot

On the road to unraveling the molecular functions of ether lipids

inferredcites →https://doi.org/10.1002/mas.20284openalex-snapshot

Mass spectrometric analysis of long‐chain lipids

inferredcites →https://doi.org/10.1002/oby.21232openalex-snapshot

Serum Autotaxin/ ENPP 2 correlates with insulin resistance in older humans with obesity

inferredcites →https://doi.org/10.1002/oby.21448openalex-snapshot

Skeletal muscle and plasma lipidomic signatures of insulin resistance and overweight/obesity in humans

inferredcites →https://doi.org/10.1002/pmic.202000013openalex-snapshot

Untargeted Lipidomics Highlight the Depletion of Deoxyceramides during Therapy‐Induced Senescence

inferredcites →https://doi.org/10.1007/s00125-011-2384-1openalex-snapshot

Plasma deoxysphingolipids: a novel class of biomarkers for the metabolic syndrome?

inferredcites →https://doi.org/10.1007/s00125-018-4590-6openalex-snapshot

Ceramide stearic to palmitic acid ratio predicts incident diabetes

inferredcites →https://doi.org/10.1007/s00125-020-05156-xopenalex-snapshot

Serine administration as a novel prophylactic approach to reduce the severity of acute pancreatitis during diabetes in mice

inferredcites →https://doi.org/10.1007/s13238-017-0423-5openalex-snapshot

Structural and functional roles of ether lipids

inferredcites →https://doi.org/10.1016/j.bbalip.2016.12.009openalex-snapshot

Critical role of the peroxisomal protein PEX16 in white adipocyte development and lipid homeostasis

inferredcites →https://doi.org/10.1016/j.bbamem.2017.04.006openalex-snapshot

The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease

inferredcites →https://doi.org/10.1016/j.celrep.2017.02.019openalex-snapshot

Plasma Dihydroceramides Are Diabetes Susceptibility Biomarker Candidates in Mice and Humans

inferredcites →https://doi.org/10.1016/j.cmet.2006.03.007openalex-snapshot

The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis

inferredcites →https://doi.org/10.1016/j.cmet.2007.01.002openalex-snapshot

Inhibition of Ceramide Synthesis Ameliorates Glucocorticoid-, Saturated-Fat-, and Obesity-Induced Insulin Resistance

inferredcites →https://doi.org/10.1016/j.cmet.2014.10.017openalex-snapshot

C16:0-Ceramide Signals Insulin Resistance

inferredcites →https://doi.org/10.1016/j.cmet.2016.10.002openalex-snapshot

Adipocyte Ceramides Regulate Subcutaneous Adipose Browning, Inflammation, and Metabolism

inferredcites →https://doi.org/10.1016/j.jdiacomp.2013.11.010openalex-snapshot

Lean versus obese diabetes mellitus patients in the United States minority population

inferredcites →https://doi.org/10.1016/j.nut.2016.08.005openalex-snapshot

High dietary choline and betaine intake is associated with low insulin resistance in the Newfoundland population

inferredcites →https://doi.org/10.1016/j.plipres.2005.11.002openalex-snapshot

Ceramides in insulin resistance and lipotoxicity

inferredcites →https://doi.org/10.1016/s0140-6736(10)60576-4openalex-snapshot

Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial

inferredcites →https://doi.org/10.1016/s0140-6736(16)00618-8openalex-snapshot

Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants

inferredcites →https://doi.org/10.1016/s0140-6736(16)30054-xopenalex-snapshot

Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants

inferredcites →https://doi.org/10.1016/s0140-6736(18)30702-5openalex-snapshot

Type 2 diabetes

inferredcites →https://doi.org/10.1016/s2213-8587(18)30051-2openalex-snapshot

Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables

inferredcites →https://doi.org/10.1021/ja111173copenalex-snapshot

Monoalkylglycerol Ether Lipids Promote Adipogenesis

inferredcites →https://doi.org/10.1038/msb.2012.43openalex-snapshot

Novel biomarkers for pre‐diabetes identified by metabolomics

inferredcites →https://doi.org/10.1038/ni.2022openalex-snapshot

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

inferredcites →https://doi.org/10.1038/nrm.2017.138openalex-snapshot

Understanding the diversity of membrane lipid composition

inferredcites →https://doi.org/10.1038/s41467-019-09654-4openalex-snapshot

Ceramides bind VDAC2 to trigger mitochondrial apoptosis

inferredcites →https://doi.org/10.1038/s42255-019-0123-yopenalex-snapshot

1-Deoxydihydroceramide causes anoxic death by impairing chaperonin-mediated protein folding

inferredcites →https://doi.org/10.1038/srep00139openalex-snapshot

A Phospholipidomic Analysis of All Defined Human Plasma Lipoproteins

inferredcites →https://doi.org/10.1039/c6sc04831eopenalex-snapshot

Structure and conserved function of iso-branched sphingoid bases from the nematode Caenorhabditis elegans

inferredcites →https://doi.org/10.1042/bj1950301openalex-snapshot

Alkaline O→N-transacylation. A new method for the quantitative deacylation of phospholipids

inferredcites →https://doi.org/10.1073/pnas.1705821114openalex-snapshot

Lipidomics reveals diurnal lipid oscillations in human skeletal muscle persisting in cellular myotubes cultured in vitro

inferredcites →https://doi.org/10.1073/pnas.95.5.2498openalex-snapshot

Fatty acid-induced β cell apoptosis: A link between obesity and diabetes

inferredcites →https://doi.org/10.1074/jbc.m109.092973openalex-snapshot

Hereditary Sensory Neuropathy Type 1 Is Caused by the Accumulation of Two Neurotoxic Sphingolipids

inferredcites →https://doi.org/10.1074/jbc.m406561200openalex-snapshot

G2A Is a Proton-sensing G-protein-coupled Receptor Antagonized by Lysophosphatidylcholine

inferredcites →https://doi.org/10.1074/jbc.m808798200openalex-snapshot

Ceramide Synthase Inhibition by Fumonisin B1 Causes Accumulation of 1-Deoxysphinganine

inferredcites →https://doi.org/10.1074/jbc.r115.658823openalex-snapshot

1-Deoxysphingolipids Encountered Exogenously and Made de Novo: Dangerous Mysteries inside an Enigma

inferredcites →https://doi.org/10.1084/jem.20081800openalex-snapshot

Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes

inferredcites →https://doi.org/10.1091/mbc.e19-07-0364openalex-snapshot

Cytotoxicity of 1-deoxysphingolipid unraveled by genome-wide genetic screens and lipidomics in Saccharomyces cerevisiae

inferredcites →https://doi.org/10.1111/j.1365-2958.2012.08087.xopenalex-snapshot

An essential function of sphingolipids in yeast cell division

inferredcites →https://doi.org/10.1126/science.aav3722openalex-snapshot

Targeting a ceramide double bond improves insulin resistance and hepatic steatosis

inferredcites →https://doi.org/10.1136/bmjdrc-2014-000073openalex-snapshot

Plasma 1-deoxysphingolipids are predictive biomarkers for type 2 diabetes mellitus

inferredcites →https://doi.org/10.1139/o90-079openalex-snapshot

Reduction in VLDL, but not HDL, in plasma of rats deficient in choline

inferredcites →https://doi.org/10.1152/japplphysiol.00664.2015openalex-snapshot

Skeletal muscle phosphatidylcholine and phosphatidylethanolamine are related to insulin sensitivity and respond to acute exercise in humans

inferredcites →https://doi.org/10.1159/000343204openalex-snapshot

Childhood Obesity Is Associated with Changes in the Serum Metabolite Profile

inferredcites →https://doi.org/10.1172/jci.insight.126925openalex-snapshot

Large-scale lipidomics identifies associations between plasma sphingolipids and T2DM incidence

inferredcites →https://doi.org/10.1186/1471-2105-12-253openalex-snapshot

Sparse PLS discriminant analysis: biologically relevant feature selection and graphical displays for multiclass problems

inferredcites →https://doi.org/10.1186/1476-511x-9-84openalex-snapshot

Deoxysphingoid bases as plasma markers in Diabetes mellitus

inferredcites →https://doi.org/10.1186/s12916-017-0901-xopenalex-snapshot

Environmental/lifestyle factors in the pathogenesis and prevention of type 2 diabetes

inferredcites →https://doi.org/10.1186/s13578-019-0324-9openalex-snapshot

Deoxysphingolipids and ether-linked diacylglycerols accumulate in the tissues of aged mice

inferredcites →https://doi.org/10.1194/jlr.d700041-jlr200openalex-snapshot

Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics

inferredcites →https://doi.org/10.1194/jlr.d800028-jlr200openalex-snapshot

Lipid profiling of FPLC-separated lipoprotein fractions by electrospray ionization tandem mass spectrometry

inferredcites →https://doi.org/10.1210/jc.2012-4132openalex-snapshot

Metabolic Signature Shift in Type 2 Diabetes Mellitus Revealed by Mass Spectrometry-based Metabolomics

inferredcites →https://doi.org/10.1212/wnl.0000000000006811openalex-snapshot

Randomized trial of l -serine in patients with hereditary sensory and autonomic neuropathy type 1

inferredcites →https://doi.org/10.1371/journal.pone.0000218openalex-snapshot

Acquired Obesity Is Associated with Changes in the Serum Lipidomic Profile Independent of Genetic Effects – A Monozygotic Twin Study

inferredcites →https://doi.org/10.1371/journal.pone.0006261openalex-snapshot

Top-Down Lipidomics Reveals Ether Lipid Deficiency in Blood Plasma of Hypertensive Patients

inferredcites →https://doi.org/10.1371/journal.pone.0041456openalex-snapshot

Plasma Lysophosphatidylcholine Levels Are Reduced in Obesity and Type 2 Diabetes

inferredcites →https://doi.org/10.1523/jneurosci.2541-18.2019openalex-snapshot

A Model of Hereditary Sensory and Autonomic Neuropathy Type 1 Reveals a Role of Glycosphingolipids in Neuronal Polarity

inferredcites →https://doi.org/10.2337/db09-1293openalex-snapshot

Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption

inferredcites →https://doi.org/10.2337/db11-0649openalex-snapshot

The l -α-Lysophosphatidylinositol/ GPR55 System and Its Potential Role in Human Obesity

inferredcites →https://doi.org/10.2337/db12-0495openalex-snapshot

Identification of Serum Metabolites Associated With Risk of Type 2 Diabetes Using a Targeted Metabolomic Approach

inferredcites →https://doi.org/10.2337/db13-1042openalex-snapshot

Deoxysphingolipids, Novel Biomarkers for Type 2 Diabetes, Are Cytotoxic for Insulin-Producing Cells

inferredcites →https://doi.org/10.2337/db14-1325openalex-snapshot

Lowering Plasma 1-Deoxysphingolipids Improves Neuropathy in Diabetic Rats

inferredcites →https://doi.org/10.2337/db17-1449openalex-snapshot

Circulating Sphingolipids, Insulin, HOMA-IR, and HOMA-B: The Strong Heart Family Study

inferredcites →https://doi.org/10.2337/dc18-0840openalex-snapshot

Plasma Lipidomic Profiling and Risk of Type 2 Diabetes in the PREDIMED Trial

inferredcites →https://doi.org/10.3390/ijms131216267openalex-snapshot

Lysophosphatidylcholine Acyltransferase 3 Is the Key Enzyme for Incorporating Arachidonic Acid into Glycerophospholipids during Adipocyte Differentiation

inferredcites →https://doi.org/10.3390/ijms17111841openalex-snapshot

Lipidomics—Reshaping the Analysis and Perception of Type 2 Diabetes

inferredcites →https://doi.org/10.3390/ijms20051149openalex-snapshot

An Updated Review of Lysophosphatidylcholine Metabolism in Human Diseases

inferredcites →https://doi.org/10.3390/nu10040399openalex-snapshot

Lysophosphatidic Acid Signaling in Obesity and Insulin Resistance

inferredcites →https://doi.org/10.3945/ajcn.115.111872openalex-snapshot

Global metabolomic profiling targeting childhood obesity in the Hispanic population

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4794969openalex-extracted

(1-Deoxy)Ceramides in Bilayers Containing Sphingomyelin and Cholesterol

inferred← citeshttps://doi.org/10.1002/9783527836512.ch15openalex-snapshot

Sphingolipids

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inferred← citeshttps://doi.org/10.1002/mnfr.202200321openalex-snapshot

Dietary Eicosapentaenoic Acid Containing Phosphoethanolamine Plasmalogens Remodels the Lipidome of White Adipose Tissue and Suppresses High‐Fat Diet Induced Obesity in Mice

inferred← citeshttps://doi.org/10.1016/j.bbalip.2026.159773openalex-snapshot

HCV clearance by direct-acting antivirals reduces serum phosphatidylethanolamine and improves phospholipid balance

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Metabolic bias: Lipid structures as determinants of their metabolic fates

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Natural daylight during office hours improves glucose control and whole-body substrate metabolism

inferred← citeshttps://doi.org/10.1016/j.colsurfb.2024.114155openalex-snapshot

(1-Deoxy)ceramides in bilayers containing sphingomyelin and cholesterol

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Targeted sphingolipidomics indicates increased C22-C24:16 ratios of virtually all assayed classes in liver, kidney, and plasma of fumonisin-fed chickens

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Targeted sphingolipid analysis in chickens suggests different mechanisms of fumonisin toxicity in kidney, lung, and brain

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Alterations of lipid homeostasis in morbid obese patients are partly reversed by bariatric surgery

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Metabolic signatures across the full spectrum of non-alcoholic fatty liver disease

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Metabolism of HSAN1- and T2DM-associated 1-deoxy-sphingolipids inhibits the migration of fibroblasts

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Regulation of metabolism by circadian rhythms: Support from time-restricted eating, intestinal microbiota & omics analysis

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Lipid metabolism around the body clocks

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Alkylglycerol: Not abundant but promising functional lipid

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AdipoAtlas: A reference lipidome for human white adipose tissue

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Circadian organization of lipid landscape is perturbed in type 2 diabetic patients

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A photoactivatable chemical lipidomics approach for local sphingolipid metabolic analysis

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Imbalanced unfolded protein response signaling contributes to 1-deoxysphingolipid retinal toxicity

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Metabolic phenotyping of BMI to characterize cardiometabolic risk: evidence from large population-based cohorts

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Role of the fatty pancreatic infiltration in pancreatic oncogenesis

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Consuming a modified Mediterranean ketogenic diet reverses the peripheral lipid signature of Alzheimer’s disease in humans

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Circadian rhythm of lipid metabolism

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Alterations of lipid homeostasis in serum and white adipose tissue in morbid obese patients are partly reversed by the bariatric surgery

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Therapeutic potential of a modified Mediterranean ketogenic diet in reversing the peripheral lipid signature of Alzheimer’s disease

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Functional Enrichment of Lipidomics Data to Characterize the Metabolism of Diabetes Mellitus and Subclinical Carotid Atherosclerosis

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1‐Deoxyceramides – Key players in lipotoxicity and progression to type 2 diabetes?

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Skeletal muscles do more than the loco‐motion

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Pathophysiology of type 2 diabetes and the impact of altered metabolic interorgan crosstalk

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Effect of a low-volume exercise intervention on the plasma lipidome in people with normal glucose, prediabetes or type 2 diabetes: a randomized controlled trial

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Next Generation, Modifiable Cardiometabolic Biomarkers: Mitochondrial Adaptation and Metabolic Resilience: A Scientific Statement From the American Heart Association

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Lipidome characterisation and sex-specific differences in type 1 and type 2 diabetes mellitus

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Melatonin promotes skeletal muscle mitochondria-associated endoplasmic reticulum membrane contacts and restores organellar membrane integrity and phospholipid composition in Zücker diabetic fatty rats of both sexes

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Type 2 diabetes disrupts circadian orchestration of lipid metabolism and membrane fluidity in human pancreatic islets

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Sex-specific modulation of circulating growth differentiation factor-15 in patients with type 2 diabetes and/or obesity

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Lipidomic markers of obesity and their dynamics after bariatric surgery

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Influence of Lipid Profiles on Type 2 Diabetes Risk in Nigerian Patients

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Lysophosphatidylinositols Are Upregulated After Human β-Cell Loss and Potentiate Insulin Release

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1-Deoxysphingolipids, Early Predictors of Type 2 Diabetes, Compromise the Functionality of Skeletal Myoblasts

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Cardiolipin Alterations during Obesity: Exploring Therapeutic Opportunities

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Multi-Omics Reveal Interplay between Circadian Dysfunction and Type2 Diabetes

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Lipidomic Analysis Reveals Differences in Bacteroides Species Driven Largely by Plasmalogens, Glycerophosphoinositols and Certain Sphingolipids

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Effects of Isocaloric Fructose Restriction on Ceramide Levels in Children with Obesity and Cardiometabolic Risk: Relation to Hepatic De Novo Lipogenesis and Insulin Sensitivity

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Improvement in Glycolipid Metabolism Parameters After Supplementing Fish Oil-Derived Omega-3 Fatty Acids Is Associated with Gut Microbiota and Lipid Metabolites in Type 2 Diabetes Mellitus

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