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Ribosomal protein S6 is hyperactivated and differentially phosphorylated in epidermal lesions of patients with psoriasis and atopic dermatitis

https://doi.org/10.1111/bjd.13248
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1016/0092-8674(92)90643-qopenalex-snapshot
Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases
inferredcites →https://doi.org/10.1016/s0021-9258(18)54634-2openalex-snapshot
Mitogen-activated 70K S6 kinase. Identification of in vitro 40 S ribosomal S6 phosphorylation sites.
inferredcites →https://doi.org/10.1016/s0021-9258(19)50382-9openalex-snapshot
Ordered multisite phosphorylation of Xenopus ribosomal protein S6 by S6 kinase II.
inferredcites →https://doi.org/10.1016/s1535-6108(03)00275-7openalex-snapshot
Will mTOR inhibitors make it as cancer drugs?
inferredcites →https://doi.org/10.1016/s1937-6448(08)00801-0openalex-snapshot
Chapter 1 Physiological Roles of Ribosomal Protein S6: One of Its Kind
inferredcites →https://doi.org/10.1074/jbc.m110.141754openalex-snapshot
Regulation of Ribosomal Protein S6 Phosphorylation by Casein Kinase 1 and Protein Phosphatase 1
inferredcites →https://doi.org/10.1074/jbc.m700906200openalex-snapshot
RAS/ERK Signaling Promotes Site-specific Ribosomal Protein S6 Phosphorylation via RSK and Stimulates Cap-dependent Translation
inferredcites →https://doi.org/10.1111/bjd.12271openalex-snapshot
Mammalian target of rapamycin and its downstream signalling components are activated in psoriatic skin
inferredcites →https://doi.org/10.1111/j.1346-8138.2009.00696.xopenalex-snapshot
Differential expression of phosphorylated extracellular signal‐regulated kinase 1/2, phosphorylated p38 mitogen‐activated protein kinase and nuclear factor‐κB p105/p50 in chronic inflammatory skin diseases
inferredcites →https://doi.org/10.1111/j.1365-2133.2004.06304.xopenalex-snapshot
The mitogen-activated protein kinases p38 and ERK1/2 are increased in lesional psoriatic skin
inferredcites →https://doi.org/10.1111/j.1365-2133.2005.06438.xopenalex-snapshot
Treatment of psoriasis with topical sirolimus: preclinical development and a randomized, double-blind trial
inferredcites →https://doi.org/10.1111/j.1365-2133.2006.07602.xopenalex-snapshot
Severe psoriasis treated with a new macrolide: everolimus
inferredcites →https://doi.org/10.1111/j.1468-3083.2010.03966.xopenalex-snapshot
Insulin‐like growth factor‐1 in psoriatic plaques treated with PUVA and methotrexate
inferredcites →https://doi.org/10.1128/mcb.26.7.2675-2687.2006openalex-snapshot
Insulin-Like Growth Factor 1 Receptor Signaling Regulates Skin Development and Inhibits Skin Keratinocyte Differentiation
inferredcites →https://doi.org/10.1158/1940-6207.capr-12-0272-topenalex-snapshot
Inhibition of mTOR Suppresses UVB-Induced Keratinocyte Proliferation and Survival

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4641141openalex-extracted
inferred← citeshttps://doi.org/10.1001/jamadermatol.2019.4141openalex-snapshot
Targeted Inhibition of the Epidermal Growth Factor Receptor and Mammalian Target of Rapamycin Signaling Pathways in Olmsted Syndrome
inferred← citeshttps://doi.org/10.1016/bs.ircmb.2015.07.006openalex-snapshot
Ribosomal Protein S6 Phosphorylation
inferred← citeshttps://doi.org/10.1016/j.gene.2023.147918openalex-snapshot
Identification of potential biomarkers and infiltrating immune cells from scalp psoriasis
inferred← citeshttps://doi.org/10.1016/j.jid.2024.07.018openalex-snapshot
Adiponectin Prevents Skin Inflammation in Rosacea by Suppressing S6 Phosphorylation in Keratinocytes
inferred← citeshttps://doi.org/10.1016/j.jid.2025.11.025openalex-snapshot
Connectivity mapping with isotretinoin’s transcriptomic signature identifies alternative therapeutics for severe acne
inferred← citeshttps://doi.org/10.1016/j.mtcomm.2022.104748openalex-snapshot
Signal profile of synthesized nano CuAlO2 on human skin epidermoid carcinoma epithelial cells
inferred← citeshttps://doi.org/10.1038/s41598-025-03833-8openalex-snapshot
Novel ribosome biogenesis-related biomarkers and therapeutic targets identified in psoriasis
inferred← citeshttps://doi.org/10.1093/bjd/ljaf210openalex-snapshot
Linear epidermal naevus associated with a novel mosaic heterozygous PTPN11 variant
inferred← citeshttps://doi.org/10.1155/dth/4418305openalex-snapshot
Oxymatrine‐Associated Clinical and Molecular Changes in Psoriasis: An Exploratory WGCNA‐Based Translational Study
inferred← citeshttps://doi.org/10.1159/000546323openalex-snapshot
Potential Key Genes for Giant Cell Arteritis Revealed Based on Single-Cell Sequencing and Mendelian Randomization Analysis
inferred← citeshttps://doi.org/10.1186/s12967-021-03006-xopenalex-snapshot
Identification of proteins associated with development of psoriatic arthritis in peripheral blood mononuclear cells: a quantitative iTRAQ-based proteomics study
inferred← citeshttps://doi.org/10.1186/s13073-015-0208-5openalex-snapshot
Proteogenomic analysis of psoriasis reveals discordant and concordant changes in mRNA and protein abundance
inferred← citeshttps://doi.org/10.21248/gups.68198openalex-snapshot
Investigations into the pharmacological action of vioprolide A on inflammatory and angiogenic processes in endothelial cells
inferred← citeshttps://doi.org/10.2340/00015555-2359openalex-snapshot
Upregulation of PI3K/AKT/mTOR, FABP5 and PPARβ/δ in Human Psoriasis and Imiquimod-induced Murine Psoriasiform Dermatitis Model
inferred← citeshttps://doi.org/10.3389/fcell.2022.942838openalex-snapshot
Post-Translational Modifications in Atopic Dermatitis: Current Research and Clinical Relevance
inferred← citeshttps://doi.org/10.3389/fnut.2024.1423524openalex-snapshot
Caloric restriction impacts skin barrier function and attenuates the development of hyperplasia skin disease
inferred← citeshttps://doi.org/10.3389/fphar.2021.650816openalex-snapshot
Fuzhenghefuzhiyang Formula (FZHFZY) Improves Epidermal Differentiation via Suppression of the Akt/mTORC1/S6K1 Signalling Pathway in Psoriatic Models
inferred← citeshttps://doi.org/10.3390/ijms26062750openalex-snapshot
Activation of the Mammalian Target of Rapamycin Pathway in Endothelial Cells in Antiphospholipid Antibody-Positive Patients with Leg Ulcers
inferred← citeshttps://doi.org/10.6084/m9.figshare.15102577openalex-snapshot
Additional file 1 of Identification of proteins associated with development of psoriatic arthritis in peripheral blood mononuclear cells: a quantitative iTRAQ-based proteomics study
inferred← citeshttps://doi.org/10.6084/m9.figshare.15102583openalex-snapshot
Additional file 2 of Identification of proteins associated with development of psoriatic arthritis in peripheral blood mononuclear cells: a quantitative iTRAQ-based proteomics study
inferred← citeshttps://doi.org/10.6084/m9.figshare.15102586openalex-snapshot
Additional file 3 of Identification of proteins associated with development of psoriatic arthritis in peripheral blood mononuclear cells: a quantitative iTRAQ-based proteomics study
inferred← citeshttps://doi.org/10.6084/m9.figshare.15102589openalex-snapshot
Additional file 4 of Identification of proteins associated with development of psoriatic arthritis in peripheral blood mononuclear cells: a quantitative iTRAQ-based proteomics study
inferred← citeshttps://doi.org/10.6084/m9.figshare.15102595openalex-snapshot
Additional file 5 of Identification of proteins associated with development of psoriatic arthritis in peripheral blood mononuclear cells: a quantitative iTRAQ-based proteomics study
inferred← citeshttps://doi.org/10.7241/ourd.20181.12openalex-snapshot
IgD, cyclooxygenase-2 and ribosomal protein S6-PS240 immune response in a case of early psoriasis
inferred← citeshttps://doi.org/10.7554/elife.97654openalex-snapshot
Downregulation of semaphorin 4A in keratinocytes reflects the features of non-lesional psoriasis
inferred← citeshttps://doi.org/10.7554/elife.97654.1openalex-snapshot
Downregulation of Semaphorin 4A in keratinocytes reflects the features of non-lesional psoriasis
inferred← citeshttps://doi.org/10.7554/elife.97654.2openalex-snapshot
Downregulation of Semaphorin 4A in keratinocytes reflects the features of non-lesional psoriasis
inferred← citeshttps://doi.org/10.7554/elife.97654.3openalex-snapshot
Downregulation of semaphorin 4A in keratinocytes reflects the features of non-lesional psoriasis
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