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Opsin 5 is a key regulator of ultraviolet radiation‐induced melanogenesis in human epidermal melanocytes*

https://doi.org/10.1111/bjd.19797

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/s00403-008-0863-0openalex-snapshot

LPS induces melanogenesis through p38 MAPK activation in human melanocytes

inferredcites →https://doi.org/10.1007/s00403-011-1143-yopenalex-snapshot

An extract of Melia toosendan attenuates endothelin-1-stimulated pigmentation in human epidermal equivalents through the interruption of PKC activity within melanocytes

inferredcites →https://doi.org/10.1016/j.bbamcr.2016.03.001openalex-snapshot

The effect of white light on normal and malignant murine melanocytes: A link between opsins, clock genes, and melanogenesis

inferredcites →https://doi.org/10.1016/j.bbamcr.2020.118789openalex-snapshot

Melanopsin mediates UVA-dependent modulation of proliferation, pigmentation, apoptosis, and molecular clock in normal and malignant melanocytes

inferredcites →https://doi.org/10.1016/j.cell.2006.12.045openalex-snapshot

Central Role of p53 in the Suntan Response and Pathologic Hyperpigmentation

inferredcites →https://doi.org/10.1016/j.cell.2009.09.029openalex-snapshot

Phototransduction Motifs and Variations

inferredcites →https://doi.org/10.1016/j.celrep.2019.12.043openalex-snapshot

Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing

inferredcites →https://doi.org/10.1016/j.cub.2011.09.047openalex-snapshot

UVA Phototransduction Drives Early Melanin Synthesis in Human Melanocytes

inferredcites →https://doi.org/10.1016/j.cub.2012.12.029openalex-snapshot

Mammalian Inner Retinal Photoreception

inferredcites →https://doi.org/10.1016/j.cub.2019.08.063openalex-snapshot

Neuropsin (OPN5) Mediates Local Light-Dependent Induction of Circadian Clock Genes and Circadian Photoentrainment in Exposed Murine Skin

inferredcites →https://doi.org/10.1016/j.ejcb.2018.01.004openalex-snapshot

Melanopsin and rhodopsin mediate UVA-induced immediate pigment darkening: Unravelling the photosensitive system of the skin

inferredcites →https://doi.org/10.1016/j.isci.2018.08.010openalex-snapshot

Impaired Circadian Photoentrainment in Opn5-Null Mice

inferredcites →https://doi.org/10.1016/j.jid.2017.07.833openalex-snapshot

Melanocytes Sense Blue Light and Regulate Pigmentation through Opsin-3

inferredcites →https://doi.org/10.1016/j.jid.2019.03.813openalex-snapshot

737 Opsin as a photoreceptor after UVA irradiation to regulate MITF signal pathway and influence melanogenesis in the cultured human melanocyte

inferredcites →https://doi.org/10.1016/j.molmed.2006.07.008openalex-snapshot

MITF: master regulator of melanocyte development and melanoma oncogene

inferredcites →https://doi.org/10.1016/s0014-5793(03)01212-2openalex-snapshot

Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue1

inferredcites →https://doi.org/10.1038/cr.2017.72openalex-snapshot

Molecular assembly of rhodopsin with G protein-coupled receptor kinases

inferredcites →https://doi.org/10.1038/jid.2008.325openalex-snapshot

Long-Lasting Molecular Changes in Human Skin after Repetitive In Situ UV Irradiation

inferredcites →https://doi.org/10.1038/jid.2010.5openalex-snapshot

Regulation of Human Skin Pigmentation in situ by Repetitive UV Exposure: Molecular Characterization of Responses to UVA and/or UVB

inferredcites →https://doi.org/10.1038/nature05660openalex-snapshot

Melanocyte biology and skin pigmentation

inferredcites →https://doi.org/10.1038/nrn2283openalex-snapshot

Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup

inferredcites →https://doi.org/10.1038/s41556-019-0301-xopenalex-snapshot

An opsin 5–dopamine pathway mediates light-dependent vascular development in the eye

inferredcites →https://doi.org/10.1038/s41586-020-2683-0openalex-snapshot

Violet-light suppression of thermogenesis by opsin 5 hypothalamic neurons

inferredcites →https://doi.org/10.1038/srep05352openalex-snapshot

Light-induced rapid Ca2+ response and MAPK phosphorylation in the cells heterologously expressing human OPN5

inferredcites →https://doi.org/10.1042/bj20051388openalex-snapshot

MITF mediates cAMP-induced protein kinase C-β expression in human melanocytes

inferredcites →https://doi.org/10.1073/pnas.1006393107openalex-snapshot

A mammalian neural tissue opsin (Opsin 5) is a deep brain photoreceptor in birds

inferredcites →https://doi.org/10.1073/pnas.1012498107openalex-snapshot

Opn5 is a UV-sensitive bistable pigment that couples with Gi subtype of G protein

inferredcites →https://doi.org/10.1073/pnas.1215555110openalex-snapshot

UV light phototransduction activates transient receptor potential A1 ion channels in human melanocytes

inferredcites →https://doi.org/10.1073/pnas.1516259112openalex-snapshot

Neuropsin (OPN5)-mediated photoentrainment of local circadian oscillators in mammalian retina and cornea

inferredcites →https://doi.org/10.1073/pnas.1801302115openalex-snapshot

Comprehensive skin microbiome analysis reveals the uniqueness of human skin and evidence for phylosymbiosis within the class Mammalia

inferredcites →https://doi.org/10.1073/pnas.1902825116openalex-snapshot

Human nonvisual opsin 3 regulates pigmentation of epidermal melanocytes through functional interaction with melanocortin 1 receptor

inferredcites →https://doi.org/10.1074/jbc.274.23.16470openalex-snapshot

Protein Kinase C-β Activates Tyrosinase by Phosphorylating Serine Residues in Its Cytoplasmic Domain

inferredcites →https://doi.org/10.1074/jbc.m113.514075openalex-snapshot

Evolution of Mammalian Opn5 as a Specialized UV-absorbing Pigment by a Single Amino Acid Mutation

inferredcites →https://doi.org/10.1074/jbc.ra119.012505openalex-snapshot

Diacylglycerol kinases regulate TRPV1 channel activity

inferredcites →https://doi.org/10.1085/jgp.201311094openalex-snapshot

UV light activates a Gαq/11-coupled phototransduction pathway in human melanocytes

inferredcites →https://doi.org/10.1096/fj.07-9080comopenalex-snapshot

Epistatic connections between microphthalmia‐associated transcription factor and endothelin signaling in Waardenburg syndrome and other pigmentary disorders

inferredcites →https://doi.org/10.1111/bjd.18410openalex-snapshot

Opsin 3 is a key regulator of ultraviolet A‐induced photoageing in human dermal fibroblast cells

inferredcites →https://doi.org/10.1111/cpr.12372openalex-snapshot

Induction of retinal‐dependent calcium influx in human melanocytes by UVA or UVB radiation contributes to the stimulation of melanosome transfer

inferredcites →https://doi.org/10.1111/j.1365-2133.2009.09565.xopenalex-snapshot

New insights into pigmentary pathways and skin cancer

inferredcites →https://doi.org/10.1111/j.1600-0625.2009.00851.xopenalex-snapshot

Expressions of rod and cone photoreceptor‐like proteins in human epidermis

inferredcites →https://doi.org/10.1111/j.1600-0625.2009.00964.xopenalex-snapshot

Hirseins inhibit melanogenesis by regulating the gene expressions of Mitf and melanogenesis enzymes

inferredcites →https://doi.org/10.1111/php.12354openalex-snapshot

Opsin Expression in Human Epidermal Skin

inferredcites →https://doi.org/10.1111/php.13178openalex-snapshot

Opsin3 Downregulation Induces Apoptosis of Human Epidermal Melanocytes via Mitochondrial Pathway

inferredcites →https://doi.org/10.1126/science.aav4632openalex-snapshot

Vision using multiple distinct rod opsins in deep-sea fishes

inferredcites →https://doi.org/10.1155/2019/9827519openalex-snapshot

Melanogenic Effects of Maclurin Are Mediated through the Activation of cAMP/PKA/CREB and p38 MAPK/CREB Signaling Pathways

inferredcites →https://doi.org/10.1371/journal.pone.0026388openalex-snapshot

UV-Sensitive Photoreceptor Protein OPN5 in Humans and Mice

inferredcites →https://doi.org/10.1371/journal.pone.0026417openalex-snapshot

Expression of Novel Opsins and Intrinsic Light Responses in the Mammalian Retinal Ganglion Cell Line RGC-5. Presence of OPN5 in the Rat Retina

inferredcites →https://doi.org/10.1371/journal.pone.0073678openalex-snapshot

Violet Light Down-Regulates the Expression of Specific Differentiation Markers through Rhodopsin in Normal Human Epidermal Keratinocytes

inferredcites →https://doi.org/10.4161/chan.25322openalex-snapshot

UV light phototransduction depolarizes human melanocytes

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Transcriptome and Metabolome Provide Insight into the Formation Mechanism of Skin Pigmentation Diversity in Chinese Soft-Shelled Turtle (Pelodiscus Sinensis)

inferred← citeshttps://doi.org/10.1002/9781119709268.rook010openalex-snapshot

Photobiology

inferred← citeshttps://doi.org/10.1002/jbio.202200257openalex-snapshot

Highlighting nuances of blue light phototherapy: Mechanisms and safety considerations

inferred← citeshttps://doi.org/10.1007/978-981-95-0233-2_7openalex-snapshot

Energy-Based Devices (EBD) and Melanin

inferred← citeshttps://doi.org/10.1007/s00403-024-03752-0openalex-snapshot

Typha pollen extract inhibit melanogenesis via α-MSH/MC1R signaling pathway in B16 and melasma mouse model

inferred← citeshttps://doi.org/10.1016/j.aquaculture.2024.741344openalex-snapshot

Integrative transcriptomics and metabolomics analysis provide insight into the formation of skin pigmentation diversity in Chinese soft-shelled turtle (Pelodiscus sinensis)

inferred← citeshttps://doi.org/10.1016/j.fbio.2025.108021openalex-snapshot

Unveiling the anti-melanogenic effect of the “Nine Steaming Nine Sun-Drying” processed Polygonatum sibiricum saponins: A synergy of network pharmacology and molecular docking

inferred← citeshttps://doi.org/10.1016/j.indcrop.2026.123751openalex-snapshot

Chrysanthemum in skin lightening and anti-photoaging: Phytochemical basis, mechanistic convergence, and translational evidence

inferred← citeshttps://doi.org/10.1016/j.jid.2022.04.022openalex-snapshot

OPN3 Regulates Melanogenesis in Human Congenital Melanocytic Nevus Cells through Functional Interaction with BRAFV600E

inferred← citeshttps://doi.org/10.1016/j.jmb.2023.168319openalex-snapshot

Molecular Property, Manipulation, and Potential Use of Opn5 and Its Homologs

inferred← citeshttps://doi.org/10.1016/j.jpap.2023.100177openalex-snapshot

Non-image-forming functional roles of OPN3, OPN4 and OPN5 photopigments

inferred← citeshttps://doi.org/10.1016/j.jpap.2023.100186openalex-snapshot

Opsins as main regulators of skin biology

inferred← citeshttps://doi.org/10.1016/j.jphotobiol.2023.112702openalex-snapshot

Melanopsin (OPN4) is a novel player in skin homeostasis and attenuates UVA-induced effects

inferred← citeshttps://doi.org/10.1016/j.jphotobiol.2024.112861openalex-snapshot

Nonvisual system-mediated body color change in fish reveals nonvisual function of Opsin 3 in skin

inferred← citeshttps://doi.org/10.1016/j.neuron.2025.05.025openalex-snapshot

Light, opsins, and life: Mammalian photophysiological functions beyond image perception

inferred← citeshttps://doi.org/10.1038/s41467-022-29265-wopenalex-snapshot

Selective optogenetic control of Gq signaling using human Neuropsin

inferred← citeshttps://doi.org/10.1038/s42003-023-04621-8openalex-snapshot

Opsin 3 mediates UVA-induced keratinocyte supranuclear melanin cap formation

inferred← citeshttps://doi.org/10.1038/s42255-024-01051-6openalex-snapshot

Circadian-independent light regulation of mammalian metabolism

inferred← citeshttps://doi.org/10.1038/s44328-024-00015-wopenalex-snapshot

Photovoltaic bioelectronics merging biology with new generation semiconductors and light in biophotovoltaics photobiomodulation and biosensing

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Cucumber-derived exosome-like nanovesicles encapsulating epigallocatechin gallate for skin depigmentation: molecular docking, stability, and efficacy in B16/F10 cells and zebrafish

inferred← citeshttps://doi.org/10.1080/07420528.2026.2679133openalex-snapshot

Melanopsin mediates thermal activation of molecular clock genes in murine preadipocytes

inferred← citeshttps://doi.org/10.1093/chemse/bjaf051openalex-snapshot

Opposing expression pattern of opsin 3 and opsin 5 in the developing and adult nasal epithelium

inferred← citeshttps://doi.org/10.1111/bjd.20052openalex-snapshot

Novel light-dependent and light-independent functions of opsin 5

inferred← citeshttps://doi.org/10.1111/exd.15007openalex-snapshot

In vitro differentiation of human amniotic epithelial stem cells into keratinocytes regulated by OPN3

inferred← citeshttps://doi.org/10.1111/nyas.70267openalex-snapshot

From Skin to Brain: Antagonism and Parallelism in the MCH and MSH Systems

inferred← citeshttps://doi.org/10.1111/pcmr.13043openalex-snapshot

Identification and functional assays of single‐nucleotide variants of opsins genes in melanocytic tumors

inferred← citeshttps://doi.org/10.1111/pcmr.13220openalex-snapshot

Interplay of Light, Melatonin, and Circadian Genes in Skin Pigmentation Regulation

inferred← citeshttps://doi.org/10.1146/annurev-physiol-022724-105249openalex-snapshot

Light Out of Sight: Signaling Mechanisms for Nonvisual Opsins

inferred← citeshttps://doi.org/10.1146/annurev-vision-100820-094018openalex-snapshot

An Expanding Role for Nonvisual Opsins in Extraocular Light Sensing Physiology

inferred← citeshttps://doi.org/10.1167/iovs.67.5.38openalex-snapshot

Opposing Roles of OPN3 and OPN5 Affecting the Intrinsic Pupillary Light Reflex of the Mammalian Iris

inferred← citeshttps://doi.org/10.1186/s12967-024-05113-xopenalex-snapshot

Melanocytes in regenerative medicine applications and disease modeling

inferred← citeshttps://doi.org/10.1186/s40662-025-00467-9openalex-snapshot

The physiological functions of OPN5m

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Baicalein Inhibits α-Melanocyte-stimulating Hormone-stimulated Melanogenesis via p38 Mitogen-activated Protein Kinase Pathway in B16F10 Mouse Melanoma Cells

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Expression and Mutation of SLC45A2 Affects Iris Color in Quail

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Assessing the Global Impact on the Mouse Kidney After Traumatic Brain Injury: A Transcriptomic Study

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Expression of Retinal G Protein-Coupled Receptor, a Member of the Opsin Family, in Human Skin Cells and Its Mediation of the Cellular Functions of Keratinocytes

inferred← citeshttps://doi.org/10.3389/fnana.2021.784478openalex-snapshot

Type II Opsins in the Eye, the Pineal Complex and the Skin of Xenopus laevis: Using Changes in Skin Pigmentation as a Readout of Visual and Circadian Activity

inferred← citeshttps://doi.org/10.3390/cells11132082openalex-snapshot

Recognition of Melanocytes in Immuno-Neuroendocrinology and Circadian Rhythms: Beyond the Conventional Melanin Synthesis

inferred← citeshttps://doi.org/10.3390/cells13131082openalex-snapshot

Light Sensing beyond Vision: Focusing on a Possible Role for the FICZ/AhR Complex in Skin Optotransduction

inferred← citeshttps://doi.org/10.3390/cimb43030101openalex-snapshot

Loss of Melanopsin (OPN4) Leads to a Faster Cell Cycle Progression and Growth in Murine Melanocytes

inferred← citeshttps://doi.org/10.3390/ijms23052884openalex-snapshot

Cosmeceutical Therapy: Engaging the Repercussions of UVR Photoaging on the Skin’s Circadian Rhythm

inferred← citeshttps://doi.org/10.3390/nu14142952openalex-snapshot

Vitamin A in Skin and Hair: An Update

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Administration Of 30% Robusta Coffee (Coffea canephora) Silverskin Ethyl Acetate Fraction Cream Inhibited The Increase Of MITF Expression And Melanin Amount In The Skin Of Male Adult Guinea Pig (Cavia porcellus) Exposed To Ultraviolet B Ray

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