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Peroxisome proliferator-activated receptor-γ signalling protects hair follicle stem cells from chemotherapy-induced apoptosis and epithelial–mesenchymal transition

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jama.2016.20939openalex-snapshot
Effect of a Scalp Cooling Device on Alopecia in Women Undergoing Chemotherapy for Breast Cancer
inferredcites →https://doi.org/10.1001/jama.2016.21038openalex-snapshot
Association Between Use of a Scalp Cooling Device and Alopecia After Chemotherapy for Breast Cancer
inferredcites →https://doi.org/10.1001/jamadermatol.2018.5071openalex-snapshot
Assessment of Quality of Life and Treatment Outcomes of Patients With Persistent Postchemotherapy Alopecia
inferredcites →https://doi.org/10.1007/s00520-009-0769-1openalex-snapshot
Unanticipated toxicities from anticancer therapies: Survivors’ perspectives
inferredcites →https://doi.org/10.1007/s00520-019-05284-0openalex-snapshot
A Chinese version of the chemotherapy-induced alopecia distress scale based on reliability and validity assessment in breast cancer patients
inferredcites →https://doi.org/10.1007/s10549-018-4855-2openalex-snapshot
Persistent major alopecia following adjuvant docetaxel for breast cancer: incidence, characteristics, and prevention with scalp cooling
inferredcites →https://doi.org/10.1016/j.cub.2008.12.005openalex-snapshot
The Hair Follicle as a Dynamic Miniorgan
inferredcites →https://doi.org/10.1016/j.jaad.2009.08.024openalex-snapshot
Scarring alopecia associated with the epidermal growth factor receptor inhibitor erlotinib
inferredcites →https://doi.org/10.1016/j.jaad.2010.03.020openalex-snapshot
Permanent chemotherapy-induced alopecia: A review
inferredcites →https://doi.org/10.1016/j.jaad.2016.12.027openalex-snapshot
Permanent alopecia in patients with breast cancer after taxane chemotherapy and adjuvant hormonal therapy: Clinicopathologic findings in a cohort of 10 patients
inferredcites →https://doi.org/10.1016/j.jaad.2018.03.056openalex-snapshot
Hair disorders in cancer survivors
inferredcites →https://doi.org/10.1016/j.jid.2015.12.021openalex-snapshot
p53 Is a Direct Transcriptional Repressor of Keratin 17: Lessons from a Rat Model of Radiation Dermatitis
inferredcites →https://doi.org/10.1016/j.jid.2017.09.047openalex-snapshot
Epithelial-to-Mesenchymal Stem Cell Transition in a Human Organ: Lessons from Lichen Planopilaris
inferredcites →https://doi.org/10.1016/j.jid.2018.01.033openalex-snapshot
Peroxisome Proliferator–Activated Receptor-γ−Mediated Signaling Regulates Mitochondrial Energy Metabolism in Human Hair Follicle Epithelium
inferredcites →https://doi.org/10.1016/j.jid.2020.05.118openalex-snapshot
Inhibition of Shh Signaling through MAPK Activation Controls Chemotherapy-Induced Alopecia
inferredcites →https://doi.org/10.1016/j.molmed.2018.03.007openalex-snapshot
Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases
inferredcites →https://doi.org/10.1016/j.tox.2020.152439openalex-snapshot
LCZ696 (sacubitril/valsartan) protects against cyclophosphamide-induced testicular toxicity in rats: Role of neprilysin inhibition and lncRNA TUG1 in ameliorating apoptosis
inferredcites →https://doi.org/10.1016/s0016-5085(11)62136-7openalex-snapshot
Preclinical Evaluation of Intestinal Anti-Inflammatory/Analgesic Properties and Phase I Clinical Trial of a New PPAR Agonist Ged-0507-34-Levo
inferredcites →https://doi.org/10.1016/s1470-2045(12)70553-3openalex-snapshot
Pathobiology of chemotherapy-induced hair loss
inferredcites →https://doi.org/10.1038/jid.2013.473openalex-snapshot
Advanced Inhibition of Undesired Human Hair Growth by PPARγ Modulation?
inferredcites →https://doi.org/10.1038/jid.2015.358openalex-snapshot
Development of a Model for Chemotherapy-Induced Alopecia: Profiling of Histological Changes in Human Hair Follicles after Chemotherapy
inferredcites →https://doi.org/10.1038/s41416-019-0520-8openalex-snapshot
Preventing chemotherapy-induced alopecia: a prospective clinical trial on the efficacy and safety of a scalp-cooling system in early breast cancer patients treated with anthracyclines
inferredcites →https://doi.org/10.1038/s41467-019-11665-0openalex-snapshot
Priming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy
inferredcites →https://doi.org/10.1038/sj.bmt.1703695openalex-snapshot
Relationship between irreversible alopecia and exposure to cyclophosphamide, thiotepa and carboplatin (CTC) in high-dose chemotherapy
inferredcites →https://doi.org/10.1046/j.1365-2354.2001.00272.xopenalex-snapshot
Hair and cancer chemotherapy: consequences and nursing care - a literature study
inferredcites →https://doi.org/10.1056/nejm199908123410706openalex-snapshot
The Biology of Hair Follicles
inferredcites →https://doi.org/10.1080/14740338.2017.1343299openalex-snapshot
Treatment options for nonalcoholic steatohepatitis - a safety evaluation
inferredcites →https://doi.org/10.1093/annonc/mds095openalex-snapshot
Permanent scalp alopecia related to breast cancer chemotherapy by sequential fluorouracil/epirubicin/cyclophosphamide (FEC) and docetaxel: a prospective study of 20 patients
inferredcites →https://doi.org/10.1111/bjd.12716openalex-snapshot
Analysis of quantitative changes in hair growth during treatment with chemotherapy or tamoxifen in patients with breast cancer: a cohort study
inferredcites →https://doi.org/10.1111/exd.12647openalex-snapshot
The role of PPAR γ‐mediated signalling in skin biology and pathology: new targets and opportunities for clinical dermatology
inferredcites →https://doi.org/10.1111/exd.12836openalex-snapshot
Human hair follicle organ culture: theory, application and perspectives
inferredcites →https://doi.org/10.1111/exd.13846openalex-snapshot
How chemotherapy and radiotherapy damage the tissue: Comparative biology lessons from feather and hair models
inferredcites →https://doi.org/10.1111/exd.14062openalex-snapshot
PPAR‐γ signalling as a key mediator of human hair follicle physiology and pathology
inferredcites →https://doi.org/10.1111/ics.12521openalex-snapshot
Transepidermal UV radiation of scalp skin ex vivo induces hair follicle damage that is alleviated by the topical treatment with caffeine
inferredcites →https://doi.org/10.1111/ijd.13906openalex-snapshot
Pathogenesis and treatment options for chemotherapy‐induced alopecia: a systematic review
inferredcites →https://doi.org/10.1111/j.0022-202x.2005.23787.xopenalex-snapshot
A Guide to Assessing Damage Response Pathways of the Hair Follicle: Lessons From Cyclophosphamide-Induced Alopecia in Mice
inferredcites →https://doi.org/10.1111/j.1365-2230.2010.03852.xopenalex-snapshot
Folliculitis decalvans associated with erlotinib
inferredcites →https://doi.org/10.1111/j.1529-8019.2011.01430.xopenalex-snapshot
Treatment of chemotherapy-induced alopecia
inferredcites →https://doi.org/10.1111/j.1600-0625.2006.00510.xopenalex-snapshot
Towards the development of a simplified long‐term organ culture method for human scalp skin and its appendages under serum‐free conditions
inferredcites →https://doi.org/10.1111/j.1600-0625.2009.00939.xopenalex-snapshot
Methods in hair research: how to objectively distinguish between anagen and catagen in human hair follicle organ culture
inferredcites →https://doi.org/10.1111/j.1600-0625.2009.01009.xopenalex-snapshot
A simple assay for the study of human hair follicle damage induced by ionizing irradiation
inferredcites →https://doi.org/10.1111/jdv.16114openalex-snapshot
Preclinical evidence that the PPAR γ modulator, N‐Acetyl‐ GED ‐0507‐34‐Levo, may protect human hair follicle epithelial stem cells against lichen planopilaris‐associated damage
inferredcites →https://doi.org/10.1172/jci27490openalex-snapshot
Gene expression profiling gets to the root of human hair follicle stem cells
inferredcites →https://doi.org/10.1186/s12906-020-03025-zopenalex-snapshot
Human placenta induces hair regrowth in chemotherapy-induced alopecia via inhibition of apoptotic factors and proliferation of hair follicles
inferredcites →https://doi.org/10.15252/emmm.201911031openalex-snapshot
CDK4/6 inhibition mitigates stem cell damage in a novel model for taxane‐induced alopecia
inferredcites →https://doi.org/10.1590/abd1806-4841.20154013openalex-snapshot
Clinical and histological study of permanent alopecia after bone marrow transplantation
inferredcites →https://doi.org/10.1634/theoncologist.2018-0184openalex-snapshot
Permanent Chemotherapy-Induced Alopecia in Patients with Breast Cancer: A 3-Year Prospective Cohort Study
inferredcites →https://doi.org/10.2217/fon-2019-0066openalex-snapshot
Final Results of a Prospective Study of Scalp Cooling in Preventing Chemotherapy-Induced Alopecia
inferredcites →https://doi.org/10.2353/ajpath.2007.061164openalex-snapshot
Dissecting the Impact of Chemotherapy on the Human Hair Follicle
inferredcites →https://doi.org/10.2353/ajpath.2010.100454openalex-snapshot
The Pathogenesis of Primary Cicatricial Alopecias
inferredcites →https://doi.org/10.3390/cells8101118openalex-snapshot
The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges
inferredcites →https://doi.org/10.4161/cbt.12.6.15956openalex-snapshot
The DNA damage mark pH2AX differentiates the cytotoxic effects of small molecule HDAC inhibitors in ovarian cancer cells

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4648218openalex-extracted
DNA Methylation of MicroRNA-365-1 Induces Apoptosis by Targeting DAP3 to Induce Apoptosis Production in Hair Follicle Stem Cells
inferred← citeshttps://doi.org/10.1007/s00105-024-05352-5openalex-snapshot
Alopezie durch Chemotherapeutika, Hedgehog-Inhibitoren, zielgerichtete Antikörpertherapien und Immuncheckpointinhibitoren
inferred← citeshttps://doi.org/10.1007/s00418-024-02282-0openalex-snapshot
Effect of N-acetylcysteine on hair follicle changes in mouse model of cyclophosphamide-induced alopecia: histological and biochemical study
inferred← citeshttps://doi.org/10.1016/b978-0-443-18653-0.00004-6openalex-snapshot
TRP channels in dermatology
inferred← citeshttps://doi.org/10.1016/b978-0-443-44579-8.00014-xopenalex-snapshot
Side effect and toxicity of nanomedicine in cancer treatment
inferred← citeshttps://doi.org/10.1016/j.ad.2026.104660openalex-snapshot
Persistent Chemotherapy-Induced Alopecia: Updates in Diagnosis and Treatment Persistent Chemotherapy Induced Alopecia: An Updated Approach
inferred← citeshttps://doi.org/10.1016/j.biopha.2023.114509openalex-snapshot
The effects of GPR40 agonists on hair growth are mediated by ANGPTL4
inferred← citeshttps://doi.org/10.1016/j.biopha.2026.119579openalex-snapshot
Venlafaxine reverses chemotherapy-induced alopecia through epithelial and dermal reprogramming at single-cell resolution
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2025.02.014openalex-snapshot
S100A8 induces cyclophosphamide-induced alopecia via NCF2/NOX2-mediated ferroptosis
inferred← citeshttps://doi.org/10.1016/j.jdrv.2024.06.002openalex-snapshot
Drug-induced scarring and permanent alopecia
inferred← citeshttps://doi.org/10.1016/j.jep.2024.118405openalex-snapshot
Discovery of petroleum ether extract of eclipta targeting p53/Fas pathway for the treatment of chemotherapy-induced alopecia: Network pharmacology and experimental validation
inferred← citeshttps://doi.org/10.1016/j.jid.2023.02.033openalex-snapshot
Low-Intensity Ultrasound as a Potential Intervention Strategy to Protect Human Scalp Hair Follicles from Taxane-Induced Toxicity
inferred← citeshttps://doi.org/10.1016/j.jid.2023.02.041openalex-snapshot
Clinical Pathobiology of Radiotherapy-Induced Alopecia: A Guide toward More Effective Prevention and Hair Follicle Repair
inferred← citeshttps://doi.org/10.1016/j.jid.2023.09.004openalex-snapshot
Melatonin Protects K15+ Human Hair Follicle Stem Cells and Hair Matrix Keratinocytes against Paclitaxel-Induced Damage Ex Vivo
inferred← citeshttps://doi.org/10.1016/j.ncrna.2024.03.001openalex-snapshot
DNA methylation of microRNA-365-1 induces apoptosis of hair follicle stem cells by targeting DAP3
inferred← citeshttps://doi.org/10.1016/j.xjidi.2022.100113openalex-snapshot
Frontiers in Lichen Planopilaris and Frontal Fibrosing Alopecia Research: Pathobiology Progress and Translational Horizons
inferred← citeshttps://doi.org/10.1080/14728222.2022.2049756openalex-snapshot
Targeting mitochondria in dermatological therapy: beyond oxidative damage and skin aging
inferred← citeshttps://doi.org/10.1080/15569527.2026.2618007openalex-snapshot
Yangxuebushen Decoction prevents cyclophosphamide-induced hair loss by inhibiting hair follicle apoptosis
inferred← citeshttps://doi.org/10.1096/fj.202200849ropenalex-snapshot
CircAGK regulates high dihydrotestosterone‐induced apoptosis in DPCs through the miR‐3180‐5p/BAX axis
inferred← citeshttps://doi.org/10.1101/2024.06.11.598522openalex-snapshot
Topically applied thyroid hormones stimulate hair growth in organ-cultured human scalp skin
inferred← citeshttps://doi.org/10.1111/1346-8138.17080openalex-snapshot
Endocrine and metabolic comorbidities in primary cicatricial alopecia: A nationwide population‐based study
inferred← citeshttps://doi.org/10.1111/bjd.20806openalex-snapshot
Prevention of chemotherapy-induced hair loss by peroxisome proliferator-activated receptor-γ modulation
inferred← citeshttps://doi.org/10.1111/cpr.13796openalex-snapshot
Mitonuclear Communication in Stem Cell Function
inferred← citeshttps://doi.org/10.1111/exd.14955openalex-snapshot
‘Speed‐ageing’ of human skin in serum‐free organ culture ex vivo: An instructive novel assay for preclinical human skin ageing research demonstrates senolytic effects of caffeine and 2,5‐dimethylpyrazine
inferred← citeshttps://doi.org/10.1111/exd.70217openalex-snapshot
Treatment With Cyclohexyl Salicylate, an OR2A4 /7 Agonist, Promotes Hair Growth and the Expansion of Epithelial Progenitor Cells in Human Hair Follicles Ex Vivo
inferred← citeshttps://doi.org/10.1111/ics.12923openalex-snapshot
Mechanical epilation exerts complex biological effects on human hair follicles and perifollicular skin: An ex vivo study approach
inferred← citeshttps://doi.org/10.1111/ics.70035openalex-snapshot
A proprietary lipidosterolic extract of Serenoa repens promotes hair growth through mechanisms that extend beyond 5‐alpha reductase inhibition: Insights from human hair follicle organ culture
inferred← citeshttps://doi.org/10.1111/jocd.16726openalex-snapshot
Integrative Proteo‐Transcriptomic Characterization of Androgenetic Alopecia Identifying ME1 ‐Mediated PPAR Signaling as a Potential Mediator
inferred← citeshttps://doi.org/10.1152/physrev.00005.2024openalex-snapshot
Frontiers in the physiology of male pattern androgenetic alopecia: beyond the androgen horizon
inferred← citeshttps://doi.org/10.1159/000539848openalex-snapshot
Lichen Planopilaris Trichoscopy in Caucasian Scalp: A Review
inferred← citeshttps://doi.org/10.1210/endrev/bnae034openalex-snapshot
Endocrine Controls of Skin Aging
inferred← citeshttps://doi.org/10.2340/actadv.v104.24213openalex-snapshot
Topical Minoxidil Rejuvenates Hair Follicles from Men with Androgenetic Alopecia in Vivo
inferred← citeshttps://doi.org/10.3389/fmed.2022.911944openalex-snapshot
Frontal fibrosing alopecia: A review of disease pathogenesis
inferred← citeshttps://doi.org/10.3390/biom14010020openalex-snapshot
Controlling Hair Loss by Regulating Apoptosis in Hair Follicles: A Comprehensive Overview
inferred← citeshttps://doi.org/10.3390/curroncol30040275openalex-snapshot
Prevention and Treatment of Chemotherapy-Induced Alopecia: What Is Available and What Is Coming?
inferred← citeshttps://doi.org/10.3390/ijms242115963openalex-snapshot
Melatonin Exerts Prominent, Differential Epidermal and Dermal Anti-Aging Properties in Aged Human Eyelid Skin Ex Vivo
inferred← citeshttps://doi.org/10.3390/ijms27104173openalex-snapshot
Chemotherapy-Induced Alopecia Beyond Cytotoxicity: Hair Follicle Immune Privilege Collapse and JAK-STAT Signaling
inferred← citeshttps://doi.org/10.3390/nu14163357openalex-snapshot
Intermediate Hair Follicles from Patients with Female Pattern Hair Loss Are Associated with Nutrient Insufficiency and a Quiescent Metabolic Phenotype
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