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Pro‐resolving mediator protectin D1 promotes epimorphic regeneration by controlling immune cell function in vertebrates

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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/aja.1002030302openalex-snapshot
Stages of embryonic development of the zebrafish
inferredcites →https://doi.org/10.1002/ana.23928openalex-snapshot
Neuroprotectin/protectin D1 protects against neuropathic pain in mice after nerve trauma
inferredcites →https://doi.org/10.1002/chem.201304526openalex-snapshot
A Versatile and Stereocontrolled Total Synthesis of Dihydroxylated Docosatrienes Containing a Conjugated E,E,Z‐Triene
inferredcites →https://doi.org/10.1002/dvdy.10248openalex-snapshot
Old questions, new tools, and some answers to the mystery of fin regeneration
inferredcites →https://doi.org/10.1002/dvdy.20181openalex-snapshot
Early fin primordia of zebrafish larvae regenerate by a similar growth control mechanism with adult regeneration
inferredcites →https://doi.org/10.1016/j.ajpath.2015.12.012openalex-snapshot
The Protectin PCTR1 Is Produced by Human M2 Macrophages and Enhances Resolution of Infectious Inflammation
inferredcites →https://doi.org/10.1016/j.biochi.2013.11.006openalex-snapshot
Confusion between protectin D1 (PD1) and its isomer protectin DX (PDX). An overview on the dihydroxy-docosatrienes described to date
inferredcites →https://doi.org/10.1016/j.chembiol.2018.04.017openalex-snapshot
PDn-3 DPA Pathway Regulates Human Monocyte Differentiation and Macrophage Function
inferredcites →https://doi.org/10.1016/j.cmet.2013.10.006openalex-snapshot
Resolvins, Specialized Proresolving Lipid Mediators, and Their Potential Roles in Metabolic Diseases
inferredcites →https://doi.org/10.1016/j.cub.2014.05.006openalex-snapshot
Resolution Mediator Chemerin15 Reprograms the Wound Microenvironment to Promote Repair and Reduce Scarring
inferredcites →https://doi.org/10.1016/j.dci.2016.02.015openalex-snapshot
Inflammation and immunity in organ regeneration
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2016.12.018openalex-snapshot
DHA-derived oxylipins, neuroprostanes and protectins, differentially and dose-dependently modulate the inflammatory response in human macrophages: Putative mechanisms through PPAR activation
inferredcites →https://doi.org/10.1016/j.it.2016.03.006openalex-snapshot
Reverse Migration of Neutrophils: Where, When, How, and Why?
inferredcites →https://doi.org/10.1016/j.jasms.2006.09.002openalex-snapshot
Resolvin D1, protectin D1, and related docosahexaenoic acid-derived products: Analysis via electrospray/low energy tandem mass spectrometry based on spectra and fragmentation mechanisms
inferredcites →https://doi.org/10.1016/j.jid.2018.03.1498openalex-snapshot
Biosynthesis of D-Series Resolvins in Skin Provides Insights into their Role in Tissue Repair
inferredcites →https://doi.org/10.1016/j.plipres.2015.10.002openalex-snapshot
Dihydroxylated E,E,Z-docosatrienes. An overview of their synthesis and biological significance
inferredcites →https://doi.org/10.1016/j.smim.2015.03.004openalex-snapshot
The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution
inferredcites →https://doi.org/10.1016/j.tetlet.2012.01.032openalex-snapshot
Stereocontrolled total synthesis of Neuroprotectin D1/Protectin D1 and its aspirin-triggered stereoisomer
inferredcites →https://doi.org/10.1016/j.tig.2013.07.003openalex-snapshot
The zebrafish as a model for complex tissue regeneration
inferredcites →https://doi.org/10.1016/j.ydbio.2007.01.033openalex-snapshot
Transactivation from Gal4-VP16 transgenic insertions for tissue-specific cell labeling and ablation in zebrafish
inferredcites →https://doi.org/10.1021/acs.analchem.5b00786openalex-snapshot
Differential Mobility Separation of Leukotrienes and Protectins
inferredcites →https://doi.org/10.1034/j.1600-065x.2000.917309.xopenalex-snapshot
Innate immune recognition: mechanisms and pathways
inferredcites →https://doi.org/10.1038/cddis.2017.374openalex-snapshot
TNF signaling and macrophages govern fin regeneration in zebrafish larvae
inferredcites →https://doi.org/10.1038/jcbfm.2010.220openalex-snapshot
Animal Research: Reporting in vivo Experiments—The ARRIVE Guidelines
inferredcites →https://doi.org/10.1038/nature11042openalex-snapshot
Infection regulates pro-resolving mediators that lower antibiotic requirements
inferredcites →https://doi.org/10.1038/nature13479openalex-snapshot
Pro-resolving lipid mediators are leads for resolution physiology
inferredcites →https://doi.org/10.1038/ncomms7227openalex-snapshot
Primitive macrophages control HSPC mobilization and definitive haematopoiesis
inferredcites →https://doi.org/10.1038/nrg1923openalex-snapshot
Bridging the regeneration gap: genetic insights from diverse animal models
inferredcites →https://doi.org/10.1038/nri1004openalex-snapshot
Innate immune sensing and its roots: the story of endotoxin
inferredcites →https://doi.org/10.1038/s41467-018-07036-wopenalex-snapshot
Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration
inferredcites →https://doi.org/10.1038/s41590-019-0356-7openalex-snapshot
Dynamic changes to lipid mediators support transitions among macrophage subtypes during muscle regeneration
inferredcites →https://doi.org/10.1038/srep01940openalex-snapshot
Novel n-3 Immunoresolvents: Structures and Actions
inferredcites →https://doi.org/10.1039/c3ib40175hopenalex-snapshot
Retrotaxis of human neutrophils during mechanical confinement inside microfluidic channels
inferredcites →https://doi.org/10.1073/pnas.1300290110openalex-snapshot
Macrophages are required for adult salamander limb regeneration
inferredcites →https://doi.org/10.1073/pnas.1415006111openalex-snapshot
Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection
inferredcites →https://doi.org/10.1073/pnas.1607003113openalex-snapshot
Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages
inferredcites →https://doi.org/10.1074/jbc.m706640200openalex-snapshot
Unraveling Tissue Regeneration Pathways Using Chemical Genetics
inferredcites →https://doi.org/10.1083/jcb.201212095openalex-snapshot
Notochord vacuoles are lysosome-related organelles that function in axis and spine morphogenesis
inferredcites →https://doi.org/10.1089/wound.2017.0761openalex-snapshot
Immune Regulation of Skin Wound Healing: Mechanisms and Novel Therapeutic Targets
inferredcites →https://doi.org/10.1093/nar/gkx1121openalex-snapshot
The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY
inferredcites →https://doi.org/10.1096/fj.11-201442openalex-snapshot
Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain
inferredcites →https://doi.org/10.1096/fj.13-227728openalex-snapshot
The novel 13 S ,14 S ‐epoxy‐maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A 4 hydrolase (LTA 4 H), and shifts macrophage phenotype
inferredcites →https://doi.org/10.1096/fj.14-259341openalex-snapshot
Molecular and cellular profiles of the resolution phase in a damage‐associated molecular pattern (DAMP)‐mediated peritonitis model and revelation of leukocyte persistence in peritoneal tissues
inferredcites →https://doi.org/10.1111/bph.13348openalex-snapshot
The Concise Guide to PHARMACOLOGY 2015/16: G protein‐coupled receptors
inferredcites →https://doi.org/10.1111/bph.14112openalex-snapshot
Goals and practicalities of immunoblotting and immunohistochemistry: A guide for submission to the British Journal of Pharmacology
inferredcites →https://doi.org/10.1111/bph.14153openalex-snapshot
Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers
inferredcites →https://doi.org/10.1111/bph.14748openalex-snapshot
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors
inferredcites →https://doi.org/10.1111/j.1476-5381.2010.00872.xopenalex-snapshot
Animal research: Reporting in vivo experiments: The ARRIVE guidelines
inferredcites →https://doi.org/10.1111/j.1524-475x.2012.00853.xopenalex-snapshot
Resolvin D 2 prevents secondary thrombosis and necrosis in a mouse burn wound model
inferredcites →https://doi.org/10.1126/sciadv.aar8320openalex-snapshot
PGE 2 production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo
inferredcites →https://doi.org/10.1126/scitranslmed.3007672openalex-snapshot
A Zebrafish Compound Screen Reveals Modulation of Neutrophil Reverse Migration as an Anti-Inflammatory Mechanism
inferredcites →https://doi.org/10.1152/ajpcell.00270.2014openalex-snapshot
Neuroprotectin/protectin D1: endogenous biosynthesis and actions on diabetic macrophages in promoting wound healing and innervation impaired by diabetes
inferredcites →https://doi.org/10.1159/000259327openalex-snapshot
Molecular Signaling Networks That Choreograph Epimorphic Fin Regeneration in Zebrafish – A Mini-Review
inferredcites →https://doi.org/10.1172/jci99888openalex-snapshot
GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain
inferredcites →https://doi.org/10.1182/blood-2006-05-024075openalex-snapshot
A transgenic zebrafish model of neutrophilic inflammation
inferredcites →https://doi.org/10.1182/blood-2010-10-314120openalex-snapshot
mpeg1 promoter transgenes direct macrophage-lineage expression in zebrafish
inferredcites →https://doi.org/10.1182/blood-2010-12-324186openalex-snapshot
Activation of hypoxia-inducible factor-1α (Hif-1α) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model
inferredcites →https://doi.org/10.1186/1471-213x-7-42openalex-snapshot
The zebrafish lysozyme C promoter drives myeloid-specific expression in transgenic fish
inferredcites →https://doi.org/10.1189/jlb.0506346openalex-snapshot
Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish
inferredcites →https://doi.org/10.1189/jlb.0905516openalex-snapshot
Neutrophil chemorepulsion in defined interleukin-8 gradients in vitro and in vivo
inferredcites →https://doi.org/10.1189/jlb.1010567openalex-snapshot
Spatiotemporal photolabeling of neutrophil trafficking during inflammation in live zebrafish
inferredcites →https://doi.org/10.1242/dev.098459openalex-snapshot
Macrophages modulate adult zebrafish tail fin regeneration
inferredcites →https://doi.org/10.1242/dmm.014498openalex-snapshot
Transient infection of the zebrafish notochord with E. coli induces chronic inflammation
inferredcites →https://doi.org/10.1371/journal.pgen.1003014openalex-snapshot
Morphogenesis and Cell Fate Determination within the Adaxial Cell Equivalence Group of the Zebrafish Myotome
inferredcites →https://doi.org/10.1371/journal.pone.0051766openalex-snapshot
In Vivo Cell and Tissue Dynamics Underlying Zebrafish Fin Fold Regeneration
inferredcites →https://doi.org/10.1371/journal.ppat.1007157openalex-snapshot
Neutrophils use superoxide to control bacterial infection at a distance
inferredcites →https://doi.org/10.3389/fimmu.2017.01400openalex-snapshot
Pro-Resolving Mediators in Regulating and Conferring Macrophage Function
inferredcites →https://doi.org/10.3389/fphar.2018.01582openalex-snapshot
The Protectin Family of Specialized Pro-resolving Mediators: Potent Immunoresolvents Enabling Innovative Approaches to Target Obesity and Diabetes
inferredcites →https://doi.org/10.4049/jimmunol.174.7.4345openalex-snapshot
Molecular Circuits of Resolution: Formation and Actions of Resolvins and Protectins
inferredcites →https://doi.org/10.4049/jimmunol.176.3.1848openalex-snapshot
Anti-Inflammatory Actions of Neuroprotectin D1/Protectin D1 and Its Natural Stereoisomers: Assignments of Dihydroxy-Containing Docosatrienes
inferredcites →https://doi.org/10.4049/jimmunol.181.7.5071openalex-snapshot
Evolution of the Inflammatory Response in Vertebrates: Fish TNF-α Is a Powerful Activator of Endothelial Cells but Hardly Activates Phagocytes
inferredcites →https://doi.org/10.7554/elife.07288openalex-snapshot
Identification of polarized macrophage subsets in zebrafish
inferredcites →https://doi.org/10.7554/elife.22716openalex-snapshot
Transient inflammatory response mediated by interleukin-1β is required for proper regeneration in zebrafish fin fold
inferredcites →https://doi.org/10.7554/elife.24623openalex-snapshot
Macrophages are necessary for epimorphic regeneration in African spiny mice
inferredcites →https://doi.org/10.7554/elife.45976openalex-snapshot
Distinct inflammatory and wound healing responses to complex caudal fin injuries of larval zebrafish

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4753794openalex-extracted
HDAC Activity Inhibition Alters Histone H4 Acetylation Dynamics Coupled to HDAC Expression and Lipid Mediator 12(S)HETE Biogenesis in Xenopus laevis Tail Regeneration
inferred← citeshttps://doi.org/10.1016/j.apsb.2026.06.056openalex-snapshot
Tocotrienol metabolites redirect lipid mediator production in innate immune cells towards inflammation resolution
inferred← citeshttps://doi.org/10.1016/j.bcp.2022.115181openalex-snapshot
A newly synthesized 17-epi-NeuroProtectin D1/17-epi-Protectin D1: Authentication and functional regulation of Inflammation-Resolution
inferred← citeshttps://doi.org/10.1016/j.cbpc.2026.110462openalex-snapshot
The silent saboteurs: How ultraviolet (UV)-aged polystyrene nanoplastics disrupt the regenerative capacity of goldfish (Carassius auratus) caudal fins
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2022.09.021openalex-snapshot
Macrophages undergo a behavioural switch during wound healing in zebrafish
inferred← citeshttps://doi.org/10.1016/j.fsi.2024.109490openalex-snapshot
What can we learn about fish neutrophil and macrophage response to immune challenge from studies in zebrafish
inferred← citeshttps://doi.org/10.1016/j.mex.2022.101651openalex-snapshot
Preparing sequencing grade RNAs from a small number of FACS-sorted larvae macrophages isolated from enzyme free dissociated zebrafish larvae
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2026.01.009openalex-snapshot
Zebrafish neural regeneration: mechanistic insights into human nervous system repair
inferred← citeshttps://doi.org/10.1016/j.pharmr.2026.100129openalex-snapshot
G protein-coupled receptors and inflammation resolution signaling networks in the heart: Pharmacology and potential for innovative therapeutics
inferred← citeshttps://doi.org/10.1016/j.toxrep.2022.06.010openalex-snapshot
Evaluation of the effects of Loxosceles intermedia’s venom in zebrafish
inferred← citeshttps://doi.org/10.1038/s41536-025-00414-1openalex-snapshot
An NF-kB/TNF-alpha signalling feedback loop acts to coordinate tissue regeneration and macrophage behaviour in zebrafish
inferred← citeshttps://doi.org/10.1042/ebc20200018openalex-snapshot
Specialized pro-resolving mediator network: an update on production and actions
inferred← citeshttps://doi.org/10.1111/all.70356openalex-snapshot
Differential Effects of Benralizumab and Mepolizumab on Pro‐Resolving Mediators
inferred← citeshttps://doi.org/10.1371/journal.ppat.1012922openalex-snapshot
Intracellular Pseudomonas aeruginosa persist and evade antibiotic treatment in a wound infection model
inferred← citeshttps://doi.org/10.26508/lsa.202503296openalex-snapshot
In vivo screen reveals specific roles of Hippo pathway components in development and regeneration
inferred← citeshttps://doi.org/10.3389/fcell.2021.718938openalex-snapshot
Pro-regenerative Dialogue Between Macrophages and Mesenchymal Stem/Stromal Cells in Osteoarthritis
inferred← citeshttps://doi.org/10.3389/fcell.2025.1600149openalex-snapshot
Molecular dynamics of inflammation resolution: therapeutic implications
inferred← citeshttps://doi.org/10.3389/fimmu.2021.636585openalex-snapshot
Damage-Induced Calcium Signaling and Reactive Oxygen Species Mediate Macrophage Activation in Zebrafish
inferred← citeshttps://doi.org/10.3389/fimmu.2022.838425openalex-snapshot
Exploring Macrophage-Dependent Wound Regeneration During Mycobacterial Infection in Zebrafish
inferred← citeshttps://doi.org/10.3389/fimmu.2026.1760968openalex-snapshot
Manuka honey and its component, methyl syringate, shift neutrophil release profiles from pro-inflammatory while preserving pro-regenerative growth factor release in vitro
inferred← citeshttps://doi.org/10.3390/biology12020153openalex-snapshot
Molecular Actors of Inflammation and Their Signaling Pathways: Mechanistic Insights from Zebrafish
inferred← citeshttps://doi.org/10.3390/metabo14060314openalex-snapshot
Is Lipid Metabolism of Value in Cancer Research and Treatment? Part II: Role of Specialized Pro-Resolving Mediators in Inflammation, Infections, and Cancer
inferred← citeshttps://doi.org/10.70675/fe270cfcz6d95z4dfaz86a6z01efaf8a5ef7openalex-snapshot
Dynamics of macrophage polarization in zebrafish during the tissue injury and infection
inferred← citeshttps://doi.org/10.7150/thno.65235openalex-snapshot
Lactate metabolism coordinates macrophage response and regeneration in zebrafish
inferred← citeshttps://doi.org/10.7554/elife.89828openalex-snapshot
Dynamics of macrophage polarization support Salmonella persistence in a whole living organism
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