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Spider peptide Phα1β induces analgesic effect in a model of cancer pain
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Intrathecal Ziconotide in the Treatment of Refractory Pain in Patients With Cancer or AIDS
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Symptoms and signs of primary melanoma
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Characterization of the Binding of Omega-Conopeptides to Different Classes of Non-L-Type Neuronal Calcium Channels
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Emerging drugs for cancer-related pain
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Intrathecal morphine in mice: A new technique
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Effects of nifedipine and Bay K 8644 on myotropic responses in aortic rings of pregnant rats
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Inhibition of protein kinase C, but not of protein kinase A, blocks the development of acute antinociceptive tolerance to an intrathecally administered μ-opioid receptor agonist in the mouse
inferredcites →https://doi.org/10.1016/0014-5793(92)81318-gopenalex-snapshot
The purification and amino acid sequences of four Tx2 neurotoxins from the venom of the Brazilian ‘armed’ spider Phoneutria nigriventer (Keys)
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Quantitative assessment of tactile allodynia in the rat paw
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Ethical guidelines for investigations of experimental pain in conscious animals
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Pre-treatment with a PKC or PKA inhibitor prevents the development of morphine tolerance but not physical dependence in mice
inferredcites →https://doi.org/10.1016/j.brainresrev.2008.12.021openalex-snapshot
Role of voltage-gated calcium channels in ascending pain pathways
inferredcites →https://doi.org/10.1016/j.metabol.2010.07.010openalex-snapshot
Opioids for cancer pain: the challenge of optimizing treatment
inferredcites →https://doi.org/10.1016/j.pain.2008.07.014openalex-snapshot
Analgesic effect in rodents of native and recombinant Phα1β toxin, a high-voltage-activated calcium channel blocker isolated from armed spider venom
inferredcites →https://doi.org/10.1016/j.pain.2010.07.006openalex-snapshot
Calcitonin gene-related peptide as a regulator of neuronal CaMKII–CREB, microglial p38–NFκB and astroglial ERK–Stat1/3 cascades mediating the development of tolerance to morphine-induced analgesia
inferredcites →https://doi.org/10.1016/j.toxicon.2011.09.008openalex-snapshot
Antiallodynic effect and side effects of Phα1β, a neurotoxin from the spider Phoneutria nigriventer: Comparison with ω-conotoxin MVIIA and morphine
inferredcites →https://doi.org/10.1016/s0014-2999(02)01450-4openalex-snapshot
Morphine analgesia suppresses tumor growth and metastasis in a mouse model of cancer pain produced by orthotopic tumor inoculation
inferredcites →https://doi.org/10.1016/s0022-3565(25)24685-7openalex-snapshot
Differential antagonism of U69,593- and bremazocine-induced antinociception by (-)-UPHIT: evidence of kappa opioid receptor multiplicity in mice.
inferredcites →https://doi.org/10.1016/s0140-6736(10)60354-6openalex-snapshot
Ziconotide for treatment of severe chronic pain
inferredcites →https://doi.org/10.1016/s0140-6736(11)60236-5openalex-snapshot
Treatment of cancer pain
inferredcites →https://doi.org/10.1016/s0304-3959(01)00436-5openalex-snapshot
The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices
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Interactions of intrathecally administered ziconotide, a selective blocker of neuronal N-type voltage-sensitive calcium channels, with morphine on nociception in rats
inferredcites →https://doi.org/10.1023/a:1021836403433openalex-snapshot
Phoneutria nigriventer Venom: A Cocktail of Toxins That Affect Ion Channels
inferredcites →https://doi.org/10.1038/sj.bjp.0706820openalex-snapshot
Decreased μ ‐opioid receptor signalling and a reduction in calcium current density in sensory neurons from chronically morphine‐treated mice
inferredcites →https://doi.org/10.1074/jbc.m300581200openalex-snapshot
Determinants of Inhibition of Transiently Expressed Voltage-gated Calcium Channels by ω-Conotoxins GVIA and MVIIA
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Cranial Neuropathy as a Presenting Sign of Recurrent Aggressive Skin Cancer
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Inhibition of High Voltage-Activated Calcium Channels by Spider Toxin PnTx3-6
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Preclinical Assessment of Candidate Analgesic Drugs: Recent Advances and Future Challenges
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Efficient Analysis of Experimental Observations
inferredcites →https://doi.org/10.1146/annurev.pa.35.040195.003423openalex-snapshot
Antagonists of Neuronal Calcium Channels: Structure, Function, and Therapeutic Implications
inferredcites →https://doi.org/10.1146/annurev.pharmtox.40.1.389openalex-snapshot
Molecular Mechanisms and Regulation of Opioid Receptor Signaling
inferredcites →https://doi.org/10.1254/jphs.91.167openalex-snapshot
Mechanical Hypersensitivity and Alterations in Cutaneous Nerve Fibers in a Mouse Model of Skin Cancer Pain
inferredcites →https://doi.org/10.1517/13543784.2011.600686openalex-snapshot
Targeting voltage-gated calcium channels for the treatment of neuropathic pain: a review of drug development
inferredcites →https://doi.org/10.1523/jneurosci.14-08-04882.1994openalex-snapshot
Voltage-sensitive calcium channels in spinal nociceptive processing: blockade of N- and P-type channels inhibits formalin-induced nociception
inferredcites →https://doi.org/10.1523/jneurosci.19-23-10289.1999openalex-snapshot
Peroxynitrite Inactivation of Tyrosine Hydroxylase: Mediation by Sulfhydryl Oxidation, not Tyrosine Nitration
inferredcites →https://doi.org/10.1523/jneurosci.2851-07.2007openalex-snapshot
Chemical Interactions between Fibrosarcoma Cancer Cells and Sensory Neurons Contribute to Cancer Pain
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4669660openalex-extracted
Antinociceptive Effects of Synthetics Peptides Derived from Phα1β in Mice Model of Cancer Pain
inferred← citeshttps://doi.org/10.1002/ijc.31911openalex-snapshot
Transient receptor potential ankyrin 1 (TRPA1) plays a critical role in a mouse model of cancer pain
inferred← citeshttps://doi.org/10.1002/ijc.32648openalex-snapshot
Dacarbazine alone or associated with melanoma‐bearing cancer pain model induces painful hypersensitivity by TRPA1 activation in mice
inferred← citeshttps://doi.org/10.1007/978-3-030-15950-4_15openalex-snapshot
Mass Spectrometry- and Computational Structural Biology-Based Investigation of Proteins and Peptides
inferred← citeshttps://doi.org/10.1007/s00210-019-01748-6openalex-snapshot
Antinociceptive and genotoxic assessments of the antagonist TRPV1 receptor SB-366791 on morphine-induced tolerance in mice
inferred← citeshttps://doi.org/10.1007/s00424-016-1801-1openalex-snapshot
Antinociceptive effect of a novel armed spider peptide Tx3-5 in pathological pain models in mice
inferred← citeshttps://doi.org/10.1007/s10989-022-10381-6openalex-snapshot
Phα1β is a Promising Neuroprotective Peptide from the Phoneutria nigriventer ‘Armed’ Spider
inferred← citeshttps://doi.org/10.1007/s12035-018-1049-1openalex-snapshot
Beneficial Effects of the Calcium Channel Blocker CTK 01512-2 in a Mouse Model of Multiple Sclerosis
inferred← citeshttps://doi.org/10.1007/s12035-022-02864-wopenalex-snapshot
Systemic, Intrathecal, and Intracerebroventricular Antihyperalgesic Effects of the Calcium Channel Blocker CTK 01512–2 Toxin in Persistent Pain Models
inferred← citeshttps://doi.org/10.1007/s13361-018-1904-3openalex-snapshot
Structural Characterization and Disulfide Assignment of Spider Peptide Phα1β by Mass Spectrometry
inferred← citeshttps://doi.org/10.1016/j.bcp.2020.114107openalex-snapshot
Multi-targeting sodium and calcium channels using venom peptides for the treatment of complex ion channels-related diseases
inferred← citeshttps://doi.org/10.1016/j.bioadv.2024.213903openalex-snapshot
Unlocking nature's arsenal: Nanotechnology for targeted delivery of venom toxins in cancer therapy
inferred← citeshttps://doi.org/10.1016/j.ejmech.2025.118138openalex-snapshot
Improving opioid analgesia: Modulation of the mu-opioid receptor phosphorylation state via combination therapy
inferred← citeshttps://doi.org/10.1016/j.ejphar.2019.172555openalex-snapshot
Nociceptive mechanisms involved in the acute and chronic phases of a complex regional pain syndrome type 1 model in mice
inferred← citeshttps://doi.org/10.1016/j.ejphar.2020.173672openalex-snapshot
Calcium channels blockers toxins attenuate abdominal hyperalgesia and inflammatory response associated with the cerulein-induced acute pancreatitis in rats
inferred← citeshttps://doi.org/10.1016/j.jpain.2014.02.007openalex-snapshot
Action of Phα1β, a Peptide From the Venom of the Spider Phoneutria nigriventer, on the Analgesic and Adverse Effects Caused by Morphine in Mice
inferred← citeshttps://doi.org/10.1016/j.lfs.2017.06.018openalex-snapshot
Synergistic antinociceptive effect of a calcium channel blocker and a TRPV1 blocker in an acute pain model in mice
inferred← citeshttps://doi.org/10.1016/j.lfs.2021.119582openalex-snapshot
Antinociceptive synergism upon the joint use of methadone and Phα1β in a model of cancer-related pain in C57BL/6J mice
inferred← citeshttps://doi.org/10.1016/j.micpath.2018.09.003openalex-snapshot
Venom as therapeutic weapon to combat dreadful diseases of 21st century: A systematic review on cancer, TB, and HIV/AIDS
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2023.12.012openalex-snapshot
Activation of Transient Receptor Potential Vanilloid 1 Is Involved in Both Pain and Tumor Growth in a Mouse Model of Cancer Pain
inferred← citeshttps://doi.org/10.1016/j.npep.2019.101980openalex-snapshot
Recombinant peptide derived from the venom the Phoneutria nigriventer spider relieves nociception by nerve deafferentation
inferred← citeshttps://doi.org/10.1016/j.pbb.2013.10.014openalex-snapshot
Effect of ω-conotoxin MVIIA and Phα1β on paclitaxel-induced acute and chronic pain
inferred← citeshttps://doi.org/10.1016/j.peptides.2015.10.009openalex-snapshot
Endogenous opiates and behavior: 2014
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2018.08.016openalex-snapshot
Neurobiology and therapeutic applications of neurotoxins targeting transmitter release
inferred← citeshttps://doi.org/10.1016/j.toxicon.2015.09.043openalex-snapshot
Characterization of the antinociceptive effect of PhTx3-4, a toxin from Phoneutria nigriventer , in models of thermal, chemical and incisional pain in mice
inferred← citeshttps://doi.org/10.1016/j.toxicon.2017.02.001openalex-snapshot
Pre-clinical evaluation of voltage-gated calcium channel blockers derived from the spider P. nigriventer in glioma progression
inferred← citeshttps://doi.org/10.1016/j.toxicon.2017.05.018openalex-snapshot
The spider toxin Phα1β recombinant possesses strong analgesic activity
inferred← citeshttps://doi.org/10.1016/j.toxicon.2018.11.298openalex-snapshot
Versatile spider venom peptides and their medical and agricultural applications
inferred← citeshttps://doi.org/10.1016/j.toxicon.2020.07.005openalex-snapshot
Pain modulatory properties of Phoneutria nigriventer crude venom and derived peptides: A double-edged sword
inferred← citeshttps://doi.org/10.1016/j.toxicon.2020.10.007openalex-snapshot
Phα1β, a dual blocker of TRPA1 and Cav2.2, as an adjuvant drug in opioid therapy for postoperative pain
inferred← citeshttps://doi.org/10.1016/j.toxicon.2021.03.012openalex-snapshot
Effects of intravenous administration of recombinant Phα1β toxin in a mouse model of fibromyalgia
inferred← citeshttps://doi.org/10.1016/j.toxicon.2024.107717openalex-snapshot
Intravenous administration of recombinant Phα1β: Antinociceptive properties and morphine tolerance reversal in a cancer-associated pain model
inferred← citeshttps://doi.org/10.1016/j.wneu.2018.01.116openalex-snapshot
Potential Uses of Isolated Toxin Peptides in Neuropathic Pain Relief: A Literature Review
inferred← citeshttps://doi.org/10.1021/acschemneuro.2c00779openalex-snapshot
Novel GluN2B-Selective NMDA Receptor Negative Allosteric Modulator Possesses Intrinsic Analgesic Properties and Enhances Analgesia of Morphine in a Rodent Tail Flick Pain Model
inferred← citeshttps://doi.org/10.1039/c8tx00022kopenalex-snapshot
Anticancer, antimicrobial, and analgesic activities of spider venoms
inferred← citeshttps://doi.org/10.1111/bcpt.13171openalex-snapshot
Evaluation of DNA damage in spinal cord and mutagenic effect of a Phα1β recombinant toxin with analgesic properties from the Phoneutria nigriventer spider
inferred← citeshttps://doi.org/10.1111/bph.13652openalex-snapshot
The peptide Phα1β, from spider venom, acts as a TRPA1 channel antagonist with antinociceptive effects in mice
inferred← citeshttps://doi.org/10.1111/bph.16407openalex-snapshot
Pronociceptive role of spinal Cav2.3 (R‐type) calcium channels in a mouse model of postoperative pain
inferred← citeshttps://doi.org/10.1124/mol.116.103770openalex-snapshot
Calcium Channels and Associated Receptors in Malignant Brain Tumor Therapy
inferred← citeshttps://doi.org/10.1586/14737175.2014.962518openalex-snapshot
Venom-based biotoxins as potential analgesics
inferred← citeshttps://doi.org/10.1590/1678-9199-jvatitd-14-63-18openalex-snapshot
Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities
inferred← citeshttps://doi.org/10.1590/1678-9199-jvatitd-2019-0070openalex-snapshot
Analgesic and side effects of intravenous recombinant Phα1β
inferred← citeshttps://doi.org/10.1590/1678-9199-jvatitd-2021-0001openalex-snapshot
Analgesic effects of Phα1β toxin: a review of mechanisms of action involving pain pathways
inferred← citeshttps://doi.org/10.1590/1678-9199-jvatitd-2021-0027openalex-snapshot
Isobolographic analysis reveals antinociceptive synergism between Phα1β recombinant toxin and morphine in a model of cancer pain in C57BL/6J mice
inferred← citeshttps://doi.org/10.1590/1678-9199-jvatitd-2024-0039openalex-snapshot
Phα1β interaction with the Kv11.1 potassium channel in HEK293 cells transfected with the human ERG channel
inferred← citeshttps://doi.org/10.18053/jctres.03.201702.002openalex-snapshot
Scorpion and spider venoms in cancer treatment: state of the art, challenges, and perspectives
inferred← citeshttps://doi.org/10.21203/rs.3.rs-1003924/v1openalex-snapshot
The Antihyperalgesic Effects of the Calcium Channel Blocker CTK 01512-2 Toxin in Persistent Pain Models
inferred← citeshttps://doi.org/10.2174/0929867325666181031122438openalex-snapshot
Animal Venom Peptides as a Treasure Trove for New Therapeutics Against Neurodegenerative Disorders
inferred← citeshttps://doi.org/10.2174/1389203724666230328133102openalex-snapshot
Ion Channels-related Neuroprotection and Analgesia Mediated by Spider Venom Peptides
inferred← citeshttps://doi.org/10.2174/1570159x18666200808151522openalex-snapshot
A Systematic Review of Traditionally Used Herbs and Animal-Derived Products as Potential Analgesics
inferred← citeshttps://doi.org/10.2174/1570159x19666210713121217openalex-snapshot
Animal Venom Peptides Cause Antinociceptive Effects by Voltage-gated Calcium Channels Activity Blockage
inferred← citeshttps://doi.org/10.3389/fchem.2024.1465459openalex-snapshot
Venom-derived peptides for breaking through the glass ceiling of drug development
inferred← citeshttps://doi.org/10.3389/fmolb.2021.770471openalex-snapshot
Mapping of Brain Activity in the Analgesia Induced by Phα1β and Morphine
inferred← citeshttps://doi.org/10.3389/fncel.2019.00306openalex-snapshot
Phα1β Spider Toxin Reverses Glial Structural Plasticity Upon Peripheral Inflammation
inferred← citeshttps://doi.org/10.3390/ijms26209895openalex-snapshot
Therapeutic Promise and Biotechnological Prospects of Dendroaspis polylepis Venom Proteins: Mambalgins, Fasciculins, and Dendrotoxins
inferred← citeshttps://doi.org/10.3390/molecules29010035openalex-snapshot
Spider-Venom Peptides: Structure, Bioactivity, Strategy, and Research Applications
inferred← citeshttps://doi.org/10.3390/toxins11020131openalex-snapshot
The Role of Toxins in the Pursuit for Novel Analgesics
inferred← citeshttps://doi.org/10.3390/toxins15060378openalex-snapshot
Recombinant Production, NMR Solution Structure, and Membrane Interaction of the Phα1β Toxin, a TRPA1 Modulator from the Brazilian Armed Spider Phoneutria nigriventer
inferred← citeshttps://doi.org/10.3390/toxins18020069openalex-snapshot
Exploring the Pain-Relieving Potential: Unveiling Antinociceptive Properties in Animal Venoms and Toxins
inferred← citeshttps://doi.org/10.5772/intechopen.77996openalex-snapshot
Role of Calcium Permeable Channels in Pain Processing
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