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Synthesis, in vitro Biological Evaluation and Molecular Docking Studies of Benzimidamides as Potential BACE1 Inhibitors

https://doi.org/10.1111/cbdd.12016

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Boom in the development of non‐peptidic β‐secretase (BACE1) inhibitors for the treatment of Alzheimer's disease

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Improved protein–ligand docking using GOLD

inferredcites →https://doi.org/10.1016/j.bmc.2008.09.041openalex-snapshot

Design, synthesis and SAR of potent statine-based BACE-1 inhibitors: Exploration of P1 phenoxy and benzyloxy residues

inferredcites →https://doi.org/10.1016/j.bmc.2010.03.043openalex-snapshot

Elaborate ligand-based pharmacophore exploration and QSAR analysis guide the synthesis of novel pyridinium-based potent β-secretase inhibitory leads

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Identification of a sub-micromolar, non-peptide inhibitor of β-secretase with low neural cytotoxicity through in silico screening

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Prediction of intestinal permeability

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The role of Aβ42 in Alzheimer's disease

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Hybrid Structure-Based Virtual Screening Protocol for the Identification of Novel BACE1 Inhibitors

inferredcites →https://doi.org/10.1021/jm025619lopenalex-snapshot

Design and Synthesis of Statine-Based Cell-Permeable Peptidomimetic Inhibitors of Human β-Secretase

inferredcites →https://doi.org/10.1021/jm0304008openalex-snapshot

Design and Synthesis of Hydroxyethylene-Based Peptidomimetic Inhibitors of Human β-Secretase

inferredcites →https://doi.org/10.1021/jm049379gopenalex-snapshot

Structure-Based Design of Potent and Selective Cell-Permeable Inhibitors of Human β-Secretase (BACE-1)

inferredcites →https://doi.org/10.1021/jm0611962openalex-snapshot

Application of Fragment Screening by X-ray Crystallography to β-Secretase

inferredcites →https://doi.org/10.1021/jm800138hopenalex-snapshot

Second Generation of Hydroxyethylamine BACE-1 Inhibitors: Optimizing Potency and Oral Bioavailability

inferredcites →https://doi.org/10.1038/nrd2896openalex-snapshot

Alzheimer's disease: strategies for disease modification

inferredcites →https://doi.org/10.1073/pnas.160115697openalex-snapshot

BACE2, a β-secretase homolog, cleaves at the β site and within the amyloid-β region of the amyloid-β precursor protein

inferredcites →https://doi.org/10.1111/j.1747-0285.2011.01087.xopenalex-snapshot

Sequential Virtual Screening Approach to the Identification of Small Organic Molecules as Potential BACE‐1 Inhibitors

inferredcites →https://doi.org/10.1126/science.1072994openalex-snapshot

The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

inferredcites →https://doi.org/10.1126/science.286.5440.735openalex-snapshot

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

inferredcites →https://doi.org/10.1126/science.286.5443.1255aopenalex-snapshot

BACE Maps to Chromosome 11 and a BACE Homolog, BACE2 , Reside in the Obligate Down Syndrome Region of Chromosome 21

inferredcites →https://doi.org/10.1517/13543784.14.11.1385openalex-snapshot

Protease inhibitors as potential disease-modifying therapeutics for Alzheimer’s disease

inferredcites →https://doi.org/10.2174/092986709788186174openalex-snapshot

Progress in the Development of Nonpeptidomimetic BACE 1 Inhibitors for Alzheimers Disease

inferredcites →https://doi.org/10.5246/jcps.2012.02.015openalex-snapshot

Design and synthesis of benzimidamides as potential BACE1 inhibitors

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Hupertimines A–E, Fawcettimine‐Type Lycopodium Alkaloids from Huperzia serrata

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Palladium‐Catalyzed Regioselective Coupling of Amidines and 1,2,3‐Triiodobenzenes: Facile Synthesis of 2,3‐Diiodinated N ‐Arylbenzimidamides as Potential MDM 2 and MDM 4 Inhibitors

inferred← citeshttps://doi.org/10.1007/s11693-015-9169-7openalex-snapshot

In silico study of peptide inhibitors against BACE 1

inferred← citeshttps://doi.org/10.1007/s13659-017-0140-zopenalex-snapshot

Lycodine-Type Lycopodium Alkaloids from the Whole Plants of Huperzia serrata

inferred← citeshttps://doi.org/10.1016/j.bmc.2013.09.033openalex-snapshot

Design and synthesis of novel 3,5-bis-N-(aryl/heteroaryl) carbamoyl-4-aryl-1,4-dihydropyridines as small molecule BACE-1 inhibitors

inferred← citeshttps://doi.org/10.1016/j.ejmech.2014.04.025openalex-snapshot

4-Oxo-1,4-dihydro-quinoline-3-carboxamides as BACE-1 inhibitors: Synthesis, biological evaluation and docking studies

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Lycogladines A-H, fawcettimine-type Lycopodium alkaloids from Lycopodium complanatum var. glaucum Ching

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Lycoplanine A, a C16N Lycopodium Alkaloid with a 6/9/5 Tricyclic Skeleton from Lycopodium complanatum

inferred← citeshttps://doi.org/10.1080/10286020.2015.1043281openalex-snapshot

Four new fawcettimine-related alkaloids fromPhlegmariurus squarrosus

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In Silico Design of Beta‐Secretase Inhibitors in Alzheimer's Disease

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One Pot Synthesis of Micromolar BACE-1 Inhibitors Based on the Dihydropyrimidinone Scaffold and Their Thia and Imino Analogues

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Potential of Ramalin and Its Derivatives for the Treatment of Alzheimer’s Disease

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Therapeutic Potential of Ramalin Derivatives with Enhanced Stability in the Treatment of Alzheimer’s Disease

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