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1,3,4‐Thiadiazole and its Derivatives: A Review on Recent Progress in Biological Activities

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Outgoing claims: the papers this work cites, builds on, or argues with.

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inferred← citeshttps://doi.org/10.1002/ardp.202300370openalex-snapshot

Synthesis, characterization, biochemical, and molecular modeling studies of carvacrol‐based new thiosemicarbazide and 1,3,4‐thiadiazole derivatives

inferred← citeshttps://doi.org/10.1002/bkcs.12585openalex-snapshot

One‐pot synthesis of 2‐imino‐1,3,4‐thiadiazolines from acylhydrazides and isothiocyanates

inferred← citeshttps://doi.org/10.1002/cbdv.202403103openalex-snapshot

In‐silico Screening of Kewra Oil Composition and Validation of Its Anti‐arthritic Efficacy Against Experimental Rat Model

inferred← citeshttps://doi.org/10.1002/cbdv.71358openalex-snapshot

Antidiabetic and Cytotoxicity Studies of Novel Quinazolinone–1,3,4‐Thiadiazole Molecular Hybrids

inferred← citeshttps://doi.org/10.1002/hc.21325openalex-snapshot

Phosphosulfonic acid‐catalyzed green synthesis and bioassay of α‐aryl‐α′‐1,3,4‐thiadiazolyl aminophosphonates

inferred← citeshttps://doi.org/10.1002/jbt.70142openalex-snapshot

Synthesis and Characterization of Schiff Bases and Their Ag(I) Complexes Containing 2,5,6‐Trisubstituted Imidazothiadiazole Derivatives: Molecular Docking and In Vitro Cytotoxic Effects Against Nonsmall Lung Cancer Cell Line

inferred← citeshttps://doi.org/10.1002/jhet.2779openalex-snapshot

Cyclization–oxidation of Benzylidenehydrazinecarbothioamides by FeCl3.6H2O or ZnCl2.6H2O Catalysts and Synthesis of New 1,3,4‐Thiadiazolo‐[3,2‐ α]Pyrimidines

inferred← citeshttps://doi.org/10.1002/jhet.2984openalex-snapshot

Synthesis and Characterization of Some New Heteroaromatic Compounds Having Chirality Adjacent to a 1,3,4‐Thiadiazole Moiety and Their Antimicrobial Activities

inferred← citeshttps://doi.org/10.1002/jhet.3108openalex-snapshot

Utility of Bis‐Hydrazonoyl Chlorides as Precursors for Synthesis of New Functionalized Bis‐Thiadiazoles as Potent Antimicrobial Agents

inferred← citeshttps://doi.org/10.1002/jhet.3513openalex-snapshot

Synthesis, Antimicrobial, and Antioxidant Screening of Aryl Acetic Acid Incorporated 1,2,4‐Triazolo‐1,3,4‐Thiadiazole Derivatives

inferred← citeshttps://doi.org/10.1002/jhet.3841openalex-snapshot

Synthesis of 5‐amino‐1,3,4‐thiadiazoles containing dithiocarbamate groups

inferred← citeshttps://doi.org/10.1002/jhet.4466openalex-snapshot

Synthesis and antimicrobial evaluation of novel tris‐thiadiazole derivatives

inferred← citeshttps://doi.org/10.1002/med.21852openalex-snapshot

Expedition of sulfur‐containing heterocyclic derivatives as cytotoxic agents in medicinal chemistry: A decade update

inferred← citeshttps://doi.org/10.1002/slct.201900630openalex-snapshot

Efficient One‐Pot Synthesis of 3,5‐Disubstituted 1,3,4‐Thiadiazole from Dithioesters under Mild Condition

inferred← citeshttps://doi.org/10.1002/slct.202204979openalex-snapshot

8‐Nitronaphthofuran Fused Urea Derivatives as Potential Antimicrobial Agents: Synthesis, Characterization and Pharmacological Studies

inferred← citeshttps://doi.org/10.1002/slct.202301070openalex-snapshot

Synthesis, Molecular Docking, and Antitumor Activity of 1,3,4‐Thiadiazole‐Based Heterocycles against Hepatocellular Carcinoma

inferred← citeshttps://doi.org/10.1002/slct.202302877openalex-snapshot

Microwave‐Assisted Synthesis and Characterization of Some Aldehyde Derivatives of Imidazo[2,1‐b][1,3,4]thiadiazole: Crystal Structure Insights, In‐Silico and Biological Studies

inferred← citeshttps://doi.org/10.1002/slct.202403436openalex-snapshot

Ascorbic Acid: An Efficient Organocatalyst for the Synthesis of 2‐Amino‐1,3,4‐oxadiazoles and Thiadiazoles via C−X Bond Formation

inferred← citeshttps://doi.org/10.1007/978-981-19-0832-3_6openalex-snapshot

Various Synthetic Strategies and Therapeutic Potential of Thiadiazole, Oxadiazole, Isoxazole and Isothiazole Derivatives

inferred← citeshttps://doi.org/10.1007/s00044-016-1561-7openalex-snapshot

Synthesis and evaluation of the trypanocidal activity of a series of 1,3,4-thiadiazoles derivatives of R-(+)-limonene benzaldehyde-thiosemicarbazones

inferred← citeshttps://doi.org/10.1007/s00044-020-02616-2openalex-snapshot

Design, synthesis, and biological evaluation of 1-(5-(benzylthio)-1,3,4-thiadiazol-2-yl)-3-phenylurea derivatives as anticancer agents

inferred← citeshttps://doi.org/10.1007/s00044-020-02683-5openalex-snapshot

Design, synthesis, docking study and urease inhibitory activity evaluation of novel 2-((5-amino-1,3,4-thiadiazol-2-yl)thio)-N-arylacetamide derivatives

inferred← citeshttps://doi.org/10.1007/s00289-022-04243-wopenalex-snapshot

Investigation of properties and applications of ZnO polymer nanocomposites

inferred← citeshttps://doi.org/10.1007/s00706-019-02478-4openalex-snapshot

Synthesis, molecular docking, antimicrobial evaluation, and DNA cleavage assay of new thiadiazole/oxadiazole ciprofloxacin derivatives

inferred← citeshttps://doi.org/10.1007/s00706-020-02686-3openalex-snapshot

Design, synthesis, and biological evaluation of new quinoline-based heterocyclic derivatives as novel antibacterial agents

inferred← citeshttps://doi.org/10.1007/s00894-021-04706-3openalex-snapshot

Unveiling the molecular mechanisms of the cycloaddition reactions of aryl hetaryl thioketones and C,N-disubstituted nitrilimines

inferred← citeshttps://doi.org/10.1007/s10337-019-03794-xopenalex-snapshot

Development and Validation of a New HPLC Method for Quantification of a Novel Antifungal Drug Based on 1,3,4-Thiadiazole and its Impurities

inferred← citeshttps://doi.org/10.1007/s10593-018-2199-9openalex-snapshot

Synthesis of 2-polyfluoroalkyl-2,3-dihydro-1,3,4-thiadiazoles via regioselective [3+2] cycloaddition of nitrile imines to polyfluoroalkanethioamides

inferred← citeshttps://doi.org/10.1007/s10593-024-03298-zopenalex-snapshot

Discovery of indole-3-acetic acid derivatives containing 1,3,4-thiadiazole thioether and amide moieties as novel antibacterial agents

inferred← citeshttps://doi.org/10.1007/s10593-024-03317-zopenalex-snapshot

3-Spiroandrostene-substituted 1,3,4-thiadiazolines

inferred← citeshttps://doi.org/10.1007/s10616-016-9979-9openalex-snapshot

Synthesis and evaluation of selected 1,3,4-oxadiazole derivatives for in vitro cytotoxicity and in vivo anti-tumor activity

inferred← citeshttps://doi.org/10.1007/s10658-018-1441-8openalex-snapshot

Effect of altering the steric hindrance of the nitrogen atom in 2,5-bis(pyridin-n-yl)-1,3,4 thiadiazole isomers on their ability to elicit tomato defense responses against Verticillium wilt and crown gall diseases

inferred← citeshttps://doi.org/10.1007/s10863-023-09982-7openalex-snapshot

In vitro evaluation of 2-(1H-pyrazol-1-yl)-1,3,4-thiadiazole derivatives against replicative and infective stages of Trypanosoma cruzi

inferred← citeshttps://doi.org/10.1007/s10973-024-13498-6openalex-snapshot

Thermodynamic study on the relative stability of 2-amino-1,3,4-thiadiazole and two alkyl-substituted aminothiadiazoles

inferred← citeshttps://doi.org/10.1007/s11030-018-9832-5openalex-snapshot

Synthesis, docking and anticancer activity of azo-linked hybrids of 1,3,4-thia-/oxadiazoles with cyclic imides

inferred← citeshttps://doi.org/10.1007/s11030-018-9851-2openalex-snapshot

Synthesis of new chiral 1,3,4-thiadiazole-based di- and tri-arylsulfonamide residues and evaluation of in vitro anti-HIV activity and cytotoxicity

inferred← citeshttps://doi.org/10.1007/s11030-019-09981-0openalex-snapshot

A synthesis of N-(1H-pyrazol-5-yl)-1,3,4-thiadiazol-2(3H)-imines from nitrile imines and Erlenmeyer thioazlactones

inferred← citeshttps://doi.org/10.1007/s11030-023-10761-0openalex-snapshot

An efficient eco-friendly, simple, and green synthesis of some new spiro-N-(4-sulfamoyl-phenyl)-1,3,4-thiadiazole-2-carboxamide derivatives as potential inhibitors of SARS-CoV-2 proteases: drug-likeness, pharmacophore, molecular docking, and DFT exploration

inferred← citeshttps://doi.org/10.1007/s11030-023-10778-5openalex-snapshot

Synthesis, biological evaluation and molecular docking studies of novel 1,3,4-thiadiazoles as potential anticancer agents and human carbonic anhydrase inhibitors

inferred← citeshttps://doi.org/10.1007/s11224-022-02052-5openalex-snapshot

Cluster formation between an oxadiazole derivative with metal nanoclusters (Ag/Au/Cu), graphene quantum dot sheets, SERS studies, and solvent effects

inferred← citeshttps://doi.org/10.1007/s11696-024-03551-xopenalex-snapshot

Modification of acetazolamide synthesis: new derivatives and investigation of their biological properties

inferred← citeshttps://doi.org/10.1007/s12010-022-04099-wopenalex-snapshot

Oxygen- and Sulphur-Containing Heterocyclic Compounds as Potential Anticancer Agents

inferred← citeshttps://doi.org/10.1007/s13721-026-00854-9openalex-snapshot

Multi-target analysis of 1,3,4-thiadiazolyl-thiazolidine-2,4-dione derivatives for type 2 diabetes mellitus: an integrated network pharmacology and molecular simulation study

inferred← citeshttps://doi.org/10.1007/s13738-024-02991-2openalex-snapshot

Synthesis, antimicrobial evaluation, and measurement of physical and thermo-acoustical parameters of novel 1,3,4-thiadiazole and benzo[d]imidazole scaffolds by ultrasonic studies

inferred← citeshttps://doi.org/10.1007/s40203-024-00222-3openalex-snapshot

Elucidating the structural basis for the enhanced antifungal activity of amide derivative against Candida albicans: a comprehensive computational investigation

inferred← citeshttps://doi.org/10.1007/s42250-018-00034-xopenalex-snapshot

Synthesis, Cytotoxicity and Antimicrobial Evaluation of Some New 2-Aryl,5-Substituted 1,3,4-Oxadiazoles and 1,3,4-Thiadiazoles

inferred← citeshttps://doi.org/10.1007/s42250-025-01369-yopenalex-snapshot

Minireview of Synthesis Process of 1,3,4-Thiadiazole Derivatives

inferred← citeshttps://doi.org/10.1016/b978-0-08-102779-0.00005-8openalex-snapshot

Azoles and related derivatives

inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.14880-2openalex-snapshot

1,3,4-Thiadiazoles

inferred← citeshttps://doi.org/10.1016/b978-0-323-90596-1.00009-2openalex-snapshot

Azole-based organometallic compounds as bioactive agents

inferred← citeshttps://doi.org/10.1016/b978-0-443-15644-1.00005-5openalex-snapshot

Caspase-3: A promising target for anticancer agents

inferred← citeshttps://doi.org/10.1016/b978-0-443-33106-0.00001-2openalex-snapshot

Benzimidazole, benzothiazole, and benzoxazole derivatives as potential anticancer agents

inferred← citeshttps://doi.org/10.1016/b978-0-443-33106-0.00004-8openalex-snapshot

Azoles (triazole and imidazole) scaffolds in anticancer drug design

inferred← citeshttps://doi.org/10.1016/b978-0-443-33106-0.00005-xopenalex-snapshot

Three and four-member nitrogen-containing heterocyclic compounds as anticancer agents

inferred← citeshttps://doi.org/10.1016/b978-0-443-33106-0.00007-3openalex-snapshot

REMOVED: Indole scaffolds in anticancer drug discovery

inferred← citeshttps://doi.org/10.1016/b978-0-443-33106-0.00008-5openalex-snapshot

Miscellaneous fused heterocyclic compounds (β-lactam derivatives, carbazoles, isatin derivatives, pyrrolo-benzodiazepines, pyrido[2,3-d] pyrimidine derivatives) as anticancer compounds

inferred← citeshttps://doi.org/10.1016/bs.aihch.2015.04.002openalex-snapshot

The Literature of Heterocyclic Chemistry, Part XIII, 2012–2013

inferred← citeshttps://doi.org/10.1016/j.arabjc.2021.103053openalex-snapshot

1,3,4-Thiadiazoline−coumarin hybrid compounds containing D-glucose/D-galactose moieties: Synthesis and evaluation of their antiproliferative activity

inferred← citeshttps://doi.org/10.1016/j.bbamem.2025.184432openalex-snapshot

An advanced spectroscopic and crystallographic study on a synergistic composition of a 1,3,4-thiadiazole derivative and amphotericin B, in model biological liposomal system

inferred← citeshttps://doi.org/10.1016/j.bcab.2019.101117openalex-snapshot

In vitro antileishmanial and antioxidant potential, cytotoxicity evaluation and phytochemical analysis of extracts from selected medicinally important plants

inferred← citeshttps://doi.org/10.1016/j.bioorg.2021.105210openalex-snapshot

Multicomponent reaction for the synthesis of new 1,3,4-thiadiazole-thiazolidine-4-one molecular hybrids as promising antidiabetic agents through α-glucosidase and α-amylase inhibition

inferred← citeshttps://doi.org/10.1016/j.bioorg.2025.108243openalex-snapshot

Novel carbazole-thiadiazole derivatives as α-amylase and α-glucosidase inhibitors: Design, biological evaluation, and computational insights

inferred← citeshttps://doi.org/10.1016/j.bioorg.2025.108319openalex-snapshot

Thiourea compounds as multifaceted bioactive agents in medicinal chemistry

inferred← citeshttps://doi.org/10.1016/j.bioorg.2026.110319openalex-snapshot

Design, robust synthesis, and anti-liver cancer activity of 2-hydrazono-5-acetyl-[1,3,4]thiadiazole and N′-ethylideneethanethiohydrazide derivatives: In vitro, gene expression, DNA damage, and DNA fragmentation

inferred← citeshttps://doi.org/10.1016/j.bmc.2017.01.022openalex-snapshot

A continuous flow synthesis and derivatization of 1,2,4-thiadiazoles

inferred← citeshttps://doi.org/10.1016/j.bmc.2017.05.005openalex-snapshot

Potential inhibitors of human carbonic anhydrase isozymes I and II: Design, synthesis and docking studies of new 1,3,4-thiadiazole derivatives

inferred← citeshttps://doi.org/10.1016/j.bmc.2018.08.004openalex-snapshot

5-Adamantan thiadiazole-based thiazolidinones as antimicrobial agents. Design, synthesis, molecular docking and evaluation

inferred← citeshttps://doi.org/10.1016/j.bmc.2020.115585openalex-snapshot

Synthetic and therapeutic perspectives of nitrogen containing heterocycles as anti-convulsants

inferred← citeshttps://doi.org/10.1016/j.bmc.2024.117876openalex-snapshot

Advancing drug discovery: Thiadiazole derivatives as multifaceted agents in medicinal chemistry and pharmacology

inferred← citeshttps://doi.org/10.1016/j.bmcl.2016.04.094openalex-snapshot

Synthesis and biological activities of novel 1,3,4-thiadiazole-containing pyrazole oxime derivatives

inferred← citeshttps://doi.org/10.1016/j.bmcl.2017.07.003openalex-snapshot

Synthesis, antioxidant and antiproliferative activities of 1,3,4-thiadiazoles derived from phenolic acids

inferred← citeshttps://doi.org/10.1016/j.bmcl.2017.07.015openalex-snapshot

Synthesis and in vitro antiproliferative activities of (5-aryl-1,2,4-oxadiazole-3-yl) methyl d-ribofuranosides

inferred← citeshttps://doi.org/10.1016/j.cdc.2019.100243openalex-snapshot

Influence of temperature and solvents on the molecular interactions of Benzotriazole substituted 1,3,4-thiadiazole derivatives

inferred← citeshttps://doi.org/10.1016/j.cdc.2022.100962openalex-snapshot

2,6-disubstituted imidazothiadiazole 5-carbaldehyde: Synthesis, crystal structure elucidation and in-silico studies

inferred← citeshttps://doi.org/10.1016/j.comptc.2022.113978openalex-snapshot

A ratiometric fluorescent probe 4-(benzothiazol-2-yl)-2-hydroxy benzaldehyde for detecting malononitrile: Theoretical investigation on the ICT and ESIPT mechanism

inferred← citeshttps://doi.org/10.1016/j.cplett.2018.10.014openalex-snapshot

Engineering and design of simple models from dye-sensitive of solar cells and photovoltaic cells applications: Theoretical study

inferred← citeshttps://doi.org/10.1016/j.dyepig.2019.108034openalex-snapshot

Colorimetric analysis of malononitrile via the formation of a novel NBD-based CH-acidic dye

inferred← citeshttps://doi.org/10.1016/j.dyepig.2020.108859openalex-snapshot

Ratiometric fluorescent strategy for malononitrile determination in organic and aqueous medium and biological imaging

inferred← citeshttps://doi.org/10.1016/j.dyepig.2023.111721openalex-snapshot

Alternative and one-pot synthesis of new conjugated 5-aryl-1,3,4-thiadiazole azo dyes

inferred← citeshttps://doi.org/10.1016/j.ecoenv.2020.110544openalex-snapshot

Thyroid-disrupting effects and mechanism of thiazole-Zn-induced thyroid cell hypertrophy and hyperplasia in male Sprague-Dawley rats

inferred← citeshttps://doi.org/10.1016/j.ejmech.2015.05.010openalex-snapshot

Efficient access to novel androsteno-17-(1′,3′,4′)-oxadiazoles and 17β-(1′,3′,4′)-thiadiazoles via N-substituted hydrazone and N,N′-disubstituted hydrazine intermediates, and their pharmacological evaluation in vitro

inferred← citeshttps://doi.org/10.1016/j.ejmech.2016.01.058openalex-snapshot

Synthesis and biological evaluation of D-ring fused 1,2,3-thiadiazole dehydroepiandrosterone derivatives as antitumor agents

inferred← citeshttps://doi.org/10.1016/j.ejmech.2016.06.044openalex-snapshot

Natural product-inspired rational design, synthesis and biological evaluation of 2,3-dihydropyrano[2,3- f ]chromen-4(8 H )-one based hybrids as potential mitochondrial apoptosis inducers

inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.04.025openalex-snapshot

Synthetic heterocyclic candidates as promising α-glucosidase inhibitors: An overview

inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.113070openalex-snapshot

4-(3H)-quinazolinones N-3 substituted with a five membered heterocycle: A promising scaffold towards bioactive molecules

inferred← citeshttps://doi.org/10.1016/j.ejmech.2021.113322openalex-snapshot

2,5-Disubstituted furan derivatives containing 1,3,4-thiadiazole moiety as potent α-glucosidase and E. coli β-glucuronidase inhibitors

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.139590openalex-snapshot

Cys44 of SARS-CoV-2 3CLpro affects its catalytic activity

inferred← citeshttps://doi.org/10.1016/j.jare.2016.09.001openalex-snapshot

A review on bis-hydrazonoyl halides: Recent advances in their synthesis and their diverse synthetic applications leading to bis-heterocycles of biological interest

inferred← citeshttps://doi.org/10.1016/j.jct.2019.03.015openalex-snapshot

Solubility and vapor pressure data of bioactive 6-(acetylamino)-N-(5-ethyl-1,3,4-thiadiazol-2-yl) hexanamide

inferred← citeshttps://doi.org/10.1016/j.jct.2024.107423openalex-snapshot

Thermochemical investigation of three 5-R-thio-1,3,4-thiadiazole derivatives: R = methyl, ethyl

inferred← citeshttps://doi.org/10.1016/j.jfluchem.2020.109702openalex-snapshot

Highly fluorinated 2,3-dihydro-1,3,4-thiadiazole derivatives via [3+2]-cycloadditions of tertiary thioamides with nitrile imines derived from trifluoroacetonitrile

inferred← citeshttps://doi.org/10.1016/j.jics.2026.102694openalex-snapshot

Design, synthesis and biological evaluation of 1,3,4-thiadiazole–benzenesulfonamide derivatives

inferred← citeshttps://doi.org/10.1016/j.jmgm.2026.109420openalex-snapshot

Structure-based design and molecular modelling of n-propylcarbazole–1,3-thiazole hybrids as potent α-glucosidase inhibitors: Kinetic, in vitro, and in vivo evaluation

inferred← citeshttps://doi.org/10.1016/j.jscs.2020.101195openalex-snapshot

Novel 1,3,4-bisthiadiazoline derivatives: Syntheses, in-vitro antimicrobial and antioxidant studies

inferred← citeshttps://doi.org/10.1016/j.jsps.2024.101962openalex-snapshot

Synthesis of tetrazole hybridized with thiazole, thiophene or thiadiazole derivatives, molecular modelling and antimicrobial activity

inferred← citeshttps://doi.org/10.1016/j.matchemphys.2021.125057openalex-snapshot

A first-principles study of thiadiazole and dimercapto-thiadiazole adsorption on copper and silver surfaces

inferred← citeshttps://doi.org/10.1016/j.mencom.2021.09.029openalex-snapshot

Bond orders and electron delocalization indices for S–N, S–C and S–S bonds in 1,2,3-dithiazole systems

inferred← citeshttps://doi.org/10.1016/j.molliq.2021.116534openalex-snapshot

Inhibitive and adsorption behavior of new thiazoldinone derivative as a corrosion inhibitor at mild steel/electrolyte interface: Experimental and theoretical studies

inferred← citeshttps://doi.org/10.1016/j.molliq.2021.117265openalex-snapshot

Heterocyclic biomolecules as green corrosion inhibitors

inferred← citeshttps://doi.org/10.1016/j.molliq.2023.122904openalex-snapshot

Thiadiazoles as potent inhibitors against corrosion of metals and alloys: Challenges and future prospects

inferred← citeshttps://doi.org/10.1016/j.molstruc.2016.01.045openalex-snapshot

Novel 2-amino-1,3,4-thiadiazoles and their acyl derivatives: Synthesis, structural characterization, molecular docking studies and comparison of experimental and computational results

inferred← citeshttps://doi.org/10.1016/j.molstruc.2019.04.039openalex-snapshot

Synthesis of novel Azol-β-lactam derivatives starting from phenyl piperazine and investigation of their antiurease activity and antioxidant capacity comparing with their molecular docking studies

inferred← citeshttps://doi.org/10.1016/j.molstruc.2019.127470openalex-snapshot

New 1,3,4-thiadiazoles based on thiophene-2-carboxylic acid: Synthesis, characterization, and antimicrobial activities

inferred← citeshttps://doi.org/10.1016/j.molstruc.2020.128570openalex-snapshot

Antiproliferative-antimicrobial properties and structural analysis of newly synthesized Schiff bases derived from some 1,3,4-thiadiazole compounds

inferred← citeshttps://doi.org/10.1016/j.molstruc.2021.130156openalex-snapshot

Synthesis and X-ray crystal structure of unexpected novel thiazolidinone/1,3,4-thiadiazole heterocycle via S-alkylation and Smiles rearrangement dual approaches

inferred← citeshttps://doi.org/10.1016/j.molstruc.2021.132228openalex-snapshot

Mechanistic elucidation and prediction of the anticancer activity of 1,3,4-thiadiazol-2-amide derivatives

inferred← citeshttps://doi.org/10.1016/j.molstruc.2022.133586openalex-snapshot

Zinc(II) catalyzed synthesis of 2-(4-methoxyphenyl)-5-(2-pyridyl)-1,3,4-thiadiazole: Characterizations, crystal structure, DFT calculation, Hirshfeld surface analysis, and molecular docking analysis

inferred← citeshttps://doi.org/10.1016/j.molstruc.2022.133629openalex-snapshot

Synthesis, antimicrobial activity and 3D-QSAR study of novel 5-substituted-1,3,4-thiadiazole Schiff base derivatives

inferred← citeshttps://doi.org/10.1016/j.molstruc.2022.134161openalex-snapshot

Studies on New Imidazo[2,1-b][1,3,4]thiadiazole Derivatives: Molecular Structure, Quantum Chemical Computational, and In silico Study of Inhibitory Activity Against Pim-1 Protein by using Molecular Modelling Methods and ADMET Profiling

inferred← citeshttps://doi.org/10.1016/j.molstruc.2022.134339openalex-snapshot

Synthesis, in-vitro α-glucosidase inhibition and molecular docking studies of 1,3,4-thiadiazole-5,6-diphenyl-1,2,4-triazine hybrids: Potential leads in the search of new antidiabetic drugs

inferred← citeshttps://doi.org/10.1016/j.molstruc.2023.135087openalex-snapshot

Synthesis and characterization of two new 2,5-bis-cycloalkylsulfanyl-[1,3,4]thiadiazoles and study of the crystal structure, thermal behavior, and biological activities compared with bismuthiol

inferred← citeshttps://doi.org/10.1016/j.molstruc.2023.135616openalex-snapshot

Recent developments in the synthesis of hybrid heterocycles, a promising approach to develop multi-target antibacterial agents

inferred← citeshttps://doi.org/10.1016/j.molstruc.2024.138339openalex-snapshot

Molecular hybrids based on 1,2,3-triazole and 1,3,4-thiadiazole cores: Synthesis, characterization, anticancer activity and in silico study

inferred← citeshttps://doi.org/10.1016/j.molstruc.2024.141209openalex-snapshot

Naphthofuran-triazoles as effective templates for bacterial tyrosinase inhibition: BTEAC catalyzed ultrasound assisted synthesis, in vitro biological evaluation and in silico validation

inferred← citeshttps://doi.org/10.1016/j.molstruc.2025.142141openalex-snapshot

Synthetic strategies, biological and computational screening of thiadiazole bearing benzothiazole derivatives as prospective anti-diabetic agents

inferred← citeshttps://doi.org/10.1016/j.molstruc.2025.142332openalex-snapshot

Synthesis, characterization and biological evaluation of new thiadiazole derivatives: Antibacterial, antifungal, antioxidant, anticancer, simulation studies

inferred← citeshttps://doi.org/10.1016/j.molstruc.2025.143828openalex-snapshot

Rational design, synthesis, and antibacterial evaluation of novel coumarin-1,3,4-thiadiazole Schiff base hybrids against multidrug-resistant bacteria: An in vitro, in silico and DFT studies

inferred← citeshttps://doi.org/10.1016/j.molstruc.2025.144625openalex-snapshot

Synthesis of novel thiazole-tagged thiadiazole: In vitro and in silico potential lead in the search of anti-diabetic drugs

inferred← citeshttps://doi.org/10.1016/j.molstruc.2026.145427openalex-snapshot

CuII complexes with N-(5-(methylthio)-1,3,4-thiadiazol-2-yl)benzamides: Synthesis, characterization and biological evaluation

inferred← citeshttps://doi.org/10.1016/j.molstruc.2026.145513openalex-snapshot

2-Methyl-4-nitrophenoxy based thiosemicarbazide, 1,2,4-triazole and 1,3,4-thiadiazole compounds as multitarget enzyme inhibitors: Synthesis, biological and computational studies

inferred← citeshttps://doi.org/10.1016/j.nxmate.2026.101794openalex-snapshot

Recent advancements in the chemistry of 1,3,4-Thiadiazole ring-containing azo dyes

inferred← citeshttps://doi.org/10.1016/j.pestbp.2017.10.002openalex-snapshot

Copper complexes of the 1,3,4-thiadiazole derivatives modulate antioxidant defense responses and resistance in tomato plants against fungal and bacterial diseases

inferred← citeshttps://doi.org/10.1016/j.poly.2024.117259openalex-snapshot

Synthesis, characterization and computational studies of the triangle shape complex of silver nitrate with 2-amino-1,3,4-thiadiazole

inferred← citeshttps://doi.org/10.1016/j.rechem.2020.100045openalex-snapshot

Synthesis, docking and biological evaluation of thiadiazole and oxadiazole derivatives as antimicrobial and antioxidant agents

inferred← citeshttps://doi.org/10.1016/j.rechem.2023.101303openalex-snapshot

Synthesis and in-silico studies of 4-(5-(2-(4-(5-aryl-1,2,4-thiadiazol-3-yl)phenyl)-1H-imidazol-4-yl)-1,3,4-thiadiazol-2-yl)pyridines

inferred← citeshttps://doi.org/10.1016/j.rechem.2026.103301openalex-snapshot

Synthesis, characterization, molecular docking study, and preliminary anticancer study of a novel ligand: 4-(4-(quinolin-8-yloxy)-1, 2, 5-thiadiazol-3-yl) morpholine

inferred← citeshttps://doi.org/10.1016/j.saa.2014.07.100openalex-snapshot

Adsorption and trace detection of pharmacologically significant 5-methylthio-1, 3, 4-thiadiazole-2-thiol molecule adsorbed on silver nanocolloids and understanding the role of Albrecht’s “A” and Herzberg–Teller contributions in the SERS spectra

inferred← citeshttps://doi.org/10.1016/j.saa.2014.08.146openalex-snapshot

A novel series of thiosemicarbazone drugs: From synthesis to structure

inferred← citeshttps://doi.org/10.1016/j.saa.2015.09.005openalex-snapshot

Synthesis and multi-spectroscopic DNA binding study of 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives of fatty acid

inferred← citeshttps://doi.org/10.1016/j.saa.2021.120135openalex-snapshot

A novel ratiometric fluorescent chemosensor for detecting malononitrile and application assisted with smartphone

inferred← citeshttps://doi.org/10.1016/j.saa.2024.124476openalex-snapshot

Comprehensive investigations of four ratiometric fluorescent chemosensors based on 4-(1H-imidazol-2-yl)benzaldehyde skeleton for malononitrile detection

inferred← citeshttps://doi.org/10.1016/j.steroids.2017.08.016openalex-snapshot

Synthesis and evaluation of antitumor, anti-inflammatory and analgesic activity of novel deoxycholic acid derivatives bearing aryl- or hetarylsulfanyl moieties at the C-3 position

inferred← citeshttps://doi.org/10.1016/j.tet.2017.02.042openalex-snapshot

One-pot synthesis of 1,3,4-thiadiazoles using Vilsmeier reagent as a versatile cyclodehydration agent

inferred← citeshttps://doi.org/10.1016/j.tetlet.2015.02.027openalex-snapshot

Reactions of 5-substituted 1,3,4-thiadiazole-2-thiones with chloroacetylenephosphonates

inferred← citeshttps://doi.org/10.1016/j.tetlet.2020.152195openalex-snapshot

A KHSO4 promoted tandem synthesis of 1,3,4-thiadiazoles from thiohydrazides and DMF derivatives

inferred← citeshttps://doi.org/10.1021/acs.chemmater.0c03975openalex-snapshot

Structural Engineering in Polymer Semiconductors with Aromatic N-Heterocycles

inferred← citeshttps://doi.org/10.1021/acs.inorgchem.2c03250openalex-snapshot

Thiol-Reactive Arylsulfonate Masks for Phenolate Donors in Antiproliferative Iron Prochelators

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6c00742openalex-snapshot

Gut Bacterial β-Glucuronidase Blockade by 1,3,4-Thiadiazole-Containing Thioester Inhibitors Mitigates Irinotecan-Induced Gastrointestinal Toxicity

inferred← citeshttps://doi.org/10.1021/acs.joc.3c00320openalex-snapshot

Chemodivergent Photocatalyzed Heterocyclization of Hydrazones and Isothiocyanates for the Selectivity Synthesis of 2-Amino-1,3,4-thiadiazoles and 1,2,4-Triazole-3-thiones

inferred← citeshttps://doi.org/10.1021/acs.joc.3c01822openalex-snapshot

Anion-Driven C–F Bond Activation of Trifluoromethyl N-Aryl Hydrazones: Application to the Synthesis of 1,3,4-Oxadiazoles

inferred← citeshttps://doi.org/10.1021/acs.joc.5c01886openalex-snapshot

A Three-Component Path to Amino Thiadiazoles and Amino Oxadiazoles via a Nitrilium Ylide

inferred← citeshttps://doi.org/10.1021/acs.jpca.5b06475openalex-snapshot

Spectroscopic Studies of Dual Fluorescence in 2-((4-Fluorophenyl)amino)-5-(2,4-dihydroxybenzeno)-1,3,4-thiadiazole

inferred← citeshttps://doi.org/10.1021/acs.jpcb.6b09371openalex-snapshot

Molecular Organization of Dipalmitoylphosphatidylcholine Bilayers Containing Bioactive Compounds 4-(5-Heptyl-1,3,4-thiadiazol-2-yl) Benzene-1,3-diol and 4-(5-Methyl-1,3,4-thiadiazol-2-yl) Benzene-1,3-diols

inferred← citeshttps://doi.org/10.1021/acs.oprd.9b00495openalex-snapshot

Development of a Scalable Route for a Key Thiadiazole Building Block via Sequential Sandmeyer Bromination and Room-Temperature Suzuki–Miyaura Coupling

inferred← citeshttps://doi.org/10.1021/acs.orglett.0c01393openalex-snapshot

Synthesis of 2-Imino-1,3,4-thiadiazoles from Hydrazides and Isothiocyanates via Sequential Oxidation and P(NMe 2 ) 3 -Mediated Annulation Reactions

inferred← citeshttps://doi.org/10.1021/acs.orglett.6b02583openalex-snapshot

Multicomponent Coupling Reactions of Two N -Tosyl Hydrazones and Elemental Sulfur: Selective Denitrogenation Pathway toward Unsymmetric 2,5-Disubstituted 1,3,4-Thiadiazoles

inferred← citeshttps://doi.org/10.1021/acsami.4c14030openalex-snapshot

Impact of Postsynthetic Modification on the Covalent Organic Framework (COF) Structures

inferred← citeshttps://doi.org/10.1021/acschemneuro.4c00329openalex-snapshot

Comparison of Neurogenesis Promotion Effects between Cinnamoylquinic Acids in Neural Stem Cells from Adult Mice Brains

inferred← citeshttps://doi.org/10.1021/acscombsci.8b00044openalex-snapshot

Current Parallel Solid-Phase Synthesis of Drug-like Oxadiazole and Thiadiazole Derivatives for Combinatorial Chemistry

inferred← citeshttps://doi.org/10.1021/acsomega.2c04252openalex-snapshot

Structural and Energetic Properties of Weak Noncovalent Interactions in Two Closely Related 3,6-Disubstituted-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole Derivatives: In Vitro Cyclooxygenase Activity, Crystallography, and Computational Investigations

inferred← citeshttps://doi.org/10.1021/acsomega.3c05854openalex-snapshot

New 1,3,4-Thiadiazole Derivatives as α-Glucosidase Inhibitors: Design, Synthesis, DFT, ADME, and In Vitro Enzymatic Studies

inferred← citeshttps://doi.org/10.1021/acsomega.5c01251openalex-snapshot

Halicin Reduces the Warburg Effect and Overcomes Drug Resistance by Activating the Pyruvate Kinase M2 Pathway for Triple-Negative Breast Cancer Treatment

inferred← citeshttps://doi.org/10.1021/acsomega.5c05103openalex-snapshot

Design, Synthesis, In Vitro Evaluation, Multitargeted Molecular Docking, and In Silico Analysis of Some Azo-Linked 1,3,4-Thiadiazole and 1,2,4-Triazole Heterocyclic Hybrids as Potent Antitubercular Agents

inferred← citeshttps://doi.org/10.1021/acsomega.5c07621openalex-snapshot

Influence of Available Hydrophobic Interactions in New 2-(Propylthio)- N -(1,3,4-thiadiazol-2-yl)nicotinamide Pharmacophore and Evaluation of Its Therapeutic Potential

inferred← citeshttps://doi.org/10.1021/acsomega.5c07709openalex-snapshot

Reactions of Nitrile Imines with Thiohydantoin Derivatives: Unexpected Chemoselectivity of the 1,3-Dipolar Cycloaddition: Preferential Addition of C=C rather than C=S Bonds

inferred← citeshttps://doi.org/10.1021/jo502518copenalex-snapshot

Synthesis of 2-Amino-1,3,4-oxadiazoles and 2-Amino-1,3,4-thiadiazoles via Sequential Condensation and I2-Mediated Oxidative C–O/C–S Bond Formation

inferred← citeshttps://doi.org/10.1038/s41467-025-61359-zopenalex-snapshot

Chemoselective synthesis of 1,3,4-thiadiazoles from acyl hydrazines and nitroalkanes using elemental sulfur

inferred← citeshttps://doi.org/10.1038/s41598-019-49425-1openalex-snapshot

Synergistic antifungal interactions of amphotericin B with 4-(5-methyl-1,3,4-thiadiazole-2-yl) benzene-1,3-diol

inferred← citeshttps://doi.org/10.1038/s41598-023-36252-8openalex-snapshot

Multi-method evaluation of a 2-(1,3,4-thiadiazole-2-yl)pyrrolidine corrosion inhibitor for mild steel in HCl: combining gravimetric, electrochemical, and DFT approaches

inferred← citeshttps://doi.org/10.1038/s41598-024-83180-2openalex-snapshot

Understanding the synergistic interaction between a 1,3,4-thiadiazole derivative and amphotericin B using spectroscopic and theoretical studies

inferred← citeshttps://doi.org/10.1038/srep20204openalex-snapshot

Synthesis and fungicidal activity of novel 2,5-disubstituted-1,3,4- thiadiazole derivatives containing 5-phenyl-2-furan

inferred← citeshttps://doi.org/10.1039/9781837674015-00163openalex-snapshot

Synthesis, Properties, and Biological Applications of 1,3,4-Thiadiazoles

inferred← citeshttps://doi.org/10.1039/9781837674015-part2openalex-snapshot

Thiadiazoles

inferred← citeshttps://doi.org/10.1039/c8md00316eopenalex-snapshot

Novel 1,3,4-thiadiazole–chalcone hybrids containing catechol moiety: synthesis, antioxidant activity, cytotoxicity and DNA interaction studies

inferred← citeshttps://doi.org/10.1039/d0nj02918aopenalex-snapshot

Unprecedented palladium( ii ) complex containing dipodal 1,3,4-thiadiazole derivatives: synthesis, structure, and biological and thermal investigations

inferred← citeshttps://doi.org/10.1039/d0ra00733aopenalex-snapshot

Quantitative assessment of the nature of noncovalent interactions in N -substituted-5-(adamantan-1-yl)-1,3,4-thiadiazole-2-amines: insights from crystallographic and QTAIM analysis

inferred← citeshttps://doi.org/10.1039/d1nj02550copenalex-snapshot

New N -(3′-acetyl-8-nitro-2,3-dihydro-1 H ,3′ H -spiro[quinoline-4,2′-[1,3,4]thiadiazol]-5′-yl) acetamides induced cell death in MCF-7 cells via G2/M phase cell cycle arrest

inferred← citeshttps://doi.org/10.1039/d3md00508aopenalex-snapshot

Synthesis, biological and molecular modelling for 1,3,4-thiadiazole sulfonyl thioureas: bacterial and fungal activity

inferred← citeshttps://doi.org/10.1039/d3nj01547eopenalex-snapshot

Design, synthesis, and in vitro and in silico studies of 1,3,4-thiadiazole-thiazolidinone hybrids as carbonic anhydrase inhibitors

inferred← citeshttps://doi.org/10.1039/d3ra00123gopenalex-snapshot

Novel asymmetrical azines appending 1,3,4-thiadiazole sulfonamide: synthesis, molecular structure analyses, in silico ADME, and cytotoxic effect

inferred← citeshttps://doi.org/10.1039/d3ra02528dopenalex-snapshot

Tail-approach based design, synthesis, and cytotoxic evaluation of novel disubstituted and trisubstituted 1,3-thiazole benzenesulfonamide derivatives with suggested carbonic anhydrase IX inhibition mechanism

inferred← citeshttps://doi.org/10.1039/d3ra02716copenalex-snapshot

New 1,3,4-thiadiazoles as potential anticancer agents: pro-apoptotic, cell cycle arrest, molecular modelling, and ADMET profile

inferred← citeshttps://doi.org/10.1039/d4cc06242fopenalex-snapshot

Silane-promoted cycloaddition of thiobenzhydrazides with carbon dioxide toward 1,3,4-thiadiazol-2(3 H )-ones

inferred← citeshttps://doi.org/10.1039/d4ra03005bopenalex-snapshot

Design, synthesis and potent anti-pancreatic cancer activity of new pyrazole derivatives bearing chalcone, thiazole and thiadiazole moieties: gene expression, DNA fragmentation, cell cycle arrest and SAR

inferred← citeshttps://doi.org/10.1039/d6cp01987kopenalex-snapshot

Solvent-controlled photodegradation pathways of a bioactive tetrazole–thiadiazole conjugate revealed by TDDFT, UV-Vis spectroscopy and LC-MS

inferred← citeshttps://doi.org/10.1039/d6ra06242copenalex-snapshot

Iodine/TBAB-promoted oxidative cyclization: an efficient approach to thiadiazoles

inferred← citeshttps://doi.org/10.1055/s-0043-1775386openalex-snapshot

Regio- and Chemoselective Synthesis of 4,6-Dithia-1,2,9-triazaspiro[4.4]non-2-en-8-ones through an Ultrasound-Promoted One-Pot Sequential Pseudo-Five-Component Reaction

inferred← citeshttps://doi.org/10.1055/s-0043-1775393openalex-snapshot

Design of Synthetic Strategies towards Sulfur Containing Scaffolds

inferred← citeshttps://doi.org/10.1055/s-0043-1775418openalex-snapshot

Efficient Synthesis of Benzoselenazoles and Benzothiazoles by an Ullmann Coupling of Dihalobenzenes with Acyl Iso(seleno/thio) cyanate–Malononitrile Adducts

inferred← citeshttps://doi.org/10.1063/5.0093814openalex-snapshot

Design, synthesis and evaluation in vitro antibacterial activity of new 1,2,3-triazole derivatives

inferred← citeshttps://doi.org/10.1063/5.0181971openalex-snapshot

Retraction: Microwave synthesis and antibacterial assay of new 1,3-thiazolidin-4-one derivatives based on 2-amino-5-mercapto-1,3,4-thiadiazole

inferred← citeshttps://doi.org/10.1063/5.0322665openalex-snapshot

Synthesis of new compounds containing β-lactam ring, derived from 4-methoxyaniline and study their antibacterial activity

inferred← citeshttps://doi.org/10.1080/00397911.2017.1416637openalex-snapshot

Synthesis and biological evaluation of some novel thiadiazole-benzofuran hybrids as potential antitumor agents

inferred← citeshttps://doi.org/10.1080/00397911.2019.1623257openalex-snapshot

A simple and efficient approach for the synthesis of a novel class aliphatic 1,3,4-thiadiazol-2(3H)-one derivatives via intramolecular nucleophilic substitution reaction

inferred← citeshttps://doi.org/10.1080/00397911.2020.1745843openalex-snapshot

Structural studies of 2,5-disubstituted 1,3,4-thiadiazole derivatives from dithioesters under the mild condition: Studies on antioxidant, antimicrobial activities, and molecular docking

inferred← citeshttps://doi.org/10.1080/00397911.2020.1843179openalex-snapshot

Synthesis, antimicrobial studies, and molecular docking of some new dihydro-1,3,4-thiadiazole and pyrazole derivatives derived from dithiocarbazates

inferred← citeshttps://doi.org/10.1080/00397911.2022.2149342openalex-snapshot

Visible-light-induced intramolecular C–S bond formation for practical synthesis of 2,5-disubstituted 1,3,4-thiadiazoles

inferred← citeshttps://doi.org/10.1080/00397911.2024.2422472openalex-snapshot

Synthesis and spectral characteristics of N -(2,2,2-trichloro-1-((5-(R-amino)-1,3,4-thiadiazol-2-yl)amino)ethyl)carboxamides

inferred← citeshttps://doi.org/10.1080/00958972.2021.1992401openalex-snapshot

Synthesis and characterization of the Co(II) and Ni(II) complexes of 1,3,4-thiadiazole-derived ketones and secondary alcohols: thermal and magnetic properties

inferred← citeshttps://doi.org/10.1080/02678292.2021.1900432openalex-snapshot

Synthesis and liquid crystalline studies of biphenylyl-1,3,4-thiadiazoles and diphenyl-1,3,4-thiadiazoles: influence of side chain semifluorination and lateral ring fluorination

inferred← citeshttps://doi.org/10.1080/07391102.2023.2203261openalex-snapshot

In silico study to recognize novel angiotensin-converting-enzyme-I inhibitors by 2D-QSAR and constraint-based molecular simulations

inferred← citeshttps://doi.org/10.1080/07391102.2023.2274967openalex-snapshot

Synthesis, characterization, molecular docking and molecular dynamics simulations of novel 2,5-disubstituted-1,3,4-thiadiazole derivatives as potential cholinesterase/monoamine oxidase dual inhibitors for Alzheimer’s disease

inferred← citeshttps://doi.org/10.1080/07391102.2023.2300125openalex-snapshot

Synthesis, molecular docking, and molecular dynamic simulation studies of new 1,3,4-thiadiazole derivatives as potential apoptosis inducers in A549 lung cancer cell line

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