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Mapping of inhibitors and activity data to the human kinome and exploring promiscuity from a ligand and target perspective

https://doi.org/10.1111/cbdd.12919
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/prot.21444openalex-snapshot
Classification and functional annotation of eukaryotic protein kinases
inferredcites →https://doi.org/10.1016/j.chembiol.2005.04.011openalex-snapshot
Features of Selective Kinase Inhibitors
inferredcites →https://doi.org/10.1016/j.coph.2013.02.008openalex-snapshot
Targeting kinases: a new approach to treating inflammatory rheumatic diseases
inferredcites →https://doi.org/10.1021/acs.jcim.6b00122openalex-snapshot
Unprecedently Large-Scale Kinase Inhibitor Set Enabling the Accurate Prediction of Compound–Kinase Activities: A Way toward Selective Promiscuity by Design?
inferredcites →https://doi.org/10.1021/cb300663jopenalex-snapshot
Strategies for the Selective Regulation of Kinases with Allosteric Modulators: Exploiting Exclusive Structural Features
inferredcites →https://doi.org/10.1021/ci3001138openalex-snapshot
MMP-Cliffs: Systematic Identification of Activity Cliffs on the Basis of Matched Molecular Pairs
inferredcites →https://doi.org/10.1021/ci900450mopenalex-snapshot
Computationally Efficient Algorithm to Identify Matched Molecular Pairs (MMPs) in Large Data Sets
inferredcites →https://doi.org/10.1021/jm400378wopenalex-snapshot
KLIFS: A Knowledge-Based Structural Database To Navigate Kinase–Ligand Interaction Space
inferredcites →https://doi.org/10.1021/jm401120gopenalex-snapshot
Recent Progress in Understanding Activity Cliffs and Their Utility in Medicinal Chemistry
inferredcites →https://doi.org/10.1021/jm5008159openalex-snapshot
Current Compound Coverage of the Kinome
inferredcites →https://doi.org/10.1021/jm9602928openalex-snapshot
The Properties of Known Drugs. 1. Molecular Frameworks
inferredcites →https://doi.org/10.1038/nchembio.1938openalex-snapshot
The ins and outs of selective kinase inhibitor development
inferredcites →https://doi.org/10.1038/nchembio.530openalex-snapshot
Navigating the kinome
inferredcites →https://doi.org/10.1038/nrc2787openalex-snapshot
Targeting the cancer kinome through polypharmacology
inferredcites →https://doi.org/10.1038/nrd773openalex-snapshot
Protein kinases — the major drug targets of the twenty-first century?
inferredcites →https://doi.org/10.1039/9781849733557openalex-snapshot
Kinase Drug Discovery
inferredcites →https://doi.org/10.1039/c2md20180aopenalex-snapshot
Approaches to discover non-ATP site kinase inhibitors
inferredcites →https://doi.org/10.1093/nar/gkp846openalex-snapshot
The Universal Protein Resource (UniProt) in 2010
inferredcites →https://doi.org/10.1093/nar/gkr777openalex-snapshot
ChEMBL: a large-scale bioactivity database for drug discovery
inferredcites →https://doi.org/10.1101/gr.1239303openalex-snapshot
Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks
inferredcites →https://doi.org/10.1126/science.1075762openalex-snapshot
The Protein Kinase Complement of the Human Genome
inferredcites →https://doi.org/10.1146/annurev-pharmtox-011112-140341openalex-snapshot
Tyrosine Kinase Inhibitors: Views of Selectivity, Sensitivity, and Clinical Performance
inferredcites →https://doi.org/10.1371/journal.pone.0126838openalex-snapshot
Quantifying the Tendency of Therapeutic Target Proteins to Bind Promiscuous or Selective Compounds
inferredcites →https://doi.org/10.1371/journal.pone.0153873openalex-snapshot
Determining the Degree of Promiscuity of Extensively Assayed Compounds
inferredcites →https://doi.org/10.7717/peerj.126openalex-snapshot
Kinome Render: a stand-alone and web-accessible tool to annotate the human protein kinome tree

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1002/ange.202011295openalex-snapshot
Fragment‐Bindung an die Kinase‐Scharnier‐Region: Wenn Ladungsverteilung und lokale pKa‐Verschiebungen etablierte Bioisosterie‐Konzepte fehlleiten
inferred← citeshttps://doi.org/10.1002/anie.202011295openalex-snapshot
Fragment Binding to Kinase Hinge: If Charge Distribution and Local pKa Shifts Mislead Popular Bioisosterism Concepts
inferred← citeshttps://doi.org/10.1002/minf.201700119openalex-snapshot
Protocols for the Design of Kinase‐focused Compound Libraries
inferred← citeshttps://doi.org/10.1007/s00044-019-02318-4openalex-snapshot
Synthesis and biological evaluation of phenyl-amino-pyrimidine and indole/oxindole conjugates as potential BCR-ABL inhibitors
inferred← citeshttps://doi.org/10.1016/bs.apcsb.2020.10.007openalex-snapshot
Structural studies of full-length receptor tyrosine kinases and their implications for drug design
inferred← citeshttps://doi.org/10.1016/j.cels.2018.07.001openalex-snapshot
Coral: Clear and Customizable Visualization of Human Kinome Data
inferred← citeshttps://doi.org/10.1016/j.drudis.2018.01.035openalex-snapshot
Progress with covalent small-molecule kinase inhibitors
inferred← citeshttps://doi.org/10.1016/j.ejmech.2024.116357openalex-snapshot
Discovery and optimization of narrow spectrum inhibitors of Tousled like kinase 2 (TLK2) using quantitative structure activity relationships
inferred← citeshttps://doi.org/10.1021/acs.jcim.7b00213openalex-snapshot
Kinase Crystal Miner: A Powerful Approach to Repurposing 3D Hinge Binding Fragments and Its Application to Finding Novel Bruton Tyrosine Kinase Inhibitors
inferred← citeshttps://doi.org/10.1021/acs.jcim.7b00729openalex-snapshot
Modeling Kinase Inhibition Using Highly Confident Data Sets
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.8b00049openalex-snapshot
How Selective Are Pharmacological Inhibitors of Cell-Cycle-Regulating Cyclin-Dependent Kinases?
inferred← citeshttps://doi.org/10.1039/c7ra07167aopenalex-snapshot
Promiscuity of inhibitors of human protein kinases at varying data confidence levels and test frequencies
inferred← citeshttps://doi.org/10.1080/17460441.2019.1654453openalex-snapshot
Dealing with frequent hitters in drug discovery: a multidisciplinary view on the issue of filtering compounds on biological screenings
inferred← citeshttps://doi.org/10.1158/0008-5472.c.6513231.v1openalex-snapshot
Data from Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5α Promotes Cancer Invasion and Tumor Growth
inferred← citeshttps://doi.org/10.1158/0008-5472.can-20-2383openalex-snapshot
Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5α Promotes Cancer Invasion and Tumor Growth
inferred← citeshttps://doi.org/10.3390/biom11081101openalex-snapshot
LRRK2 Targeting Strategies as Potential Treatment of Parkinson’s Disease
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