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Fingerprint‐based computational models of 5‐lipo‐oxygenase activating protein inhibitors: Activity prediction and structure clustering
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Applicability domain for in silico models to achieve accuracy of experimental measurements
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Molecular Docking and 3‐D QSAR Studies of Substituted 2,2‐Bisaryl‐Bicycloheptanes as Human 5‐Lipoxygenase‐Activating Protein (FLAP) Inhibitors
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In vitro pharmacology of BAY X1005, a new inhibitor of leukotriene synthesis
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Multiobjective evolutionary algorithms to identify highly autocorrelated areas: the case of spatial distribution in financially compromised farms
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Dual coordinate descent methods for logistic regression and maximum entropy models
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A pattern recognition approach to understanding the multi-layer perception
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Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP)
inferredcites →https://doi.org/10.1016/j.bmcl.2005.05.027openalex-snapshot
Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886
inferredcites →https://doi.org/10.1016/j.bmcl.2008.01.105openalex-snapshot
Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein
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5-Lipoxygenase-activating protein inhibitors. Part 2: 3-{5-((S)-1-Acetyl-2,3-dihydro-1H-indol-2-ylmethoxy)-3-tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-1H-indol-2-yl}-2,2-dimethyl-propionic acid (AM679)—A potent FLAP inhibitor
inferredcites →https://doi.org/10.1016/j.bmcl.2010.10.024openalex-snapshot
Potent and selective 5-LO inhibitor bearing benzothiophene pharmacophore: Discovery of MK-5286
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Evaluation of endo- and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors
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QSAR studies of the bioactivity of hepatitis C virus (HCV) NS3/4A protease inhibitors by multiple linear regression (MLR) and support vector machine (SVM)
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Discovery and optimization of oxadiazole-based FLAP inhibitors
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How important is to detect systematic error in predictions and understand statistical applicability domain of QSAR models?
inferredcites →https://doi.org/10.1016/j.drudis.2006.10.005openalex-snapshot
Similarity-based virtual screening using 2D fingerprints
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Drug discovery approaches targeting 5-lipoxygenase-activating protein (FLAP) for inhibition of cellular leukotriene biosynthesis
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A novel therapeutic potential of cysteinyl leukotrienes and their receptors modulation in the neurological complications associated with Alzheimer's disease
inferredcites →https://doi.org/10.1016/j.tips.2007.11.006openalex-snapshot
What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases
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Development of L-689,065 - the prototype of a new class of potent 5-lipoxygenase inhibitors
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A new class of leukotriene biosynthesis inhibitors: The discovery of MK0591
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Substituted indoles as potent and orally active 5-lipoxygenase activating protein (FLAP) inhibitors
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The role of leukotrienes in allergic rhinitis
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The Relative Importance of Domain Applicability Metrics for Estimating Prediction Errors in QSAR Varies with Training Set Diversity
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Topological torsion: a new molecular descriptor for SAR applications. Comparison with other descriptors
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Prediction ofn-Octanol/Water Partition Coefficients from PHYSPROP Database Using Artificial Neural Networks and E-State Indices
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Similarity to Molecules in the Training Set Is a Good Discriminator for Prediction Accuracy in QSAR
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QSAR − How Good Is It in Practice? Comparison of Descriptor Sets on an Unbiased Cross Section of Corporate Data Sets
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Applicability Domains for Classification Problems: Benchmarking of Distance to Models for Ames Mutagenicity Set
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Symmetrical Bis(heteroarylmethoxyphenyl)alkylcarboxylic Acids as Inhibitors of Leukotriene Biosynthesis
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5-Lipoxygenase-Activating Protein (FLAP) Inhibitors. Part 4: Development of 3-[3- tert -Butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1 H -indol-2-yl]-2,2-dimethylpropionic Acid (AM803), a Potent, Oral, Once Daily FLAP Inhibitor
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Synthesis, SAR, and Series Evolution of Novel Oxadiazole-Containing 5-Lipoxygenase Activating Protein Inhibitors: Discovery of 2-[4-(3-{(R)-1-[4-(2-Amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915)
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5-Lipoxygenase-Activating Protein Inhibitors: Development of 3-[3-tert-Butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic Acid (AM103)
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In Vitro Metabolism of 2-Acetylbenzothiophene: Relevance to Zileuton Hepatotoxicity
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The molecular mechanism of the inhibition by licofelone of the biosynthesis of 5‐lipoxygenase products
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Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening
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Eicosanoids: mediators and therapeutic targets in fibrotic lung disease
inferredcites →https://doi.org/10.1046/j.1525-1381.1999.t01-1-99242.xopenalex-snapshot
Asthma Therapy with Agents Preventing Leukotriene Synthesis or Action
inferredcites →https://doi.org/10.1073/pnas.81.3.689openalex-snapshot
Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 synthesis from arachidonic acid.
inferredcites →https://doi.org/10.1080/1062936x.2018.1513952openalex-snapshot
SAR and QSAR models of cyclooxygenase-1 (COX-1) inhibitors
inferredcites →https://doi.org/10.1080/13543776.2017.1276568openalex-snapshot
Novel leukotriene biosynthesis inhibitors (2012-2016) as anti-inflammatory agents
inferredcites →https://doi.org/10.1084/jem.185.6.1123openalex-snapshot
Collagen-induced Arthritis Is Reduced in 5-Lipoxygenase-activating Protein-deficient Mice
inferredcites →https://doi.org/10.1093/cvr/cvq016openalex-snapshot
The 5-lipoxygenase/leukotriene pathway in preclinical models of cardiovascular disease
inferredcites →https://doi.org/10.1093/nar/gkr777openalex-snapshot
ChEMBL: a large-scale bioactivity database for drug discovery
inferredcites →https://doi.org/10.1096/fj.201500210ropenalex-snapshot
5‐Lipoxygenase‐activating protein rescues activity of 5‐lipoxygenase mutations that delay nuclear membrane association and disrupt product formation
inferredcites →https://doi.org/10.1111/cts.12546openalex-snapshot
Initial Clinical Experience with AZD5718, a Novel Once Daily Oral 5‐Lipoxygenase Activating Protein Inhibitor
inferredcites →https://doi.org/10.1126/science.1144346openalex-snapshot
Crystal Structure of Inhibitor-Bound Human 5-Lipoxygenase-Activating Protein
inferredcites →https://doi.org/10.1136/ard.2009.127993openalex-snapshot
Relationship between bone marrow lesions, cartilage loss and pain in knee osteoarthritis: results from a randomised controlled clinical trial using MRI
inferredcites →https://doi.org/10.1139/y89-073openalex-snapshot
L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor
inferredcites →https://doi.org/10.1186/1758-2946-5-26openalex-snapshot
Open-source platform to benchmark fingerprints for ligand-based virtual screening
inferredcites →https://doi.org/10.1186/1758-2946-6-10openalex-snapshot
Cross-validation pitfalls when selecting and assessing regression and classification models
inferredcites →https://doi.org/10.1517/14728222.2014.945425openalex-snapshot
Targeting 5-lipoxygenase-activating protein in asthma and chronic obstructive pulmonary disease
inferredcites →https://doi.org/10.2174/157018011793663903openalex-snapshot
QSAR Study on 5-Lipoxygenase Activating Protein (FLAP) Inhibitors: The Derivatives of 2,2-Bisaryl-Bicycloheptane
inferredcites →https://doi.org/10.2174/187152809789352177openalex-snapshot
Targeting Leukotrienes for the Treatment of COPD?
inferredcites →https://doi.org/10.48550/arxiv.1201.0490openalex-snapshot
Scikit-learn: Machine Learning in Python
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