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A minireview of 1,2,3‐triazole hybrids with O‐heterocycles as leads in medicinal chemistry

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Concise synthesis and antibacterial evaluation of novel 3‐(1,4‐disubstituted‐1,2,3‐triazolyl)uridine nucleosides
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2‐Phenylquinoline–Sugar Hybrids as Photoswitchable α‐Glucosidase Inhibitors
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Synthesis, Cytotoxicity and Antimicrobial Evaluation of New Coumarin‐Tagged β‐Lactam Triazole Hybrid
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Design, Synthesis and Antifungal Activity of Benzofuran and Its Analogues
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Synthesis and In Vitro Anticancer Activity of Novel 1,3,4‐Oxadiazole‐Linked 1,2,3‐Triazole/Isoxazole Hybrids
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Quinolone–Triazole Hybrids and their Biological Activities
inferredcites →https://doi.org/10.1002/jhet.3475openalex-snapshot
Design, Synthesis, and Evaluation of Tetraethylene Glycol‐Tethered Isatin–1,2,3‐Triazole–Coumarin Hybrids as Novel Anticancer Agents
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Some Pharmaceutical Properties of Novobiocin **Received August 21, 1959, from Merck Sharp and Dohme Research Laboratories, West Point, Pa.
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Benzofuran‐2‐acetic esters as a new class of natural‐like herbicides
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Puerarin: A Review of Pharmacological Effects
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Millepachine showed novel antitumor effects in cisplatin‐resistant human ovarian cancer through inhibiting drug efflux function of ATP ‐binding cassette transporters
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Synthesis, Characterization, Antibacterial and Antioxidant Studies of Some Heterocyclic Compounds from Triazole‐Linked Chalcone Derivatives
inferredcites →https://doi.org/10.1002/slct.201801905openalex-snapshot
Synthesis and Antimalarial Evaluation of [1, 2,3]‐Triazole‐Tethered Sulfonamide‐Berberine Hybrids
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Bioactive 1,2,3‐Triazoles: An Account on their Synthesis, Structural Diversity and Biological Applications
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THEMATIC ISSUE ''HETEROCYCLIC COMPOUNDS IN MEDICINAL CHEMISTRY''
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Evaluation of triazole and isoxazole derivatives as potential anti-infective agents
inferredcites →https://doi.org/10.1007/s00436-018-6164-4openalex-snapshot
Anti-Trichomonas vaginalis activity of chalcone and amino-analogues
inferredcites →https://doi.org/10.1007/s10593-020-02711-7openalex-snapshot
Thematic issue “Heterocyclic Compounds in Medicinal Chemistry”
inferredcites →https://doi.org/10.1007/s10593-020-02724-2openalex-snapshot
Synthesis and antiproliferative activity of salicylidenehydrazones based on indole-2(3)-carboxylic acids
inferredcites →https://doi.org/10.1007/s11030-016-9710-yopenalex-snapshot
Synthesis and antimicrobial evaluation of ester-linked 1,4-disubstituted 1,2,3-triazoles with a furyl/thienyl moiety
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Synthesis and anti-inflammatory activity of novel triazole hybrids of (+)-usnic acid, the major dibenzofuran metabolite of the lichen Usnea longissima
inferredcites →https://doi.org/10.1007/s11030-018-9833-4openalex-snapshot
Synthesis and biological evaluation of novel flavone/triazole/benzimidazole hybrids and flavone/isoxazole-annulated heterocycles as antiproliferative and antimycobacterial agents
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Antiviral efficacy of pyrazofurin against selected rna viruses
inferredcites →https://doi.org/10.1016/j.arabjc.2015.10.004openalex-snapshot
Access to the substituted benzyl-1,2,3-triazolyl hesperetin derivatives expressing antioxidant and anticancer effects
inferredcites →https://doi.org/10.1016/j.bioorg.2017.01.010openalex-snapshot
Medicinal attributes of 1,2,3-triazoles: Current developments
inferredcites →https://doi.org/10.1016/j.bioorg.2018.01.016openalex-snapshot
Design, synthesis, characterization, antimicrobial evaluation and molecular modeling studies of some dehydroacetic acid-chalcone-1,2,3-triazole hybrids
inferredcites →https://doi.org/10.1016/j.bioorg.2018.03.005openalex-snapshot
Synthesis of some novel orcinol based coumarin triazole hybrids with capabilities to inhibit RANKL-induced osteoclastogenesis through NF-κB signaling pathway
inferredcites →https://doi.org/10.1016/j.bioorg.2018.03.032openalex-snapshot
New advances in synthesis and clinical aspects of pyrazolo[3,4-d]pyrimidine scaffolds
inferredcites →https://doi.org/10.1016/j.bioorg.2018.04.030openalex-snapshot
Novel 3-phenylcoumarin–lipoic acid conjugates as multi-functional agents for potential treatment of Alzheimer's disease
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Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity
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Novel tacrine-coumarin hybrids linked to 1,2,3-triazole as anti-Alzheimer’s compounds: In vitro and in vivo biological evaluation and docking study
inferredcites →https://doi.org/10.1016/j.bioorg.2019.103161openalex-snapshot
Synthesis and biological evaluation of bergenin-1,2,3-triazole hybrids as novel class of anti-mitotic agents
inferredcites →https://doi.org/10.1016/j.bioorg.2019.103206openalex-snapshot
Biscoumarin-1,2,3-triazole hybrids as novel anti-diabetic agents: Design, synthesis, in vitro α-glucosidase inhibition, kinetic, and docking studies
inferredcites →https://doi.org/10.1016/j.bioorg.2019.103505openalex-snapshot
Click chemistry synthesis, biological evaluation and docking study of some novel 2′-hydroxychalcone-triazole hybrids as potent anti-inflammatory agents
inferredcites →https://doi.org/10.1016/j.bioorg.2020.103839openalex-snapshot
Synthesis and carbonic anhydrase inhibition studies of sulfonamide based indole-1,2,3-triazole chalcone hybrids
inferredcites →https://doi.org/10.1016/j.bioorg.2020.104384openalex-snapshot
Synthesis and neuroprotective effects of novel chalcone-triazole hybrids
inferredcites →https://doi.org/10.1016/j.bioorg.2021.104733openalex-snapshot
Synthesis and antiplasmodial evaluation of 1H-1,2,3-triazole grafted 4-aminoquinoline-benzoxaborole hybrids and benzoxaborole analogues
inferredcites →https://doi.org/10.1016/j.bioorg.2021.105053openalex-snapshot
1H-1,2,3-triazole grafted tacrine-chalcone conjugates as potential cholinesterase inhibitors with the evaluation of their behavioral tests and oxidative stress in mice brain cells
inferredcites →https://doi.org/10.1016/j.bmc.2017.02.068openalex-snapshot
Covalently linked kanamycin – Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance
inferredcites →https://doi.org/10.1016/j.bmc.2018.06.026openalex-snapshot
Synthesis, antitumor activity evaluation and mechanistic study of novel hederacolchiside A1 derivatives bearing an aryl triazole moiety
inferredcites →https://doi.org/10.1016/j.bmc.2018.08.025openalex-snapshot
Synthesis and SAR of new isoxazole-triazole bis-heterocyclic compounds as analogues of natural lignans with antiparasitic activity
inferredcites →https://doi.org/10.1016/j.bmc.2019.07.005openalex-snapshot
1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview
inferredcites →https://doi.org/10.1016/j.bmcl.2016.09.059openalex-snapshot
1H-1,2,3-Triazolyl-substituted 1,3,4-oxadiazole derivatives containing structural features of ibuprofen/naproxen: Their synthesis and antibacterial evaluation
inferredcites →https://doi.org/10.1016/j.bmcl.2017.01.092openalex-snapshot
Synthesis and antimicrobial evaluation of cationic low molecular weight amphipathic 1,2,3-triazoles
inferredcites →https://doi.org/10.1016/j.bmcl.2017.07.069openalex-snapshot
Triazole tethered isatin-coumarin based molecular hybrids as novel antitubulin agents: Design, synthesis, biological investigation and docking studies
inferredcites →https://doi.org/10.1016/j.bmcl.2018.12.061openalex-snapshot
Fragment splicing-based design, synthesis and safener activity of novel substituted phenyl oxazole derivatives
inferredcites →https://doi.org/10.1016/j.bmcl.2020.127136openalex-snapshot
Synthesis of novel of 2, 5-disubstituted 1, 3, 4- oxadiazole derivatives and their in vitro anti-inflammatory, anti-oxidant evaluation, and molecular docking study
inferredcites →https://doi.org/10.1016/j.bmcl.2020.127304openalex-snapshot
Synthesis and anti-proliferative activity of a novel 1,2,3-triazole tethered chalcone acetamide derivatives
inferredcites →https://doi.org/10.1016/j.bmcl.2020.127576openalex-snapshot
Design and synthesis of 4-Aminoquinoline-isoindoline-dione-isoniazid triads as potential anti-mycobacterials
inferredcites →https://doi.org/10.1016/j.canlet.2015.10.025openalex-snapshot
Carboxyamidotriazole inhibits oxidative phosphorylation in cancer cells and exerts synergistic anti-cancer effect with glycolysis inhibition
inferredcites →https://doi.org/10.1016/j.cbi.2019.108876openalex-snapshot
4-Methylesculetin, a natural coumarin with intestinal anti-inflammatory activity, elicits a glutathione antioxidant response by different mechanisms
inferredcites →https://doi.org/10.1016/j.cdc.2020.100605openalex-snapshot
Microwave assisted synthesis and antimicrobial and antioxidant activities of dimers of 1,2,3-triazole-benzofuran bearing alkyl spacer derivatives
inferredcites →https://doi.org/10.1016/j.drudis.2017.05.014openalex-snapshot
The 1,2,3-triazole ring as a bioisostere in medicinal chemistry
inferredcites →https://doi.org/10.1016/j.ejmech.2014.11.039openalex-snapshot
Bioactive Benzofuran derivatives: A review
inferredcites →https://doi.org/10.1016/j.ejmech.2014.11.047openalex-snapshot
Bioactive benzofuran derivatives: Moracins A–Z in medicinal chemistry
inferredcites →https://doi.org/10.1016/j.ejmech.2015.08.018openalex-snapshot
Recent developments regarding the use of thieno[2,3-d]pyrimidin-4-one derivatives in medicinal chemistry, with a focus on their synthesis and anticancer properties
inferredcites →https://doi.org/10.1016/j.ejmech.2016.02.041openalex-snapshot
Synthesis of newer 1,2,3-triazole linked chalcone and flavone hybrid compounds and evaluation of their antimicrobial and cytotoxic activities
inferredcites →https://doi.org/10.1016/j.ejmech.2016.08.039openalex-snapshot
Hybrid molecules: The privileged scaffolds for various pharmaceuticals
inferredcites →https://doi.org/10.1016/j.ejmech.2016.09.044openalex-snapshot
4-Aminoquinoline-ferrocenyl-chalcone conjugates: Synthesis and anti-plasmodial evaluation
inferredcites →https://doi.org/10.1016/j.ejmech.2016.11.030openalex-snapshot
Green synthesis and anticancer potential of chalcone linked-1,2,3-triazoles
inferredcites →https://doi.org/10.1016/j.ejmech.2017.05.004openalex-snapshot
Recent developments of coumarin-containing derivatives and their anti-tubercular activity
inferredcites →https://doi.org/10.1016/j.ejmech.2017.06.051openalex-snapshot
Triazole derivatives and their anti-tubercular activity
inferredcites →https://doi.org/10.1016/j.ejmech.2017.07.059openalex-snapshot
Recent advances of pyrazole-containing derivatives as anti-tubercular agents
inferredcites →https://doi.org/10.1016/j.ejmech.2017.07.061openalex-snapshot
Quinoline hybrids and their antiplasmodial and antimalarial activities
inferredcites →https://doi.org/10.1016/j.ejmech.2017.09.039openalex-snapshot
2-Aminothiophene scaffolds: Diverse biological and pharmacological attributes in medicinal chemistry
inferredcites →https://doi.org/10.1016/j.ejmech.2017.12.017openalex-snapshot
1,3,5-triazaspiro[5.5]undeca-2,4-dienes as selective Mycobacterium tuberculosis dihydrofolate reductase inhibitors with potent whole cell activity
inferredcites →https://doi.org/10.1016/j.ejmech.2017.12.044openalex-snapshot
Recent advance in oxazole-based medicinal chemistry
inferredcites →https://doi.org/10.1016/j.ejmech.2018.01.017openalex-snapshot
In vitro antiplasmodial efficacy of synthetic coumarin-triazole analogs
inferredcites →https://doi.org/10.1016/j.ejmech.2018.02.017openalex-snapshot
The 4-N-acyl and 4-N-alkyl gemcitabine analogues with silicon-fluoride-acceptor: Application to 18F-Radiolabeling
inferredcites →https://doi.org/10.1016/j.ejmech.2018.02.067openalex-snapshot
Synthesis and antimycobacterial activity of 1-(β-d-Ribofuranosyl)-4-coumarinyloxymethyl- / -coumarinyl-1,2,3-triazole
inferredcites →https://doi.org/10.1016/j.ejmech.2018.03.035openalex-snapshot
Syntheses and in vitro evaluation of new S1PR1 compounds and initial evaluation of a lead F-18 radiotracer in rodents
inferredcites →https://doi.org/10.1016/j.ejmech.2018.03.059openalex-snapshot
Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus
inferredcites →https://doi.org/10.1016/j.ejmech.2018.03.082openalex-snapshot
Novel sarsasapogenin-triazolyl hybrids as potential anti-Alzheimer's agents: Design, synthesis and biological evaluation
inferredcites →https://doi.org/10.1016/j.ejmech.2018.05.055openalex-snapshot
Synthesis, crystal structure and antimicrobial potential of some fluorinated chalcone-1,2,3-triazole conjugates
inferredcites →https://doi.org/10.1016/j.ejmech.2018.06.028openalex-snapshot
Dihydropyrimidinone/1,2,3-triazole hybrid molecules: Synthesis and anti-varicella-zoster virus (VZV) evaluation
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Synthesis and antiplasmodial activity of glyco-conjugate hybrids of phenylhydrazono-indolinones and glycosylated 1,2,3-triazolyl-methyl-indoline-2,3-diones
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Pyrrole: An insight into recent pharmacological advances with structure activity relationship
inferredcites →https://doi.org/10.1016/j.ejmech.2018.11.025openalex-snapshot
Benzofuran derivatives and their anti-tubercular, anti-bacterial activities
inferredcites →https://doi.org/10.1016/j.ejmech.2018.12.001openalex-snapshot
Recent advances of tetrazole derivatives as potential anti-tubercular and anti-malarial agents
inferredcites →https://doi.org/10.1016/j.ejmech.2019.01.017openalex-snapshot
Quinolone hybrids and their anti-cancer activities: An overview
inferredcites →https://doi.org/10.1016/j.ejmech.2019.02.055openalex-snapshot
Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids
inferredcites →https://doi.org/10.1016/j.ejmech.2019.03.020openalex-snapshot
Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies
inferredcites →https://doi.org/10.1016/j.ejmech.2019.05.013openalex-snapshot
New chalcone-sulfonamide hybrids exhibiting anticancer and antituberculosis activity
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Neurobehavioral investigation and acetylcholinesterase inhibitory activity study for some new coumarin derivatives
inferredcites →https://doi.org/10.1016/j.ejmech.2019.111700openalex-snapshot
1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships
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1,2,3-Triazole-Chalcone hybrids: Synthesis, in vitro cytotoxic activity and mechanistic investigation of apoptosis induction in multiple myeloma RPMI-8226
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Recent advancements in the development of heterocyclic anti-inflammatory agents
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Recent accomplishments on the synthetic/biological facets of pharmacologically active 1H-1,2,3-triazoles
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Apigenin: A natural bioactive flavone-type molecule with promising therapeutic function
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Copper(II) complexes of coumarin-derived Schiff base ligands: Pro- or antioxidant activity in MCF-7 cells?
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Synthesis, characterization and antibacterial studies of schiff based 1,2,3-triazole bridged silatranes
inferredcites →https://doi.org/10.1016/j.jorganchem.2019.05.025openalex-snapshot
Click-chemistry approach to synthesis of functionalized isatin-ferrocenes and their biological evaluation against the human pathogen Trichomonas vaginalis
inferredcites →https://doi.org/10.1016/j.molstruc.2019.127487openalex-snapshot
A step-by-step synthesis of triazole-benzimidazole-chalcone hybrids: Anticancer activity in human cells+
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5-Fluoro-1H-indole-2,3-dione-triazoles- synthesis, biological activity, molecular docking, and DFT study
inferredcites →https://doi.org/10.1016/j.molstruc.2020.128356openalex-snapshot
Synthesis, biological evaluation and molecular docking studies of novel 1,2,3-triazole tethered chalcone hybrids as potential anticancer agents
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Synthesis and biological evaluation of novel 3- O -tethered triazoles of diosgenin as potent antiproliferative agents
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Synthesis, antimicrobial potency with in silico study of Boc-leucine-1,2,3-triazoles
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Clozapine causes oxidation of proteins involved in energy metabolism: a possible mechanism for antipsychotic-induced metabolic alterations
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In Vitro and in Vivo Evaluation of Fully Substituted (5-(3-Ethoxy-3-oxopropynyl)-4-(ethoxycarbonyl)-1,2,3-triazolyl-glycosides as Original Nucleoside Analogues to Circumvent Resistance in Myeloid Malignancies
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Design, Synthesis, and in Vitro and in Vivo Evaluation of Ouabain Analogues as Potent and Selective Na,K-ATPase α4 Isoform Inhibitors for Male Contraception
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Extra Sugar on Vancomycin: New Analogues for Combating Multidrug-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci
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Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity
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From Oxiranes to Oligomers: Architectures of U.S. FDA Approved Pharmaceuticals Containing Oxygen Heterocycles
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Halogenation of Biotin Protein Ligase Inhibitors Improves Whole Cell Activity against Staphylococcus aureus
inferredcites →https://doi.org/10.1021/acsomega.8b02481openalex-snapshot
Design, Synthesis, Antimicrobial Evaluation, and Molecular Modeling Studies of Novel Indolinedione–Coumarin Molecular Hybrids
inferredcites →https://doi.org/10.1021/ar7000843openalex-snapshot
Hybrid Molecules with a Dual Mode of Action: Dream or Reality?
inferredcites →https://doi.org/10.1021/cr300122topenalex-snapshot
Acid Hydrazides, Potent Reagents for Synthesis of Oxygen-, Nitrogen-, and/or Sulfur-Containing Heterocyclic Rings
inferredcites →https://doi.org/10.1021/cr900028popenalex-snapshot
Enzymology of Purine and Pyrimidine Antimetabolites Used in the Treatment of Cancer
inferredcites →https://doi.org/10.1021/jm300125eopenalex-snapshot
Design, Synthesis, and Structure–Activity Correlations of Novel Dibenzo[b,d]furan, Dibenzo[b,d]thiophene, and N-Methylcarbazole Clubbed 1,2,3-Triazoles as Potent Inhibitors of Mycobacterium tuberculosis
inferredcites →https://doi.org/10.1021/jm900028nopenalex-snapshot
Design, Synthesis, and Evaluation of Novel Fluoroquinolone−Aminoglycoside Hybrid Antibiotics
inferredcites →https://doi.org/10.1038/bjc.1978.18openalex-snapshot
Effect of ditazole, an inhibitor of platelet aggregation, on a metastasizing tumour in mice
inferredcites →https://doi.org/10.1038/ja.2016.80openalex-snapshot
Synthesis and biological evaluation of lipophilic teicoplanin pseudoaglycon derivatives containing a substituted triazole function
inferredcites →https://doi.org/10.1038/s41598-018-37515-5openalex-snapshot
Amino acid substitutions at sugar-recognizing codons confer ABO blood group system-related α1,3 Gal(NAc) transferases with differential enzymatic activity
inferredcites →https://doi.org/10.1038/s41598-019-41984-7openalex-snapshot
3D-QSAR, Docking, ADME/Tox studies on Flavone analogs reveal anticancer activity through Tankyrase inhibition
inferredcites →https://doi.org/10.1038/s41598-019-55207-6openalex-snapshot
Fe-doped mayenite electride composite with 2D reduced Graphene Oxide: As a non-platinum based, highly durable electrocatalyst for Oxygen Reduction Reaction
inferredcites →https://doi.org/10.1039/c5ob01353dopenalex-snapshot
Synthesis and antimicrobial potential of nitrofuran–triazole congeners
inferredcites →https://doi.org/10.1039/c6md00169fopenalex-snapshot
Design, synthesis and antiproliferative activity studies of 1,2,3-triazole–chalcones
inferredcites →https://doi.org/10.1039/c7nj04060aopenalex-snapshot
Synthesis, optical properties, and antioxidant and anticancer activity of benzoheterazole dendrimers with triazole bridging unit
inferredcites →https://doi.org/10.1039/c7nj04271jopenalex-snapshot
Synthesis of novel 1,2,3-triazole based artemisinin derivatives and their antiproliferative activity
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Synthesis and in vitro biological evaluation of novel diaminothiophene scaffolds as antitumor and anti-influenza virus agents. Part 2
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Synthesis and biological evaluation of triazole and isoxazole-tagged benzothiazole/benzoxazole derivatives as potent cytotoxic agents
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Oxa/thiazole-tetrahydropyran triazole-linked hybrids with selective antiproliferative activity against human tumour cells
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Synthesis, molecular docking and DFT studies on biologically active 1,4-disubstituted-1,2,3-triazole-semicarbazone hybrid molecules
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Effect of oxolamine on cough sensitivity in COPD patients
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Antimicrobial Screening, in Silico Studies and QSAR of Chalcone-based 1,4-disubstituted 1,2,3-triazole Hybrids
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Copper-Mediated Late-Stage Iodination and 123I-Labelling of Triazole-benzimidazole Bioactives
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The behavior of some chalcones on acetylcholinesterase and carbonic anhydrase activity
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In - Silico molecular docking and simulation studies on novel chalcone and flavone hybrid derivatives with 1, 2, 3-triazole linkage as vital inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase
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Synthesis and in-vitro antioxidant activities of some coumarin derivatives containing 1,2,3-triazole ring
inferredcites →https://doi.org/10.1080/14786419.2017.1405408openalex-snapshot
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What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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