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N‐methylpiperazinyl and piperdinylalkyl‐ O‐chalcone derivatives as potential polyfunctional agents against Alzheimer's disease: Design, synthesis and biological evaluation

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Monoamine Oxidase Inhibitory Activity: Methyl‐ versus Chlorochalcone Derivatives

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An Update of Synthetic Approaches and Structure‐Activity Relationships of Various Classes of Human MAO‐B Inhibitors

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Base Catalysis for Fine Chemicals Production: Claisen-Schmidt Condensation on Zeolites and Hydrotalcites for the Production of Chalcones and Flavanones of Pharmaceutical Interest

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Calcineurin-Mediated Hippocampal Inflammatory Alterations in Streptozotocin-Induced Model of Dementia

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Dietary chalcones with chemopreventive and chemotherapeutic potential

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Novel nicotinonitrile-coumarin hybrids as potential acetylcholinesterase inhibitors: design, synthesis, in vitro and in silico studies

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A new and rapid colorimetric determination of acetylcholinesterase activity

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Developments of a water-maze procedure for studying spatial learning in the rat

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Neuropathologic Changes Provide Insights into Key Mechanisms of Alzheimer Disease and Related Dementia

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Heteroaryl chalcones: Mini review about their therapeutic voyage

inferredcites →https://doi.org/10.1016/j.bioorg.2018.06.009openalex-snapshot

Multi-targetable chalcone analogs to treat deadly Alzheimer’s disease: Current view and upcoming advice

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Design, synthesis and bioevaluation of tricyclic fused ring system as dual binding site acetylcholinesterase inhibitors

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Ultrasound-assisted synthesis of novel chalcone, heterochalcone and bis-chalcone derivatives and the evaluation of their antioxidant properties and as acetylcholinesterase inhibitors

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Anti-amnesic effects of Ganoderma species: A possible cholinergic and antioxidant mechanism

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Counteracting role of nuclear factor erythroid 2-related factor 2 pathway in Alzheimer's disease

inferredcites →https://doi.org/10.1016/j.bmc.2008.04.026openalex-snapshot

Design, synthesis, and biological evaluation of thiophene analogues of chalcones

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Exploration of multi-target potential of chromen-4-one based compounds in Alzheimer’s disease: Design, synthesis and biological evaluations

inferredcites →https://doi.org/10.1016/j.brainres.2022.148175openalex-snapshot

Animal model of Alzheimer’s disease induced by streptozotocin: New insights about cholinergic pathway

inferredcites →https://doi.org/10.1016/j.cbi.2010.01.042openalex-snapshot

Acetylcholinesterase: From 3D structure to function

inferredcites →https://doi.org/10.1016/j.ddtec.2004.11.007openalex-snapshot

Lead- and drug-like compounds: the rule-of-five revolution

inferredcites →https://doi.org/10.1016/j.ejmech.2011.02.004openalex-snapshot

Antiprotozoal activity of chloroquinoline based chalcones

inferredcites →https://doi.org/10.1016/j.ejmech.2013.02.014openalex-snapshot

Synthesis and evaluation of 7,8-dehydrorutaecarpine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease

inferredcites →https://doi.org/10.1016/j.ejmech.2014.08.033openalex-snapshot

Recent developments in biological activities of chalcones: A mini review

inferredcites →https://doi.org/10.1016/j.ejmech.2015.01.051openalex-snapshot

Chalcones and their therapeutic targets for the management of diabetes: Structural and pharmacological perspectives

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Isolation of Pleurotus florida derived acetylcholinesterase inhibitor for the treatment of cognitive dysfunction in mice

inferredcites →https://doi.org/10.1016/j.ibneur.2023.01.005openalex-snapshot

Melatonin reduces β-amyloid accumulation and improves short-term memory in streptozotocin-induced sporadic Alzheimer’s disease model

inferredcites →https://doi.org/10.1016/j.jep.2016.10.026openalex-snapshot

Evaluation of anti-amnesic effect of extracts of selected Ocimum species using in-vitro and in-vivo models

inferredcites →https://doi.org/10.1016/j.lfs.2014.05.017openalex-snapshot

Animal models of dementia and cognitive dysfunction

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Poly (ADP-ribose) polymerase-1 as a promising drug target for neurodegenerative diseases

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An ongoing journey of chalcone analogues as single and multi-target ligands in the field of Alzheimer's disease: A review with structural aspects

inferredcites →https://doi.org/10.1016/j.neubiorev.2011.03.001openalex-snapshot

Revisiting the cholinergic hypothesis in the development of Alzheimer's disease

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PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

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Acetylcholinesterase in Alzheimer's disease

inferredcites →https://doi.org/10.1016/s0165-0173(96)00016-1openalex-snapshot

Advanced glycation endproducts in ageing and Alzheimer's disease

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Chalcone: A Privileged Structure in Medicinal Chemistry

inferredcites →https://doi.org/10.1038/1811199a0openalex-snapshot

Antioxidant Determinations by the Use of a Stable Free Radical

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SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

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Bio-medical potential of chalcone derivatives and their metal complexes as antidiabetic agents: a review

inferredcites →https://doi.org/10.1080/15569543.2022.2150646openalex-snapshot

Streptozotocin mechanisms and its role in rodent models for Alzheimer’s disease

inferredcites →https://doi.org/10.1080/21691401.2018.1523181openalex-snapshot

Amelioration of ischaemia reperfusion-induced cerebral injury in mice by liposomes containing Allium cepa fraction administered intranasally

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Pharmacological activation of protein kinase A improves memory loss and neuropathological changes in a mouse model of dementia of Alzheimer’s type

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Scalable Algorithms for Molecular Dynamics Simulations on Commodity Clusters

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Synthesis, Molecular Modeling, and Biological Evaluation of Novel 1, 3‐Diphenyl‐2‐propen‐1‐one Based Pyrazolines as Anti‐inflammatory Agents

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Molecular dynamics---Scalable algorithms for molecular dynamics simulations on commodity clusters

inferredcites →https://doi.org/10.1177/11795735211029113openalex-snapshot

The State of The Art on Acetylcholinesterase Inhibitors in the Treatment of Alzheimer’s Disease

inferredcites →https://doi.org/10.1186/s12936-019-3060-zopenalex-snapshot

In vitro anti-malarial efficacy of chalcones: cytotoxicity profile, mechanism of action and their effect on erythrocytes

inferredcites →https://doi.org/10.1248/jhs.48.520openalex-snapshot

Screening System for the Maillard Reaction Inhibitor from Natural Product Extracts.

inferredcites →https://doi.org/10.1515/jbcpp-2017-0070openalex-snapshot

Antioxidant-mediated neuroprotection by Allium schoenoprasum L. leaf extract against ischemia reperfusion-induced cerebral injury in mice

inferredcites →https://doi.org/10.1515/jbcpp-2020-0330openalex-snapshot

Pharmacological investigations on efficacy of Phlorizin a sodium-glucose co-transporter (SGLT) inhibitor in mouse model of intracerebroventricular streptozotocin induced dementia of AD type

inferredcites →https://doi.org/10.2165/00003495-200161010-00005openalex-snapshot

Cholinesterase Inhibitors for Alzheimer??s Disease

inferredcites →https://doi.org/10.2174/0929867053363153openalex-snapshot

Chalcones: An Update on Cytotoxic and Chemoprotective Properties

inferredcites →https://doi.org/10.2174/138955708786141034openalex-snapshot

Chalcones and their Potential Role in Inflammation

inferredcites →https://doi.org/10.2174/1389557520666200212104742openalex-snapshot

Medicinal Potential of Heterocyclic Compounds from Diverse Natural Sources for the Management of Cancer

inferredcites →https://doi.org/10.2174/1566524022666220404112843openalex-snapshot

Current Status of Alzheimer’s Disease and Pathological Mechanisms Investigating the Therapeutic Molecular Targets

inferredcites →https://doi.org/10.2174/1567202615666180813125125openalex-snapshot

Calcineurin Inhibition and Protein Kinase A Activation Limits Cognitive Dysfunction and Histopathological Damage in a Model of Dementia of the Alzheimer’s Type

inferredcites →https://doi.org/10.2174/1570159x19666210517114016openalex-snapshot

Mitochondrial Dysfunction in Alzheimer’s Disease: Opportunities for Drug Development

inferredcites →https://doi.org/10.2174/157488410790410579openalex-snapshot

Trends in Utilization of the Pharmacological Potential of Chalcones

inferredcites →https://doi.org/10.2174/1574892809666140819153902openalex-snapshot

Advances in Chalcones with Anticancer Activities

inferredcites →https://doi.org/10.2174/1871527318666190610111246openalex-snapshot

Perspective Design of Chalcones for the Management of CNS Disorders: A Mini-Review

inferredcites →https://doi.org/10.3390/molecules22081210openalex-snapshot

Chalcone Derivatives: Promising Starting Points for Drug Design

inferredcites →https://doi.org/10.4103/1673-5374.160076openalex-snapshot

Streptozotocin induced Alzheimer′s disease like changes and the underlying neural degeneration and regeneration mechanism

inferredcites →https://doi.org/10.4172/2161-0444.1000291openalex-snapshot

Diverse Molecular Targets for Chalcones with Varied Bioactivities

inferredcites →https://doi.org/10.5214/ans.0972.7531.2008.150403openalex-snapshot

Acetylcholinesterase :A Versatile Enzyme of Nervous System

inferredcites →https://doi.org/10.5483/bmbrep.2011.44.6.410openalex-snapshot

Effects of novel chalcone derivatives on α-glucosidase, dipeptidyl peptidase-4, and adipocyte differentiation in vitro

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4761237openalex-extracted

Assessment of Polyphenol Oxidase Inhibition, Antimicrobial and Antioxidant Properties of Some Chalcone Derivates: Experimental and Computational Approaches

inferred← citeshttps://doi.org/10.1002/slct.202500743openalex-snapshot

Oxindole Derivatives as Multi‐Target Agents for Alzheimer's Disease: A Promising Therapeutic Strategy

inferred← citeshttps://doi.org/10.1002/slct.202501573openalex-snapshot

Assessment of Polyphenol Oxidase Inhibition, Antibacterial, and Antioxidant Activity of Some Chalcone Derivatives: Experimental and Computational Approaches

inferred← citeshttps://doi.org/10.1007/s00044-026-03587-6openalex-snapshot

Design, synthesis, biological evaluation, and computational studies of N-benzoylethylenediamine derivatives as cholinesterase inhibitors

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Study of multifunctional anti-AD ligands: design, synthesis, X-ray crystal structure and biological evaluation of diosmetin derivatives

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Hesperidin Attenuates Chronic Stress-Induced Depression via 5-HT2A-Linked Modulation of Neurochemical, Oxidative, and Inflammatory Pathways: Experimental and In Silico Evidence

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Ferulic acid attenuates early life stress induced behavioral and neurochemical alterations via modulating HPA axis, oxidative stress, and NF-κB mediated neuroinflammation

inferred← citeshttps://doi.org/10.1016/b978-0-443-43812-7.00001-0openalex-snapshot

Chalcones as neuroprotective and anti-Alzheimer’s disease agents

inferred← citeshttps://doi.org/10.1016/j.ejmech.2025.117277openalex-snapshot

Analysis of skeletal diversity of multi-target directed ligands (MTDLs) targeting Alzheimer's disease

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Synthesis of novel aryl-substituted 2-aminopyridine derivatives by the cascade reaction of 1,1-enediamines with vinamidinium salts to develop novel anti-Alzheimer agents

inferred← citeshttps://doi.org/10.1111/cbdd.14638openalex-snapshot

Recent Advances in Medicinal Chemistry of Memantine Against Alzheimer's Disease

inferred← citeshttps://doi.org/10.3390/biomedicines11102784openalex-snapshot

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Computational Studies to Understand the Neuroprotective Mechanism of Action Basil Compounds

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