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A hybrid of two major Blomia tropicalis allergens as an allergy vaccine candidate

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/jsfa.7240openalex-snapshot

N‐terminal truncation contributed to increasing thermal stability of mannanase Man1312 without activity loss

inferredcites →https://doi.org/10.1007/s00251-005-0798-yopenalex-snapshot

Automated generation and evaluation of specific MHC binding predictive tools: ARB matrix applications

inferredcites →https://doi.org/10.1016/j.imlet.2018.01.012openalex-snapshot

Characterization of a hybrid protein designed with segments of allergens from Blomia tropicalis and Dermatophagoides pteronyssinus

inferredcites →https://doi.org/10.1016/j.jaci.2007.02.032openalex-snapshot

Identification and characterization of a novel allergen from Blomia tropicalis: Blo t 21

inferredcites →https://doi.org/10.1016/j.jaci.2011.01.064openalex-snapshot

Reshaping the Bet v 1 fold modulates TH polarization

inferredcites →https://doi.org/10.1016/j.jaci.2012.10.037openalex-snapshot

Cor a 1–reactive T cells and IgE are predominantly cross-reactive to Bet v 1 in patients with birch pollen–associated food allergy to hazelnut

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Respiratory allergy caused by house dust mites: What do we really know?

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The allergy epidemics: 1870-2010

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Fold stability during endolysosomal acidification is a key factor for allergenicity and immunogenicity of the major birch pollen allergen

inferredcites →https://doi.org/10.1016/j.jaci.2015.12.1299openalex-snapshot

Vaccine development for allergen-specific immunotherapy based on recombinant allergens and synthetic allergen peptides: Lessons from the past and novel mechanisms of action for the future

inferredcites →https://doi.org/10.1016/j.jaci.2016.09.055openalex-snapshot

Tackling Bet v 1 and associated food allergies with a single hybrid protein

inferredcites →https://doi.org/10.1016/j.jaci.2018.09.039openalex-snapshot

Nasal allergen-neutralizing IgG4 antibodies block IgE-mediated responses: Novel biomarker of subcutaneous grass pollen immunotherapy

inferredcites →https://doi.org/10.1016/j.rmr.2016.10.877openalex-snapshot

Blomia tropicalis : un acarien sous les tropiques

inferredcites →https://doi.org/10.1016/j.str.2007.10.022openalex-snapshot

Roles of Structure and Structural Dynamics in the Antibody Recognition of the Allergen Proteins: An NMR Study on Blomia tropicalis Major Allergen

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PROPHYLACTIC INOCULATION AGAINST HAY FEVER

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N-Terminal Truncation of an Isolated Human IgG1 CH2 Domain Significantly Increases Its Stability and Aggregation Resistance

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Generation of tissue-specific and promiscuous HLA ligand databases using DNA microarrays and virtual HLA class II matrices

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CD4+ Th2 cells are directly regulated by IL-10 during allergic airway inflammation

inferredcites →https://doi.org/10.1038/srep22465openalex-snapshot

Truncation of the unique N-terminal domain improved the thermos-stability and specific activity of alkaline α-amylase Amy703

inferredcites →https://doi.org/10.1074/jbc.m110.128306openalex-snapshot

Der p 5 Crystal Structure Provides Insight into the Group 5 Dust Mite Allergens

inferredcites →https://doi.org/10.1074/jbc.m112.348730openalex-snapshot

NMR Structure and IgE Epitopes of Blo t 21, a Major Dust Mite Allergen from Blomia tropicalis

inferredcites →https://doi.org/10.1080/02770900500497958openalex-snapshot

Dust Mite Species and Allergen Concentrations in Beds of Individuals Belonging to Different Urban Socioeconomic Groups in Brazil

inferredcites →https://doi.org/10.1080/073911012010525018openalex-snapshot

Modelling and Bioinformatics Analysis of the Dimeric Structure of House Dust Mite Allergens from Families 5 and 21: Der f 5 Could Dimerize as Der p 5

inferredcites →https://doi.org/10.1080/13543776.2020.1712360openalex-snapshot

Dermatophagoidesspp. hypoallergens design: what has been achieved so far?

inferredcites →https://doi.org/10.1097/aci.0000000000000216openalex-snapshot

Effect of allergen-specific immunotherapy on CD4+ T cells

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The Impact of a Program for Control of Asthma in a Low-Income Setting

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Recombinant Mal d 1 facilitates sublingual challenge tests of birch pollen‐allergic patients with apple allergy

inferredcites →https://doi.org/10.1111/all.12859openalex-snapshot

Efficacy of a therapeutic treatment using gas‐filled microbubble‐associated phospholipase A2 in a mouse model of honeybee venom allergy

inferredcites →https://doi.org/10.1111/all.13196openalex-snapshot

Amb a 1 isoforms: Unequal siblings with distinct immunological features

inferredcites →https://doi.org/10.1111/all.13684openalex-snapshot

Der p 1‐specific regulatory T‐cell response during house dust mite allergen immunotherapy

inferredcites →https://doi.org/10.1111/all.14176openalex-snapshot

N‐terminal peptide deletion influences immunological and structural features of Blo t 5

inferredcites →https://doi.org/10.1111/cea.12294openalex-snapshot

Hypoallergenic derivatives of Fel d 1 obtained by rational reassembly for allergy vaccination and tolerance induction

inferredcites →https://doi.org/10.1111/cea.12399openalex-snapshot

Effect of urban vs. rural residence on the association between atopy and wheeze in Latin America: findings from a case–control analysis

inferredcites →https://doi.org/10.1111/cea.12880openalex-snapshot

Revisiting T ype 2‐high and T ype 2‐low airway inflammation in asthma: current knowledge and therapeutic implications

inferredcites →https://doi.org/10.1111/cea.13098openalex-snapshot

The Blomia tropicalis allergen Blo t 7 stimulates innate immune signalling pathways through TLR 2

inferredcites →https://doi.org/10.1111/febs.13343openalex-snapshot

Rigidity versus flexibility: the dilemma of understanding protein thermal stability

inferredcites →https://doi.org/10.1111/imm.12772openalex-snapshot

Blomia tropicalis allergen 5 ( Blo t 5) T‐cell epitopes and their ability to suppress the allergic immune response

inferredcites →https://doi.org/10.1111/j.1398-9995.2007.01612.xopenalex-snapshot

EU Forum: The CREATE Project: development of certified reference materials for allergenic products and validation of methods for their quantification

inferredcites →https://doi.org/10.1111/j.1398-9995.2010.02468.xopenalex-snapshot

Treatment with a Fel d 1 hypoallergen reduces allergic responses in a mouse model for cat allergy

inferredcites →https://doi.org/10.1111/j.1399-3038.2010.01019.xopenalex-snapshot

Specific profiles of house dust mite sensitization in children with asthma and in children with eczema

inferredcites →https://doi.org/10.1111/j.1432-1033.2004.04220.xopenalex-snapshot

The optimization of protein secondary structure determination with infrared and circular dichroism spectra

inferredcites →https://doi.org/10.1111/jpc.12806openalex-snapshot

Fifty years of allergy: 1965–2015

inferredcites →https://doi.org/10.1136/thoraxjnl-2011-200225openalex-snapshot

Urbanisation is associated with prevalence of childhood asthma in diverse, small rural communities in Ecuador

inferredcites →https://doi.org/10.1155/2013/832404openalex-snapshot

The Fold Variant BM4 Is Beneficial in a Therapeutic Bet v 1 Mouse Model

inferredcites →https://doi.org/10.1159/000464325openalex-snapshot

Allergens of Blomia tropicalis: An Overview of Recombinant Molecules

inferredcites →https://doi.org/10.1159/000501964openalex-snapshot

Proteomic Analysis Reveals Allergen Variability among Breeds of the Dust Mite Blomia tropicalis

inferredcites →https://doi.org/10.1186/1471-2105-8-238openalex-snapshot

Prediction of MHC class II binding affinity using SMM-align, a novel stabilization matrix alignment method

inferredcites →https://doi.org/10.1186/1471-2172-14-11openalex-snapshot

Blomia tropicalis Blo t 5 and Blo t 21 recombinant allergens might confer higher specificity to serodiagnostic assays than whole mite extract

inferredcites →https://doi.org/10.1186/1939-4551-7-12openalex-snapshot

Allergic diseases and asthma: a global public health concern and a call to action

inferredcites →https://doi.org/10.1186/2045-7022-2-2openalex-snapshot

Mechanisms of allergen‐specific immunotherapy

inferredcites →https://doi.org/10.1371/journal.pone.0017278openalex-snapshot

Assessing Protein Immunogenicity with a Dendritic Cell Line-Derived Endolysosomal Degradome

inferredcites →https://doi.org/10.1371/journal.pone.0174089openalex-snapshot

Dissociation between skin test reactivity and anti-aeroallergen IgE: Determinants among urban Brazilian children

inferredcites →https://doi.org/10.1517/13543776.2016.1170809openalex-snapshot

Advances in patent applications related to allergen immunotherapy

inferredcites →https://doi.org/10.2217/imt-2015-0027openalex-snapshot

Allergen Immunotherapy for Birch Pollen-Allergic Patients: Recent Advances

inferredcites →https://doi.org/10.3349/ymj.2014.55.4.839openalex-snapshot

Molecular Approach to Allergy Diagnosis and Therapy

inferredcites →https://doi.org/10.4049/jimmunol.1100259openalex-snapshot

Airway Inflammation and IgE Production Induced by Dust Mite Allergen-Specific Memory/Effector Th2 Cell Line Can Be Effectively Attenuated by IL-35

inferredcites →https://doi.org/10.4049/jimmunol.1400064openalex-snapshot

Conversion of Der p 23, a New Major House Dust Mite Allergen, into a Hypoallergenic Vaccine

inferredcites →https://doi.org/10.4049/jimmunol.181.4.2586openalex-snapshot

Nuclear Magnetic Resonance Structure and IgE Epitopes of Blo t 5, a Major Dust Mite Allergen

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4605215openalex-extracted

The Reproductive Anatomy of Blomia Tropicalis (Acari: Astigmata: Glycyphagidae)

inferred← citeshttps://doi.org/10.1007/s10493-026-01123-0openalex-snapshot

House dust mites in three contrasting climatic regions of Saudi Arabia

inferred← citeshttps://doi.org/10.1007/s11033-021-06361-6openalex-snapshot

Purification and characterisation of the dimeric group 12 allergen from Blomia tropicalis heterologously expressed by Escherichia coli Top10F´

inferred← citeshttps://doi.org/10.1016/j.bbagen.2022.130096openalex-snapshot

Rationally designed hypoallergenic mutant variants of the house dust mite allergen Der p 21

inferred← citeshttps://doi.org/10.1016/j.jsb.2024.108138openalex-snapshot

NMR residual dipolar couplings investigation in the topology of house dust mite Group V allergens

inferred← citeshttps://doi.org/10.1016/j.molimm.2024.09.005openalex-snapshot

Therapeutic potential of a novel hybrid protein: Mitigating allergy and airway remodeling in chronic asthma models induced by Dermatophagoides pteronyssinus

inferred← citeshttps://doi.org/10.1016/j.waojou.2022.100692openalex-snapshot

Efficacy and safety of subcutaneous immunotherapy with a mixture of glutaraldehyde-modified extracts of Dermatophagoides pteronyssinus, Dermatophagoides farinae, and Blomia tropicalis

inferred← citeshttps://doi.org/10.1038/s41541-025-01311-wopenalex-snapshot

The adeno associated viral vectored Dp12S vaccine effective alleviation of asthma symptoms in mice

inferred← citeshttps://doi.org/10.1111/all.70232openalex-snapshot

Microarrayed Allergen Molecules Distinguish IgE Sensitisation to Blomia tropicalis and Dermatophagoides pteronyssinus

inferred← citeshttps://doi.org/10.1111/cea.14046openalex-snapshot

Developments in the field of allergy in 2020 through the eyes of Clinical and Experimental Allergy

inferred← citeshttps://doi.org/10.1111/cea.14238openalex-snapshot

Recombinant T‐cell epitope conjugation: A new approach for Dermatophagoides hypoallergen design

inferred← citeshttps://doi.org/10.1111/cea.14293openalex-snapshot

The hybrid protein BTH2 suppresses allergic airway inflammation in a murine model of HDM ‐specific immunotherapy

inferred← citeshttps://doi.org/10.1111/cea.14377openalex-snapshot

Immunotherapy and prevention of allergic diseases

inferred← citeshttps://doi.org/10.3389/falgy.2021.769728openalex-snapshot

Abundance and Stability as Common Properties of Allergens

inferred← citeshttps://doi.org/10.3389/falgy.2024.1440360openalex-snapshot

To stay or not to stay intact as an allergen: the endolysosomal degradation assay used as tool to analyze protein immunogenicity and T cell epitopes

inferred← citeshttps://doi.org/10.3389/falgy.2026.1936335openalex-snapshot

The optimized endolysosomal degradation assay with standardized enzyme activity represents an orthogonal method for predicting protein immunogenicity and T cell epitopes

inferred← citeshttps://doi.org/10.3389/fimmu.2026.1815807openalex-snapshot

Multi-country IgE reactivity determination of isoforms of the Blomia tropicalis mite allergen Blo t 2 revealed a potential biomarker of asthma severity

inferred← citeshttps://doi.org/10.3390/allergies3030012openalex-snapshot

Removal of N-Terminal Peptide Impacts Structural Aspects of an IgE-Reactive Recombinant Der p 5

inferred← citeshttps://doi.org/10.3390/biomedicines13112657openalex-snapshot

Long-Term Administration of BTH2 Hypoallergenic Vaccine Candidate Induces Hallmarks of Allergen Immunotherapy in Murine Model of Blomia tropicalis-Induced Asthma

inferred← citeshttps://doi.org/10.3390/cells11020212openalex-snapshot

Allergen Immunotherapy: Current and Future Trends

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