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EF 1A1/ HSC 70 Cooperatively Suppress Brain Endothelial Cell Apoptosis via Regulating JNK Activity

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/jnr.21124openalex-snapshot

Translocation of constitutively expressed heat shock protein Hsc70 to synapse‐enriched areas of the cerebral cortex after hyperthermic stress

inferredcites →https://doi.org/10.1007/978-1-4614-3573-0_10openalex-snapshot

Phosphorylation of Mammalian Cytochrome c and Cytochrome c Oxidase in the Regulation of Cell Destiny: Respiration, Apoptosis, and Human Disease

inferredcites →https://doi.org/10.1007/s00011-007-6199-yopenalex-snapshot

The effect of an anti-inflammatory pentapeptide produced by Entamoeba histolytica on gene expression in the U-937 monocytic cell line

inferredcites →https://doi.org/10.1007/s00011-010-0261-xopenalex-snapshot

Anti-inflammatory defense mechanisms of Entamoeba histolytica

inferredcites →https://doi.org/10.1016/j.biocel.2003.11.009openalex-snapshot

Chaperone-like activity of mammalian elongation factor eEF1A: renaturation of aminoacyl-tRNA synthetases

inferredcites →https://doi.org/10.1016/j.biochi.2015.10.026openalex-snapshot

Translation elongation factor eEF1A1 is a novel partner of a multifunctional protein Sgt1

inferredcites →https://doi.org/10.1016/j.cyto.2010.04.014openalex-snapshot

Extracellular heat shock cognate protein 70 induces cardiac functional tolerance to endotoxin: Differential effect on TNF-α and ICAM-1 levels in heart tissue

inferredcites →https://doi.org/10.1016/j.neuroscience.2009.06.051openalex-snapshot

Interaction of elongation factor 1-alpha with leucine-rich repeat kinase 2 impairs kinase activity and microtubule bundling in vitro

inferredcites →https://doi.org/10.1016/j.pharmthera.2012.08.014openalex-snapshot

Comprehensive review on the HSC70 functions, interactions with related molecules and involvement in clinical diseases and therapeutic potential

inferredcites →https://doi.org/10.1016/j.yexcr.2008.10.042openalex-snapshot

EF1A1-actin interactions alter mRNA stability to determine differential osteopontin expression in HepG2 and Hep3B cells

inferredcites →https://doi.org/10.1016/s0304-3835(02)00456-1openalex-snapshot

What's in the ‘BAG’? – a functional domain analysis of the BAG-family proteins

inferredcites →https://doi.org/10.1042/bj20050412openalex-snapshot

Heat-shock cognate 70 is required for the activation of heat-shock factor 1 in mammalian cells

inferredcites →https://doi.org/10.1046/j.1471-4159.2003.02026.xopenalex-snapshot

Flow cytometric analysis of mitochondria from CA1 and CA3 regions of rat hippocampus reveals differences in permeability transition pore activation

inferredcites →https://doi.org/10.1073/pnas.0232966100openalex-snapshot

Caspase 3 activation is essential for neuroprotection in preconditioning

inferredcites →https://doi.org/10.1073/pnas.0507903103openalex-snapshot

Differential effects of Hsc70 and Hsp70 on the intracellular trafficking and functional expression of epithelial sodium channels

inferredcites →https://doi.org/10.1074/jbc.272.51.32206openalex-snapshot

Renaturation of Rhodanese by Translational Elongation Factor (EF) Tu

inferredcites →https://doi.org/10.1074/jbc.273.19.11478openalex-snapshot

Chaperone Properties of Bacterial Elongation Factor EF-Tu

inferredcites →https://doi.org/10.1091/mbc.e05-08-0742openalex-snapshot

A Critical Role for Eukaryotic Elongation Factor 1A-1 in Lipotoxic Cell Death

inferredcites →https://doi.org/10.1093/carcin/bgt111openalex-snapshot

The HSP70 family and cancer

inferredcites →https://doi.org/10.1111/cns.12266openalex-snapshot

Amelioration of Ischemic Mitochondrial Injury and Bax‐Dependent Outer Membrane Permeabilization by Mdivi‐1

inferredcites →https://doi.org/10.1111/cns.12502openalex-snapshot

Allosteric Modulation of Sigma‐1 Receptors Elicits Rapid Antidepressant Activity

inferredcites →https://doi.org/10.1146/annurev.bi.62.070193.002025openalex-snapshot

MOLECULAR CHAPERONE FUNCTIONS OF HEAT-SHOCK PROTEINS

inferredcites →https://doi.org/10.1152/ajpheart.00292.2009openalex-snapshot

Myocardial TLR4 is a determinant of neutrophil infiltration after global myocardial ischemia: mediating KC and MCP-1 expression induced by extracellular HSC70

inferredcites →https://doi.org/10.1152/ajpheart.00299.2008openalex-snapshot

Critical role of extracellular heat shock cognate protein 70 in the myocardial inflammatory response and cardiac dysfunction after global ischemia-reperfusion

inferredcites →https://doi.org/10.1161/strokeaha.112.657908openalex-snapshot

A Pentapeptide Monocyte Locomotion Inhibitory Factor Protects Brain Ischemia Injury by Targeting the eEF1A1/Endothelial Nitric Oxide Synthase Pathway

inferredcites →https://doi.org/10.1371/journal.pone.0047366openalex-snapshot

Elongation Factor 1 alpha1 and Genes Associated with Usher Syndromes Are Downstream Targets of GBX2

inferredcites →https://doi.org/10.1379/1466-1268(2002)007<0330:lidtca>2.0.co;2openalex-snapshot

Lipid interaction differentiates the constitutive and stress-induced heat shock proteins Hsc70 and Hsp70

inferredcites →https://doi.org/10.1379/1466-1268(2003)008<0309:mfrohf>2.0.co;2openalex-snapshot

Mechanisms for regulation of Hsp70 function by Hsp40

inferredcites →https://doi.org/10.1385/cbb:47:1:73openalex-snapshot

Expression of signaling molecules associated with apoptosis in human ischemic stroke tissue

inferredcites →https://doi.org/10.1517/13543781003781898openalex-snapshot

An overview of investigational antiapoptotic drugs with potential application for the treatment of neurodegenerative disorders

inferredcites →https://doi.org/10.2174/1568007023339472openalex-snapshot

Targeting the JNK Pathway for Therapeutic Benefit in CNS Disease

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4822275openalex-extracted

Four Clef1a Genes Involved in Self-Incompatibility in 'Xiangshui Lemon' Confer Early Fowering and Increase Stress Tolerance in Transgenic Arabidopsis

inferred← citeshttps://doi.org/10.1002/ptr.8178openalex-snapshot

Salidroside directly activates HSC70 , revealing a new role for HSC70 in BDNF signalling and neurogenesis after cerebral ischemia

inferred← citeshttps://doi.org/10.1007/s10517-018-4090-1openalex-snapshot

Analysis of Blood Plasma Protein Composition in Patients with Cerebral Ischemia

inferred← citeshttps://doi.org/10.1007/s10753-022-01664-7openalex-snapshot

CircOAS3 Regulates Keratinocyte Proliferation and Psoriatic Inflammation by Interacting with Hsc70 via the JNK/STAT3/NF-κB Signaling Pathway

inferred← citeshttps://doi.org/10.1007/s12035-024-04230-4openalex-snapshot

Chaperone-Mediated Autophagy in Brain Injury: A Double-Edged Sword with Therapeutic Potentials

inferred← citeshttps://doi.org/10.1007/s13258-024-01516-8openalex-snapshot

eEF1A1 regulates the expression and alternative splicing of genes associated with Parkinson’s disease in U251 cells

inferred← citeshttps://doi.org/10.1016/bs.apcsb.2023.10.001openalex-snapshot

Understanding functions of eEF1 translation elongation factors beyond translation. A proteomic approach

inferred← citeshttps://doi.org/10.1016/j.aquaculture.2025.742326openalex-snapshot

Vibrio splendidus virulence factor hop mediates coelomocytes apoptosis by interacting with HSC70 to promote JNK phosphorylation in Apostichopus japonicus

inferred← citeshttps://doi.org/10.1016/j.bbadva.2022.100067openalex-snapshot

The Eef1 Family of Mammalian Translation Elongation Factors

inferred← citeshttps://doi.org/10.1016/j.bmt.2025.100088openalex-snapshot

Targeting HSPA8 to repress GPX4 and induce ferroptosis in BCR-ABL positive leukemia

inferred← citeshttps://doi.org/10.1016/j.ejphar.2025.177553openalex-snapshot

Regulation of blood-brain barrier integrity by brain microvascular endothelial cells in ischemic stroke: A therapeutic opportunity

inferred← citeshttps://doi.org/10.1016/j.intimp.2025.115031openalex-snapshot

Tripartite motif containing 27 alleviated septic liver injury via the HSPA8/JNK pathway in mice

inferred← citeshttps://doi.org/10.1016/j.isci.2024.110900openalex-snapshot

Superenhancer-driven circRNA Myst4 involves in pulmonary artery smooth muscle cell ferroptosis in pulmonary hypertension

inferred← citeshttps://doi.org/10.1016/j.jare.2025.06.014openalex-snapshot

Development and characterization of endolysosomal trafficking targeting chimera degraders of α1A-adrenergic receptor

inferred← citeshttps://doi.org/10.1016/j.jep.2022.115592openalex-snapshot

Xueshuantong injection alleviates cerebral microcirculation disorder in middle cerebral artery occlusion/reperfusion rats by suppressing inflammation via JNK mediated JAK2/STAT3 and NF-κB signaling pathways

inferred← citeshttps://doi.org/10.1016/j.mad.2021.111594openalex-snapshot

Effect of age on the vascular proteome in middle cerebral arteries and mesenteric resistance arteries in mice

inferred← citeshttps://doi.org/10.1016/j.nbd.2025.107080openalex-snapshot

POU6F1 promote lumbar motor circuit reorganization following spinal cord injury

inferred← citeshttps://doi.org/10.1016/j.phymed.2024.155455openalex-snapshot

N-Cinnamoylpyrrole-derived alkaloids from the genus Piper as promising agents for ischemic stroke by targeting eEF1A1

inferred← citeshttps://doi.org/10.1016/j.plaphy.2024.109255openalex-snapshot

Four ClEF1A genes involved in self-incompatibility in 'Xiangshui Lemon' confer early fowering and increase stress tolerance in transgenic Arabidopsis

inferred← citeshttps://doi.org/10.1049/syb2.12095openalex-snapshot

Revealing the potential role of hub metabolism‐related genes and their correlation with immune cells in acute ischemic stroke

inferred← citeshttps://doi.org/10.1111/cbdd.14354openalex-snapshot

Jasminoidin reduces ischemic stroke injury by regulating microglia polarization via PASK‐EEF1A1 axis

inferred← citeshttps://doi.org/10.1111/cns.70209openalex-snapshot

Investigation of Anti‐Apoptotic Effects and Mechanisms of Astragaloside IV in a Rat Model of Cerebral Ischemia–Reperfusion Injury

inferred← citeshttps://doi.org/10.1155/2022/2292481openalex-snapshot

DNAJA1 Stabilizes EF1A1 to Promote Cell Proliferation and Metastasis of Liver Cancer Mediated by miR-205-5p

inferred← citeshttps://doi.org/10.1186/s12872-019-1002-xopenalex-snapshot

Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery – a sub-analysis of the RIPHeart-Study

inferred← citeshttps://doi.org/10.1186/s13578-024-01239-zopenalex-snapshot

The suppression of HSPA8 attenuates NLRP3 ubiquitination through SKP2 to promote pyroptosis in sepsis-induced lung injury

inferred← citeshttps://doi.org/10.1371/journal.pbio.3000606openalex-snapshot

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells

inferred← citeshttps://doi.org/10.15698/cst2019.11.203openalex-snapshot

The impact of endothelial cell death in the brain and its role after stroke: A systematic review

inferred← citeshttps://doi.org/10.21203/rs.3.rs-2899233/v1openalex-snapshot

EEF1A1 knock-down regulates the expression and alternative splicing of genes associated with Parkinson`s disease in U251 cells

inferred← citeshttps://doi.org/10.3389/fphar.2021.725268openalex-snapshot

MLIF Modulates Microglia Polarization in Ischemic Stroke by Targeting eEF1A1

inferred← citeshttps://doi.org/10.3390/genes14061171openalex-snapshot

Association between HSPA8 Gene Variants and Ischemic Stroke: A Pilot Study Providing Additional Evidence for the Role of Heat Shock Proteins in Disease Pathogenesis

inferred← citeshttps://doi.org/10.3390/jcm11020339openalex-snapshot

New Candidates for Biomarkers and Drug Targets of Ischemic Stroke—A First Dynamic LC-MS Human Serum Proteomic Study

inferred← citeshttps://doi.org/10.3390/v17050682openalex-snapshot

Multidimensional Regulatory Mechanisms and Targeting Strategies of the eEF1 Family in RNA Virus Infection

inferred← citeshttps://doi.org/10.4103/1673-5374.331539openalex-snapshot

Do pyroptosis, apoptosis, and necroptosis (PANoptosis) exist in cerebral ischemia? Evidence from cell and rodent studies

inferred← citeshttps://doi.org/10.5114/aoms.2019.82818openalex-snapshot

Sulodexide up-regulates glutathione S-transferase P1 by enhancing Nrf2 expression and translocation in human umbilical vein endothelial cells injured by oxygen glucose deprivation

inferred← citeshttps://doi.org/10.6084/m9.figshare.25744362openalex-snapshot

Additional file 1 of The suppression of HSPA8 attenuates NLRP3 ubiquitination through SKP2 to promote pyroptosis in sepsis-induced lung injury

inferred← citeshttps://doi.org/10.7124/bc.00092fopenalex-snapshot

Non-canonical interactions of the β subunit of the translation elongation complex eEF1B and analysis of their possible functional role

inferred← citeshttps://doi.org/10.7150/ijbs.38962openalex-snapshot

ALDH 2 conferred neuroprotection on cerebral ischemic injury by alleviating mitochondria-related apoptosis through JNK/caspase-3 signing pathway

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