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Animal models for the study of depressive disorder

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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/0471141755.ph0565s61openalex-snapshot
Models of Depression: Unpredictable Chronic Mild Stress in Mice
inferredcites →https://doi.org/10.1002/1096-9861(20000710)422:4<556::aid-cne6>3.0.co;2-uopenalex-snapshot
Orbitomedial prefrontal cortical projections to distinct longitudinal columns of the periaqueductal gray in the rat
inferredcites →https://doi.org/10.1002/mpr.138openalex-snapshot
The epidemiology of major depressive episodes: results from the International Consortium of Psychiatric Epidemiology (ICPE) surveys
inferredcites →https://doi.org/10.1007/7854_2014_314openalex-snapshot
Stress, Arousal, and Sleep
inferredcites →https://doi.org/10.1007/s00213-014-3734-8openalex-snapshot
Social stress and escalated drug self-administration in mice II. Cocaine and dopamine in the nucleus accumbens
inferredcites →https://doi.org/10.1007/s00213-015-4034-7openalex-snapshot
Treatment-resistant depression: are animal models of depression fit for purpose?
inferredcites →https://doi.org/10.1007/s002130050230openalex-snapshot
Acquisition of cocaine self-administration after social stress: role of accumbens dopamine
inferredcites →https://doi.org/10.1007/s002130050456openalex-snapshot
Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation
inferredcites →https://doi.org/10.1007/s11682-012-9179-yopenalex-snapshot
Brain regions associated with psychological pain: implications for a neural network and its relationship to physical pain
inferredcites →https://doi.org/10.1016/0091-3057(82)90054-5openalex-snapshot
A further parametric study of imipramine in an animal model of depression
inferredcites →https://doi.org/10.1016/0149-7634(81)90005-1openalex-snapshot
Acute and chronic stress effects on open field activity in the rat: Implications for a model of depression
inferredcites →https://doi.org/10.1016/0278-5846(84)90021-6openalex-snapshot
Responding for brain stimulation: Stress and desmethylimipramine
inferredcites →https://doi.org/10.1016/j.bbr.2004.05.013openalex-snapshot
Effect of repeated corticosterone injections and restraint stress on anxiety and depression-like behavior in male rats
inferredcites →https://doi.org/10.1016/j.bbr.2014.12.044openalex-snapshot
Effects of Npas4 deficiency on anxiety, depression-like, cognition and sociability behaviour
inferredcites →https://doi.org/10.1016/j.biopsych.2008.09.031openalex-snapshot
Remodeling of Hippocampal Spine Synapses in the Rat Learned Helplessness Model of Depression
inferredcites →https://doi.org/10.1016/j.biopsych.2008.11.029openalex-snapshot
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
inferredcites →https://doi.org/10.1016/j.brainresprot.2005.09.002openalex-snapshot
Learned helplessness: Validity and reliability of depressive-like states in mice
inferredcites →https://doi.org/10.1016/j.cell.2007.09.018openalex-snapshot
Molecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward Regions
inferredcites →https://doi.org/10.1016/j.coph.2007.10.013openalex-snapshot
VEGF as a potential target for therapeutic intervention in depression
inferredcites →https://doi.org/10.1016/j.ejpain.2005.06.009openalex-snapshot
Survey of chronic pain in Europe: Prevalence, impact on daily life, and treatment
inferredcites →https://doi.org/10.1016/j.euroneuro.2015.06.007openalex-snapshot
Inflammation and clinical response to treatment in depression: A meta-analysis
inferredcites →https://doi.org/10.1016/j.euroneuro.2015.12.039openalex-snapshot
The 5-HT1A receptor in Major Depressive Disorder
inferredcites →https://doi.org/10.1016/j.jad.2008.11.021openalex-snapshot
Structural brain abnormalities in major depressive disorder: A selective review of recent MRI studies
inferredcites →https://doi.org/10.1016/j.jad.2010.10.022openalex-snapshot
Pain as a symptom of depression: Prevalence and clinical correlates in patients attending psychiatric clinics
inferredcites →https://doi.org/10.1016/j.neubiorev.2005.03.010openalex-snapshot
The olfactory bulbectomised rat as a model of depression
inferredcites →https://doi.org/10.1016/j.neubiorev.2005.03.015openalex-snapshot
The Flinders Sensitive Line rat: A selectively bred putative animal model of depression
inferredcites →https://doi.org/10.1016/j.neuroimage.2010.12.013openalex-snapshot
Contribution of chronic pain and neuroticism to abnormal forebrain gray matter in patients with temporomandibular disorder
inferredcites →https://doi.org/10.1016/j.neuron.2010.03.002openalex-snapshot
Predicting Value of Pain and Analgesia: Nucleus Accumbens Response to Noxious Stimuli Changes in the Presence of Chronic Pain
inferredcites →https://doi.org/10.1016/j.neuron.2016.04.015openalex-snapshot
Circuit-wide Transcriptional Profiling Reveals Brain Region-Specific Gene Networks Regulating Depression Susceptibility
inferredcites →https://doi.org/10.1016/j.neuropharm.2011.02.024openalex-snapshot
Overlapping neurobiology of learned helplessness and conditioned defeat: Implications for PTSD and mood disorders
inferredcites →https://doi.org/10.1016/j.neuroscience.2015.06.033openalex-snapshot
The ins and outs of the striatum: Role in drug addiction
inferredcites →https://doi.org/10.1016/j.nicl.2014.08.019openalex-snapshot
Disrupted functional connectivity of the periaqueductal gray in chronic low back pain
inferredcites →https://doi.org/10.1016/j.pain.2014.05.018openalex-snapshot
Activation of mesocorticolimbic reward circuits for assessment of relief of ongoing pain: A potential biomarker of efficacy
inferredcites →https://doi.org/10.1016/j.pneurobio.2010.05.002openalex-snapshot
Heat shock proteins: Cellular and molecular mechanisms in the central nervous system
inferredcites →https://doi.org/10.1016/j.pnpbp.2010.12.017openalex-snapshot
The new ‘5-HT’ hypothesis of depression: Cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression
inferredcites →https://doi.org/10.1016/j.pnpbp.2010.12.026openalex-snapshot
Structural and functional neuroimaging studies of the suicidal brain
inferredcites →https://doi.org/10.1016/j.pnpbp.2016.02.006openalex-snapshot
A meta-analysis of chemokines in major depression
inferredcites →https://doi.org/10.1016/j.tins.2008.08.002openalex-snapshot
Limbic and cortical information processing in the nucleus accumbens
inferredcites →https://doi.org/10.1016/j.yhbeh.2006.06.022openalex-snapshot
Social conflict models: Can they inform us about human psychopathology?
inferredcites →https://doi.org/10.1016/j.ynstr.2016.08.002openalex-snapshot
The chronic mild stress (CMS) model of depression: History, evaluation and usage
inferredcites →https://doi.org/10.1016/s0006-3223(00)01036-2openalex-snapshot
Regional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response
inferredcites →https://doi.org/10.1016/s0006-3223(01)01336-1openalex-snapshot
Reduced volume of orbitofrontal cortex in major depression
inferredcites →https://doi.org/10.1016/s0031-9384(03)00209-9openalex-snapshot
Chronic psychosocial stress persistently alters autonomic function and physical activity in mice
inferredcites →https://doi.org/10.1016/s0079-6123(02)36037-0openalex-snapshot
Chapter 35 Serotonin brain circuits involved in major depression and suicide
inferredcites →https://doi.org/10.1016/s0149-7634(05)80194-0openalex-snapshot
Chronic mild stress-induced anhedonia: A realistic animal model of depression
inferredcites →https://doi.org/10.1016/s0893-133x(99)00124-4openalex-snapshot
Atrophy and High Intensity Lesions Complementary Neurobiological Mechanisms in Late-Life Major Depression
inferredcites →https://doi.org/10.1016/s1734-1140(13)71517-2openalex-snapshot
Oxidative stress markers in affective disorders
inferredcites →https://doi.org/10.1017/s1461145708009863openalex-snapshot
Association of X-box binding protein 1 ( XBP1) genotype with morning cortisol and 1-year clinical course after a major depressive episode
inferredcites →https://doi.org/10.1017/s1461145713001570openalex-snapshot
Optogenetic activation of GABAergic neurons in the nucleus accumbens decreases the activity of the ventral pallidum and the expression of cocaine-context-associated memory
inferredcites →https://doi.org/10.1021/cn300238jopenalex-snapshot
Social Stress Alters Inhibitory Synaptic Input to Distinct Subpopulations of Raphe Serotonin Neurons
inferredcites →https://doi.org/10.1037//0033-2909.112.2.218openalex-snapshot
Uncontrollability and unpredictability in post-traumatic stress disorder: An animal model.
inferredcites →https://doi.org/10.1037/rev0000033openalex-snapshot
Learned helplessness at fifty: Insights from neuroscience.
inferredcites →https://doi.org/10.1038/mp.2009.124openalex-snapshot
Genome-wide association study of recurrent early-onset major depressive disorder
inferredcites →https://doi.org/10.1038/mp.2012.32openalex-snapshot
Exposure to violence during childhood is associated with telomere erosion from 5 to 10 years of age: a longitudinal study
inferredcites →https://doi.org/10.1038/mp.2013.105openalex-snapshot
Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N=9484)
inferredcites →https://doi.org/10.1038/nature07455openalex-snapshot
The molecular neurobiology of depression
inferredcites →https://doi.org/10.1038/nature11713openalex-snapshot
Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons
inferredcites →https://doi.org/10.1038/ncomms8062openalex-snapshot
Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression
inferredcites →https://doi.org/10.1038/nn.3153openalex-snapshot
Corticostriatal functional connectivity predicts transition to chronic back pain
inferredcites →https://doi.org/10.1038/nn.3591openalex-snapshot
Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway
inferredcites →https://doi.org/10.1038/nn.4034openalex-snapshot
Excitatory transmission at thalamo-striatal synapses mediates susceptibility to social stress
inferredcites →https://doi.org/10.1038/nn.4086openalex-snapshot
Mechanisms of stress in the brain
inferredcites →https://doi.org/10.1038/npp.2011.220openalex-snapshot
Depression, Antidepressants, and Neurogenesis: A Critical Reappraisal
inferredcites →https://doi.org/10.1038/npp.2012.73openalex-snapshot
Epigenetics of the Depressed Brain: Role of Histone Acetylation and Methylation
inferredcites →https://doi.org/10.1038/nrn3516openalex-snapshot
Cognitive and emotional control of pain and its disruption in chronic pain
inferredcites →https://doi.org/10.1038/s41398-019-0550-2openalex-snapshot
Genome-wide profiling of DNA methylome and transcriptome in peripheral blood monocytes for major depression: A Monozygotic Discordant Twin Study
inferredcites →https://doi.org/10.1038/sj.mp.4002097openalex-snapshot
Repeated social defeat-induced depression-like behavioral and biological alterations in rats: involvement of cholecystokinin
inferredcites →https://doi.org/10.1038/sj.npp.1300506openalex-snapshot
Discovering Endophenotypes for Major Depression
inferredcites →https://doi.org/10.1038/sj.npp.1301408openalex-snapshot
Deep Brain Stimulation to Reward Circuitry Alleviates Anhedonia in Refractory Major Depression
inferredcites →https://doi.org/10.1038/srep19615openalex-snapshot
Overlapping signatures of chronic pain in the DNA methylation landscape of prefrontal cortex and peripheral T cells
inferredcites →https://doi.org/10.1073/pnas.0407162101openalex-snapshot
Accelerated telomere shortening in response to life stress
inferredcites →https://doi.org/10.1073/pnas.1214605109openalex-snapshot
Pain relief produces negative reinforcement through activation of mesolimbic reward–valuation circuitry
inferredcites →https://doi.org/10.1073/pnas.1816456116openalex-snapshot
REM sleep’s unique associations with corticosterone regulation, apoptotic pathways, and behavior in chronic stress in mice
inferredcites →https://doi.org/10.1080/15622970903131571openalex-snapshot
Anatomical and functional correlates in major depressive disorder: The contribution of neuroimaging studies
inferredcites →https://doi.org/10.1093/brain/awt211openalex-snapshot
Shape shifting pain: chronification of back pain shifts brain representation from nociceptive to emotional circuits
inferredcites →https://doi.org/10.1097/00001756-199806220-00021openalex-snapshot
Amygdala core nuclei volumes are decreased in recurrent major depression
inferredcites →https://doi.org/10.1097/psy.0b013e31820ad12bopenalex-snapshot
Depression and Hypothalamic-Pituitary-Adrenal Activation: A Quantitative Summary of Four Decades of Research
inferredcites →https://doi.org/10.1111/cns.12760openalex-snapshot
Fibroblast growth factor 22 is a novel modulator of depression through interleukin‐1β
inferredcites →https://doi.org/10.1111/cns.12998openalex-snapshot
A brain network model for depression: From symptom understanding to disease intervention
inferredcites →https://doi.org/10.1111/cns.13463openalex-snapshot
Low‐intensity pulsed ultrasound ameliorates depression‐like behaviors in a rat model of chronic unpredictable stress
inferredcites →https://doi.org/10.1111/gbb.12106openalex-snapshot
Beyond modules and hubs: the potential of gene coexpression networks for investigating molecular mechanisms of complex brain disorders
inferredcites →https://doi.org/10.1111/j.1460-9568.2011.07668.xopenalex-snapshot
Reduction in hippocampal neurogenesis after social defeat is long-lasting and responsive to late antidepressant treatment
inferredcites →https://doi.org/10.1111/j.1601-183x.2012.00848.xopenalex-snapshot
Hippocampal SPARC regulates depression‐related behavior
inferredcites →https://doi.org/10.1124/pr.116.012484openalex-snapshot
The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis
inferredcites →https://doi.org/10.1126/science.1249240openalex-snapshot
Enhancing Depression Mechanisms in Midbrain Dopamine Neurons Achieves Homeostatic Resilience
inferredcites →https://doi.org/10.1126/scisignal.aaj1549openalex-snapshot
Neuropathic pain promotes adaptive changes in gene expression in brain networks involved in stress and depression
inferredcites →https://doi.org/10.1146/annurev.me.23.020172.002203openalex-snapshot
Learned Helplessness
inferredcites →https://doi.org/10.1155/2016/4842159openalex-snapshot
Maladaptive Plasticity and Neuropathic Pain
inferredcites →https://doi.org/10.1155/2016/6402942openalex-snapshot
The Role of Stress Regulation on Neural Plasticity in Pain Chronification
inferredcites →https://doi.org/10.1159/000350094openalex-snapshot
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
inferredcites →https://doi.org/10.1159/000369974openalex-snapshot
Molecular and Genetic Characterization of Depression: Overlap with Other Psychiatric Disorders and Aging
inferredcites →https://doi.org/10.1176/ajp.2006.163.10.1784openalex-snapshot
Lack of Ventral Striatal Response to Positive Stimuli in Depressed Versus Normal Subjects
inferredcites →https://doi.org/10.1176/appi.ajp.160.1.64openalex-snapshot
The Neural Substrates of Affective Processing in Depressed Patients Treated With Venlafaxine
inferredcites →https://doi.org/10.1186/1741-7015-10-156openalex-snapshot
Data-driven subtypes of major depressive disorder: a systematic review
inferredcites →https://doi.org/10.1186/1744-8069-9-21openalex-snapshot
Peripheral Nerve Injury is Accompanied by Chronic Transcriptome-Wide Changes in the Mouse Prefrontal Cortex
inferredcites →https://doi.org/10.1186/2045-5380-1-9openalex-snapshot
Criteria of validity for animal models of psychiatric disorders: focus on anxiety disorders and depression
inferredcites →https://doi.org/10.1186/s12874-015-0080-4openalex-snapshot
Decomposing the heterogeneity of depression at the person-, symptom-, and time-level: latent variable models versus multimode principal component analysis
inferredcites →https://doi.org/10.1186/s13059-018-1436-yopenalex-snapshot
Ythdf2-mediated m6A mRNA clearance modulates neural development in mice
inferredcites →https://doi.org/10.1242/jcs.110379openalex-snapshot
An α7 nicotinic receptor-G protein pathway complex regulates neurite growth in neural cells*
inferredcites →https://doi.org/10.1248/bpb.b18-00221openalex-snapshot
Activation of GABAergic Neurons in the Nucleus Accumbens Mediates the Expression of Cocaine-Associated Memory
inferredcites →https://doi.org/10.1371/journal.pone.0017837openalex-snapshot
Leukocyte Telomere Length in Major Depression: Correlations with Chronicity, Inflammation and Oxidative Stress - Preliminary Findings
inferredcites →https://doi.org/10.1371/journal.pone.0040516openalex-snapshot
High Phobic Anxiety Is Related to Lower Leukocyte Telomere Length in Women
inferredcites →https://doi.org/10.1503/jpn.140119openalex-snapshot
Voxel-wise meta-analyses of brain blood flow and local synchrony abnormalities in medication-free patients with major depressive disorder
inferredcites →https://doi.org/10.1523/eneuro.0229-16.2016openalex-snapshot
Activation of a Habenulo–Raphe Circuit Is Critical for the Behavioral and Neurochemical Consequences of Uncontrollable Stress in the Male Rat
inferredcites →https://doi.org/10.1523/jneurosci.3862-14.2015openalex-snapshot
Endogenous Opioid Activity in the Anterior Cingulate Cortex Is Required for Relief of Pain
inferredcites →https://doi.org/10.2174/1570159x14666160229114755openalex-snapshot
Mitochondrial Dysfunction in Depression
inferredcites →https://doi.org/10.3109/10253899609001093openalex-snapshot
Changes in Behaviour and Body Weight Following a Single or Double Social Defeat in Rats
inferredcites →https://doi.org/10.3109/15622970109027497openalex-snapshot
Structural Neuroimaging Studies in Late-Life Depression: A Review
inferredcites →https://doi.org/10.3109/15622970903131571openalex-snapshot
Anatomical and functional correlates in major depressive disorder: The contribution of neuroimaging studies
inferredcites →https://doi.org/10.3109/15622971003611319openalex-snapshot
Serum and plasma BDNF levels in major depression: A replication study and meta-analyses
inferredcites →https://doi.org/10.31887/dcns.2002.4.1/bbondyopenalex-snapshot
Pathophysiology of depression and mechanisms of treatment
inferredcites →https://doi.org/10.3389/fendo.2016.00137openalex-snapshot
Paraventricular Hypothalamic Mechanisms of Chronic Stress Adaptation
inferredcites →https://doi.org/10.3389/fgene.2019.00703openalex-snapshot
Co-Expression Network Analysis Revealed That the ATP5G1 Gene Is Associated With Major Depressive Disorder
inferredcites →https://doi.org/10.3389/fnhum.2015.00018openalex-snapshot
Risk assessment and predicting outcomes in patients with depressive symptoms: a review of potential role of peripheral blood based biomarkers
inferredcites →https://doi.org/10.3389/fnins.2018.00386openalex-snapshot
Mitochondria and Mood: Mitochondrial Dysfunction as a Key Player in the Manifestation of Depression
inferredcites →https://doi.org/10.3389/fnmol.2017.00454openalex-snapshot
Profiling and Co-expression Network Analysis of Learned Helplessness Regulated mRNAs and lncRNAs in the Mouse Hippocampus
inferredcites →https://doi.org/10.4088/jcp.08m04114openalex-snapshot
Frequency of Painful Physical Symptoms With Major Depressive Disorder in Asia
inferredcites →https://doi.org/10.5152/npa.2017.19482openalex-snapshot
Suggested Biomarkers for Major Depressive Disorder
inferredcites →https://doi.org/10.7150/ijms.13800openalex-snapshot
Systematic Review of Metabolic Syndrome Biomarkers: A Panel for Early Detection, Management, and Risk Stratification in the West Virginian Population

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1002/bab.70043openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/fsn3.70961openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/978-1-0716-5226-8_23openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/978-3-031-50624-6_6openalex-snapshot
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Chronic social comparison elicits depression- and anxiety-like behaviors and alterations in brain-derived neurotrophic factor expression in male rats
inferred← citeshttps://doi.org/10.1007/s11011-025-01748-xopenalex-snapshot
Lactobacillus fermentum ATCC 9338 ameliorates immune dysregulation via indoleamine 2, 3-dioxygenase through modulating gut microbial diversity of chronic unpredictable mild stressed mouse
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Astrocytic P2X7 receptor regulates depressive-like behavioral reactions of mice in response to acute stressful stimulation
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inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e35363openalex-snapshot
Comparison of CUMS at different pregnancy stages, maternal separation, and their effects on offspring in postpartum depression mouse models
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Activation differentiates illness trajectories among youth seeking mental health care
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inferred← citeshttps://doi.org/10.1016/j.joim.2025.09.003openalex-snapshot
Acupuncture in depression treatment: Insights into astrocyte regulation
inferred← citeshttps://doi.org/10.1016/j.jpsychires.2025.07.039openalex-snapshot
Association between depressive symptoms and cognitive performance in middle-aged and older adults across digital divide
inferred← citeshttps://doi.org/10.1016/j.jveb.2025.04.004openalex-snapshot
Toward a diagnostic framework for the equine depressive phenotype: A narrative review
inferred← citeshttps://doi.org/10.1016/j.nbd.2026.107533openalex-snapshot
Effects of paternal and maternal depression on offspring: Manifestations, mechanisms, and interventions
inferred← citeshttps://doi.org/10.1016/j.neubiorev.2024.105925openalex-snapshot
Role of the locus coeruleus-noradrenergic system in stress-related psychopathology and resilience: Clinical and pre-clinical evidences
inferred← citeshttps://doi.org/10.1016/j.neuro.2023.06.007openalex-snapshot
Isochlorogenic acid B alleviates lead-induced anxiety, depression and neuroinflammation in mice by the BDNF pathway
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2024.10.057openalex-snapshot
Comparative transcriptional analyses of the striatum in the chronic social defeat stress model in C57BL/6J male mice and the gut microbiota-dysbiosis model in Kumming mice
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2025.08.013openalex-snapshot
New insights into the molecular pathophysiology and treatment of depression
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2024.108624openalex-snapshot
Immunotherapy for depression: Recent insights and future targets
inferred← citeshttps://doi.org/10.1016/j.physbeh.2023.114374openalex-snapshot
Smooth muscle contraction of the fundus of stomach, duodenum and bladder from mice exposed to a stress-based model of depression
inferred← citeshttps://doi.org/10.1016/j.pnpbp.2025.111400openalex-snapshot
Sirtuin 1 underlies depression-related behaviors by modulating the serotonin system in the dorsal raphe nucleus in female mice
inferred← citeshttps://doi.org/10.1016/j.psyneuen.2024.107261openalex-snapshot
Chronic stress induces depression-like behavior in rats through affecting brain mitochondrial function and inflammation
inferred← citeshttps://doi.org/10.1016/j.redox.2024.103060openalex-snapshot
NADPH-oxidases as potential pharmacological targets for thrombosis and depression comorbidity
inferred← citeshttps://doi.org/10.1016/j.tips.2025.08.012openalex-snapshot
Emerging mechanisms of psilocybin-induced neuroplasticity
inferred← citeshttps://doi.org/10.1016/j.wjam.2024.03.002openalex-snapshot
The rapid antidepressant effect of acupuncture on two animal models of depression by increasing the expression of synaptic proteins in the prefrontal cortex
inferred← citeshttps://doi.org/10.1017/9781009342919.035openalex-snapshot
Individual Differences
inferred← citeshttps://doi.org/10.1017/9781009342919.039openalex-snapshot
Preclinical Models of Emotional Dysregulations in Animals
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.4c02467openalex-snapshot
Insights for the Next Generation of Ketamine for the Treatment of Depressive Disorder
inferred← citeshttps://doi.org/10.1038/s41380-022-01725-1openalex-snapshot
Integrative multi-omics landscape of fluoxetine action across 27 brain regions reveals global increase in energy metabolism and region-specific chromatin remodelling
inferred← citeshttps://doi.org/10.1038/s41398-025-03326-2openalex-snapshot
Dynamic alterations of depressive-like behaviors, gut microbiome, and fecal metabolome in social defeat stress mice
inferred← citeshttps://doi.org/10.1038/s41398-025-03761-1openalex-snapshot
NADPH alleviates LPS-induced neuropathology and depression-like behaviors by suppressing microglial inflammatory response
inferred← citeshttps://doi.org/10.1038/s41401-026-01874-xopenalex-snapshot
GATA3 drives chronic stress-induced depressive-like behaviors by reducing hippocampal CA3 pyramidal neuronal activity in male mice
inferred← citeshttps://doi.org/10.1038/s41598-025-22321-7openalex-snapshot
Depression in mice causes decreased neuronal excitability and enhanced frequency adaptation in medial prefrontal cortex pyramidal neurons
inferred← citeshttps://doi.org/10.1038/s41598-026-35400-0openalex-snapshot
Targeting the NLRP3 inflammasome alleviates the comorbidity of chronic pain and depression via enhancing the autophagy
inferred← citeshttps://doi.org/10.1039/d5fo05615bopenalex-snapshot
Dietary polyphenols as modulators of the microbiota–gut–brain axis in depression and anxiety: a preclinical perspective
inferred← citeshttps://doi.org/10.1055/a-2784-3589openalex-snapshot
Intestinal Flora and Depression: Interaction Mechanisms and Therapeutic Prospects
inferred← citeshttps://doi.org/10.1097/fbp.0000000000000845openalex-snapshot
Resveratrol improves ovariectomy and chronic restraint stress-induced depression-like behaviors in mice through brain-derived neurotrophic factor associated structural synaptic remodeling
inferred← citeshttps://doi.org/10.1097/wnf.0000000000000568openalex-snapshot
Changes of Serum C-Reactive Protein Level in Patients With Depressive Disorders After Treatment With Agomelatine Combined With Aerobic Exercise and Its Significance
inferred← citeshttps://doi.org/10.1111/cns.14091openalex-snapshot
Sex difference in prebiotics on gut and blood–brain barrier dysfunction underlying stress‐induced anxiety and depression
inferred← citeshttps://doi.org/10.1111/cns.14614openalex-snapshot
Transcutaneous auricular vagus nerve stimulation ameliorates adolescent depressive‐ and anxiety‐like behaviors via hippocampus glycolysis and inflammation response
inferred← citeshttps://doi.org/10.1111/eos.12882openalex-snapshot
Effect of daily treadmill running exercise on masseter muscle nociception associated with social defeat stress in mice
inferred← citeshttps://doi.org/10.1134/s0022093023060340openalex-snapshot
Peculiarities of Fear Memory Extinction in Male and Female Disc1-Q31L Mice
inferred← citeshttps://doi.org/10.11569/wcjd.v32.i12.878openalex-snapshot
Role of oral-gut-brain axis in psychiatric and neurological disorders
inferred← citeshttps://doi.org/10.11606/t.5.2023.tde-01022024-162418openalex-snapshot
Caracterização comportamental e alterações fisiológicas de camundongos BALB/c (Mus musculus) infectados com cepas geneticamente distintas de Toxoplasma gondii
inferred← citeshttps://doi.org/10.1186/s12903-025-05886-7openalex-snapshot
The association between traumatic temporomandibular joint bony ankylosis and depressive disorder in growing rats
inferred← citeshttps://doi.org/10.1186/s12974-023-02964-xopenalex-snapshot
Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis
inferred← citeshttps://doi.org/10.15212/amm-2024-0097openalex-snapshot
Catapol: a promising natural neuroprotective agent for neurologic disorders
inferred← citeshttps://doi.org/10.17816/ped16125-34openalex-snapshot
Early postnatal maternal temporary isolation stress in rats contributes to the development of anxiety-depressive symptoms in adulthood
inferred← citeshttps://doi.org/10.17816/rcf622940openalex-snapshot
Early stress in maternal deprivation affects the expression of OX1R in the limbic system of the brain and contributes to the development of anxiety-depressive symptoms in rats
inferred← citeshttps://doi.org/10.20944/preprints202407.1951.v1openalex-snapshot
Evaluation of the Correlation Between Depression Intensity and Inflammation Levels in Patients with Major Depressive Disorder: A Case-Control Study
inferred← citeshttps://doi.org/10.21203/rs.3.rs-3740670/v1openalex-snapshot
Lithium Carbonate Alleviate Neuronal Apoptosis to Improve Depression Symptoms in Mice by the JNK/c-Jun Signaling Pathway
inferred← citeshttps://doi.org/10.2147/ijn.s456632openalex-snapshot
Nanomaterial-Based Strategies for Attenuating T-Cell-Mediated Immunodepression in Stroke Patients: Advancing Research Perspectives
inferred← citeshttps://doi.org/10.2174/0115672026403497250910124233openalex-snapshot
Cannabinoid Receptor 1: The Neural Gatekeeper of Health and Disease
inferred← citeshttps://doi.org/10.2174/0115734099305381240613114436openalex-snapshot
Antidepressant Properties of a Four-compound Cocktail Identified from Si-Ni-San by HIF-1 Pathway Modulation
inferred← citeshttps://doi.org/10.2174/2215083809666230223121504openalex-snapshot
Terpenoids and Triterpenoid Saponins: Future Treatment for Depression
inferred← citeshttps://doi.org/10.31083/fbl25706openalex-snapshot
Oxidative and Excitatory Neurotoxic Stresses in CRISPR/Cas9-Induced Kynurenine Aminotransferase Knockout Mice: A Novel Model for Despair-Based Depression and Post-Traumatic Stress Disorder
inferred← citeshttps://doi.org/10.31857/s0869813923120038openalex-snapshot
Peculiarities of Fear Memory Disturbance in Male and Female Disc1-Q31L Mice
inferred← citeshttps://doi.org/10.3389/fcimb.2023.1282431openalex-snapshot
Review of microbiota gut brain axis and innate immunity in inflammatory and infective diseases
inferred← citeshttps://doi.org/10.3389/fmicb.2026.1820578openalex-snapshot
Transcutaneous auricular vagus nerve stimulation improves depressive-like behaviors in CUMS rats through regulation of gut microbiome, serum metabolites, and immune factors
inferred← citeshttps://doi.org/10.3389/fncir.2025.1516839openalex-snapshot
Optogenetics and chemogenetics: key tools for modulating neural circuits in rodent models of depression
inferred← citeshttps://doi.org/10.3389/fnins.2022.1013363openalex-snapshot
Olfactory loss is a predisposing factor for depression, while olfactory enrichment is an effective treatment for depression
inferred← citeshttps://doi.org/10.3389/fpsyt.2025.1539596openalex-snapshot
Utilizing metagenomic profiling and machine learning model to identify bacterial biomarkers for major depressive disorder
inferred← citeshttps://doi.org/10.3389/fvets.2026.1757427openalex-snapshot
An overview of the benefits of animal-assisted interventions in medical and therapeutic contexts for human health: cognitive mechanisms, sensory perception and welfare considerations
inferred← citeshttps://doi.org/10.3389/fvets.2026.1878991openalex-snapshot
Emotional pain in non-human mammals: from neural circuitry and opioid signaling to dysthymia-like states, grief-like behaviors, and physiological dysregulation
inferred← citeshttps://doi.org/10.3390/ani15111525openalex-snapshot
Stoicism or Defeat? The Psychological Impact of the Kiln Environment on Working Donkeys and Mules
inferred← citeshttps://doi.org/10.3390/bioengineering13040425openalex-snapshot
Hypoglossal Nerve Transection Induces Anxiety- and Depression-like Behaviors with HPA Axis Dysregulation in Rats
inferred← citeshttps://doi.org/10.3390/biomedicines12112501openalex-snapshot
Predictive Value of Inflammatory Biomarkers in Assessing Major Depression in Adults
inferred← citeshttps://doi.org/10.3390/cells12030381openalex-snapshot
StressMatic: A Novel Automated System to Induce Depressive- and Anxiety-like Phenotype in Rats
inferred← citeshttps://doi.org/10.3390/ijms231911423openalex-snapshot
Postsynaptic Proteins at Excitatory Synapses in the Brain—Relationship with Depressive Disorders
inferred← citeshttps://doi.org/10.3390/ijms24076014openalex-snapshot
The Role of Gasotransmitter-Dependent Signaling Mechanisms in Apoptotic Cell Death in Cardiovascular, Rheumatic, Kidney, and Neurodegenerative Diseases and Mental Disorders
inferred← citeshttps://doi.org/10.3390/ijms252011315openalex-snapshot
Extremely Low-Frequency Electromagnetic Field (ELF-EMF) Increases Mitochondrial Electron Transport Chain Activities and Ameliorates Depressive Behaviors in Mice
inferred← citeshttps://doi.org/10.3390/ijms26199359openalex-snapshot
Effect of Chronic Social Defeat Stress on the Small-Intestinal Environment, Including the Gut Flora, Immune System, and Mucosal Barrier Integrity
inferred← citeshttps://doi.org/10.3390/scipharm90030050openalex-snapshot
Antidepressant Effect of Neuropeptide Y in Models of Acute and Chronic Stress
inferred← citeshttps://doi.org/10.36347/sjmcr.2023.v11i02.002openalex-snapshot
A Short Review on Animal Models in Psychopharmacology
inferred← citeshttps://doi.org/10.5498/wjp.v14.i6.985openalex-snapshot
Bibliometric analysis of research in epilepsy and comorbid depression from 2014 to 2023
inferred← citeshttps://doi.org/10.5498/wjp.v15.i12.113433openalex-snapshot
Selecting an appropriate stress model of depression in rodents
inferred← citeshttps://doi.org/10.64898/2026.02.17.706464openalex-snapshot
A shared transcriptional network in the nucleus accumbens supports resilience to chronic stress across sex
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