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Metformin‐associated lactic acidosis ( MALA ): M oving towards a new paradigm
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Outgoing claims: the papers this work cites, builds on, or argues with.
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The Effect of Intravenous Lactate on Cerebral Function During Hypoglycaemia
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Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus
inferredcites →https://doi.org/10.1002/14651858.cd002967.pub4openalex-snapshot
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus
inferredcites →https://doi.org/10.1002/bdd.2041openalex-snapshot
Metoprolol decreases the plasma exposure of metformin via the induction of liver, kidney and muscle uptake in rats
inferredcites →https://doi.org/10.1002/pds.3501openalex-snapshot
Metformin therapy and kidney disease: a review of guidelines and proposals for metformin withdrawal around the world
inferredcites →https://doi.org/10.1002/pds.3689openalex-snapshot
Mortality rate in so-called “metformin-associated lactic acidosis”: a review of the data since the 1960s
inferredcites →https://doi.org/10.1007/bf02067117openalex-snapshot
The metabolic effects of thermal injury
inferredcites →https://doi.org/10.1007/bf02440866openalex-snapshot
Metformin-associated lactic acidosis in Sweden 1977–1991
inferredcites →https://doi.org/10.1007/s00125-015-3844-9openalex-snapshot
Metformin and the gastrointestinal tract
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A Comprehensive Review of Drug–Drug Interactions with Metformin
inferredcites →https://doi.org/10.1007/s40262-015-0323-xopenalex-snapshot
Therapeutic Concentrations of Metformin: A Systematic Review
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Kinetics of lactate transport into rat liver in vivo
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Can acute overdose of metformin lead to lactic acidosis?
inferredcites →https://doi.org/10.1016/j.annemergmed.2009.04.023openalex-snapshot
Acute Metformin Overdose: Examining Serum pH, Lactate Level, and Metformin Concentrations in Survivors Versus Nonsurvivors: A Systematic Review of the Literature
inferredcites →https://doi.org/10.1016/j.cmet.2015.01.003openalex-snapshot
Metformin Action: Concentrations Matter
inferredcites →https://doi.org/10.1016/j.diabet.2013.12.003openalex-snapshot
Metformin accumulation without hyperlactataemia and metformin-induced hyperlactataemia without metformin accumulation
inferredcites →https://doi.org/10.1016/j.ejps.2016.03.020openalex-snapshot
Metformin and cimetidine: Physiologically based pharmacokinetic modelling to investigate transporter mediated drug–drug interactions
inferredcites →https://doi.org/10.1016/j.jdiacomp.2015.06.001openalex-snapshot
Adverse event notifications implicating metformin with lactic acidosis in Australia
inferredcites →https://doi.org/10.1016/j.metabol.2015.10.014openalex-snapshot
Metformin-associated lactic acidosis: Current perspectives on causes and risk
inferredcites →https://doi.org/10.1016/j.mito.2014.05.007openalex-snapshot
Comprehensive review on lactate metabolism in human health
inferredcites →https://doi.org/10.1016/j.phrs.2009.07.001openalex-snapshot
Asymmetric dimethylarginine (ADMA) as a prospective marker of cardiovascular disease and mortality—An update on patient populations with a wide range of cardiovascular risk
inferredcites →https://doi.org/10.1016/s0006-2952(02)00858-4openalex-snapshot
Obligatory role of membrane events in the regulatory effect of metformin on the respiratory chain function
inferredcites →https://doi.org/10.1016/s0140-6736(05)71045-xopenalex-snapshot
Relation between muscle Na+K+ ATPase activity and raised lactate concentrations in septic shock: a prospective study
inferredcites →https://doi.org/10.1016/s0168-8278(00)80126-9openalex-snapshot
Splanchnic metabolism of fuel substrates in acute liver failure
inferredcites →https://doi.org/10.1016/s1262-3636(07)70024-1openalex-snapshot
Mild acute renal failure potentiates metformin accumulation in the diabetic rat kidney without further impairment of renal function
inferredcites →https://doi.org/10.1021/mp400013topenalex-snapshot
Ischemia/Reperfusion-Inducible Protein Modulates the Function of Organic Cation Transporter 1 and Multidrug and Toxin Extrusion 1
inferredcites →https://doi.org/10.1034/j.1600-0773.2003.930207.xopenalex-snapshot
Survival Following a Metformin Overdose of 63 g: A Case Report
inferredcites →https://doi.org/10.1038/ki.2008.682openalex-snapshot
The Case ∣ A suicidal woman with delayed high anion gap metabolic acidosis
inferredcites →https://doi.org/10.1038/ki.2014.19openalex-snapshot
Metformin and other antidiabetic agents in renal failure patients
inferredcites →https://doi.org/10.1038/nature13270openalex-snapshot
Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
inferredcites →https://doi.org/10.1042/bj2620881openalex-snapshot
Hypoglycaemic effect of metformin in genetically obese (fa/fa) rats results from an increased utilization of blood glucose by intestine
inferredcites →https://doi.org/10.1042/bj3480607openalex-snapshot
Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
inferredcites →https://doi.org/10.1042/cs0450543openalex-snapshot
The Effect of Simulated Metabolic Acidosis on Intracellular pH and Lactate Metabolism in the Isolated Perfused Rat Liver
inferredcites →https://doi.org/10.1042/cs0600537openalex-snapshot
The Effect of Combined Ischaemia and Acidosis on Lactate Uptake and Gluconeogenesis in the Perfused Rat Liver
inferredcites →https://doi.org/10.1042/cs0740403openalex-snapshot
Regulation of lactate uptake and lactate production in liver from 48-h-starved rats: Effects of pH, flow and glucose concentration
inferredcites →https://doi.org/10.1042/cs0940157openalex-snapshot
Intravenous Lactate Prevents Cerebral Dysfunction during Hypoglycaemia in Insulin-Dependent Diabetes Mellitus
inferredcites →https://doi.org/10.1046/j.1365-2796.2003.01271.xopenalex-snapshot
Metformin and lactic acidosis: cause or coincidence? A review of case reports
inferredcites →https://doi.org/10.1046/j.1463-1326.2000.00053.xopenalex-snapshot
Metformin and lactic acidosis in diabetic humans
inferredcites →https://doi.org/10.1046/j.1463-1326.2001.00128.xopenalex-snapshot
Lactic acidosis in metformin therapy: searching for a link with metformin in reports of ‘metformin‐associated lactic acidosis’
inferredcites →https://doi.org/10.1046/j.1463-1326.2003.00241.xopenalex-snapshot
Measurement of metformin concentration in erythrocytes:clinical implications
inferredcites →https://doi.org/10.1046/j.1464-5491.1999.00006.xopenalex-snapshot
Metformin‐associated lactic acidosis: a rare or very rare clinical entity?
inferredcites →https://doi.org/10.1056/nejm199508313330902openalex-snapshot
Efficacy of Metformin in Patients with Non-Insulin-Dependent Diabetes Mellitus
inferredcites →https://doi.org/10.1056/nejm199508313330903openalex-snapshot
Metabolic Effects of Metformin in Non-Insulin-Dependent Diabetes Mellitus
inferredcites →https://doi.org/10.1056/nejm199801223380415openalex-snapshot
Lactic Acidosis in Patients with Diabetes Treated with Metformin
inferredcites →https://doi.org/10.1074/jbc.275.1.223openalex-snapshot
Dimethylbiguanide Inhibits Cell Respiration via an Indirect Effect Targeted on the Respiratory Chain Complex I
inferredcites →https://doi.org/10.1081/clt-120026533openalex-snapshot
A Fatal Case of Metformin Poisoning
inferredcites →https://doi.org/10.1093/ajcp/80.4.484openalex-snapshot
Definition of Clinically Relevant Lactic Acidosis in Patients with Internal Diseases
inferredcites →https://doi.org/10.1093/jn/134.10.2848sopenalex-snapshot
Elimination of Asymmetric Dimethylarginine by the Kidney and the Liver: A Link to the Development of Multiple Organ Failure?
inferredcites →https://doi.org/10.1093/ndt/gfn152openalex-snapshot
Metformin-associated lactic acidosis in type 2 diabetes mellitus: incidence and presentation in common clinical practice
inferredcites →https://doi.org/10.1097/ccm.0b013e3181a98899openalex-snapshot
Blood lactate monitoring in critically ill patients: A systematic health technology assessment *
inferredcites →https://doi.org/10.1097/fpc.0b013e32834c0010openalex-snapshot
The pharmacogenetics of metformin and its impact on plasma metformin steady-state levels and glycosylated hemoglobin A1c
inferredcites →https://doi.org/10.1097/shk.0000000000000782openalex-snapshot
Impact of Metformin Use on Lactate Kinetics in Patients with Severe Sepsis and Septic Shock
inferredcites →https://doi.org/10.1111/dme.12017openalex-snapshot
The criteria for metformin‐associated lactic acidosis: the quality of reporting in a large pharmacovigilance database
inferredcites →https://doi.org/10.1111/dme.12959openalex-snapshot
Unexpectedly long half‐life of metformin elimination in cases of metformin accumulation
inferredcites →https://doi.org/10.1111/j.1365-2710.2010.01192.xopenalex-snapshot
Metformin associated lactic acidosis: incidence and clinical correlation with metformin serum concentration measurements
inferredcites →https://doi.org/10.1111/j.1432-1033.1972.tb01846.xopenalex-snapshot
Interaction of Biguanides with Mitochondrial and Synthetic Membranes
inferredcites →https://doi.org/10.1111/j.1476-5381.1992.tb09093.xopenalex-snapshot
Effect of metformin on glucose metabolism in the splanchnic bed
inferredcites →https://doi.org/10.1124/dmd.107.020180openalex-snapshot
Mechanisms Underlying Saturable Intestinal Absorption of Metformin
inferredcites →https://doi.org/10.1124/dmd.112.044875openalex-snapshot
Ablation of Both Organic Cation Transporter (Oct)1 and Oct2 Alters Metformin Pharmacokinetics but Has No Effect on Tissue Drug Exposure and Pharmacodynamics
inferredcites →https://doi.org/10.1124/jpet.114.220350openalex-snapshot
Four Cation-Selective Transporters Contribute to Apical Uptake and Accumulation of Metformin in Caco-2 Cell Monolayers
inferredcites →https://doi.org/10.1124/mol.63.4.844openalex-snapshot
Involvement of Organic Cation Transporter 1 in the Lactic Acidosis Caused by Metformin
inferredcites →https://doi.org/10.1128/mcb.25.15.6496-6508.2005openalex-snapshot
IRIP, a New Ischemia/Reperfusion-Inducible Protein That Participates in the Regulation of Transporter Activity
inferredcites →https://doi.org/10.1136/bmj.1.6055.234-bopenalex-snapshot
Biguanides and lactic acidosis.
inferredcites →https://doi.org/10.1152/ajpendo.00318.2004openalex-snapshot
Impact of flow rate on lactate uptake and gluconeogenesis in glucagon-stimulated perfused livers
inferredcites →https://doi.org/10.1152/ajprenal.1980.239.2.f135openalex-snapshot
Pathophysiology of experimental lactic acidosis in dogs
inferredcites →https://doi.org/10.1152/japplphysiol.01189.2009openalex-snapshot
Lactic acidosis in vivo: testing the link between lactate generation and H+ accumulation in ischemic mouse muscle
inferredcites →https://doi.org/10.1155/2014/717198openalex-snapshot
Interpreting the Consequences of Metformin Accumulation in an Emergency Context: Impact of the Time Frame on the Blood Metformin Levels
inferredcites →https://doi.org/10.1172/jci30558openalex-snapshot
Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action
inferredcites →https://doi.org/10.1186/2110-5820-3-12openalex-snapshot
Clinical use of lactate monitoring in critically ill patients
inferredcites →https://doi.org/10.1186/cc11332openalex-snapshot
Metformin overdose, but not lactic acidosis per se, inhibits oxygen consumption in pigs
inferredcites →https://doi.org/10.1186/cc8885openalex-snapshot
Oxygen consumption is depressed in patients with lactic acidosis due to biguanide intoxication
inferredcites →https://doi.org/10.1186/s12915-016-0287-9openalex-snapshot
Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase
inferredcites →https://doi.org/10.1186/s13054-014-0503-3openalex-snapshot
Sepsis-associated hyperlactatemia
inferredcites →https://doi.org/10.1186/s13054-015-0928-3openalex-snapshot
Impairment of exogenous lactate clearance in experimental hyperdynamic septic shock is not related to total liver hypoperfusion
inferredcites →https://doi.org/10.1186/s40560-015-0105-4openalex-snapshot
Lactate kinetics in sepsis and septic shock: a review of the literature and rationale for further research
inferredcites →https://doi.org/10.1378/chest.124.3.1053openalex-snapshot
Vital Organ Blood Flow During Hyperdynamic Sepsis
inferredcites →https://doi.org/10.1378/chest.15-1703openalex-snapshot
Lactic Acidosis in Sepsis: It’s Not All Anaerobic
inferredcites →https://doi.org/10.1530/jme-12-0007openalex-snapshot
Metformin in cancer: translational challenges
inferredcites →https://doi.org/10.15441/ceem.15.025openalex-snapshot
The effect of liver disease on lactate normalization in severe sepsis and septic shock: a cohort study
inferredcites →https://doi.org/10.2165/11534750-000000000-00000openalex-snapshot
Clinical Pharmacokinetics of Metformin
inferredcites →https://doi.org/10.2165/11536790-000000000-00000openalex-snapshot
Lactic Acidosis Induced by Metformin
inferredcites →https://doi.org/10.2165/11588310-000000000-00000openalex-snapshot
Establishment of a Database of Metformin Plasma Concentrations and Erythrocyte Levels in Normal and Emergency Situations
inferredcites →https://doi.org/10.2169/internalmedicine.55.5415openalex-snapshot
A Fatal Case of Metformin-associated Lactic Acidosis
inferredcites →https://doi.org/10.2337/dc08-1171openalex-snapshot
Metformin, Sulfonylureas, or Other Antidiabetes Drugs and the Risk of Lactic Acidosis or Hypoglycemia
inferredcites →https://doi.org/10.2337/dc13-3023openalex-snapshot
Risk of Lactic Acidosis or Elevated Lactate Concentrations in Metformin Users With Renal Impairment: A Population-Based Cohort Study
inferredcites →https://doi.org/10.2337/dc14-0464openalex-snapshot
Incidence of Lactic Acidosis in Patients With Type 2 Diabetes With and Without Renal Impairment Treated With Metformin: A Retrospective Cohort Study
inferredcites →https://doi.org/10.2337/diab.37.8.1020openalex-snapshot
Measurement of Plasma Glucose, Free Fatty Acid, Lactate, and Insulin for 24 h in Patients With NIDDM
inferredcites →https://doi.org/10.2337/diab.46.9.1406openalex-snapshot
Effects of Metformin on Lactate Uptake and Gluconeogenesis in the Perfused Rat Liver
inferredcites →https://doi.org/10.2337/diacare.18.6.779openalex-snapshot
Role of Metformin Accumulation in Metformin-Associated Lactic Acidosis
inferredcites →https://doi.org/10.2337/diacare.21.10.1659openalex-snapshot
Lactic Acidosis Rates in Type 2 Diabetes
inferredcites →https://doi.org/10.2337/diacare.22.6.925openalex-snapshot
Incidence of lactic acidosis in metformin users.
inferredcites →https://doi.org/10.29046/tmf.016.1.008openalex-snapshot
Metformin Associated Lactic Acidosis
inferredcites →https://doi.org/10.3109/00498259409043220openalex-snapshot
Accumulation of metformin by tissues of the normal and diabetic mouse
inferredcites →https://doi.org/10.5527/wjn.v5.i4.367openalex-snapshot
Metformin associated lactic acidosis in Auckland City Hospital 2005 to 2009
inferredcites →https://doi.org/10.5694/j.1326-5377.2008.tb01713.xopenalex-snapshot
Metformin and lactic acidosis in an Australian community setting: the Fremantle Diabetes Study
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4689669openalex-extracted
The Association between Premorbid Metformin Prescription and Hyperlactataemia in Patients Admitted to Intensive Care with Sepsis: Reanalysis of 2 Retrospective Cohorts
inferred← citeshttps://doi.org/10.1002/2211-5463.70165openalex-snapshot
Metformin promotes mitochondrial integrity through AMPK ‐signaling in Leber's hereditary optic neuropathy
inferred← citeshttps://doi.org/10.1002/9781119329725.ch37openalex-snapshot
Metformin and Lactic Acidosis
inferred← citeshttps://doi.org/10.1002/ccr3.1255openalex-snapshot
Hypoglycemia and severe lactic acidosis in a dog following metformin exposure
inferred← citeshttps://doi.org/10.1002/hsr2.352openalex-snapshot
Association of metformin use on metabolic acidosis in diabetic patients with chronic hepatitis B‐related cirrhosis and renal impairment
inferred← citeshttps://doi.org/10.1002/jcph.70280openalex-snapshot
Endogenous Biomarkers to Evaluate Transporter‐Mediated Drug–Drug Interactions: Current Evidence, Impact on Clinical Pharmacology Strategy, Remaining Gaps, and Future Directions
inferred← citeshttps://doi.org/10.1002/jja2.12513openalex-snapshot
持続血液濾過透析により改善したメトホルミンによる乳酸アシドーシスの1例(A case of intractable lactic acidosis associated with Metformin overdose)
inferred← citeshttps://doi.org/10.1007/s00228-020-02857-5openalex-snapshot
Extracorporeal treatment of metforminassociated lactic acidosis in clinical practice: a retrospective cohort study
inferred← citeshttps://doi.org/10.1007/s00330-021-08395-7openalex-snapshot
Continuous use of metformin in patients receiving contrast medium: what is the evidence? A systematic review and meta-analysis
inferred← citeshttps://doi.org/10.1007/s00508-019-1447-zopenalex-snapshot
Diabetesmanagement im Krankenhaus (Update 2019)
inferred← citeshttps://doi.org/10.1007/s00508-022-02121-zopenalex-snapshot
Positionspapier: Operation und Diabetes mellitus (Update 2023)
inferred← citeshttps://doi.org/10.1007/s00508-023-02177-5openalex-snapshot
Diabetesmanagement im Krankenhaus (Update 2023)
inferred← citeshttps://doi.org/10.1007/s00508-026-02717-9openalex-snapshot
[Hospital diabetes management (Update 2026)].
inferred← citeshttps://doi.org/10.1007/s00726-024-03383-9openalex-snapshot
GC–MS analysis of 4-hydroxyproline: elevated proline hydroxylation in metformin-associated lactic acidosis and metformin-treated Becker muscular dystrophy patients
inferred← citeshttps://doi.org/10.1007/s11096-020-01069-2openalex-snapshot
Identifying patients with metformin associated lactic acidosis in the emergency department
inferred← citeshttps://doi.org/10.1007/s40261-017-0564-6openalex-snapshot
Lactate Levels with Chronic Metformin Use: A Narrative Review
inferred← citeshttps://doi.org/10.1007/s40264-019-00854-xopenalex-snapshot
The Association between Metformin Therapy and Lactic Acidosis
inferred← citeshttps://doi.org/10.1007/s40620-018-00562-2openalex-snapshot
Sustained low-efficiency dialysis for metformin-associated lactic acidosis in patients with acute kidney injury
inferred← citeshttps://doi.org/10.1016/b978-0-12-814466-4.00022-7openalex-snapshot
The Role of Carbohydrate Response Element–Binding Protein in the Development of Liver Diseases
inferred← citeshttps://doi.org/10.1016/b978-0-323-52978-5.00017-3openalex-snapshot
Improving Drug Use and Dosing in Chronic Kidney Disease
inferred← citeshttps://doi.org/10.1016/j.ajem.2018.01.097openalex-snapshot
Metformin-Induced Lactic Acidosis (MILA): Review of current diagnostic paradigm
inferred← citeshttps://doi.org/10.1016/j.ajem.2023.01.048openalex-snapshot
High risk and low prevalence diseases: Toxic alcohol ingestion
inferred← citeshttps://doi.org/10.1016/j.ajem.2023.07.020openalex-snapshot
High risk and low prevalence diseases: Metformin toxicities
inferred← citeshttps://doi.org/10.1016/j.ajem.2026.01.027openalex-snapshot
Clinical differences between metformin-associated lactic acidosis and metformin-unrelated lactic acidosis: A descriptive study
inferred← citeshttps://doi.org/10.1016/j.amjms.2022.01.026openalex-snapshot
Relationship Between Metformin Use and Lactic Acidosis in Advanced Chronic Kidney Disease: The REMIND-TMU Study
inferred← citeshttps://doi.org/10.1016/j.diabet.2018.03.001openalex-snapshot
Metformin-associated lactic acidosis: Are we looking in the right direction?
inferred← citeshttps://doi.org/10.1016/j.diabet.2020.07.006openalex-snapshot
Metformin and COVID-19: From cellular mechanisms to reduced mortality
inferred← citeshttps://doi.org/10.1016/j.diabres.2019.107879openalex-snapshot
Metformin lactic acidosis: Should we still be afraid?
inferred← citeshttps://doi.org/10.1016/j.diii.2021.01.007openalex-snapshot
Kidney and contrast media: Common viewpoint of the French Nephrology societies (SFNDT, FIRN, CJN) and the French Radiological Society (SFR) following ESUR guidelines
inferred← citeshttps://doi.org/10.1016/j.dsx.2020.10.024openalex-snapshot
Importance of de-escalating anti-diabetic medication to prevent hypoglycaemia
inferred← citeshttps://doi.org/10.1016/j.eclinm.2024.102568openalex-snapshot
Clinical outcomes following discontinuation of metformin in patients with type 2 diabetes and advanced chronic kidney disease in Hong Kong: a territory-wide, retrospective cohort and target trial emulation study
inferred← citeshttps://doi.org/10.1016/j.ekir.2020.01.021openalex-snapshot
Long-Standing Hypokalemia and Lactic Acidosis as the Primary Presentation of Mitochondrial Myopathy
inferred← citeshttps://doi.org/10.1016/j.ekir.2020.06.009openalex-snapshot
Renal Trapping in Accidental Metformin Intoxication
inferred← citeshttps://doi.org/10.1016/j.jemermed.2019.06.047openalex-snapshot
Reversible Acute Blindness in Suspected Metformin-Associated Lactic Acidosis
inferred← citeshttps://doi.org/10.1016/j.nefro.2018.04.007openalex-snapshot
Incidencia, factores relacionados con la presentación, evolución y mortalidad de la acidosis láctica asociada a metformina en el área sanitaria de un hospital de tercer nivel
inferred← citeshttps://doi.org/10.1016/j.nefro.2025.501429openalex-snapshot
Intoxicación por metformina: características clínicas, tratamiento y pronóstico
inferred← citeshttps://doi.org/10.1016/j.nefroe.2018.04.012openalex-snapshot
Incidence, factors related to presentation, course and mortality of metformin-associated lactic acidosis in the healthcare area of a tertiary hospital
inferred← citeshttps://doi.org/10.1016/j.nefroe.2026.501429openalex-snapshot
Metformin intoxication: clinical characteristics, treatment and prognosis
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Recommandations ESUR sur l’utilisation des produits de contraste : enquête de pratique, revue et commentaire par le CJN, le FIRN et la SFNDT
inferred← citeshttps://doi.org/10.1016/j.phrs.2022.106114openalex-snapshot
Mitochondria as an important target of metformin: The mechanism of action, toxic and side effects, and new therapeutic applications
inferred← citeshttps://doi.org/10.1016/j.revmed.2024.11.014openalex-snapshot
Acidose lactique liée à la metformine : expérience du centre hospitalier de Saint-Denis
inferred← citeshttps://doi.org/10.1016/j.therap.2024.12.009openalex-snapshot
Lactic acidosis with metformin accumulation in the intensive care units of the Nord Pas de Calais region: A known serious adverse event that can be better prevented
inferred← citeshttps://doi.org/10.1016/j.toxac.2024.08.034openalex-snapshot
Cent acidoses lactiques graves à la metformine (ALAM) : étude observationnelle régionale monocentrique de Pharmacovigilance 2007–2023
inferred← citeshttps://doi.org/10.1016/s0140-6736(24)02384-5openalex-snapshot
The legacy effect of hyperglycaemia in type 2 diabetes – Authors' reply
inferred← citeshttps://doi.org/10.1016/s1957-2557(18)30093-2openalex-snapshot
La metformine dans l’insuffisance rénale : place (enfin) aux faits
inferred← citeshttps://doi.org/10.1016/s2211-9698(25)47062-9openalex-snapshot
Intoxication par la metformine
inferred← citeshttps://doi.org/10.1016/s2213-8587(20)30231-xopenalex-snapshot
Management of diabetes in patients with COVID-19
inferred← citeshttps://doi.org/10.1038/s41598-021-86905-9openalex-snapshot
Metformin prevents stroke damage in non-diabetic female mice with chronic kidney disease
inferred← citeshttps://doi.org/10.1038/s41598-025-87624-1openalex-snapshot
Efficacy of continuous venovenous hemodiafiltration in patients with metformin associated lactic acidosis and acute kidney injury
inferred← citeshttps://doi.org/10.1055/a-2884-3481openalex-snapshot
Diabetes im Krankenhaus – Praxisempfehlung der DDG
inferred← citeshttps://doi.org/10.1080/1028415x.2020.1840050openalex-snapshot
Not only metformin, but also D-allulose, alleviates metabolic disturbance and cognitive decline in prediabetic rats
inferred← citeshttps://doi.org/10.1080/14656566.2021.1912735openalex-snapshot
Careful use to minimize adverse events of oral antidiabetic medications in the elderly
inferred← citeshttps://doi.org/10.1080/14740338.2017.1361400openalex-snapshot
Acid-base and electrolyte disorders associated with the use of antidiabetic drugs
inferred← citeshttps://doi.org/10.1080/14740338.2018.1497159openalex-snapshot
The safety of empagliflozin plus metformin for the treatment of type 2 diabetes
inferred← citeshttps://doi.org/10.1080/14740338.2021.1928072openalex-snapshot
Assessment of suspected adverse drug reactions in elderly patients with diabetes mellitus based on a Portuguese spontaneous reporting database: analysis of reporting from 2008 to 2018
inferred← citeshttps://doi.org/10.1080/15563650.2019.1678757openalex-snapshot
Comment on ‘metformin-related lactic acidosis with acute kidney injury: results of a French observational multicenter study’
inferred← citeshttps://doi.org/10.1080/15563650.2019.1688342openalex-snapshot
Authors’ reply to the comment on « Metformin-Related lactic acidosis with acute kidney injury: results of a French observationnal multicenter study »
inferred← citeshttps://doi.org/10.1093/ckj/sfaf286openalex-snapshot
Regional citrate anticoagulation ensures safe and effective kidney replacement therapy in metformin-associated lactic acidosis
inferred← citeshttps://doi.org/10.1097/ccm.0000000000004589openalex-snapshot
A Study of Associations Between Plasma Metformin Concentration, Lactic Acidosis, and Mortality in an Emergency Hospitalization Context
inferred← citeshttps://doi.org/10.1097/ftd.0000000000001015openalex-snapshot
Relationship Between Plasmatic Metformin Concentration and Renal Replacement Therapy: A Multicenter Cohort Study
inferred← citeshttps://doi.org/10.1097/md.0000000000022492openalex-snapshot
Osmolar-gap in the setting of metformin-associated lactic acidosis
inferred← citeshttps://doi.org/10.1097/md.0000000000032659openalex-snapshot
Metformin-associated severe lactic acidosis combined with multi-organ insufficiency induced by infection with Aeromonas veronii: A case report
inferred← citeshttps://doi.org/10.1097/md.0000000000045007openalex-snapshot
Comprehensive analysis of metformin-associated lactic acidosis: Insights from the FDA Adverse Event Reporting System (FAERS)
inferred← citeshttps://doi.org/10.1097/shk.0000000000002275openalex-snapshot
METFORMIN MITIGATES SEPSIS-ASSOCIATED PULMONARY FIBROSIS BY PROMOTING AMPK ACTIVATION AND INHIBITING HIF-1α–INDUCED AEROBIC GLYCOLYSIS
inferred← citeshttps://doi.org/10.1101/2020.05.26.115337openalex-snapshot
Activation of the Anaphase Promoting Complex reverses multiple drug resistant cancer
inferred← citeshttps://doi.org/10.1111/bcp.14919openalex-snapshot
Does the intact nephron hypothesis provide a reasonable model for metformin dosing in chronic kidney disease?
inferred← citeshttps://doi.org/10.1111/bcpt.13139openalex-snapshot
Using a semi‐mechanistic model to identify the main sources of variability of metformin pharmacokinetics
inferred← citeshttps://doi.org/10.1111/bcpt.13273openalex-snapshot
Metformin overdose: A serious iatrogenic complication—Western France Poison Control Centre Data Analysis
inferred← citeshttps://doi.org/10.1111/dom.12994openalex-snapshot
Metformin‐associated lactic acidosis: M oving towards a new paradigm?
inferred← citeshttps://doi.org/10.1111/dom.13984openalex-snapshot
Metformin and cardiorenal outcomes in diabetes: A reappraisal
inferred← citeshttps://doi.org/10.1111/dom.15663openalex-snapshot
Metformin: Therapeutic profile in the treatment of type 2 diabetes
inferred← citeshttps://doi.org/10.1111/dom.15749openalex-snapshot
Optimizing metformin therapy in practice: Tailoring therapy in specific patient groups to improve tolerability, efficacy and outcomes
inferred← citeshttps://doi.org/10.1111/hdi.13113openalex-snapshot
Metformin‐associated lactic acidosis ( MALA ): Is it an underestimated entity? A retrospective, single‐center case series
inferred← citeshttps://doi.org/10.1136/bcr-2020-235608openalex-snapshot
Metformin-associated lactic acidosis: reinforcing learning points
inferred← citeshttps://doi.org/10.1136/bmjdrc-2019-000816openalex-snapshot
Increasing metformin concentrations and its excretion in both rat and porcine ex vivo normothermic kidney perfusion model
inferred← citeshttps://doi.org/10.1136/dtb.2021.235608repopenalex-snapshot
Republished: Metformin-associated lactic acidosis: reinforcing learning points
inferred← citeshttps://doi.org/10.1159/000528252openalex-snapshot
Metformin’s Role in Hyperlactatemia and Lactic Acidosis in ICU Patients: A Systematic Review
inferred← citeshttps://doi.org/10.1159/000531953openalex-snapshot
Calcium-Citrate Anticoagulation during Continuous Renal Replacement Therapy in Patients with Metformin Intoxication: A Case Series, Mathematical Estimation of Citrate Accumulation, and Literature Review
inferred← citeshttps://doi.org/10.1159/000537712openalex-snapshot
Uncomplicated Calcium-Citrate Anticoagulation during Continuous Renal Replacement Therapy in 2 Other Patients with Metformin Accumulation
inferred← citeshttps://doi.org/10.1177/00368504241262116openalex-snapshot
Metformin exposure and the incidence of lactic acidosis in critically ill patients with T2DM: A retrospective cohort study
inferred← citeshttps://doi.org/10.1177/20101058231204703openalex-snapshot
Unusual case of concurrent metformin-associated lactic acidosis and euglycaemic ketoacidosis
inferred← citeshttps://doi.org/10.1186/s12902-020-00626-0openalex-snapshot
Repurposing existing drugs for COVID-19: an endocrinology perspective
inferred← citeshttps://doi.org/10.1186/s13256-018-1809-6openalex-snapshot
Effect of high-flow high-volume-intermittent hemodiafiltration on metformin-associated lactic acidosis with circulatory failure: a case report
inferred← citeshttps://doi.org/10.1186/s13256-020-02655-8openalex-snapshot
The usefulness of measuring the anion gap in diagnosing metformin-associated lactic acidosis: a case series
inferred← citeshttps://doi.org/10.1186/s40360-022-00588-0openalex-snapshot
Utility of support vector machine and decision tree to identify the prognosis of metformin poisoning in the United States: analysis of National Poisoning Data System
inferred← citeshttps://doi.org/10.1186/s40360-025-00882-7openalex-snapshot
Past use of metformin is associated with increased risk of myelodysplastic syndrome development in diabetes mellitus patients: a cross-sectional study of 54,869 patients
inferred← citeshttps://doi.org/10.1186/s40635-018-0186-1openalex-snapshot
Bioenergetic bypass using cell-permeable succinate, but not methylene blue, attenuates metformin-induced lactate production
inferred← citeshttps://doi.org/10.1186/s40798-019-0192-1openalex-snapshot
Resources to Guide Exercise Specialists Managing Adults with Diabetes
inferred← citeshttps://doi.org/10.1186/s41182-026-00973-zopenalex-snapshot
Metformin-associated lactic acidosis during flood-related healthcare disruption in southern Thailand, 2025: a case series
inferred← citeshttps://doi.org/10.1210/jcemcr/luag109openalex-snapshot
Fatal metformin-associated lactic acidosis in a healthy woman after massive overdose
inferred← citeshttps://doi.org/10.1213/xaa.0000000000001561openalex-snapshot
Achieving High Dialysis Dose via Continuous Renal Replacement Therapy in the Setting of Metformin Associated Lactic Acidosis. A Case Series
inferred← citeshttps://doi.org/10.1371/journal.pone.0246247openalex-snapshot
Metformin doses to ensure efficacy and safety in patients with reduced kidney function
inferred← citeshttps://doi.org/10.1371/journal.pone.0273678openalex-snapshot
Metformin-associated lactic acidosis and factors associated with 30-day mortality
inferred← citeshttps://doi.org/10.14336/ad.2024.0168openalex-snapshot
Delaying Renal Aging: Metformin Holds Promise as a Potential Treatment
inferred← citeshttps://doi.org/10.1530/edm-17-0148openalex-snapshot
Recurrent lactic acidosis and hypoglycemia with inadvertent metformin use: a case of look-alike pills
inferred← citeshttps://doi.org/10.15406/jdmdc.2018.05.00166openalex-snapshot
Metformin-associated lactic acidosis refractory to hemodialysis in the setting of concomitant alcohol intoxication
inferred← citeshttps://doi.org/10.1542/peds.2024-068939openalex-snapshot
Persistent Biventricular Cardiac Dysfunction Following a Large, Acute Metformin Overdose
inferred← citeshttps://doi.org/10.21203/rs.3.rs-4214516/v1openalex-snapshot
Metformin Can Decrease Serum levels of 12(S)-Hydroxyeicosatetraenoic Acid in Adults with Type 2 Diabetes Mellitus and Diabetic Kidney Disease
inferred← citeshttps://doi.org/10.2147/tcrm.s372430openalex-snapshot
Quality and Characteristics of 4241 Case Reports of Lactic Acidosis in Metformin Users Reported to a Large Pharmacovigilance Database
inferred← citeshttps://doi.org/10.2174/1570161117666190405164749openalex-snapshot
Pharmacological Management of Diabetic Nephropathy
inferred← citeshttps://doi.org/10.2298/sarh210420122lopenalex-snapshot
Early initiation of continuous renal replacement therapy for metformin-associated lactic acidosis
inferred← citeshttps://doi.org/10.2337/dc17-2231openalex-snapshot
Metformin Treatment in Patients With Type 2 Diabetes and Chronic Kidney Disease Stages 3A, 3B, or 4
inferred← citeshttps://doi.org/10.23876/j.krcp.20.012openalex-snapshot
Metformin treatment for patients with diabetes and chronic kidney disease: A Korean Diabetes Association and Korean Society of Nephrology consensus statement
inferred← citeshttps://doi.org/10.33590/emjdiabet/19-00177openalex-snapshot
Metformin: From Immediate Release to Extended Release Formula, Effectiveness, And Safety in Patients With Chronic Kidney Disease
inferred← citeshttps://doi.org/10.3389/fmed.2021.704666openalex-snapshot
Metformin in Patients With COVID-19: A Systematic Review and Meta-Analysis
inferred← citeshttps://doi.org/10.3389/fmed.2025.1547725openalex-snapshot
Systematic review and meta-analysis of current guidelines, and their evidence base, on risk of renal function after administration of contrast medium for diabetic patients receiving metformin
inferred← citeshttps://doi.org/10.3389/fphar.2020.00168openalex-snapshot
Adjuvant Therapy With Mushroom Polysaccharides for Diabetic Complications
inferred← citeshttps://doi.org/10.3390/biom13050779openalex-snapshot
Molecular Mechanisms of Obesity-Induced Development of Insulin Resistance and Promotion of Amyloid-β Accumulation: Dietary Therapy Using Weak Organic Acids via Improvement of Lowered Interstitial Fluid pH
inferred← citeshttps://doi.org/10.3390/ecm1020012openalex-snapshot
Metformin-Associated Lactic Acidosis: Which Elimination Therapy to Use in Case of Haemodynamic Instability? A Retrospective Cohort Study
inferred← citeshttps://doi.org/10.3390/ijerph20075300openalex-snapshot
Risk of Lactic Acidosis in Hospitalized Diabetic Patients Prescribed Biguanides in Japan: A Retrospective Total-Population Cohort Study
inferred← citeshttps://doi.org/10.3390/ijms23084338openalex-snapshot
The Role of Systemic Filtrating Organs in Aging and Their Potential in Rejuvenation Strategies
inferred← citeshttps://doi.org/10.3390/jcm10092036openalex-snapshot
SGLT2 Inhibitors, What the Emergency Physician Needs to Know: A Narrative Review
inferred← citeshttps://doi.org/10.3390/jcm13133692openalex-snapshot
Comprehensive GC-MS Measurement of Amino Acids, Metabolites, and Malondialdehyde in Metformin-Associated Lactic Acidosis at Admission and during Renal Replacement Treatment
inferred← citeshttps://doi.org/10.3390/livers5030035openalex-snapshot
Synthalin, Buformin, Phenformin, and Metformin: A Century of Intestinal “Glucose Excretion” as Oral Antidiabetic Strategy in Overweight/Obese Patients
inferred← citeshttps://doi.org/10.3390/ph15091140openalex-snapshot
Attenuated Risk Association of End-Stage Kidney Disease with Metformin in Type 2 Diabetes with eGFR Categories 1–4
inferred← citeshttps://doi.org/10.34172/jcvtr.32877openalex-snapshot
The role of probiotics on microvascular complications of type-2 diabetes: Nephropathy and retinopathy
inferred← citeshttps://doi.org/10.4093/dmj.2020.0004openalex-snapshot
Metformin Treatment for Patients with Diabetes and Chronic Kidney Disease: A Korean Diabetes Association and Korean Society of Nephrology Consensus Statement
inferred← citeshttps://doi.org/10.4103/bjem.bjem_26_24openalex-snapshot
A Case of Metformin Associated Lactic Acidosis
inferred← citeshttps://doi.org/10.4269/ajtmh.20-0766openalex-snapshot
More Studies are Needed on the Link between Metformin and Decreased Mortality in Diabetic COVID-19 Patients
inferred← citeshttps://doi.org/10.53986/ibjm.2025.0007openalex-snapshot
Metformin-Associated Lactic Acidosis (MALA). Our experiencie and a review
inferred← citeshttps://doi.org/10.5772/intechopen.1011446openalex-snapshot
Perspective Chapter: Metformin and its Role in Diabetic Kidney Disease and Glucose Control
inferred← citeshttps://doi.org/10.5937/mgiszm2602085mopenalex-snapshot
Metformin: Associated lactic acidosis
inferred← citeshttps://doi.org/10.70675/bcd240b7z43c2z4dd5z9ed8zae89b2a38dd4openalex-snapshot
Impact de l'insuffisance rénale chronique sur la sévérité des accidents vasculaires cérébraux dans un modèle de souris : rôle de l'adénosine monophosphate-activated protein kinase, AMPK
inferred← citeshttps://doi.org/10.7759/cureus.105129openalex-snapshot
When Metabolism Recovers but the Brain Does Not: A Case Report of Posterior Reversible Encephalopathy Syndrome (PRES)-Like Encephalopathy After Extreme Metformin-Associated Lactic Acidosis
inferred← citeshttps://doi.org/10.7759/cureus.48683openalex-snapshot
Metformin-Associated Lactic Acidosis in Individuals Without Chronic Kidney Disease on Therapeutic Dose: A Case Report
inferred← citeshttps://doi.org/10.7759/cureus.9533openalex-snapshot
A Case Report on Metformin-Associated Lactic Acidosis
inferred← citeshttps://doi.org/10.7759/cureus.97415openalex-snapshot
Metformin-Induced Lactic Acidosis Following Intentional Overdose: A Case Report and Mini Review
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